In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human,
2018
Chulalongkorn University
In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human, Teni Ernawati
The Thai Journal of Pharmaceutical Sciences
The aim of this study was to observe molecular interactions between alpha glucosidase inhibitor waith alpha glucosidase enzyme derived from Saccharomyces cereviseae, Rattus norvegicus and GANC-human. Therefore, they were used against four of the well-kno.
Anti-Hyperglycemic Effect And Subchronic Toxicity Of The Combined Extract From Sattagavata- Mathurameha -Tubpikarn Anti-Diabetic Herbal Formulae,
2018
Chulalongkorn University
Anti-Hyperglycemic Effect And Subchronic Toxicity Of The Combined Extract From Sattagavata- Mathurameha -Tubpikarn Anti-Diabetic Herbal Formulae, Penchom Peungvicha
The Thai Journal of Pharmaceutical Sciences
The three herbal formulae (Sattagavata, Mathurameha, Tubpikarn) were prescribed to diabetic patients for a long times and they included Sattagavata for circulatory system promotion, Mathurameha for diabetics and Tubpikarn for hepatoprotection with less s.
Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals,
2018
Chulalongkorn University
Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals, Kanakapura Basavaiah, Nagaraju Rajendraprasad
The Thai Journal of Pharmaceutical Sciences
A reversed phase high performance liquid chromatographic (RP-HPLC) method for the determination of miglitol (MGL) in pharmaceuticals is presented. The assay was performed on a Phenomenex Luna C18 (150 × 4.6 mm; 5µm particle size) column using phosphate...
Validated Thin-Layer Chromatography-Densitometric Method For Simultaneous Determination Of Piperine And Plumbagin In “Benjakul” Thai Polyherbal Formulation And Its Antioxidant Activities,
2018
Chulalongkorn University
Validated Thin-Layer Chromatography-Densitometric Method For Simultaneous Determination Of Piperine And Plumbagin In “Benjakul” Thai Polyherbal Formulation And Its Antioxidant Activities, Savita Chewchinda, Pattamapan Lomarat, Pongtip Sithisarn
The Thai Journal of Pharmaceutical Sciences
The purpose of this study was to evaluate antioxidant activity and quantitative analysis of piperine and plumbagin content in “Benjukul (BEN)” Thai polyherbal formulation by TLC densitometric method. BEN was recognized in the list of herbal medicinal...
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations,
2018
Chulalongkorn University
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung
The Thai Journal of Pharmaceutical Sciences
Introduction: The history of Dendropanax morbifera LEV., which is indigenous plant in Korea, is quit old and simultaneously, known for locals as remedy of various diseases such as migraine and inflammation. The aim of this study is evaluating the antioxi.
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds,
2018
Chulalongkorn University
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho
The Thai Journal of Pharmaceutical Sciences
Paracetamol is a widely used drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Curcuma xanthorrhiza Roxb. is the one of Indonesian medicinal plants that traditionally used to treat liver disorders. The present study .
Examining The Issue Of Compliance With Personal Protective Equipment Among Wastewater Workers Across The Southeast Region Of The United States,
2018
Georgia Southern University
Examining The Issue Of Compliance With Personal Protective Equipment Among Wastewater Workers Across The Southeast Region Of The United States, Tamara L. Wright
Electronic Theses and Dissertations
Wastewater workers are exposed to different occupational hazards such as chemicals, gases, viruses, and bacteria. Personal Protective Equipment (PPE) is a significant factor that can reduce or increase the probability of an accident from hazardous exposures to chemicals and microbial contaminants. The purpose of this study was to identify wastewater worker’s beliefs and practices on wearing PPE and protections offered by PPE through the integration of the Health Belief Model (HBM). Participants were workers in the wastewater industry, which included wastewater operators, laboratory analysts, maintenance workers, wastewater collection workers, equipment operators, managers, and supervisors (n=272). The instrument was a self-administered …
Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors,
2018
Chulalongkorn University
Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors, Anand Gaurav, Gabriel Akyirem Akowuah, Choo Shiuan Por
The Thai Journal of Pharmaceutical Sciences
A QSAR analysis was conducted on a series of 2-arylpyrimidine and s-triazine derivatives as selective PDE4B inhibitors. Primary objective of the study is to develop predictive QSAR models for s-triazines and 2-arylpyrimidines as selective PDE4B and to id.
Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats,
2018
Chulalongkorn University
Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan
The Thai Journal of Pharmaceutical Sciences
Objectives: To explore the effect of C. asiatica extract on intima-media thickness, eNOS expression, and macrophage M1/M2 ratio in diabetic rats aorta. Materials and Methods: Wistar rats consisted of normal group and diabetic group which divided into neg.
Antihypercholesterol Activity Of Costus Speciosus Water Extract,
2018
Chulalongkorn University
Antihypercholesterol Activity Of Costus Speciosus Water Extract, Hari Susanti, Subagus Wahyuono, Ratna Asmah Susidarti, Ika Puspita Sari
The Thai Journal of Pharmaceutical Sciences
Hypercholesterol is one of cause of cardiovascular disease. Costus speciosus is known empirically as an antihypercholesterol remedy. The study was conducted to determine the effect of water extract of Costus speciosus (CS) on cholesterol blood serum leve.
Exosomes Released From Multiple Myeloma Cells Influence The Angiogenic Function Of Endothelial Cells By Regulating Microrna-29b,
2018
Wright State University
Exosomes Released From Multiple Myeloma Cells Influence The Angiogenic Function Of Endothelial Cells By Regulating Microrna-29b, Qinmao Ye
Browse all Theses and Dissertations
Multiple myeloma is a hematological malignancy characterized by clonal proliferation of plasma cells generally caused by chromosomal abnormalities. It occurs in the bone marrow, which is the microenvironment of multiple myeloma. Exosomes (EXs) are 30-100 nm membrane-derived micro-vesicles containing various of bioactive molecules, such as microRNAs, to mediate the cell-cell interaction. Numerous studies reported that exosomes play a significant role in tumor microenvironment. Angiogenesis has the important implication in tumor exacerbation to supply nutrients to promote the progression of cancer cells through endothelial cells (ECs). Some studies demonstrated that microRNA-29b (miR-29b) can suppress tumor development and inhibit angiogenesis. Therefore, in …
Application Of Polymer-Coated Magnetic Nanoparticles For Oil Separation,
2018
University of South Carolina
Application Of Polymer-Coated Magnetic Nanoparticles For Oil Separation, Seyyedali Mirshahghassemi
Theses and Dissertations
Oil spills and storm water runoffs can have serious impact on the environment with potentially major economic impacts. Given the limitation of current oil clean-up technique, the application of nanotechnology for oil remediation has been widely studied showing a promising avenue of research. This dissertation reports a cheap, facile and cost-effective nanotechnology-based oil clean-up technique that has been optimized for effectiveness and feasibility and reduced adverse environmental impacts. The synthesized polyvinylpyrrolidone (PVP)-coated magnetic nanoparticles (NPs) have been characterized using different techniques and the oil removal efficiency investigated under a wide range of environmentally relevant conditions. Based on the characterization data, …
Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment,
2018
University of South Carolina
Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment, Kamelia Afshinnia
Theses and Dissertations
Understanding the environmental factors that affect the fate and effects of engineered nanoparticles (ENPs) in the environment is crucial for NP risk assessment. Silver nanoparticles (Ag NPs) readily transform in the environment, which alters their properties and subsequently their transport, fate, and toxicity. The overall aim of this dissertation was to evaluate the effects of Ag NPs physicochemical properties (e.g., size, surface charge, surface coating) and water chemistry (e.g., buffer concentration, organic ligands, natural organic matter) in controlling Ag NPs colloidal stability. This aim was achieved by systematically 1) review and rationalize many studies that investigated the aggregation kinetics of …
5-Ht2b Receptor-Mediated Cardiac Valvulopathy,
2018
VCU School of Pharmacy, Dept. of Medicinal Chemistry
5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala
Theses and Dissertations
5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens …
Linking Microbial Phylogenetic And Functional Gene Diversity To Microbial Mat Ecosystem Function Following Environmental Disturbance,
2018
University of South Carolina
Linking Microbial Phylogenetic And Functional Gene Diversity To Microbial Mat Ecosystem Function Following Environmental Disturbance, Eva Christine Preisner
Theses and Dissertations
