Toxicology Commons^™

Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde

Electronic Theses and Dissertations

Chronic alcohol consumption is a leading cause of liver disease and liver-related death worldwide. Alcoholic liver disease includes, hepatic steatosis, steatohepatitis and ultimately fibrosis and cirrhosis. Emerging evidence has established the important role of the “gut-liver” axis in the development of alcoholic liver disease (ALD). Our recent work indicated that chronic alcohol induced perturbations in the gut microbiome and consequent changes in fatty acids have a major impact on the development of intestinal barrier dysfunction and ALD. The aim of this study was to investigate whether treatment with tributyrin - a butyrate prodrug results in protection against ALD in terms …

Use Of Spirometry For Medical Clearance And Surveillance In Occupations Requiring Respirator Use, Ushang Prakshbhai Desai

USF Tampa Graduate Theses and Dissertations

Medical certification of workers for respirator use is an important activity of occupational medicine health professionals. Spirometry is a diagnostic tool to evaluate respiratory distress/insufficiency that may affect respirator use. In this study, we analyzed the pulmonary function data of 337 workers from different occupations which required medical evaluation to wear a respirator. The American Thoracic Society and National Fire Protection Association criteria were used to evaluate employees. Of 337 workers who were cleared for respiratory use on the basis of medical questionnaires for respirator compliance, 14 (4.15%) failed to pass respirator compliance on the basis of NFPA criteria and …

Elucidation Of The Role Of Poly(Adp-Ribose) Polymerase In Drug-Induced Toxicity, Kambria Haire

USF Tampa Graduate Theses and Dissertations

Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an activation of poly (ADP-ribose) polymerase (PARP). A study was conducted to determine if cocaine and acetaminophen toxicity lead to DNA damage and to the activation of the repair protein, PARP in the liver using the hepatotoxicants: cocaine and acetaminophen (APAP).

A dose-response analysis for cocaine concluded that a dose as low as 20 mg/kg resulted in elevated ALT levels. A higher dose of 60 mg/kg was tested for analyses but resulted in severe hemorrhaging. The …

Mercury Emissions From Coal-Fired Powerplants, Divya Gade

Environmental Management & Risk Assessment (PH 560)

Mercury is a neurotoxic heavy metal that pose a risk to the public as well as the environmental health. It is a naturally occurring element that is released into the environment from the natural or anthropogenic emissions. Among the anthropogenic emissions, coal-fired powerplants account for approximately 50 percent of the emissions because of the lack of regulations for the emissions from these facilities. The other larger sources of mercury emissions such as municipal waste combustors and medical waste incinerators are subjected to the stringent regulations thereby minimizing their total contribution. Mercury is a natural component of coal and is released …

Relationship Between Emissions Of Human Activities And Ozone Layer Depletion, Umer Murtaza

Environmental Management & Risk Assessment (PH 560)

Ozone depletion always holds an importance being a protective shield to humans and environment as well. Human activities and man-made substances are playing major role to this depletion which is increasing day by day. In this paper influence of man-made substances on ozone depletion and consequences of this depletion have been discussed. Role of chlorofluorocarbons as depleting agents is more comparatively other substances. Due to ozone depletion life on earth is affecting which are resulting different consequences like skin cancer, eye diseases and destruction of crops and aquatic life. EPA has worked a lot to save the ozone and many …

An Investigation Of The Effect Of Malathion On Adaptive Plasticity Of Pseudacris Sierra, Michael Jonathan Maples

Master's Theses

This thesis is composed of two chapters. Chapter one reviews what is known about adaptive plasticity in response to predators, describes the physiological systems involved in such plasticity, and outlines the evolutionary consequences of adaptive plasticity. Chapter two describes a scientific experiment that investigates how malathion may impact adaptive plasticity in the Sierran Treefrog, Pseudacris sierra. Anuran tadpoles suffer high mortality rates due to predation. In response to strong selective forces relating to these high predation rates, tadpoles evolved the ability to adaptively respond to predators through morphological and behavioral plasticity. The morphological and behavioral responses are varied and depend …

Assessment Of Heavy Metal Concentration In Water Around The Proposed Mkuju River Uranium Project In Tanzania, Firmi P. Banzi, Peter K. Msaki, Najat K. Mohammed

