Fostering Environmental Sustainability Through Early Childhood Education(Ece).,
2024
Aga Khan University
Fostering Environmental Sustainability Through Early Childhood Education(Ece)., Tahira Jabeen, Fozia Parveen, Nasima Shakeel
Books
No abstract provided.
Exploring The Dual Role Of Vegf165 In Bleomycin Induced Lung Injury And Recovery In A Aav Mice Model,
2024
Saint John's University, Jamaica New York
Exploring The Dual Role Of Vegf165 In Bleomycin Induced Lung Injury And Recovery In A Aav Mice Model, Igor Ban
Theses and Dissertations
Pulmonary fibrosis (PF) poses a significant challenge in respiratory medicine due to its complex etiology and progression characterized by excessive lung scarring, leading to compromised pulmonary function. The multifaceted roles of Vascular Endothelial Growth Factor A (VEGF-A) and specifically its isoform VEGF-A165 are critical in this context, given their involvement in angiogenesis, lymphangiogenesis, and tissue repair. The dual nature of VEGF-A165, promoting angiogenesis and potentially exacerbating or mitigating fibrosis, underscores its significance in both the progression and recovery phases of PF. Our work, explores the nuanced functions of VEGF-A165 using AAV1 as a gene delivery vector to overexpress this growth …
The Effects Of Length, Weight, Age, And Gender On Mercury Concentrations In Burbot In North-Central Minnesota Lakes,
2024
Bemidji State University
The Effects Of Length, Weight, Age, And Gender On Mercury Concentrations In Burbot In North-Central Minnesota Lakes, Liam Hanley
Journal of Earth and Life Science
Burbot Lota lota in north-central Minnesota lakes have the potential to reach large sizes and consume large volumes of prey. This caveat may make burbot susceptible to higher rates of biocontamination, bioaccumulation and biomagnification. The objective of this study was to determine how changes in age, length, gender, weight, and lake affect total mercury concentrations in burbot. In this experiment 28 burbot were angled from three lakes: Cass (n = 17), Winnibigoshish (n = 4), and Bad Medicine (n = 7). Then tissue samples were taken from each fish and were lyophilized and homogenized. Homogenized tissue samples were analyzed by …
Therapeutic Intervention Of Neuroinflammation In Alzheimer Disease By Inhibition Of Classical Complement Pathway Using Anti-C1r Loaded Exosomes,
2024
Saint John's University, Jamaica New York
Therapeutic Intervention Of Neuroinflammation In Alzheimer Disease By Inhibition Of Classical Complement Pathway Using Anti-C1r Loaded Exosomes, Terjahna Richards
Theses and Dissertations
Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory decline and cognitive impairment. It is a growing global health and socioeconomic concern, affecting more than 50 million people worldwide. Current therapeutics focus solely on symptomatic management instead of preventative or curative strategies. This is mainly a result of the complexity of the pathophysiological mechanism and the poor understanding of the disease progression. Recently, studies have focused on bridging knowledge gaps giving rise to substantial evidence on the vital role of neuroinflammation in the progression of AD. Neuroinflammation has been shown to be a precursor to apparent amyloid plaque accumulation …
Hjp 272, An Endothelin Receptor Antagonist, And Its Role In Cancer Cell Migration And Invasion,
2024
Saint John's University, Jamaica New York
Hjp 272, An Endothelin Receptor Antagonist, And Its Role In Cancer Cell Migration And Invasion, Nabeela Fatima Baig
Theses and Dissertations
Endothelins are a family of versatile peptides composed of 21 amino acids with three isoforms: ET-1, ET-2, and ET-3. As the most abundant of the three isoforms, ET-1 is involved in various biological processes, such as regulation of vascular tone, humoral homeostasis, and neural crest development. However, focus is now being directed towards investigating the functions of the Endothelin axis in the progression of different tumor types including ovarian, prostate, breast, lungs etc. HJP 272 is a novel ETAR antagonist and while our group has previously researched its effects on lung inflammation and preterm birth, this study marks the first …
Characterizing The Role Of Epigenetic Regulator Menin In Pediatric Neuroblastoma Growth Using Pre-Clinical Models,
2024
Saint John's University, Jamaica New York
Characterizing The Role Of Epigenetic Regulator Menin In Pediatric Neuroblastoma Growth Using Pre-Clinical Models, Rameswari Chilamakuri