The ability of ecosystems to adapt to environmental perturbations depends on the duration and intensity of change and the overall biological diversity of the system. In this study, a microbial mat ecosystem located on San Salvador Island, the Bahamas was used as a model to examine how environmental disturbance affects microbial community resistance, their protein synthesis potential (PSP), ecosystem function as measured by biogeochemical cycling, community stability, and resilience. This ecosystem experienced a large shift in salinity (230 to 65 g kg-1) during 2011–2012 following the landfall of Hurricane Irene on San Salvador Island. High throughput sequencing and analysis of …
The Effects Of The Red Tide Producing Dinoflagellate, Karenia Brevis, And Associated Brevetoxins On Viability And Sublethal Stress Responses In Scleractinian Coral: A Potential Regional Stressor To Coral Reefs,
2018
University of North Florida
The Effects Of The Red Tide Producing Dinoflagellate, Karenia Brevis, And Associated Brevetoxins On Viability And Sublethal Stress Responses In Scleractinian Coral: A Potential Regional Stressor To Coral Reefs, David A. Reynolds
UNF Graduate Theses and Dissertations
Coral cover is in decline on a global scale, with increased mortality events being attributed to a number of global and regional stressors. While the impacts of global stressors (e.g. sea surface temperature rise, ocean acidification) are well documented, there is growing interest in identifying and understanding the impacts of regional stressors. The reason for this change in focus is that regional stressors can often work in combination, sometimes synergistically, with global stressors and that stressors on a regional scale tend to be more easily mitigated by management practices. One regional stressor that impacts a myriad of marine organisms in …
Regulation Of Microvesicle Particle Release In Keratinocytes,
2018
Wright State University
Regulation Of Microvesicle Particle Release In Keratinocytes, Azeezat Afolake Awoyemi
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Microvesicle particles (MVPs) are produced from cellular membranes and are thought to mediate cell-cell communication, including in response to stressors such as UVB radiation and thermal burn injury. Previous studies have shown that stress-induced MVP release requires the platelet-activating factor (PAF) receptor in human keratinocytes and that pharmacological inhibition of acid sphingomyelinase (ASM) blocked this release. To validate a genetic role for ASM in MVP release, we used CRISPR-Cas9 gene silencing in human keratinocytes and primary fibroblasts derived from ASM-knockout mice. Though MVP release was partially blocked in ASM-deficient mouse fibroblasts, the inability to fully knockdown ASM in HaCaT cells …
Nanomaterial Charge-Dependent Platelet Activating Factor Receptor Agonism In Human Epidermal Cells,
2018
Wright State University
Nanomaterial Charge-Dependent Platelet Activating Factor Receptor Agonism In Human Epidermal Cells, Shahryar Jamshed Qureshi
Browse all Theses and Dissertations
Platelet Activating Factor (PAF) and its associated receptor, the PAF Receptor (PAFR), are important mediators of intercellular communication during an immune response. Once a physiological stimulus triggers an inflammatory response, epithelial, endothelial and immune cells synthesize and release PAF. PAF mediates the recruitment of immune cells, platelets, angiogenesis, expression of various genes, and increased PAF biosynthesis (Brown, 2006; Han, 2006; Whatley, 1988; Axelrod, 1988). In this study, we utilized HaCaT cells and a well characterized KB cell line derived from nasopharyngeal cells, which do not natively express the PAFR. KB cells had previously been transfected with a PAF receptor (KBP) …
Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms,
2018
Chulalongkorn University
Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms, Bikshal Babu Kasimala, Venkateswara Rao Anna, Useni Reddy Mallu, L. Maheshwara Reddy
The Thai Journal of Pharmaceutical Sciences
Norfloxacin [NFXC] is an active pharmaceutical ingredient belongs to 4-quinolone antibacterial agent used for the prophylaxis of gram +ve and gram-ve bacterial infections. A reliable stability-indicating RP-HPLC method was developed for the separation an.
Effects Of Age, Hydration Level, And Cosmetic Treatment On Skin Mechanical Properties Of Thai,
2018
Chulalongkorn University
Effects Of Age, Hydration Level, And Cosmetic Treatment On Skin Mechanical Properties Of Thai, Anyarporn Tansirikongkol
The Thai Journal of Pharmaceutical Sciences
Purpose: Age and skin hydration influence skin mechanical properties. However, correlation between hydration improved by cosmetic and mechanical properties is uncertain. This study aimed to investigate the relationship between age, intrinsic skin hydrati.
