Pharmacology, Toxicology and Environmental Health Commons^™

Associations Between The Quality Of The Residential Built Environment And Pregnancy Outcomes Among Women In North Carolina, Marie Lynn Miranda, Lynne C. Messer, Gretchen L. Kroeger

Community Health Faculty Publications and Presentations

Background: The built environment, a key component of environmental health, may be an important contributor to health disparities, particularly for reproductive health outcomes.Objective: In this study we investigated the relationship between seven indices of residential built environment quality and adverse reproductive outcomes for the City of Durham, North Carolina (USA).

Methods: We surveyed approximately 17,000 residential tax parcels in central Durham, assessing > 50 individual variables on each. These data, collected using direct observation, were combined with tax assessor, public safety, and U.S. Census data to construct seven indices representing impor­tant domains of the residential built environment: housing damage, property disorder, …

Research, Monitoring, Assessment And Development Plan 2011 – 2012, Department Of Fisheries

Fisheries Occasional Publications

No abstract provided.

Anthropogenic Climate Change And Allergic Diseases, James Blando, Leonard Bielory, Viann Nguyen, Rafael Diaz, Hueiwang Anna Jeng

Community & Environmental Health Faculty Publications

Climate change is expected to have an impact on various aspects of health, including mucosal areas involved in allergic inflammatory disorders that include asthma, allergic rhinitis, allergic conjunctivitis and anaphylaxis. The evidence that links climate change to the exacerbation and the development of allergic disease is increasing and appears to be linked to changes in pollen seasons (duration, onset and intensity) and changes in allergen content of plants and their pollen as it relates to increased sensitization, allergenicity and exacerbations of allergic airway disease. This has significant implications for air quality and for the global food supply.

Northern Gateway Pipeline: Why American Environmental Groups Are Funding Canadian Ones In The Fight Against It., Richard Philp

Data and Test Instruments

The Canadian federal government, supported by the right wing press, has being trying to paint as a conspiracy the financial support of Canadian aboriginal groups and environmental ones by offshore environmental interests. This brief article points out why such action is entirely legitimate and discusses the recent history of oil leaks and the risks associated with the Northern Gateway pipeline.

The Cyclin-Like Protein Spy1/Ringo Promotes Mammary Transformation And Is Elevated In Human Breast Cancer, Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R. Fratiloiu, Bonnie F. Sloane, Lisa A. Porter

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary development and forced overexpression in mammary mouse models accelerates mammary tumorigenesis.

Methods

Using human tissue samples, cell culture models and in vivo analysis we study the implications of Spy1 as a mediator of mammary transformation and breast cancer proliferation.

Results

We demonstrate that this protein can facilitate transformation in a manner dependent upon the activation of the G2/M Cdk, Cdk1, and the subsequent inhibition of the anti-apoptotic regulator FOXO1. …

Toxicological Assessment Of Intra‐Tracheal Instilled Nanoceria On Kidneys Of Sprague‐Dawley Rats, Geeta Nandyala

Theses, Dissertations and Capstones

Recent studies suggest that use of nanoceria in industry is associated with increased risk of human and environmental exposure. How inhaled nanoceria might affect the kidneys is not yet known. To investigate this possibility, Sprague Dawley rats were exposed to a single dose of 7mg/kg body weight cerium oxide nanoparticles by intratracheal instillation. Animals were sacrificed at day 1, 3, 14, or 28 days after exposure and the kidneys collected for histological and biochemical analysis. No significant difference was observed in kidney to body weight ratio between the different groups. Hematoxylin and eosin staining did not reveal any significant changes …

Reduce, Reuse, Recycle? An Examination Of Factors Influencing Environmental Behavior In Denver, Colorado, Dan J. Kasper

Electronic Theses and Dissertations

Non-recycling and non-composting of municipal solid waste have important natural resource management implications, in that they both reduce energy, water, and raw natural resource use. Responsible waste management also likely has positive climate impacts by virtue of reducing greenhouse gas emissions. Recycling and composting are pro-environmental behaviors that have been shown to be influenced by numerous socio-demographic and psychological factors. This study analyzes the correlation of a number of variables with frequency of recycling and composting in select census tracts in Denver, CO, USA, with the goals of informing waste management policy and contributing to the overall pro-environmental behavior literature. …

Toxic Effects Of Copper, Cadmium, And Methoxychlor Shown By Neutral Red Retention Assay In Two Species Of Freshwater Molluscs, Nikolett Molnar, Peter Fong

Biology Faculty Publications

We used neutral red retention assay in lysosomes of digestive gland cells as an indicator for stress effects by the environmental contaminants Cu, Cd, and the pesticide methoxychlor in two freshwater molluscs, the unionid mussel, Elliptio complanata (Lightfoot) and the ramshorn snail Helisoma trivolvis (Say). Mussels and snails were exposed for 7 and 14 days to Cu and Cd each at nominal concentrations of 2.5 μg/L, 5.0 μg/L, and 10.0 μg/L, and to methoxychlor concentrations of 1.0 μg/L, 10.0μg/L, and 100.0 μg/L. Both mussels and snails exposed to Cu showed a significant increase in the percent of destabilized lysosomes compared …

The Structural Requirements Of Histone Deacetylase (Hdac) Inhibitors: Suberoylanilide Hydroxamic Acid (Saha) Analogues Modified At C3, C6, And C7 Positions Enhance Selectivity, Sun Ea Choi

Wayne State University Dissertations

Histone deacetylase (HDAC) proteins are targets for drug design towards the treatment of cancers since overexpression of HDAC is linked to cancer. Several HDAC inhibitors, including the FDA approved drug suberoylanilide hydroxamic acid (SAHA, Vorinostat), have cleared clinical trials and emerged as anti-cancer drugs. However, SAHA inhibits all of the 11 metal ion-dependent HDAC proteins. Therefore, we synthesized several libraries of small molecule HDAC inhibitors based on SAHA to help understand the structural requirements of inhibitory potency and isoform selectivity.

