Azithromycin Therapy Reduces Cardiac Inflammation And Mitigates Adverse Cardiac Remodeling After Myocardial Infarction,
2019
University of Kentucky
Azithromycin Therapy Reduces Cardiac Inflammation And Mitigates Adverse Cardiac Remodeling After Myocardial Infarction, Ahmed Hamish Neamah Al-Darraji
Theses and Dissertations--Pharmacology and Nutritional Sciences
Introduction: Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Induced by cardiomyocyte death, MI initiates a prolonged and uncontrolled inflammatory response which impairs the healing process. Immune cells, such as macrophages, play a central role in organizing the early post-MI inflammatory response and the subsequent repair phase. Two activation states of macrophages have been identified with distinct and complementary functions (inflammatory vs. reparatory). This bimodal pattern of macrophage activation is an attractive therapeutic target to favorably resolve post-MI inflammation and enhance recovery. It has been demonstrated that azithromycin (AZM), a commonly used antibiotic with immunomodulatory effects, …
Exploring The Role Of Insulin Receptor Signaling In Hippocampal Learning And Memory, Neuronal Calcium Dysregulation, And Glucose Metabolism,
2019
University of Kentucky
Exploring The Role Of Insulin Receptor Signaling In Hippocampal Learning And Memory, Neuronal Calcium Dysregulation, And Glucose Metabolism, Hilaree N. Frazier
Theses and Dissertations--Pharmacology and Nutritional Sciences
In the late 90’s, emerging evidence revealed that the brain is insulin-sensitive, highlighted by broad expression of brain-specific insulin receptors and reports of circulating brain insulin. Contemporary literature robustly supports the role of insulin signaling in normal brain function and suggests that insulin-related processes diminish with aging, evidenced by decreased signaling markers, reduced insulin receptor density, and lower levels of insulin transport across the blood-brain barrier. In the context of pathological cognitive decline, clinical trials using intranasal insulin delivery have reported positive outcomes on memory and learning in patients with mild cognitive decline or early-stage Alzheimer’s disease. However, while the …
Role Of Mcp-1 And Ccr2 In Ethanol-Induced Damage In The Developing Brain,
2019
University of Kentucky
Role Of Mcp-1 And Ccr2 In Ethanol-Induced Damage In The Developing Brain, Kai Zhang
Theses and Dissertations--Pharmacology and Nutritional Sciences
Fetal alcohol spectrum disorders (FASD) are caused by alcohol exposure during pregnancy and is the leading cause of mental retardation. Alcohol exposure during development results in the loss of neurons in the developing brain. The underlying molecular mechanisms are unclear and there currently is no cure for FASD. Ethanol-induced neuronal death is accompanied by neuroinflammation. Chemokine monocyte chemoattractant protein 1 (MCP-1) and its receptor C-C chemokine receptor type 2 (CCR2) are critical mediators of neuroinflammation and microglial activation. Using a third trimester equivalent mouse model of ethanol exposure, we found that treatment of Bindarit (MCP-1 synthesis inhibitor) and RS504393 (CCR2 …
The Effect Of Glucose, Adenosine-5’-Triphosphate, And Adenosine On Glucose Transporter 9 Expression In Mdck Cells,
2019
Chulalongkorn University
The Effect Of Glucose, Adenosine-5’-Triphosphate, And Adenosine On Glucose Transporter 9 Expression In Mdck Cells, Jamras Kanchanapiboon, Thitima Pengsuparp
The Thai Journal of Pharmaceutical Sciences
This study aimed to investigate the effect of glucose, adenosine triphosphate (ATP) and adenosine and their concentration dependence on GLUT9 expression in hyperglycemic conditions. These compounds have been reported to be associated with hyperglycemia i.
Implementing Mass Spectrometry For The Structural And Compositional Analysis Of Proteins,
2019
University of Mississippi
Implementing Mass Spectrometry For The Structural And Compositional Analysis Of Proteins, Mohammad Riaz
Electronic Theses and Dissertations
Lectins are sugar-binding proteins that perform various biological functions such as cellular recognition attachments etc. Pulses the dried edible seeds of certain plants are great sources of lectins and a proteomics approach directed at lectins identification would bring substantial improvement in the lectin identification process. Lectins from nine different plant species were analyzed through SDS-PAGE and proteomics analysis. After LC-MS/MS analysis proteins were identified with protein database searches using Uniprot. Functionally uncharacterized proteins were identified with database searches were annotated with the Pfam and NCBI-CCD databases. In-vitro pharmacological screening will be carried out to assess the pharmacological effects of these …
Effects Of A Heroin Conjugate Vaccine On The Antinociceptive And Abuse-Related Effects Of Heroin In Rats And Monkeys,
2019
Virginia Commonwealth University
Effects Of A Heroin Conjugate Vaccine On The Antinociceptive And Abuse-Related Effects Of Heroin In Rats And Monkeys, Kathryn L. Schwienteck
Theses and Dissertations
The increase in heroin use is one factor contributing to the current opioid epidemic in the United States. There are three Food and Drug Administration (FDA) approved medications for the treatment of opioid use disorder (OUD), and these include agonist (i.e. methadone and buprenorphine) and antagonist (i.e. naltrexone) therapies. Although these medications are effective for some patients, regulatory constraints for agonist therapies limit access and patient compliance for naltrexone is poor. The development of new therapies, such as immunopharmacotherapies, for the treatment of OUD is a priority for the National Institute of Drug Abuse. A heroin immunopharmacotherapy, or vaccine, produces …
Diuretic And Natriuretic Activity Of Faah Inhibition In The Renal Medulla: A Proposed Role Of Palmitoylethanolamide And Its Regulation By Renal Medullary Interstitial Cells,
2019
Virginia Commonwealth University
Diuretic And Natriuretic Activity Of Faah Inhibition In The Renal Medulla: A Proposed Role Of Palmitoylethanolamide And Its Regulation By Renal Medullary Interstitial Cells, Sara Dempsey
Theses and Dissertations
Hypertension is a critical public health issue worldwide, and in the United States, it is the leading cause of heart disease, stroke, and kidney failure, contributing to more than 1,100 deaths per day. It is proposed that the renal medulla combats increased blood pressure by releasing a neutral lipid from the lipid droplets of medullary interstitial cells, termed medullipin, which induces diuresis- natriuresis and vasodepression. The renal medulla is enriched with fatty acid lipid ethanolamides including the endocannabinoid anandamide (AEA), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA), along with their primary hydrolyzing enzyme fatty acid amide hydrolase (FAAH). Our lab is investigating …
Mitragynine Reduced Morphine-Induced Conditioned Place Preference And Withdrawal In Rodents,
2019
Chulalongkorn University
Mitragynine Reduced Morphine-Induced Conditioned Place Preference And Withdrawal In Rodents, Rittinarong Meepong, Thongchai Sooksawate
The Thai Journal of Pharmaceutical Sciences
Introduction: Kratom (Mitragyna speciosa Korth) has been long used in folklore medicine in Southeast Asian countries for its analgesic effects and the treatment of opioid withdrawal. Mitragynine is a major alkaloid found in the leaves of kratom plant th.
Allium Cepa Extract Attenuates Ccl4-Induced Oxidative Stress In Rat Brain,
2019
Chulalongkorn University
Allium Cepa Extract Attenuates Ccl4-Induced Oxidative Stress In Rat Brain, Israel Oghenevwodokohwo Okoro, Helen Ejiro Kadiri, Augusta Inegbedion
The Thai Journal of Pharmaceutical Sciences
Introduction: Carbon tetrachloride (CCl4) has been used extensively to evaluate the probable mechanisms of toxicity in experimental animals. The CCl4 induced oxidative stress in rat brain has been established. This study aim to investigate the neuro-prot.
Potentiating Role Of Palm Oil And Its Extracts In Cadmium Induced Alteration Of Amino Transferase,
2019
Chulalongkorn University
Potentiating Role Of Palm Oil And Its Extracts In Cadmium Induced Alteration Of Amino Transferase, Patrick Chukwuyenum Ichipi-Ifukor
The Thai Journal of Pharmaceutical Sciences
Aims: This study examined the effects of palm oil and palm oil extracts pre-treatment on the activities of serum and tissue amino transferases in acute cadmium induced toxicity. Methodology: Six experimental groups was used and group A served as the con..
Three Functional Foods From Garcinia Mangostana L. Using Low-Alpha-Mangostin Aqueous Extract Of The Pericarp: Product Development, Bioactive Compound Extractions And Analyses, And Sensory Evaluation,
2019
Chulalongkorn University
Three Functional Foods From Garcinia Mangostana L. Using Low-Alpha-Mangostin Aqueous Extract Of The Pericarp: Product Development, Bioactive Compound Extractions And Analyses, And Sensory Evaluation, Pattamapan Lomarat, Primchanien Moongkarndi, Jutaphen Jaengprajak, Jutima Samer, Vimol Srisukh
The Thai Journal of Pharmaceutical Sciences
Background: As a result of the expansion of aging society worldwide, the trend in consuming healthy foods as well as functional foods for maintaining good health and preventing chronic diseases is increasing. Currently, functional foods are commercially .
