Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection,
2022
Chulalongkorn University
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
The Thai Journal of Pharmaceutical Sciences
In this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core–shell column (S-30/70 = Styrene/divinylbenzene – 5 tetramethyldiaminohexane). Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers,
2022
Chulalongkorn University
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles,
2022
Chulalongkorn University
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
The Thai Journal of Pharmaceutical Sciences
Objectives: Methotrexate (MTX) is a biopharmaceutics classification system Class IV drug having potential cytotoxic action against cancer cells. However, short half-life and poor bioavailability have limited its application. The object of this work was to entrap MTX and an herbal bioenhancer in a nanoparticle system to improve its bioavailability. Methods: We prepared the nanoparticles (NPs) by emulsion solvent evaporation method with Eudragit RLPO (ERLPO) polymer. Results: The result revealed good in vitro properties with 110 to 228 nm particle size range. The percentage of drugs released from all the batches in 72 h was within the range of 82.71 to …
Identification And Quantitation Of Unspecified Impurities Discovered In Novel Oral Irinotecan By Lc-Ms/Ms And Uhplc,
2022
State University of New York College at Buffalo - Buffalo State College
Identification And Quantitation Of Unspecified Impurities Discovered In Novel Oral Irinotecan By Lc-Ms/Ms And Uhplc, Laura B. Miller
Forensic Science Master's Projects
Irinotecan is a cancer medication approved for medical use in the United States in 1996. It is currently administered via intravenous injection. However, intravenous dosing has disadvantages such as requirement of administration by a trained professional in a medical facility, possible severe adverse effects, pain at the injection site, and possible hemolysis if injected too rapidly. Previously oral administration was not feasible because the p-glycoprotein (p-GP) on the cell membrane of stomach cells acts as a defense mechanism against harmful substances by pumping the irinotecan back into the intestinal lumen for excretion. With the discovery of the p-GP inhibitor encequidar …
Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony,
2022
East Tennessee State University
Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza
Electronic Theses and Dissertations
Schizophrenia is a troubling and severe mental illness that is only incompletely treated by currently available drugs. New drug development is hindered by a scarcity of functionally relevant pharmacodynamic biomarkers that are translatable across preclinical and human subjects. Although psychosis is a major feature of schizophrenia, cognitive and negative symptoms determine the long-term functional outcomes for patients. Stimulus-evoked neural synchrony at gamma (~ 40 Hz) frequency plays an important role in the processing and integration of sensory information. Not surprisingly, schizophrenia patients show deficits in gamma oscillations. NMDA receptor (NMDAR) activation on fast-spiking parvalbumin-positive interneurons is deemed important for the …
Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression,
2022
The Texas Medical Center Library
Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression, Mary Figueroa
Dissertations and Theses (Open Access)
Acute myeloid leukemia (AML) is a commonly diagnosed cancer in smokers. When current or former smokers have AML, they have worse survival compared to never smoking patients. This has been observed clinically for decades, but then it is unknown how smoking leads to worsened AML survival. Smoking causes oxidative stress and altered DNA methylation that persists for decades in peripheral blood mononuclear cells, but these changes from smoking have not been evaluated in the context of AML. We hypothesize that smoking-induced molecular changes, including altered DNA methylation associated with poor AML prognosis, promote AML. We developed a novel model to …
Dibutyl Amine Detection, Quantification, And Removal With Iron(Ii)Tetrasulfophthalocyanine (Fetspc),
2022
East Tennessee State University
Dibutyl Amine Detection, Quantification, And Removal With Iron(Ii)Tetrasulfophthalocyanine (Fetspc), Kyle Bittner
Electronic Theses and Dissertations
