Medicinal Chemistry and Pharmaceutics Commons^™

Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee

Journal of Food and Drug Analysis

The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to …

Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal

Journal of Food and Drug Analysis

Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier …

Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari

Journal of Food and Drug Analysis

Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt …

Mechanobactericidal Nanotopographies For Food Industry: A Promising Strategy For Eradicating Foodborne Pathogens - Progress And Challenges, Deepak Patil

Journal of Food and Drug Analysis

Nowadays, food preservation, quality maintenance, and safety are major emerging concerns in the food industry. Methods for removing pathogens from the outside surfaces of food products would be an effective way to prevent bacterial contamination. Nanotopographies found on natural surfaces have been shown to mechanically damage the membranes of foodborne bacteria. Thus, using bioinspired mechanobactericidal nanostructures in food packaging and processing materials has the potential to lower surface bacterial contamination while increasing food safety. However, putting this concept into practice remains a challenge. This review discussed recent advances in understanding mechanobactericidal mechanisms, issues concerning the durability of nanotopography under external …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …

Analysis Of Adverse Events Associated With Sglt2 Inhibitors And Molecular Mechanisms Using Faers Database And Transcriptome Data, Rahinatu Bawah Ali

USF Tampa Graduate Theses and Dissertations

In this thesis, we explored the differential effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on cardiovascular and renal health, utilizing both clinical data and molecular insights. Focusing on three commonly prescribed SGLT2 inhibitors—Dapagliflozin, Canagliflozin, and Empagliflozin—we employed the Food and Drug Administration Adverse Event Reporting System (FAERS) database to assess adverse events, including myocardial infarction, cardiac failure, tachycardia, acute kidney injury (AKI), renal failure, urinary tract infections, and fungal infections. This analysis was complemented by transcriptomic data from kidney cell lines treated with these drugs, processed through NCBI’s GEO2R and Limma programs, to reveal the gene expression profiles linked to these …

Corrigendum To "Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019," Journal Of Food And Drug Analysis: Vol. 32 : Iss. 2 , Article 3.

Journal of Food and Drug Analysis

No abstract provided.

Corrigendum To “Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference.”

Journal of Food and Drug Analysis

No abstract provided.

Characterization Of Carbon Dots From Fructus Gardeniae (Zhi-Zi) And Gardenia Charcoal (Black Zhi-Zi) Via Microwave-Assisted Extraction, Hung-Wen Tsai, Nelly Fitri Tampubolon, Tsunghsueh Wu, Mei-Yao Wu, Yang-Wei Lin

Journal of Food and Drug Analysis

We employed a straightforward microwave-assisted extraction technique to investigate the presence of carbon dots (CDs) in Chinese herbal extracts derived from fructus gardeniae and gardenia charcoal, designated as CDs-1 and CDs-2, respectively. The found CDs exhibited unique photoluminescence with quantum yields of 0.95% for CDs-1 and 1.81% for CDs-2, indicating significant potential for bioimaging applications. Both CD types maintain approximately 80% of their fluorescence intensity after 120 minutes of continuous 365 nm UV exposure, underscoring their stability and suitability for prolonged biological studies. Moreover, antioxidant activity tests showed that CDs-2 have a higher scavenging capacity, with an SC-50 value of …

Optimization, Physicochemical Stability And In Vivo Study Of Alginate-Chitosan Composites As Nanocarriers For Low Molecular Weight Angiotensin I-Converting Enzyme (Ace)-Inhibitory Peptide, Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari

Journal of Food and Drug Analysis

Chitosan and alginate, are non-toxic and biodegradable polymers used to enhance the stability of biotherapeutics by loading them into nanocarriers. In this study, the stone fish-derived low molecular weight peptide (Ala-Leu-Gly-Pro-Gln-Phe-Tyr), exhibited an in vitro ACE-inhibitory activity of 94.43 ± 2.05% and an IC₅₀ of 0.012 ± 0.001 mM. The peptide was encapsulated via ionic gelation with alginate followed by polyelectrolyte complexation with chitosan. The resulting ACE-inhibitory peptide-loaded alginate-chitosan nanoparticles (ACE-I-ALG-CS NPs) were optimized to achieve small particle size (212.60 nm) and high encapsulation efficiency (EE, 74.48%). This was based on an optimum chitosan concentration (0.420%w/v), homogenization speed (6000 …

Sensitive Electrochemical Sensor Of Levofloxacin Using Boron-Doped Diamond (Bdd) Electrode Modified With Ti3c2tx (Mxene) Material, Prastika Krisma Jiwanti, Indah Harindy Putri, Grandprix T.M. Kadja, Yasuaki Einaga, Laurencia Gabrielle Sutanto, Siti Wafiroh, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Tahta Amrillah, Ilma Amalina, Qonita Kurnia Anjani, Wan Jeffrey Basirun

Journal of Food and Drug Analysis

Overuse of levofloxacin (LEV) is often associated with bacterial resistance and serious health problems, underscoring the need for reliable sensing and monitoring of LEV molecules. Therefore, this study aimed to investigate LEV using boron-doped diamond (BDD) and boron-doped diamond modified with MXene (Ti₃C₂T_X) (BDD-MXene) electrode. The successful deposition of MXene on the BDD surface was confirmed using scanning electron microscope (SEM). Cyclic voltammetry (CV) and square wave voltammetry (SWV) methods were also applied to evaluate the electrochemical behavior. The results showed that both electrodes had a linear response in the range of 30-100 µM. …

Production And Characterization Of Encapsulated Thymoquinone Loaded Bacterial Cellulose/Chitosan Composite Nano Film And Investigation Of Its In Vitro Antibacterial Activity, Aytul Bayraktar, Tunc Tuba

Journal of Food and Drug Analysis

In this study, nanostructured thin films were produced from thymoquinone (TQ)-loaded composites encapsulated with different ratios of bacterial nanocellulose (BNC) to chitosan (CS). The study aimed to investigate their characterization, antibacterial effects, and potential as drug film coating materials. Chemical features and morphological characteristics were determined, and release tests and antibacterial assays were conducted on the thin film layers. As a result, BNC/CS-thymoquinone composite films obtained at different ratios were found to exhibit the highest antibacterial effect, particularly films with a 70% BNC/CS to 30% thymoquinone ratio, against Salmonella typhimurium bacteria.

Enhancing Mango Shelf Life Through Natural Preservation: Investigating The Efficacy Of Polysaccharide Edible Coating And Leaf Extracts, Binh Minh Nguyen Dac, Khoa Hai Le, Van Anh Phan Thi, Van Minh Dao, Trung Dinh Do, Phuong Nguyen-Tri, S. Woong Chang, D. Duc Nguyen, Duong Duc La

Journal of Food and Drug Analysis

A sustainable solution to prevent the waste of fruits and vegetables from spoilage is the use of edible coatings or films. This research project aimed to create a fresh coating recipe that could effectively extend the shelf life of mangoes. The coating was composed of chitosan, glycerol, and gum Arabic mixed with the extract obtained from the extraction of Cleistocalyx operculatus plant. The prepared exact has a total polyphenol content of 17% and showed potent free radical scavenging abilities in a dose-dependent manner. The chitosan/gum Arabic/Glycerol/extract edible coatings were analyzed using SEM and FTIR spectroscopy, revealing a smooth and uniform …

Unlocking Early Detection Of Alzheimer's Disease: The Emerging Role Of Nanomaterial-Based Optical Sensors, Chun-Hsien Chen, Hsin-Hua Liang, Chun-Chi Wang, Yi-Ting Yang, Yi-Hui Lin, Yen-Ling Chen