Theses and Dissertations
Epigenetic regulators such as Menin and MLL1 drive cancer progression, metastasis, and relapse. MLL1 forms a COMPASS complex with its binding partners, including Menin, to function as an epigenetic enzyme H3K4 methyltransferase. H3K4 methyltransferases are known to promote cancer stem cells' (CSCs) self-renewal capacity and metastasis. CSCs are one of the major causes of tumor relapse and metastasis conditions, ultimately leading to poor overall patient survival. Neuroblastoma (NB) is an extracranial solid tumor that accounts for 8-10% of all pediatric cancers, and approximately 50% of patients display metastasis at the time of diagnosis. In this study, we hypothesized and used …
How Does Marijuana Affect Reproductive Health?,
2024
Touro College and University System
How Does Marijuana Affect Reproductive Health?, Miriam Blatner
The Science Journal of the Lander College of Arts and Sciences
Marijuana use has become prevalent worldwide, especially amongst men and women of reproductive age. Marijuana acts on Cannabinoid receptors, which are a part of the Endocannabinoid system. CB1 and CB2 receptors are most found in humans. Activation of Cannabinoid receptors in males cause a reduction in healthy sperm parameters and inhibits the acrosomal reaction, and therefore minimizes fertility potential. Researchers have not yet discovered any significant interactions between marijuana and the female reproductive system. There has also been limited evidence displaying the effects that marijuana has on pregnancy and breastfeeding of infants. Nevertheless, physicians have recommended against marijuana use while …
Full Issue: Volume 17, Number 2, Spring 2024,
2024
Touro College and University System
Full Issue: Volume 17, Number 2, Spring 2024
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 17, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2024.
Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?,
2024
Touro College and University System
Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller
The Science Journal of the Lander College of Arts and Sciences
Cystic fibrosis is a genetic disease with over 2,000 reported mutation varieties. It affects a chloride channel called CFTR, which by the transmembrane transport of chlorine, maintains an apical membrane electrolyte equilibrium in luminal epithelial cells. Its malfunction results in cystic fibrosis which causes excess mucus in various organs and is associated with respiratory complications and salty sweat. Treatment of cystic fibrosis has primarily taken two approaches: a mutation-specific method, targeted at a particular mutation to restore its function, and a mutation-non-specific method, which modulates intracellular barriers to CFTR trafficking or cellular repression of mutant protein function. This paper presents …
Sibo And The Effectiveness Of Treatment Via Diet And Medication,
2024
Touro College and University System
Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko
The Science Journal of the Lander College of Arts and Sciences
This study delves into small intestinal bacterial overgrowth (SIBO), exploring its origins, diagnosis, and treatment methods. The research illuminates the complexities of SIBO, a condition characterized by an abnormal surge of bacteria in the small intestine. Factors contributing to SIBO include impaired motility, anatomical abnormalities, and digestive system dysfunctions. Diagnosing SIBO proves challenging due to its nonspecific symptoms which often overlap with other conditions like irritable bowel syndrome (IBS). Various diagnostic approaches, including lactulose breath testing, blood tests, stool analysis, and imaging, aim to identify SIBO and its underlying causes. Treatment involves dietary modifications—such as low FODMAP, biphasic, or fast …
Non-Surgical Treatment Options For Male-Pattern Baldness,
2024
Touro College and University System
Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer
The Science Journal of the Lander College of Arts and Sciences
Male pattern baldness affects nearly 50% of the world’s male population. It is associated with physiological conditions such as cardiovascular disease as well as psychological issues with self-image and self-esteem. Although surgical treatments exist, they are associated with risks and complications. Various non-surgical treatment modalities for male pattern baldness are available for patients. Topical and oral formulations of minoxidil, finasteride, and dutasteride can be used, in addition to low level light therapy (LLLT) and platelet rich plasma (PRP) therapy. As many treatment options exist, it may be challenging for patients to decide which to choose. Although there have been few …