Pesticide testing is of practical interest in various areas of today’s world due to their prevalence and toxicity. These areas include agriculture, environmental, chemical plants, and many others. Herbicides, like Roundup, contain secondary amines such as glyphosate. The ability to detect secondary amines could offer a method for glyphosate detection in agricultural and environmental samples. Secondary amines can interact with metal complexes through electron charge transfer. Such interactions can cause a change in the metal’s electron configuration and energy state and can be seen in the UV-Vis spectrum. Metal phthalocyanines (MPc’s) and other organometallic complexes have been of interest for …
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats,
2022
Chulalongkorn University
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain
The Thai Journal of Pharmaceutical Sciences
Background: Tithonia diversifolia has been widely developed as an anticancer therapy. Our previous study before showed that T. diversifolia was able to inhibit cell proliferation and collagen accumulation of keloid fibroblasts and decrease the index of rabbit scar hypertrophy. The acute dermal toxicity study of T. diversifolia gel formulation did not show toxic effect for 14 days and the LD50 was estimated more than 2%. However, toxicity data subchronic dermal toxicity study was not available for this T. diversifolia gel formulation. Objectives: Our study aimed to evaluate the subchronic dermal toxicity of T. diversifolia gel formulation in rats. Materials and …
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment,
2022
Chulalongkorn University
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
The Thai Journal of Pharmaceutical Sciences
Purpose: Fluocinolone acetonide (FA) preparations were developed in the forms of premicroemulsion concentrates and microemulsions and their stabilities were evaluated. Materials and Methods: A pseudoternary diagram of clove oil, surfactant mixture (containing polysorbate80: Polyethylene glycol 400 [PEG400] at the ratio of 2:1), and water was constructed for the formulation of FA premicroemulsion concentrates and microemulsions. Physical properties and chemical stabilities of the preparations were monitored in the absence and presence of three antioxidants. Their beyond-use dates were determined. Results and Discussion: The premicroemulsion concentrates and microemulsions containing polysorbate 80, PEG400, and clove oil successfully improved FA solubility. Average diameters of …
Metal Accumulation In Soils, Invertebrates, And Whiptail Lizards In The Northern Chihuahuan Desert,
2022
University of Texas at El Paso
Metal Accumulation In Soils, Invertebrates, And Whiptail Lizards In The Northern Chihuahuan Desert, Allyson Benson-Pedraza
Open Access Theses & Dissertations
Smelting activities by the American Smelting and Refining Company (ASARCO) lead to the substantial release of metal pollution into the El Paso, Texas, and border cities region. To-date few studies have examined metal accumulation within vertebrate taxa in these areas. As reptiles are currently experiencing population declines globally for a variety of reasons including pollution, lizards were chosen to be evaluated for trace element (As, Cu, Cr, Cd, Pb, and Zn) concentrations. These metals were measured within soils, invertebrate prey items, and the livers of three species of whiptail lizards (Aspidoscelis) from the un-remediated University of Texas at El Paso …
Preclinical Development Of Novel Chemotherapeutic Agent Ac1lpszg: Formulation Optimization, In Vitro Characterization, And In Vivo Pharmacokinetics,
2022
Texas Southern University
Preclinical Development Of Novel Chemotherapeutic Agent Ac1lpszg: Formulation Optimization, In Vitro Characterization, And In Vivo Pharmacokinetics, Ritu Gupta
Dissertations (2016-Present)
Preclinical development of novel chemotherapeutic agent AC1LPSZG, a mammalian target of rapamycin (mTOR) inhibitor, involved development of sensitive reverse-phase ultra-performance liquid chromatography (UPLC) and LC-MS/MS methods for quantification of AC1LPSZG in in vitro study samples and rat plasma, respectively. Pharmacokinetic studies were done in SD rats after intravenous injection of cosolvent formulations. The resulting pharmacokinetic parameters were analyzed using non-compartmental analysis (NCA) and two-compartmental modeling. Poly (D, L-lactic-co-glycolic acid) (PLGA) is most used biodegradable synthetic polymer for nano drug delivery due to its non-toxic and biodegradable nature, and tunable release properties. PLGA nanoparticles (NPs) were prepared by ‘nanoprecipitation’ technique using …
Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis,
