Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera),
2019
University of Mississippi
Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera), Omer I. Fantoukh
Electronic Theses and Dissertations
The first chapter discusses the significance of natural products, safety challenges, and quality issues concisely. Specifically, the impact of herb-drug interaction on consumers and the quest for chemical markers for chemical fingerprinting development are provided. Rooibos tea (Aspalathus linearis) is a popular South African herbal tea enjoyed worldwide. Limited reports indicate the potential of rooibos tea to alter the activity of CYP450 isozymes. In chapter two, the phytochemical investigation of A. linearis resulted in the isolation and characterization of 14 phenolic compounds. Safety assessment of the phytochemicals through interaction with CYP, PXR, and P gp was conducted. The …
Allium Cepa Extract Attenuates Ccl4-Induced Oxidative Stress In Rat Brain,
2019
Chulalongkorn University
Allium Cepa Extract Attenuates Ccl4-Induced Oxidative Stress In Rat Brain, Israel Oghenevwodokohwo Okoro, Helen Ejiro Kadiri, Augusta Inegbedion
The Thai Journal of Pharmaceutical Sciences
Introduction: Carbon tetrachloride (CCl4) has been used extensively to evaluate the probable mechanisms of toxicity in experimental animals. The CCl4 induced oxidative stress in rat brain has been established. This study aim to investigate the neuro-prot.
Potentiating Role Of Palm Oil And Its Extracts In Cadmium Induced Alteration Of Amino Transferase,
2019
Chulalongkorn University
Potentiating Role Of Palm Oil And Its Extracts In Cadmium Induced Alteration Of Amino Transferase, Patrick Chukwuyenum Ichipi-Ifukor
The Thai Journal of Pharmaceutical Sciences
Aims: This study examined the effects of palm oil and palm oil extracts pre-treatment on the activities of serum and tissue amino transferases in acute cadmium induced toxicity. Methodology: Six experimental groups was used and group A served as the con..
Three Functional Foods From Garcinia Mangostana L. Using Low-Alpha-Mangostin Aqueous Extract Of The Pericarp: Product Development, Bioactive Compound Extractions And Analyses, And Sensory Evaluation,
2019
Chulalongkorn University
Three Functional Foods From Garcinia Mangostana L. Using Low-Alpha-Mangostin Aqueous Extract Of The Pericarp: Product Development, Bioactive Compound Extractions And Analyses, And Sensory Evaluation, Pattamapan Lomarat, Primchanien Moongkarndi, Jutaphen Jaengprajak, Jutima Samer, Vimol Srisukh
The Thai Journal of Pharmaceutical Sciences
Background: As a result of the expansion of aging society worldwide, the trend in consuming healthy foods as well as functional foods for maintaining good health and preventing chronic diseases is increasing. Currently, functional foods are commercially .
The Activity Of Red Ginger Oil In Antioxidant Study In Vitro And Antihyperalgesia Effect In Alloxan-Induced Painful Diabetic Neuropathy In Mice,
2019
Chulalongkorn University
The Activity Of Red Ginger Oil In Antioxidant Study In Vitro And Antihyperalgesia Effect In Alloxan-Induced Painful Diabetic Neuropathy In Mice, Fifteen Aprila Fajrin
The Thai Journal of Pharmaceutical Sciences
Background: Red ginger oil (RGO) was reported had the highest bio-constituent, especially its essensial oil which was important for antioxidant, than the other varieties. Chronic diabetic triggered the increasing of reactive oxygen species (ROS) which re.
Antiformation And Antimutagenic Activities Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella (Dennst.) Alston,
2019
Chulalongkorn University
Antiformation And Antimutagenic Activities Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella (Dennst.) Alston, Patamawan Wipoosanapan, Keaw Kangsadalampai, Linna Tongyonk
The Thai Journal of Pharmaceutical Sciences
Zanthoxylum limonella aston (Z. limonella) is a popular spice in northern Thailand. It is used as a flavoring agent for certain foods. There have been studies about the biological activity of this spice including, antioxidant antimicrobial and anticancer.
Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate,
2019
Chulalongkorn University
Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate, Theerayut Baubhom, Kannikar Chatsantiprapa
The Thai Journal of Pharmaceutical Sciences
Off-season longans in Thailand were stimulated by potassium chlorate (KClO3). KClO3 is hazardous chemical and prohibited in food since it might cause harm to human health. This research aimed to observe for chemical effects on longan trees, and analyze t.
In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent,
2019
Chulalongkorn University
In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent, Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Wahyu Widowati, Satrio Haryo Benowo Wibowo, Fajar Sukma Perdana, Rizal Rizal
The Thai Journal of Pharmaceutical Sciences
Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function of the skin. Snake fruit (Salacca zalacca) is an important fruit crop native from Indonesia. Its waste is a potential sour.
Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair,
2019
Chulalongkorn University
Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair, Azadeh Mesripour, Ahmad Purhasani, Valiollah Hajhashemi
The Thai Journal of Pharmaceutical Sciences
Introduction: Treatment with interferon-alpha (IFNa) can induce depression that is likely the result of its effect on the tryptophan–kynurenine pathway. Kynurenine passes through the blood-brain barrier and breaks to neurotoxic metabolites, such as qui...
Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract,
2019
Chulalongkorn University
Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract, Oksana Ya. Mishchenko, Kateryna O. Kalko, Marharyta Yu. Zolotaikina, Tatyana M. Gontova, Victoria V. Mashtaler, Catherine Yu. Yurchenko, Lyudmyla V. Derymedvid, Anastasia Yu. Pozdniakova
The Thai Journal of Pharmaceutical Sciences
Objectives: The article presents the study of hepatoprotective and choleretic properties of Tanacetum vulgare flores dry extract (TVFDE) in vivo. Materials and Methods: The research was carried out using model of subchronic toxi? hepatitis in rats, caus..
Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary,
2019
Chulalongkorn University
Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary, Cicilia Primiani, Pujiati Pujiati, Sutiman Sumitro
The Thai Journal of Pharmaceutical Sciences
Objectives: The objective of this study to analyze the estrogenic compounds in pigeon pea seeds and the effect of the plant seeds on the development of rat ovaries. Materials and method: Liquid chromatography-mass spectrometry (MS) and gas chromatography.
Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae,
2019
Chulalongkorn University
Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae, Vipaporn Sareedenchai
The Thai Journal of Pharmaceutical Sciences
Objective: This research was to investigate acetylcholinesterase inhibitory activity of the essential oil from Myrtaceae and its components. Methods: The essential oils were extracted from fresh leave of Myrtaceae plants: Eucalyptus globulus Labill (Euca.
Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils,
2019
Chulalongkorn University
Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils, Penpun Wetwitayaklung
The Thai Journal of Pharmaceutical Sciences
Introduction: Payena lucida A.DC. seed oil has long been used as edible oil and treating various kinds of diseases as oral and topical applications in some local areas of Myanmar. Objectives: This research aimed to identify and qualify the physicochemi...
Microwave-Assisted Synthesis, In Silico Studies And In Vivo Evaluation For Antidiabetic Activity Of New Brominated Pyrazoline Analogues,
2019
Chulalongkorn University
Microwave-Assisted Synthesis, In Silico Studies And In Vivo Evaluation For Antidiabetic Activity Of New Brominated Pyrazoline Analogues, Neni Frimayanti, Jasril Jasril, Ihsan Ikhtiarudin, Syilfia Hasti, Anisa Indah Reza
The Thai Journal of Pharmaceutical Sciences
Introduction: Pyrazolines have played crucial role in the drug discovery researches and have been used widely as an important pharmacophores or intermediet for synthesis of bioactive compounds. Objective: The aim of this work is to explore the potentia...