In previous work, SAHA analogues functionalized at the C2 position (C2-SAHA analogues) near the metal binding hydroxamic acid displayed decreased …

Effects Of Sediment-Associated Copper To The Deposit-Feeding Snail, Potamopyrgus Antipodarum: A Comparison Of Cu Added In Aqueous Form Or As Nano- And Micro-Cuo Particles, Chengfang Pang, Henriette Selck, Superb K. Misra, Deborah Berhanu, Agnieszka Dybowska, Eugenia Valsami-Jones, Valery E. Forbes

Valery Forbes Publications

Increasing use of engineered nanoparticles (NPs) is likely to result in release of these particles to the aquatic environment where the NPs may eventually accumulate in sediment. However, little is known about the potential ecotoxicity of sediment-associated engineered NPs. We here consider the case of metal oxide NPs using CuO to understand if the effects of NPs differ from micron-sized particles of CuO and aqueous Cu (CuCl₂). To address this issue, we compared effects of copper added to the sediment as aqueous Cu, nano- (6 nm) and micro- (μm) CuO particles on the deposit-feeding snail, Potamopyrgus antipodarum. …

Development Of A Framework Based On An Ecosystem Services Approach For Deriving Specific Protection Goals For Environmental Risk Assessment Of Pesticides, Karin M. Nienstedt, Theo C. M. Brock, Joke Van Wensem, Mark Montforts, Andy Hart, Alf Aagaard, Anne Alix, Joes Boesten, Stephanie K. Bopp, Colin Brown, Ettore Capri, Valery E. Forbes, Herbert Köpp, Matthias Liess, Robert Luttik, Lorraine Maltby, José P. Sousa, Franz Streissl, Anthony R. Hardy

Valery Forbes Publications

General protection goals for the environmental risk assessment (ERA) of plant protection products are stated in European legislation but specific protection goals (SPGs) are often not precisely defined. These are however crucial for designing appropriate risk assessment schemes. The process followed by the Panel on Plant Protection Products and their Residues (PPR) of the European Food Safety Authority (EFSA) as well as examples of resulting SPGs obtained so far for environmental risk assessment (ERA) of pesticides is presented. The ecosystem services approach was used as an overarching concept for the development of SPGs, which will likely facilitate communication with stakeholders …

The Role Of Ecological Models In Linking Ecological Risk Assessment To Ecosystem Services In Agroecosystems, Nika Galic, Amelie Schmolke, Valery E. Forbes, Hans Baveco, Paul Van Den Brink

Valery Forbes Publications

Agricultural practices are essential for sustaining the human population, but at the same time they can directly disrupt ecosystem functioning. Ecological risk assessment (ERA) aims to estimate possible adverse effects of human activities on ecosystems and their parts. Current ERA practices, however, incorporate very little ecology and base the risk estimates on the results of standard tests with several standard species. The main obstacles for a more ecologically relevant ERA are the lack of clear protection goals and the inherent complexity of ecosystems that is hard to approach empirically. In this paper, we argue that the ecosystem services framework offers …

Analysis Of Gene Expression Alterations In Premalignant Progression From Normal Mammary Epithelium To Ductal Carcinoma In Situ By Multiple Orthogonal Tools, Hitchintan Kaur

Wayne State University Dissertations

Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine gene expression changes in different DCIS models (MCF10.DCIS, SUM102 and SUM225) in comparison to normal breast epithelial cells (MCF10A) that may enable us to identify novel markers of disease progression and potential therapeutic targets. We cultured the cells in three dimensional reconstituted basement membrane (3D rBM) for RNA extraction and used the …

Xanthones And Biphenyls From Garcinia Schomburgkiana Wood And Their Cytotoxicity, Chutichot Mungmee, Supotchana Sitthigool, Rutt Suttisri, Anumart Buakeaw

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Purification And Characterization Of Chemical Marker Compound From Azadirachta Indica Var. Siamensis Flowers, Noppunt Prakitboonyarit, Thitima Lhinhatrakool, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Determination Of Some Phenolic Compounds In Ethanolic Extract Of Elephantopus Scaber Linn. Leaves, Ubon Rerk-Am, Bantika Kongsombat, Sinn Tangsatirapakdee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Free Radical Scavenging Activity, Total Phenolic And Total Anthocyanin Contents Of Extracts From Mamao (Antidesma Ghaesembilla) Fruits, Paponpat Worasakungiat, Apirat Jamnonkoon, Wandee Gritsanapan, Pongtio Sithisam

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Anti-Inflammatory Activity Of Fruit Extracts From Phyllanthusemblica And Zanthoxylumlimenella, Amonrat Khayungamnawee, Sitthiphong Soradech, Buppachart Potduang, Tuanta Sematong, Sarunya Laovitthayanggoon, Isara Keeta, Cholticha Niwaspragrif, Arkachai Tantrawong

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Topical Anti-Inflammatory Activity Of Saponin Rich Extract From Sapindus Rarak, Amomrat Khayungamnawee, Siripen Jarikasem, Tuanta Sematong, Sarunya Laovithayanggoon, Jintara Khapang

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.