2022
Aga Khan University
Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis, Malika Hameed, Naureen Akber Ali, Khalid Ahsan, Mohsin Nazir
Department of Anaesthesia
Intraoperative shivering is quite common after regional anaesthesia, which not only increases the total body oxygen requirement but also causes discomfort to the patients. The aim of this systematic review is to determine the effectiveness of pharmacological agents administered intra-operatively for treating shivering in adult patients who are undergoing elective surgery under regional (i.e., central neuraxial) anaesthesia so that an optimal choice of an agent can be recommended for clinical application. A literature search was carried out using PubMed, Cochrane Library, CINAHL databases, and hand searches to identify relevant studies. After literature screening and information extraction, a systematic review was …
Respect Your Elders: An Examination Of Elder Care In The United States,
2022
Indiana State University
Respect Your Elders: An Examination Of Elder Care In The United States, Amy Jassman
University Honors Program
Insurance, healthcare, and workplace conditions are concerns of many senior citizens in the United States. This paper examines the repercussions of governmental policies and older adult stereotypes on the overall quality of care for older adults in the United States of America. This quality of care will be determined by analyzing how England’s, South Korea’s, Germany’s, Canada’s, and India’s programs and values with respect to elder care have impacted the health and well-being of the elderly. Studies on insurance systems, long-term care facilities, and workplace discrimination will be reviewed and compared. The findings show the United States to be trailing …
Bioaccumulation Of As, Cd, Cr, Cu, Pb, Zn In Ambrosia Artemisiifolia L. In The Polluted Area By Enterprise For The Production And Processing Of Batteries,
2022
Universite Rennes I
Bioaccumulation Of As, Cd, Cr, Cu, Pb, Zn In Ambrosia Artemisiifolia L. In The Polluted Area By Enterprise For The Production And Processing Of Batteries, Ryzhenko Nataliia, El Amrani Abdelhak, Michelle Giltrap, Furong Tian, Volodymyr Laptev
Articles
In this paper, the concentration of As, Cd, Cr, Cu, Pb, Zn was investigated in soil and Ambrosia artemisiifolia L. sampling from polluted cite near the enterprises for the production and processing of batteries in the city of Dnipro in Ukraine. The obtained results of the study provided to assess plants regarding bio-monitoring and phytoremediation. Although Ambrosia artemisiifolia L. is a weed that causes serious allergic reactions in humans, this species can also have a high bioaccumulative capacity regarding metals. The metals’ concentration in roots was scientifically higher than in inflorescence part. Zn and Cu had the highest …
Phytochemicals, Acute Toxicity And Genotoxicity Of Chewing Sticks From Zanthoxylum Zanthoxyloides Root And Distemonanthus Benthamianus Stem,
2022
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Nigeria.
Phytochemicals, Acute Toxicity And Genotoxicity Of Chewing Sticks From Zanthoxylum Zanthoxyloides Root And Distemonanthus Benthamianus Stem, Chinwe S. Alaribe, Akolade R. Oladipupo, Anjola T. Adebesin, Omolayomi Kaska, Emuejevoke T. Toye
Bulletin of Faculty of Pharmacy Cairo University
Dental caries has been reported to touch almost half of the world’s population, making it one of the most prevalent disease conditions in the world. Studies have shown that chewing sticks could be useful in cleaning of teeth and could offer protection against dental conditions, including caries. Given the increasing usage of chewing sticks and their unstandardized nature, in this study we investigated the acute toxicity, genotoxic effects on liver and kidney, and phytochemical constituents of chewing sticks from Zanthoxylum zanthoxyloides root and Distemonanthus benthamianus stem, widely used in West Africa. Chemical tests showed the presence of saponins, alkaloids, flavonoids, …
Prior Exposure To Microcystin Alters Host Gut Resistome And Is Associated With Dysregulated Immune Homeostasis In Translatable Mouse Models,
2022
University of South Carolina
Prior Exposure To Microcystin Alters Host Gut Resistome And Is Associated With Dysregulated Immune Homeostasis In Translatable Mouse Models, Punnag Saha, Dipro Bose, Vitalii Stebliankin, Trevor Cickovski, Ratanesh K. Seth, Dwayne E. Porter Ph.D., Bryan W. Brooks, Kalai Mathee, Giri Narashimhan, Rita Colwell, Geoffry Ivan Scott Ph.D., Saurabh Chatterjee Ms., Ph.D