Tanzania Journal of Science

Effective verification for compliance with water quality standards in uranium mining in Tanzania requires data sensitive to monitor heavy metal concentration in water around the Mkuju River Uranium Project before mining commences. The area susceptible for pollution by the project was estimated using AERMOD dispersion model and found to cover about 1300 km2. Thirty one surface and groundwater samples were collected and analysed for heavy metals and physicochemical properties using ICP-MS and standards techniques, respectively. The physicochemical properties for water samples analysed ranges from 5.7 to 7.8 for pH, 2.8 to 80.2 mg/L for TDS and 15 to 534.5 mS/cm …

Removal Of Heavy Metal Ions From Aqueous Solution Using Rice Husks-Based Adsorbents, Fanuel J Ligate, James E.G Mdoe

Tanzania Journal of Science

This study reports on the preparation and characterization of rice husks-based adsorbents and their application in the removal of heavy metal ions from aqueous solution. Three different adsorbents were developed: rice husks ash (RHA), rice husks ash-derived silica (RHS) and triaminopropyl-silica hybrid (TSH-R). The prepared materials were characterized by acid titration, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy, Scanning Electron Microscopy-Energy Dispersive X-ray (SEM-EDX) spectroscopy and nitrogen physisorption analysis. Results from the ATR-FTIR analysis indicated that pure silica was obtained from RHA and that after surface modification the triaminopropyl group was successfully attached onto the silica framework with a …

Quantitative Sequencing For The Determination Of Kdr-Type Resistance Allele (V419l,L925i, I936f) Frequencies In Common Bed Bug, Cimex Lectularius L., (Hemiptera: Cimicidae) Populations Collected From Israel, Daniel J. Palencar, Kyle J. Gellatly, Kyong-Sup Yoon, Kosta Y. Mumcuoglu, Uri Shalom, J Marshall Clark

SIUE Faculty Research, Scholarship, and Creative Activity

Human bed bug infestations have dramatically increased worldwide since the mid-1990s. A similar phenomenon was also observed in Israel since 2005, when infestations were reported from all over the country. Two single nucleotide polymorphisms (V419L and L925I) in the bed bug voltage sensitive sodium channel confer kdr-type resistance to pyrethroids. Using quantitative sequencing (QS), the resistance allele frequencies of Israeli bed bug populations from across the country were determined. Genomic DNA was extracted from samples of 12 populations of bed bugs collected from Israel and DNA fragments containing the V419L or L925I and I936F mutations sites were PCR amplified. The …

Examining The Toxicity, Exposure, And Regulatory Approach To Potential Human Health Risks Of The Algal Toxin Domoic Acid, Thomas H. Angus

Graduate Doctoral Dissertations

Domoic acid is a neurotoxin produced by the marine diatom genus Pseudo-nitzschia and causes cell death primarily in the area of the brain responsible for long-term memory. The resulting severe illness has been termed amnesic shellfish poisoning. Domoic acid accumulates in shellfish and planktivorous fish that consume Pseudo-nitzschia, resulting in exposure to humans through consumption of planktivorous seafood. A regulatory standard in seafood was developed shortly after its discovery in 1987 to protect against acute effects. This regulatory standard has not been revised despite significant recent data in the scientific literature.

This dissertation is divided into four sections: (1) …

Surface And Subsurface Application Of Chemical Dispersants And Associated Ecosystem Impacts, Adam V. Radpour

Master's Projects and Capstones

Chemical dispersants are applied to spilled oil in marine environments when other, less controversial, methods are not adequate for the incident. They are considered to be a response method as opposed to a direct cleanup method, with the intended goals of reducing risk of exposure to sensitive shorelines, reducing environmental injury to surface-dwelling sea birds and marine mammals, and facilitating the biodegradation of spilled oil into the water column.

For this research, both surface and subsurface application of dispersants were evaluated in terms of oil characteristics and volume, and oceanic and atmospheric conditions. More data exists to support the effectiveness …

Microbial Communities Of The Providence River, Jacqueline Kratch

Honors Projects in Science and Technology

The Providence River has been industrialized for over one-hundred years. Industries such as oil storage and metal recycling facilities have left high levels of pollutant metals, including lead (Pb), in the soil and water. The elevated Pb concentrations in these environments influence the selection of Pb resistance mechanisms in the bacterial community1. One mechanism of heavy metal resistance is the Pb efflux pump, consisting of proteins in the cell membrane that aid in the transport of Pb out of the cell2. In this study we investigated the co-occurrence of Pb efflux pumps and antibiotic efflux pumps in bacteria from Pb …

Fighting For The Right To Breathe: Exploring Perspectives Of Environmenal Threats In The South Durban Basin, Kayleigh Bhangdia

