Nutrition Commons^™

Glycemia And Gluconeogenesis With Metformin And Liraglutide: A Randomized Trial In Youth-Onset Type 2 Diabetes, Katrina B Dietsche, Sheela N Magge, Sydney A Dixon, Faith S Davis, Andrea Krenek, Aruba Chowdhury, Lilian Mabundo, Michael Stagliano, Amber B Courville, Shanna Yang, Sara Turner, Hongyi Cai, Kannan Kasturi, Arthur S Sherman, Joon Ha, Eileen Shouppe, Mary Walter, Peter J Walter, Kong Y Chen, Robert J Brychta, Cody Peer, Yi Zeng, William Figg, Fran Cogen, D Elizabeth Estrada, Shaji Chacko, Stephanie T Chung

Children’s Nutrition Research Center Staff Publications

OBJECTIVE: Elevated rates of gluconeogenesis are an early pathogenic feature of youth-onset type 2 diabetes (Y-T2D), but targeted first-line therapies are suboptimal, especially in African American (AA) youth. We evaluated glucose-lowering mechanisms of metformin and liraglutide by measuring rates of gluconeogenesis and β-cell function after therapy in AA Y-T2D.

METHODS: In this parallel randomized clinical trial, 22 youth with Y-T2D-age 15.3 ± 2.1 years (mean ± SD), 68% female, body mass index (BMI) 40.1 ± 7.9 kg/m2, duration of diagnosis 1.8 ± 1.3 years-were randomized to metformin alone (Met) or metformin + liraglutide (Lira) (Met + Lira) and evaluated before …

Patterns Of Fruit And Vegetable Incentive Use By Consumers With Low-Incomes, Sarah Moore Smith

Student Research Symposium

Situation:

• 9.5% or 316,980 Utahns are food insecure. That’s 1 in every 11 people who are experiencing hunger.¹
• Hunger is often accompanied by poor diet quality as a result of inadequate access or resources to purchase nutrient dense foods² (i.e. fruits and vegetables, F&V).

Public Health Response:

• Utah Double-Up Food Bucks (Double-Up) addresses this situation by providing a monetary incentive to Supplemental Nutrition Assistance Program (SNAP) customers to purchase fresh F&V. Double Up matches the amount of SNAP EBT withdrawn (up to $30) to be spent on F&V.
• Double Up has resulted in:
• New farmers market customers
• Increased …

Impact Of Snac On Physical And Mental Health, Halle Larson, Kaylee West

Student Research Symposium

Food insecurity is a common occurrence among college students and may have profound impacts on a student’s physical and mental well-being. It is vital that college campuses create not only access to food, but a culture of food security among students and student service organizations. Many institutions are striving to provide food assistance to their students and create this culture through a variety of methods. Ninety seven percent of institutions involved in programs to fight food insecurity implement a food pantry to combat this issue, but only 54% track the impact of their food pantries. Through this study, the impact …

Social And Economic Impacts Of Snac, Sara Marshall, Carson Johnson

Student Research Symposium

Food security is a common concern among college students.¹ Compared to 10% of U.S. households experiencing food insecurity², many college campuses report food insecurity prevalence about four times the national average.³ Approximately 39% of Utah's higher education student's face food insecurity.⁴ The stability of food for an individual can greatly impact different aspects of life including social and economic factors, such as social relationships.⁵

Leavening Agents Substitution In Chocolate Chip Muffins, Cassie Alder, Ashley Dawes, Savannah Harbison

Student Research Symposium

The primary function of leavening agents in baking is to cause the dough or batter to rise, allowing the baked product to be less dense, have more volume and be more aesthetically pleasing.¹ The three main types of leavening agents are baking powder, yeast, and the production of carbon dioxide steam as the product is baked.² These different types of leavening agents behave very differently and the purpose of this experiment was to discover and record the differences that occur in chocolate chip muffins. This research is important because if baking powder is unavailable the research shows what …