Faculty Publications
A strong association between exposure to the common harmful algal bloom toxin microcystin and the altered host gut microbiome has been shown. We tested the hypothesis that prior exposure to the cyanotoxin microcystin-LR may alter the host resistome. We show that the mice exposed to microcystin-LR had an altered microbiome signature that harbored antibiotic resistance genes. Host resistome genotypes such as mefA, msrD, mel, ant6, and tet40 increased in diversity and relative abundance following microcystin-LR exposure. Interestingly, the increased abundance of these genes was traced to resistance to common antibiotics such as tetracycline, macrolides, glycopeptide, and aminoglycosides, crucial for modern-day …
A Conserved Mechanism For Hormesis In Molecular Systems,
2022
Rowan University
A Conserved Mechanism For Hormesis In Molecular Systems, Sharon N. Greenwood, Regina G. Belz, Brian P. Weiser
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Hormesis refers to dose-response phenomena where low dose treatments elicit a response that is opposite the response observed at higher doses. Hormetic dose-response relationships have been observed throughout all of biology, but the underlying determinants of many reported hormetic dose-responses have not been identified. In this report, we describe a conserved mechanism for hormesis on the molecular level where low dose treatments enhance a response that becomes reduced at higher doses. The hormetic mechanism relies on the ability of protein homo-multimers to simultaneously interact with a substrate and a competitor on different subunits at low doses of competitor. In this …
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia,
2022
Nova Southeastern University
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna
HPD Articles
Although severe cases and mortality of coronavirus disease 2019 (COVID-19) are proportionally infrequent, these cases are strongly linked to patients with conditions of metabolic syndrome (obesity, hypertension, diabetes, and dyslipidemia). However, the pathophysiology of COVID-19 in relation to metabolic syndrome is not well understood. Thus, the goal of this secondary literature review was to examine the relationship between severe acute respiratory syndrome (SARS-CoV-2) infection and the individual conditions of metabolic syndrome. The objective of this secondary literature review was achieved by examining primary studies, case studies, and other secondary studies, to obtain a comprehensive perspective of theories and observations of …
Electrospray Deposition Of Polyvinylidene Fluoride (Pvdf) Microparticles: Impact Of Solvents And Flow Rate,
2022
Tennessee State University
Electrospray Deposition Of Polyvinylidene Fluoride (Pvdf) Microparticles: Impact Of Solvents And Flow Rate, Akinwunmi Joaquim, Omari Paul, Michael Ibezim, Dewayne Johnson, April Falconer, Ying Wu, Frances Williams, Richard Mu
TIGER Institute Faculty Research
Polymeric microparticles have been shown to have great impacts in the area of drug delivery, biosensing, and tissue engineering. Electrospray technology, which provides a simple yet effective technique in the creation of microparticles, was utilized in this work. In addition, altering the electrospray experimental parameters such as applied voltage, flow rate, collector distance, solvents, and the polymer-solvent mixtures can result in differences in the size and morphology of the produced microparticles. The effects of the flow rate at (0.15, 0.3, 0.45, 0.6, 0.8, and 1 mL/h) and N, N-Dimethylformamide (DMF)/acetone solvent ratios (20:80, 40:60, 60:40, 80:20, 100:0 v/v) in the …
Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18,
2022
University of South Carolina
Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18, Jacob Chandler Massey
Theses and Dissertations
The NUDIX hydrolases are a super family of enzymes with purported enzymatic activities of nucleotide hydrolases. The activity of the founding member, NUDT1 (also known as MTH1) is established to be a nucleotide hydrolase for d-8-oxoGTP, which is a mutagenic precursor if incorporated into DNA. Therefore, its activity serves to sanitize the nucleotide pool of mutagenic precursors. While known to be highly conserved among all organisms, the enzymatic and biological functions for nearly all the family members remain largely unexplored and unknown. Substrates of family members have been found to include canonical (deoxy)nucleotide triphosphates, oxidized (deoxy)nucleotide triphosphates, and non-nucleoside polyphosphates. …
