Diagnosis Commons^™

Nanosecond Pulsed Electric Fields For Extracellular Vesicle Engineering: From Electro-Exocytosis To Cargo Modulation, Art Neal, Teresa Graham, Mohamadmahdi Samandari, Arash Ghorbannia, Anca Dobrian, Stephen J. Beebe, Ruben M. L. Colunga-Biancatelli

Bioelectrics Publications

Extracellular vesicles (EVs), including small extracellular vesicles (sEVs) and medium/large extracellular vesicles (MVs), have emerged as promising therapeutic vectors and diagnostic biomarkers across various branches of biomedicine. However, the clinical translation of EV-based technologies remains constrained by persistent challenges in manufacturing: insufficient yield from primary cell sources, limited control over cargo composition, and the absence of scalable, standardized production platforms. Nanosecond pulsed electric fields (nsPEF) represent an emerging biophysical approach that can address several of these limitations. Unlike conventional electroporation, which targets the plasma membrane using microsecond-to-millisecond pulses, nsPEF delivers ultrashort (1–300 ns), high-amplitude (10–300 kV/cm) pulses that penetrate intracellularly …

A Chicken Model For Non-Invasive Diagnosis Of Infant Developmental Dysplasia Of The Hip (Ddh) Using Acoustic Transmission Measurements, Aliza Shah

Honors Undergraduate Theses

Developmental dysplasia of the hip (DDH) is a condition characterized by abnormal development and stability of the hip joint. In a healthy infant, the femoral head (ball) fits securely within the acetabulum (socket of the pelvis), allowing for proper joint function. In DDH, the relationship is disrupted, ranging from mild acetabular dysplasia to partial (subluxation) or complete dislocation of the femoral head. This condition represents a range of structural abnormalities that develop during early growth. The integrity of the hip joint is essential for physical mobility, and disruption of this structure can lead to significant functional impairment. DDH may result …

Health Literacy/Numeracy-Related Factors Affecting Interpretation In Medical Laboratory Values, Rachel L. Childs

School of Medical Diagnostics & Translational Sciences Publications

Background

Health literacy and numeracy are broad terms that relate to a patient’s understanding of their health information. While there is a substantial amount of research on this topic in a general sense as well as in relation to how deficiencies in these skills impact patients’ understanding of laboratory results, little is known regarding the extent to which underlying factors, which are impacted by health literacy/numeracy, affect how patients interpret their results. This literature review attempts to shed light on the current literature on this more focused and narrow issue, including recommendations to address these barriers.

Content

To perform this …

The Myopia Epidemic: Integrating Genetic, Environmental, And Epigenetic Pathways To Define A Critical Window For Intervention, Pranavika Balaji

UROP Posters

Myopia, or nearsightedness, has increased rapidly worldwide and is now a major public health concern caused by both genetic and environmental factors. Current understanding shows that too much near work, limited time spent outdoors, and prolonged screen use contribute to abnormal eye growth in individuals who may already have a genetic predisposition. At the molecular level, epigenetic changes and shifts in DNA activity, often influenced by environmental conditions, affect the signaling pathways that regulate eye development and may help explain why myopia is increasingly common among children. This paper synthesizes recent environmental, genetic, and epigenetic research to explain how these …

An Analysis Of Pediatric Retinoblastoma Medical Malpractice Litigation, Victoria Miller, Alyssa D. Reese, Katherine Foote, Alejandro Navarro, Andrew Galfano, Christian Hietanen

Department Surgery Faculty Publications

BACKGROUND: Retinoblastoma is a cancer of the retina that is most commonly diagnosed in the pediatric population. Unfortunately, this cancer can spread, leading to poor outcomes such as enucleation. The purpose of this study was to determine the characteristics of medical malpractice litigation associated with a diagnosis of retinoblastoma in the pediatric population.

METHODS: A search for all available cases associated with "retinoblastoma" in the Westlaw Campus Research Legal Database was conducted. This spanned from database inception to August 2023. Cases were included if there was a complaint of medical malpractice related to retinoblastoma present in a pediatric patient. Demographic …

Prognostic Factors For Patients Under 45 Undergoing Surgery For Colorectal Liver Metastases: A Seer Population-Based Study, Gabrielle Grob, Fang Fang, Matvey Karpov, Eric Feliberti, Marybeth Hughes, Rachel Burke, Winifred Lo

Department Surgery Faculty Publications

Background and Objectives: Colorectal cancer (CRC) has been on the rise in adults younger than 50. Surgical resection is a potentially curative treatment option for patients with colorectal liver metastases (CRLM). The aim of this study was to describe patient and tumor characteristics associated with disease-specific survival in young patients (<  45 years) versus older patients (≥ 45 years) with isolated CRLM.