Journal of Food and Drug Analysis

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder that affects millions of individuals worldwide. Researchers have conducted numerous studies to find accurate biomarkers for early AD diagnosis and develop more effective treatments. The main pathological hallmarks of AD are amyloid beta and Tau proteins. Other biomarkers, such as DNA, RNA, and proteins, can also be helpful in early AD diagnosis. To diagnose and treat AD promptly, it is essential to accurately measure the concentration of biomarkers in the cerebrospinal fluid or blood. However, due to the low concentrations of these biomarkers in the body, highly sensitive analytical techniques …

Harnessing Gold Nanomaterials For Advanced Multicolor Colorimetric Biosensors In Food Hazards Detection, Longyingzi Xie, Chenxi Guo, Lu Yang, Yue He

Journal of Food and Drug Analysis

Hazards such as pathogenic bacteria, mycotoxins, pesticides, antibiotics, heavy metal ions, etc., cause serious food safety problems worldwide due to their toxicity and frequent contamination. Rapid screening is an effective way for food safety control, which highly relies on the development of sensitive, specific, and convenient detection methods. The multicolor colorimetric biosensors based on gold nanomaterials have evolved into advanced tools for detecting various hazards in food, with intuitive readout. The excellent localized surface plasmon resonance (LSPR) properties of gold nanomaterials enable them to exhibit bright colors when used as chromophores. In addition, the small changes in the morphology of …

Functional Gold Nanoparticles For Analysis And Delivery Of Nucleic Acids, Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang

Journal of Food and Drug Analysis

Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects …

Preface, Chih-Ching Huang, Yang-Wei Lin, Amit Nain

Journal of Food and Drug Analysis

No abstract provided.

Perilous Consequences Of Chemotherapy Induced Alopecia In Afflicted Cancer Survivors: A Comprehensive State Of The Art Review, Salma A. Fereig, Mona Gamal Arafa, Ghada Mamdouh Elzaafarany, Mona Mohamed Ahmed Abdelmottaleb, John Youshia

Pharmacy

Due to researchers’ great efforts during previous and current centuries to cure cancer, a remarkable increase in the number of cancer survivors has been observed. However, side effects of chemotherapeutic agents greatly affect the quality of life of cancer cases, usually referred to as cancer stigma, the most psychologically traumatizing of which is chemotherapy-induced alopecia (anagen effluvium). Unfortunately, there is no preventive protocol for chemotherapy-induced alopecia to date. The only suggested technique is vasoconstriction by scalp cooling during and after chemotherapy sessions to minimize the absorption of cytotoxic agents within the hair follicle area; a technique that is not very …

Incorporating Solvation Thermodynamic Mapping In Computer-Aided Drug Design, Yeonji Ji

Dissertations, Theses, and Capstone Projects

Advancements in computational techniques have revolutionized structure-based drug design, substantially improving the efficiency and effectiveness of the drug discovery process by reducing time, costs, and labor requirements. These advancements include various methods, such as investigating small molecule ligands binding to proteins, exploring alternative protein conformations, and solvation mapping on the protein surfaces. Among these methods, understanding the correlation between protein-ligand binding and the role of solvation is important.

A fundamental concept in protein-ligand binding is shape and electrostatic complementarity, which is complicated by the inherent flexibility of proteins. In the absence of small molecule ligands, proteins are complementary to surface …

Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan

Journal of Food and Drug Analysis

Cell nucleus status decides the activities of corresponding cells, making its rapid and effective staining important for revealing the actual condition of biological environment in life science and related fields. In this study, fast staining of cell nucleus is realized by fluorescent carbon nanodots (CDs). The staining mechanism is due to the positively charged CD surface-induced cell membrane penetration, which facilitates the CD-nucleus binding via electrostatic attraction. The size of cell nucleus is easily measured with fluorescence imaging technique. In addition, the CD-based cell nucleus stain is applied for discriminating the normal and cancer cells by determining the cell-to-nucleus ratio …