What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?,
2024
Touro College and University System
What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?, Shirah Balakhane
The Science Journal of the Lander College of Arts and Sciences
The historical understanding of Recurrent Aphthous Stomatitis (RAS), also known as canker sores, has evolved. This paper aims to collect data that determines the underlying factors that can cause RAS and highlights treatments or preventive measures one should take. RAS is a common mucosal disease of the mouth that affects healthy people and presents atypically in immunocompromised people. Geographical, age, and gender-related factors can all affect the prevalence. RAS still has no known cause; however, several systemic, local, immunologic, genetic, dietary, allergy, and microbiological factors—including immunosuppressive medications and stress—have been suggested as potential culprits. Using topical and systemic medicines, the …
The Effects Of Electronic Cigarettes On The Oral Cavity,
2024
Touro College and University System
The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh
The Science Journal of the Lander College of Arts and Sciences
Electronic cigarettes, which became available for purchase in the United States in 2007, were initially touted as a harmless aid for smoking cessation. However, recent research into the impact of electronic cigarettes on the human body has shown potential deleterious effects. This paper aims to examine the effects electronic cigarette usage has on the oral cavity. The methods to compile research involved reading through many peer-reviewed articles to analyze the most current information on the topic. The findings indicate several potentially adverse effects on the oral cavity including oral cancer, periodontitis, dental caries, xerostomia, facial fractures, failed dental implants, and …
Is Manual Therapy An Effective Modality Of Physical Therapy?,
2024
Touro College and University System
Is Manual Therapy An Effective Modality Of Physical Therapy?, Caryn Karfunkel
The Science Journal of the Lander College of Arts and Sciences
Physical therapy provides relief to patients with musculoskeletal disorders who experience pain and have difficulty functioning. Manual therapy is one of the therapeutic modalities of physical therapy, and helps treat patients through utilizing human touch and pressure. This paper analyzes studies that aim to understand the reasoning behind manual therapy’s effectiveness as a physical therapy modality, questioning whether its benefits are primarily biomechanical or psychological. The research was conducted by analyzing relevant literature on academic databases on topics such as pain, physical therapy, manual therapy, and human touch. The findings reveal that manual therapy is an effective modality of physical …
Ethanol-Containing Mouthwash: Is It Safe? Exploring The Potential Risks And Benefits,
2024
Touro College and University System
Ethanol-Containing Mouthwash: Is It Safe? Exploring The Potential Risks And Benefits, Michoel Adler
The Science Journal of the Lander College of Arts and Sciences
This thesis investigates the safety of ethanol-containing mouthwash, focusing on the risks and benefits associated with the ethanol in mouthwash and its metabolic product, acetaldehyde. While ethanol is an effective antimicrobial agent, its carcinogenic and cytotoxic effects raise some concerns. This paper examines ethanol and acetaldehyde exposure, its toxicity, and its effects on oral health. Existing studies have found risks associated with ethanol exposure and have not found decreased effectiveness in ethanol-free mouthwash controlling oral bacteria. Further research is needed to determine the exact risks associated with ethanol-containing mouthwash and should focus on identifying the most effective and safest combination …
Is It Possible For Glp-1ras To Combat Type 2 Diabetes And Its Comorbidities?,
2024
Touro College and University System
Is It Possible For Glp-1ras To Combat Type 2 Diabetes And Its Comorbidities?, Michael Weingarten
The Science Journal of the Lander College of Arts and Sciences