Independent Study Project (ISP) Collection

The goal of this project is to understand the way in which community members in South Durban perceive the environmental threats that they face. I have contextualized the current environmental injustices present in the wake of the Apartheid legacy. I worked closely with the South Durban Environmental Conservation Alliance in preparing my questions and conducting my interviews. I conducted 24 interviews in three different communities in the South Durban Basin including Wentworth, Merebank, and Clairwood. Following the interviews in Merebank and Clairwood, I engaged the participants in a short participatory mapping exercise in which they highlighted where the pollution was …

Hybrid Computational Toxicology Models For Regulatory Risk Assessment, Prachi Pradeep

Dissertations (1934 -)

Computational toxicology is the development of quantitative structure activity relationship (QSAR) models that relate a quantitative measure of chemical structure to a biological effect. In silico QSAR tools are widely accepted as a faster alternative to time-consuming clinical and animal testing methods for regulatory risk assessment of xenobiotics used in consumer products. However, different QSAR tools often make contrasting predictions for a new xenobiotic and may also vary in their predictive ability for different class of xenobiotics. This makes their use challenging, especially in regulatory applications, where transparency and interpretation of predictions play a crucial role in the development of …

An Evaluation Of Carbon Concentrations Associated With Biodiesel Particulate Matter In An Underground Metal Mine, David Evans

Graduate Theses & Non-Theses

Exposure to diesel particulate matter from diesel exhaust has been shown to have adverse health effects in humans. In 2012 The International Agency for Research on Cancer classified diesel exhaust as a group 1 know human carcinogen. Because of the associated health effects, there has been a strong push to reduce the amount of diesel exhaust present in the mining industry. Biodiesel is one to the more common and promising control options used to reduce the amount of diesel particulate matter that is generated during fuel combustion. The use of biodiesel over petroleum diesel has been shown to reduce not …

Development Of Culturing Methods For Native Mayfly Taxa For Use In Laboratory Toxicity Testing, Kevin Nicholas Rowsey

Theses, Dissertations and Capstones

Salinity is increasing in freshwaters throughout the world due to anthropogenic impacts with the implication of the increases to biological communities only now being realized. Declining mayfly populations in Appalachian streams have generated increased interest in elevated dissolved solids in that region and their effect on benthic macroinvertebrates, particularly the sensitive Ephemeroptera taxa. Field and laboratory evaluations have indicated high sensitivity of mayflies to elevated dissolved solids. The research described herein is part of an ongoing effort to provide opportunity for toxicity testing with native mayflies in the laboratory. A successful endeavor would establish mayfly sensitivity to total dissolved solids …

The Effect Of Silver Nanoparticles On Synaptic Responses In The Lateral Giant Escape Circuit Of The Crayfish, Samantha N. Adkins

Theses, Dissertations and Capstones

The lateral giant neuron in the crayfish is a neuron that controls the reflexive escape response; the context and experience-dependent tuning of this response is critical for survival. Serotonin modulates synaptic responses in this neuron, and social experiences (stress) changes the modulatory role of serotonin. I investigated the mechanisms of induced synaptic response changes and serotonergic modulatory changes after silver nanoparticle exposure to ask if 1) contaminant induced stress changes serotonergic modulation in a manner consistent with social stress and 2) shed light on potential neurotoxic effects of widely used, but poorly understood nanomaterials. Our data show that stress induced …

Acute Toxicity Assessment Of N,N-Diethyl-M-Toluamide (Deet) On The Photosynthetic Activity Of The Dinoflagellate Gymnodinium Instriatum, Eloy Martinez, Sylvia Velez, Marietta Mayo, Miguel Sastre

Faculty Research & Creative Activity

Despite the ubiquitous occurrence of N, N-diethyl-m-toluamide (DEET) in aquatic systems, assessments evaluating the toxicity of DEET on phytoplankton species are summed to a single study on a unicellular green alga. In particular, the toxicological effects of DEET in dinoflagellates are unknown. In this study, we employed the mixotrophic dinoflagellate Gymnodinium instriatum as a study system to evaluate acute effects of DEET on the oxygen flux of laboratory cultures. This study reports an inhibitory reaction model of DEET described by the equation y = 4.99 x 0.54, where y represents the percent inhibition of oxygen flux and x represents DEET …

Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix B. Nimblegen Processed Data Report For Nearest Methylated Peaks, Trevor Fish, Abby Benninghoff

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No abstract provided.

Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix A. Nimblegen Processed Data Report For All Methylated Peaks, Trevor Fish, Abby Benninghoff

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No abstract provided.