The Activity Of Red Ginger Oil In Antioxidant Study In Vitro And Antihyperalgesia Effect In Alloxan-Induced Painful Diabetic Neuropathy In Mice,
2019
Chulalongkorn University
The Activity Of Red Ginger Oil In Antioxidant Study In Vitro And Antihyperalgesia Effect In Alloxan-Induced Painful Diabetic Neuropathy In Mice, Fifteen Aprila Fajrin
The Thai Journal of Pharmaceutical Sciences
Background: Red ginger oil (RGO) was reported had the highest bio-constituent, especially its essensial oil which was important for antioxidant, than the other varieties. Chronic diabetic triggered the increasing of reactive oxygen species (ROS) which re.
Antiformation And Antimutagenic Activities Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella (Dennst.) Alston,
2019
Chulalongkorn University
Antiformation And Antimutagenic Activities Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella (Dennst.) Alston, Patamawan Wipoosanapan, Keaw Kangsadalampai, Linna Tongyonk
The Thai Journal of Pharmaceutical Sciences
Zanthoxylum limonella aston (Z. limonella) is a popular spice in northern Thailand. It is used as a flavoring agent for certain foods. There have been studies about the biological activity of this spice including, antioxidant antimicrobial and anticancer.
Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate,
2019
Chulalongkorn University
Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate, Theerayut Baubhom, Kannikar Chatsantiprapa
The Thai Journal of Pharmaceutical Sciences
Off-season longans in Thailand were stimulated by potassium chlorate (KClO3). KClO3 is hazardous chemical and prohibited in food since it might cause harm to human health. This research aimed to observe for chemical effects on longan trees, and analyze t.
In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent,
2019
Chulalongkorn University
In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent, Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Wahyu Widowati, Satrio Haryo Benowo Wibowo, Fajar Sukma Perdana, Rizal Rizal
The Thai Journal of Pharmaceutical Sciences
Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function of the skin. Snake fruit (Salacca zalacca) is an important fruit crop native from Indonesia. Its waste is a potential sour.
Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair,
2019
Chulalongkorn University
Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair, Azadeh Mesripour, Ahmad Purhasani, Valiollah Hajhashemi
The Thai Journal of Pharmaceutical Sciences
Introduction: Treatment with interferon-alpha (IFNa) can induce depression that is likely the result of its effect on the tryptophan–kynurenine pathway. Kynurenine passes through the blood-brain barrier and breaks to neurotoxic metabolites, such as qui...
Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract,
2019
Chulalongkorn University
Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract, Oksana Ya. Mishchenko, Kateryna O. Kalko, Marharyta Yu. Zolotaikina, Tatyana M. Gontova, Victoria V. Mashtaler, Catherine Yu. Yurchenko, Lyudmyla V. Derymedvid, Anastasia Yu. Pozdniakova
The Thai Journal of Pharmaceutical Sciences
Objectives: The article presents the study of hepatoprotective and choleretic properties of Tanacetum vulgare flores dry extract (TVFDE) in vivo. Materials and Methods: The research was carried out using model of subchronic toxi? hepatitis in rats, caus..
Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary,
2019
Chulalongkorn University
Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary, Cicilia Primiani, Pujiati Pujiati, Sutiman Sumitro
The Thai Journal of Pharmaceutical Sciences
Objectives: The objective of this study to analyze the estrogenic compounds in pigeon pea seeds and the effect of the plant seeds on the development of rat ovaries. Materials and method: Liquid chromatography-mass spectrometry (MS) and gas chromatography.
Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae,
2019
Chulalongkorn University
Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae, Vipaporn Sareedenchai
The Thai Journal of Pharmaceutical Sciences
Objective: This research was to investigate acetylcholinesterase inhibitory activity of the essential oil from Myrtaceae and its components. Methods: The essential oils were extracted from fresh leave of Myrtaceae plants: Eucalyptus globulus Labill (Euca.
Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils,
2019
Chulalongkorn University
Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils, Penpun Wetwitayaklung
The Thai Journal of Pharmaceutical Sciences
Introduction: Payena lucida A.DC. seed oil has long been used as edible oil and treating various kinds of diseases as oral and topical applications in some local areas of Myanmar. Objectives: This research aimed to identify and qualify the physicochemi...