Type 2 Diabetes Mellitus is a prevalent metabolic disorder characterized by insulin resistance and pancreatic beta-cell dysfunction, leading to chronic hyperglycemia and comorbidities such as obesity and cardiovascular disease. Traditional treatments focus on glycemic control, but often fail to address the broader spectrum of related conditions. This study investigates the potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to combat type 2 diabetes and its comorbidities through their diverse mechanisms of action. GLP-1RAs not only improve glycemic control by enhancing insulin secretion and inhibiting glucagon release, but also promote weight loss, reduce inflammation, and lower cardiovascular risk. The efficacy of GLP-1RAs …
Overview Of Weight Loss Medications,
2024
Touro College and University System
Overview Of Weight Loss Medications, Malky Mandel
The Science Journal of the Lander College of Arts and Sciences
Obesity is a complex medical condition that is multifactorial in origin. About one-third of adults in the United States are obese, and another third are overweight (Ogden et al., 2007). Obesity is associated with a multitude of comorbidities, such as cardiovascular disease, diabetes mellitus, and osteoarthritis (Lim, Boster, 2023). Additionally, obesity may cause psychological disorders due to social prejudice and discrimination toward obese people (Wadden et al. 2002). Economically, obesity is also a tremendous financial burden (Tremmel et al. 2017). It is estimated that the overall cost of obesity-related illness in the US is nearly $500 billion (Cawley et al., …
What Is The Best Way To Combat The Symptoms Of Knee Osteoarthritis?,
2024
Touro College and University System
What Is The Best Way To Combat The Symptoms Of Knee Osteoarthritis?, Anna Reich
The Science Journal of the Lander College of Arts and Sciences
Osteoarthritis is a debilitating disease that a significant percentage of adults contend with. This degenerative joint disease causes the breakdown of tissue at the joint, which leads to symptoms of pain, decreased function, and limited range of motion. There are various methods of combating these symptoms. Treatment options include basic lifestyle modifications and other nonpharmacological methods, oral and topical drugs, intraarticular injections, and surgery. There are benefits and risks, as well as a lack of effectiveness associated with these treatments. The purpose of this paper is to determine whether there is an optimal treatment for this disease. Based on the …
Maximum Entropy Species Distribution Modeling For The Spring Ephemeral Herb Bloodroot (Sanguinaria Canadensis) In Eastern North America,
2024
The University of Akron
Maximum Entropy Species Distribution Modeling For The Spring Ephemeral Herb Bloodroot (Sanguinaria Canadensis) In Eastern North America, Velan Manivannan
Williams Honors College, Honors Research Projects
The spring ephemeral plant Bloodroot (Sanguinaria canadensis) has a widespread native range in North America, spanning much of the eastern United States and Canada. While its current NatureServe conservation status is designated as ‘secure’ (NatureServe, 2023), its status as a spring ephemeral places it at a heightened risk for climate change-induced phenological mismatch with advancing forest canopy closure. Additionally, under continued anthropogenic climate change, Bloodroot may also experience range shifts or contractions as the edges of its present range warm past physiological thresholds. To determine the potential for range shifts and contractions under future warming, I generated a …
Field And Laboratory Evaluation Of The Interactions Between Pesticides And The Gut Microbiome In Honey Bees (Apis Mellifera),
2024
Eastern Washington University
Field And Laboratory Evaluation Of The Interactions Between Pesticides And The Gut Microbiome In Honey Bees (Apis Mellifera), Macee R. Mitchell
EWU Masters Thesis Collection
Western honey bees (Apis mellifera) are important pollinators yet are threatened by a combination of factors such as poor nutrition, pathogens, parasites, and pesticide use. Bees encounter numerous pesticides while foraging (e.g. imidacloprid, a neonicotinoid insecticide) or in the hive colony (e.g. Tau-fluvalinate, a miticide commonly used to treat Varroa mite parasites). Similar to most organisms, the gut microbiome is important for bee health, metabolism, and behavior, however it is not well known how environmental factors like pesticides impact their gut bacterial symbionts. I hypothesized that 1) pesticide concentrations in bees are correlated with gut bacterial community structure, and 2) …