Methods: The SEER database was queried for patients with CRLM who underwent colon and liver resection from 2010 to 2021. Patients under age 20, with metastases beyond the liver, or who had not had surgery for liver metastases were excluded. Cox regression was used to analyze demographic factors, tumor …

Pt/Zno-Decorated Laser-Induced Graphene For Nonenzymatic Glucose Monitoring Under Physiological Conditions, Reagan Aviha, Gymama Slaughter

Center for Bioelectronics Publications

Diabetes continues to impose significant global health and economic burdens, driving the demand for robust, enzyme-free glucose sensors capable of reliable operation under physiological conditions. Here, we report the development of a high-performance nonenzymatic glucose sensor based on laser-induced graphene (LIG) modified with zinc oxide (ZnO) and platinum (Pt) nanostructures. ZnO was electrodeposited onto LIG with modulation potential and deposition duration systematically optimized. The ZnO/LIG electrodes were characterized electrochemically using potassium ferricyanide and evaluated for glucose oxidation in phosphate-buffered solution. Subsequent electrodeposition of Pt under analogous optimized conditions yielded a ternary Pt/ZnO/LIG architecture with enhanced electrocatalytic activity. Sensor performance was …

Use Of Ultrasound In The Pre-Hospital Setting To Differentiate Acute Dyspnea, Kenith D'Souza, Michael Cabebe, Taryn Hoffman, Martin Wegman, Justin Deaton, Christopher Carney

South Atlantic Division GME Research Days 2026

No abstract provided.

Utility Of Pocus In Expediting Time To Diagnosis In Two Separate Presentations Of Fournier's Gangrene, Arjavon Talebzadeh, Charles Budzyn, Taryn Hoffman, Mark Attlesey

South Atlantic Division GME Research Days 2026

No abstract provided.

A Rare Cause Of Pelvic Pain: Emergency Department Diagnosis Of Hematometra Using Point-Of-Care Ultrasound, Casey Wilson, Lena O'Field, Hannah Chotiner

South Atlantic Division GME Research Days 2026

No abstract provided.

The Role Of Full Femur Imaging For Early Detection Of Incomplete Atypical Femur Fractures, Ashley B. Humrickhouse, Donald Eagerton, Anne G. La Rochelle

South Atlantic Division GME Research Days 2026

No abstract provided.

Case Report: Wellens Syndrome In The Emergency Department, Johnathan Abdool, John Robinson, Daniel Regino

South Atlantic Division GME Research Days 2026

No abstract provided.

Gross Findings With Point-Of-Care Ultrasound In Median Arcuate Ligament Syndrome: A Case Report, Justin Stanziola, Yelena Pecheny, Casey Wilson

South Atlantic Division GME Research Days 2026

No abstract provided.

Improving Inpatient Colonoscopy Bowel Preparation Quality In A Community Hospital Via Split-Dose Polyethylene Glycol Regimen, Brenden Pearce, Yashaswi Koguru, Schuyler Nebeker, Minh Nguyen, Lauren Roper, Kathleen Raynor

South Atlantic Division GME Research Days 2026

No abstract provided.

Ulcer Osteoma: The Role Of Mri In Differentiating Reactive Proliferative Periostitis From Osteomyelitis, Reza Ayoubi, Mathew Dixon

South Atlantic Division GME Research Days 2026

No abstract provided.

Cholecystocolonic Fistula: Ct Diagnosis And Confirmation On Hida Scan, Adam Webb, John T. Belflower, Brian Helmly

South Atlantic Division GME Research Days 2026

No abstract provided.

Hyperechoic Amniotic Fluid In The Setting Of Fetal Bowel Distention And Echogenicity, Abigail Haythorn, Katherine Cuadrado, Anthony Royek

South Atlantic Division GME Research Days 2026

No abstract provided.

Prenatal Detection Of Grade Iv Germinal Matrix-Intraventricular Hemorrhage With White Matter Loss And Corpus Callosum Thinning Confirmed By Fetal Mri, Avery G. Kanemasu, Sara K. Wiggins, Keisha L. Reddick

South Atlantic Division GME Research Days 2026

No abstract provided.

Finding Foxg1 Syndrome In An Adult Patient, Claudia Ludden, Timothy P. Connelly

South Atlantic Division GME Research Days 2026

No abstract provided.

Stability Of Salivary Microrna Measures Across An Ncaa Division I Football Season: Implications For Microrna As A Biomarker Of Concussion, Thomas R. Campbell, Martina Zamponi, Delaney Leathers, Julie Cavallario, Jessica C. Martinez, Peter A. Mollica

Rehabilitation Sciences Faculty Publications

Background

Clinicians often face challenges in concussion care due to a heavy reliance on subjective patient input. Recently, research has sought objective biomarkers, like salivary microRNAs, to improve concussion management. However, significant limitations hinder the use of microRNAs as a diagnostic tool, including the cumulative effects of a contact sport season. A better understanding of the response to a contact sport season would help researchers and clinicians interpret expression changes at the time of injury in the context of seasonal variation. in Therefore, this study investigated the reliability of previously identified salivary microRNA targets across one contact sport season.

Methods …