Thickened Carbonated Beverages, Adam Hair, Marissa Cook, Clarissa Richins

Student Research Symposium

Dysphagia, or difficulty swallowing, affects many individuals around the world with an array of underlying medical conditions, and rates of dysphagia are expected to increase as the population ages^1,2. Dysphagia affects the swallowing reflex, which can lead to a greater risk of aspiration and subsequent infections. In order to mitigate this, thin liquids are thickened following IDDSI standards so they can be more easily swallowed by those with dysphagia. Research has shown that carbonation in beverages improves the swallowing reflex over non-carbonated beverages¹. There are different methods and products that can be used to thicken beverages …

Diet Considerations To Promote Bone Health, Prevent Chronic Disease, And Optimize Healing After Orthopedic Surgery, Amanda Albright

Undergraduate Research Conference

No abstract provided.

Snac Patrons' Typical Use And Overall Evaluation Of Services, Joy Bruneel, Melody Loutzenhiser

Student Research Symposium

Food insecurity among students in higher education programs is a relatively new area of research with the first study being published only 14 years ago.¹ Over the years, the costs associated with higher education have steadily increased leading to more financial burdens for students than ever before. According to the 2019-20 National Postsecondary Student Aid Study, over 4 million students nationwide struggle with food insecurity.²

While the incidence of food insecurity among students is increasing, many students are not taking advantage of community and university resources aimed at targeting this issue on college campuses.³ In a study …

A Gnotobiotic Mouse Model With Divergent Equol-Producing Phenotypes: Potential For Determining Microbial-Driven Health Impacts Of Soy Isoflavone Daidzein, Lindsay M. Leonard, Abigayle M.R. Simpson, Shiyu Li, Lavanya Reddivari, Tzu-Wen L. Cross

Purdue University Libraries Open Access Publishing Fund

The implications of soy consumption on human health have been a subject of debate, largely due to the mixed evidence regarding its benefits and potential risks. The variability in responses to soy has been partly attributed to differences in the metabolism of soy isoflavones, compounds with structural similarities to estrogen. Approximately one-third of humans possess gut bacteria capable of converting soy isoflavone daidzein into equol, a metabolite produced exclusively by gut microbiota with significant estrogenic potency. In contrast, lab-raised rodents are efficient equol producers, except for those raised germ-free. This discrepancy raises concerns about the applicability of traditional rodent models …

Ambiguity In Statistical Analysis Methods And Nonconformity With Prespecified Commitment To Data Sharing In A Cluster Randomized Controlled Trial, Yasaman Jamshidi-Naeini, Lilian Golzarri-Arroyo, Deependra K Thapa, Andrew W Brown, Daniel E Kpormegbey, David B Allison

Children’s Nutrition Research Center Staff Publications

No abstract provided.

Fruit And Vegetable Intake, Food Security, Barriers To Healthy Eating, And Empowerment Among Dietetic Interns And Physician Assistant Interns: A Cross-Sectional Pilot Study, Alison Campbell, Maren Stirling, Natalie Keele, Alisse Larkin, Rachel Crandall, Aubree N. Wilcox, Meghan Adair, Cloie Malan, Jaidyn Thomson, Alexis Bennett, Heather Jensen, Hadyn Flygare, Lacie Peterson, Holly Hopkins, Nikki Kendrick, Maria Givler, Rebecca Charlton, Katie N. Kraus

Nutrition, Dietetics, and Food Sciences Faculty Publications

Students are required to complete supervised practice hours prior to becoming Registered Dietitians and Physician Assistants. Research suggests that environmental and social factors affect dietetic interns’ diets during their internship, although these factors have not been studied among physician assistant interns. This cross-sectional study utilized an online survey to compare dietetic interns’ (n = 81) and physician assistant interns’ (n = 79) fruit and vegetable intake, food security, barriers to healthy eating, and empowerment for making healthy dietary choices during an internship. Differences were assessed via independent t-tests and chi-square distributions. The significance was set at p …

Nhm 728: Advanced Survey Data Analysis, Yunhee Chang

GMAS Course Syllabi

No abstract provided.

Nutri-Score, Warning Signs, And Facts Up Front – In Theory And In Practice A Comparative Analysis Of The Effectiveness Of Front-Of-Package Labeling Systems, