Systemic Adiponectin Malfunction As A Risk Factor For Cardiovascular Disease.,
2011
Department of Emergency Medicine, Thomas Jefferson University
Systemic Adiponectin Malfunction As A Risk Factor For Cardiovascular Disease., Wayne Bond Lau, Ling Tao, Yajing Wang, Rong Li, Xin L Ma
Department of Emergency Medicine Faculty Papers
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes. The 30 kDa protein originates from adipose tissue, with full-length and globular domain circulatory forms. A collagenous domain within Ad leads to spontaneous self-assemblage into various oligomeric isoforms, including trimers, hexamers, and high-molecular-weight multimers. Two membrane-spanning receptors for Ad have been identified, with differing concentration distribution in various body tissues. The major intracellular pathway activated by Ad includes phosphorylation of AMP-activated protein kinase, which is responsible for many of Ad's metabolic regulatory, anti-inflammatory, vascular protective, and anti-ischemic properties. Additionally, several AMP-activated protein kinase-independent mechanisms responsible for Ad's anti-inflammatory …
Advanced Glycation End Products Accelerate Ischemia/Reperfusion Injury Through Receptor Of Advanced End Product/Nitrative Thioredoxin Inactivation In Cardiac Microvascular Endothelial Cells.,
2011
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, China
Advanced Glycation End Products Accelerate Ischemia/Reperfusion Injury Through Receptor Of Advanced End Product/Nitrative Thioredoxin Inactivation In Cardiac Microvascular Endothelial Cells., Yi Liu, Yanzhuo Ma, Rutao Wang, Chenhai Xia, Rongqing Zhang, Kun Lian, Ronghua Luan, Lu Sun, Lu Yang, Wayne B Lau, Haichang Wang, Ling Tao
Department of Emergency Medicine Faculty Papers
The advanced glycation end products (AGEs) are associated with increased cardiac endothelial injury. However, no causative link has been established between increased AGEs and enhanced endothelial injury after ischemia/reperfusion. More importantly, the molecular mechanisms by which AGEs may increase endothelial injury remain unknown. Adult rat cardiac microvascular endothelial cells (CMECs) were isolated and incubated with AGE-modified bovine serum albumin (BSA) or BSA. After AGE-BSA or BSA preculture, CMECs were subjected to simulated ischemia (SI)/reperfusion (R). AGE-BSA increased SI/R injury as evidenced by enhanced lactate dehydrogenase release and caspase-3 activity. Moreover, AGE-BSA significantly increased SI/R-induced oxidative/nitrative stress in CMECs (as measured …
Reduced Cardioprotective Action Of Adiponectin In High-Fat Diet-Induced Type Ii Diabetic Mice And Its Underlying Mechanisms.,
2011
Department of Emergency Medicine, Thomas Jefferson University; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xian, P.R. China
Reduced Cardioprotective Action Of Adiponectin In High-Fat Diet-Induced Type Ii Diabetic Mice And Its Underlying Mechanisms., Wei Yi, Yang Sun, Erhe Gao, Xufeng Wei, Wayne Bond Lau, Qijun Zheng, Yajing Wang, Yuexing Yuan, Xiaoliang Wang, Ling Tao, Rong Li, Walter Koch, Xin-Liang Ma
Department of Emergency Medicine Faculty Papers
Diabetes exacerbates ischemic heart disease morbidity and mortality via incompletely understood mechanisms. Although adiponectin (APN) reduces myocardial ischemia/reperfusion (MI/R) injury in nondiabetic animals, whether APN's cardioprotective actions are altered in diabetes, a pathologic condition with endogenously reduced APN, has never been investigated. High-fat diet (HD)-induced diabetic mice and normal diet (ND) controls were subjected to MI via coronary artery ligation, and given vehicle or APN globular domain (gAPN, 2 μg/g) 10 min before reperfusion. Compared to ND mice (where gAPN exerted pronounced cardioprotection), HD mice manifested greater MI/R injury, and a tripled gAPN dose was requisite to achieve cardioprotective extent …
La Medicina Tradicional Y La Medicina Moderna En Cusco,
2011
SIT Study Abroad
La Medicina Tradicional Y La Medicina Moderna En Cusco, Katelyn Scott
Independent Study Project (ISP) Collection
Cuando estaba tratando a escoger un tema para esta investigación encontré esta cita, “In the assessment of the World Health Organization (WHO), the majority of the population of most developing countries regularly use and rely on traditional medicine for their everyday healthcare needs[1]” (Bodeker 23). En hecho, WHO dice que casi 80% de la población de un país desarrollado todavía usa la medicina tradicional (Mendoza, 439). Estas citas me interesé y por eso decidí a investigar las perspectivas que las personas en Cusco tienen sobre la medicina tradicional y la medicina moderna. Quiera aprender si la medicina tradicional …
Asclepias Currasavica- A Multicentric, Randomized, Double-Blind Homoeopathic Pathogenetic Trial,
2011
Central Council for Research in Homoeopathy, New Delhi
Asclepias Currasavica- A Multicentric, Randomized, Double-Blind Homoeopathic Pathogenetic Trial, Rajpal Rajpal, Vinay Singh, V Siddiqui, C Nayak, A Majunder, D Sardar, P Sivadas, K Banoth
Indian Journal of Research in Homoeopathy
Objective: To elicit the pathogenetic response of the drug Asclepias currasavica in homoeopathic potencies on healthy human beings. Methodology: Drug Asclepias currasavica was proved by the Central Council for Research in Homoeopathy through randomized, double-blind, placebo-controlled method. The study was conducted at four centers. The drug was proved in two potencies (6C and 30C) on 67 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses …
Neuroprotective Effect Of Bellis Perennis And Hypericum Perforatum On Pc12 Cells,
2011
Neurotoxicology laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062
Neuroprotective Effect Of Bellis Perennis And Hypericum Perforatum On Pc12 Cells, Andleeb Khan, Kumar Vaibhav, Hayate Javed, Mohd Khan, Rizwana Tabassum, Md Ahmed, Syed Raza, Mohd Ashafaq, V Khuwaja
Indian Journal of Research in Homoeopathy
The rat pheochromocytoma (PC12) cell line is widely applied as a model system to study a variety of neuronal functions. Upon addition of nerve growth factor (NGF), these cells undergo differentiation characterized by an increase in acetylcholinesterase (AChE) activity, and extension of neurite-like processes. Oxidative stress is implicated in the pathogenesis of neurodegenerative disorders and the purpose of this study was to evaluate the effect of Bellis perennis (Be) and Hypericum perforatum (Hy) (6C and 30C) on healthy neuronal cells. Both homeopathic medicines have been studied at three different concentrations of 2 μl/ml, 4 μl/ml and 8 μl/ml for 96 …
Alfalfa - A Multicentric Clinical Verification Study,
2011
Central Council for Research in Homoeopathy. New Delhi
Alfalfa - A Multicentric Clinical Verification Study, P Chakraborty, Subhash Kaushik, S Nain, Pramodji Singh, V Prasad, Darshan Singh, K Das, Ojit Singh, Gulrana Pradhan
Indian Journal of Research in Homoeopathy
Introduction: Clinical verification programme is an ongoing research programme of the Central Council for Research in Homoeopathy since its inception, under which many Indian and rarely used drugs in Homoeopathy have been undertaken. Alfalfa is a flowering plant and known for its use as a medicine in toning up the appetite and digestion and favorably influencing nutrition. Disorders like anorexia, nervousness, insomnia, diabetes, lethargy and malnutrition are mainly within its therapeutic range. The Council had undertaken an observational study on Alfalfa from October 2005 to March 2010, to determine its therapeutic effect through clinical verification. Objectives: The primary objective was …
Study Of Homoeopathic Medicines Through Clinical Verification-A New Perspective (Volume-I & Ii),
2011
,
Study Of Homoeopathic Medicines Through Clinical Verification-A New Perspective (Volume-I & Ii), V Gupta
Indian Journal of Research in Homoeopathy
No abstract provided.
Standardisation Of Homoeopathic Drug - Syzygium Jambos (L.) Alston,
2011
Drug Standardisation Unit, Hyderabad
Standardisation Of Homoeopathic Drug - Syzygium Jambos (L.) Alston, P Rao, P Subramanian, P Reddy, H Gupta
Indian Journal of Research in Homoeopathy
Syzygium jambos, a small tree belonging to the family Myrtaceae is a potential drug in Homoeopathy. The drug is useful in clinical conditions like acne, pimples, nausea, comedones, headache, heartburn, abdominal colic, diarrhoea and fever. The seeds are up to 2.5 cm long, ellipsoid to oblong, narrowed at middle. Seed coat is rough, thick, sclerotic and papery, made of tangentially elongated lignified cells with dense contents and separating from the endosperm. Cortex is 20 - 40 layered, interspersed with groups of sclerenchyma fibers. The endosperm possess large secretory cavities in the hypodermal areas. The endosperm is filled with starch grains …
Editorial,
2011
,
Germination And Vigor Of Lettuce Seeds (Lactuca Sativa L.) Pelleted With Homoeopathic Preparations Alumina And Calcarea Carbonica Subjected To Toxic Levels Of Aluminum,
2011
Federal University of Viçosa, MG
Germination And Vigor Of Lettuce Seeds (Lactuca Sativa L.) Pelleted With Homoeopathic Preparations Alumina And Calcarea Carbonica Subjected To Toxic Levels Of Aluminum, Filipe Bonfim, Rosana Rodrigues Das Dores, Ernane Martins, Vicente Dias Casali
Indian Journal of Research in Homoeopathy
Background: Aluminum toxicity is the most important factor limiting the growth of plants in acid soils, whereas current treatments are unfeasible. For this reason, alternatives are sought for, among which homoeopathic treatment. Aims: This study aimed at evaluating the influence of homoeopathic preparations Alumina 6cH, Alumina 12cH, Calcarea carbonica 6cH and Calcarea carbonica 12cH on the germination and vigor of lettuce seeds subjected to toxic levels of aluminum in paper-solution. At the same time, it was sought to develop a new procedure to apply homoeopathic preparations in plants (pelleting). Methods: The statistical design was entirely randomized (CRD) with 6 treatments …
A Prospective Multicentre Observational Study To Evolve The Usefulness Of Group Of Homoeopathic Medicines In The Management Of Acute Tracheobronchitis,
2011
Central Council for Research in Homoeopathy, New Delhi
A Prospective Multicentre Observational Study To Evolve The Usefulness Of Group Of Homoeopathic Medicines In The Management Of Acute Tracheobronchitis, C Nayak, V Singh, H Singh, V Siddiqui, J Gupta, A Mishra, M Padmanabhan, S Sharma, Prasad
Indian Journal of Research in Homoeopathy
Abstract : Sn open multicentre clinical trial was aimed to evolve the usefulness of a group of homoeopathic medicines in the management of acute tracheobronchitis with regard to improvement in its symptom complex. Patients presenting coryza with irritable dry or productive cough, oppression chest and neutrophillic leucocytosis were enrolled in the study from October 2005 to September 2008. Severity of patients′ disease condition was evaluated as per tracheobronchitis symptom scale. Symptoms of disease as well as characteristic symptoms of individual patients were considered for selection of medicine from a group of 14 trial medicines. Selected medicine was prescribed in 6C …
Discovery Of An Apoptosis Inducing Ligand For Burkitt Lymphoma,
2011
California State University - Sacramento
Discovery Of An Apoptosis Inducing Ligand For Burkitt Lymphoma, Carolyn Laymon, Kyla Bradylong, Mary Saunders, David Olivos, Kit Lam
STAR Program Research Presentations
One-bead two-compound (OB2C) combinatorial chemistry libraries enable the discovery of novel synthetic compounds which can be used to evoke specific signaling response in cells. The library configuration is composed of a fixed known cell adhesion ligand and a random chemical library displayed on the surface of Tentagel beads. The cell adhesion ligand binds to specific receptors located on the surface of cells enabling the random immobilized chemical molecules on each bead resin bead to evoke specific cellular responses such as apoptosis or cell death. To validate this concept, a OB2C combinatorial library comprised of an α4β1 integrin targeting ligand, LLP2A, …
Relationships Among Rubus (Rosaceae) Species Used In Traditional Chinese Medicine,
2011
Western Kentucky University
Relationships Among Rubus (Rosaceae) Species Used In Traditional Chinese Medicine, Yinu Wang
Masters Theses & Specialist Projects
Traditional Chinese medicine has a long history of using plants therapeutically including multiple species of the genus Rubus (Rosaceae). Fruits and other parts of Rubus plants have had a significant effect on human health and nutrition in both ancient and modern times. The pharmacological effects of Rubus include anti-inflammatory, antibacterial, anti-stress, anti-cancer and anti-aging properties. One of the current challenges limiting further development of Rubus resources in traditional Chinese medicine is a poor understanding of phylogenetic relationships among Rubus species in general and especially among Asian species, and also the need for additional studies of phytochemicals. Several confounding factors are …
Integrative Health Studies Newsletter,
2011
California Institute of Integral Studies
Integrative Health Studies Newsletter, Ciis
Integrative Health Studies Newsletter
This is the Summer 2011 issue of the Integrative Health Studies Newsletter at CIIS.
Healers And Researchers: Towards A More Balanced Relationship,
2011
SIT Study Abroad
Healers And Researchers: Towards A More Balanced Relationship, Gracie Tewkesbury
Independent Study Project (ISP) Collection
In my seminar paper, I discussed the benefits for both parties of collaboration between traditional healers and modern scientific researchers. If research is done on the medicinal effects of plants, these cures can be used more safely and effectively by members of the community. This relationship is greatly beneficial in theory, but the reality is less than ideal. Researchers, especially foreign ones, depreciate and exploit the knowledge of healers, and as a result, healers are often distrustful and unwilling to collaborate. The relationship between healers and researchers potentially holds the cures to countless diseases and can contribute directly to greater …
The Benefits Of Having An Integrated Health Care System In Madagascar,
2011
SIT Study Abroad
The Benefits Of Having An Integrated Health Care System In Madagascar, Elizabeth Miller
Independent Study Project (ISP) Collection
For my individual research, I wanted to look into all the benefits that could be offered by collaborating allopathic and traditional healthcare systems and how such a system is accomplished in Madagascar, in order to weigh and to discover the feasibility of using integrated healthcare systems as sustainable development in other parts of the world. Furthermore, as Madagascar sets the example in my research this summer, the use of traditional and modern medicine as an integrated health care system best serves the majority of the Malagasy population for several important reasons.
Editorial,
2011
,
Putative Protective Effect Of Cadmium Chloride High Diluted Solution On Llc-Pk1 Cell Intoxicated By High Concentration Of This Same Metal: An Isopathic In Vitro Assay,
2011
Laboratory of Pharmacy Science, Federal University of Rio de Janeiro
Putative Protective Effect Of Cadmium Chloride High Diluted Solution On Llc-Pk1 Cell Intoxicated By High Concentration Of This Same Metal: An Isopathic In Vitro Assay, Roberta Ghilosso-Bortolini, Leoni Bonamin, Carla Holandino
Indian Journal of Research in Homoeopathy
Cadmium is an important toxic environmental heavy metal. Several studies have demonstrated that a major site of cadmium toxicity in humans and in other animals is the proximal tubule of the kidney. A well established model for nephrotoxicity is the use of in vitro technique with proximal tubule epithelial cell lines, as LLC-PK1. Herein, we have the intention to study the possible protective effect of high diluted CdCl2 solutions. In a blinding way, LLC-PK1 cells were pre-treated with high diluted Cadmium chloride in the potencies 10cH, 15cH and 20cH. After 4 days, these cells have received CdCl2 in a pre-determined …
Standardisation Of Homoeopathic Drug - Aquilegia Vulgaris L,
2011
Central Council for Research in Homoeopathy, New Delhi
Standardisation Of Homoeopathic Drug - Aquilegia Vulgaris L, H Gupta, P Subramanian, P Rao, J Raj, Santosh Sharma
Indian Journal of Research in Homoeopathy
In this present investigation, drug standardization studies are undertaken for quality assurance of a homoeopathic drug Aquilegia vulgaris. In Homoeopathy, it has been reported to have clinical indications for clavus hystericus and globus hystericus in women, sleeplessness and dysmenorrhoea. To establish the drug in the system, the standardization studies are mandatory and the useful parts of the plant drug are analyzed according to the standards of Homoeopathic Pharmacopoeia of India. The pharmacognostic and physico-chemical studies of the leaf and petiole are undertaken in present study. The diagnostic macro and microscopical characters of leaf and petiole, moisture content, ash and extractive …