Association Between The Appropriate Antimicrobial Therapy And Clinical Outcomes In Patients With Sepsis,
2019
Chulalongkorn University
Association Between The Appropriate Antimicrobial Therapy And Clinical Outcomes In Patients With Sepsis, Ploylarp Lertvipapath, Chankit Puttilerpong, Peerawong Werarak, Tipa Chakorn, Nasikarn Angkasekwinai, Napakadol Noppakusomboon, Apichaya Monsomboon
The Thai Journal of Pharmaceutical Sciences
Sepsis is leading cause of death in hospitals, but appropriate antimicrobial therapy canreduce the mortality rate and improve the clinical outcome. This prospective studyanalyzed the association between appropriate antimicrobial therapy and clinical outc.
Continuous Production Of Raloxifene Hydrochloride Loaded Nanostructured Lipid Carriers Using Hot-Melt Extrusion Technology,
2019
University of Mississippi
Continuous Production Of Raloxifene Hydrochloride Loaded Nanostructured Lipid Carriers Using Hot-Melt Extrusion Technology, Derick Muhindo
Electronic Theses and Dissertations
The aim of this study was to utilize a continuous process for the production of Raloxifene Hydrochloride (RX-HCl) loaded NLC formulations for extended drug release using hot-melt extrusion technology coupled with probe sonication, and also to evaluate the in vitro characteristics of the prepared NLCs by particle size, PDI, zeta potential, entrapment efficiency, drug loading, and in vitro drug release profile. Preparation of the NLCs using HME technology involved two main steps, first formation of a pre-emulsion after extrusion and then size reduction of the pre-emulsion using probe sonication to obtain the NLCs. Process parameters for the extrusion process like …
Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer,
2019
University of Mississippi
Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan
Electronic Theses and Dissertations
Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective new therapies is imperative for the treatment of BC and targeting metastasis. The goal herein is to further expand the applicability of in vivo xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC …
Elucidation Of The Molecular Mechanisms Of Electrically-Induced Cardioprotection,
2019
Loyola University Chicago
Elucidation Of The Molecular Mechanisms Of Electrically-Induced Cardioprotection, Anne Elizabeth Roessler
Dissertations
Cardiovascular disease is the leading cause of death worldwide. A myocardial infarction (MI), commonly known as a heart attack, is a major event in cardiovascular disease characterized by reduced blood flow to the heart. The ischemia and reperfusion (I/R) injury associated with an MI results in a region of dead tissue in the heart called an infarct, the size of which influences patient prognosis. In the 1980s, it was discovered that short, non-lethal episodes of I/R, termed ischemic preconditioning (IPC), can protect the heart against a subsequent MI. Ischemic preconditioning demonstrated the phenomenon of endogenous cardioprotection. Cardioprotection has great potential …
Medication Adherence For Foster Children From The Perspective Of Foster Care Providers,
2019
Walden University
Medication Adherence For Foster Children From The Perspective Of Foster Care Providers, Odette Boyd
Walden Dissertations and Doctoral Studies
In 2015, over 427,000 children were in foster care and the largest population were in California's system. Of those children, more than 9,400 were prescribed psychotropic medications. Increases of psychotropic medication use have led to investigations and findings of medication oversights in foster care. Medication oversights included medication nonadherence, which was linked to an increase of problematic behaviors in foster children. The purpose of this phenomenological study was to explore the issues of medication adherence for foster care providers who care for foster children of mild to chronic health concerns who were prescribed medications and experienced multiple placements. By utilizing …
Pharmacokinetic Study Of Novel Anthraquinone Analogues,
2019
University of Mississippi
Pharmacokinetic Study Of Novel Anthraquinone Analogues, Yuhan Guo
Electronic Theses and Dissertations
Small molecules functioning as negative regulators of MDM2 have been considered as promising anti-cancer agents. A series of novel anthraquinone (AQ) analogues upregulate p53, a well-known tumor suppressor, by inactivating its antagonist protein MDM2. The novel AQ compounds synthesized through the modifications on the rhein scaffold were reported to have successfully arrested tumor growth. To have a better understanding of their underlying metabolism in vivo, pharmacokinetic (PK) studies were performed for the AQ compounds. A selective, accurate and reproducible assay methodology for PK study was set up for each AQ compound. The stabilities of AQ compounds were then evaluated …
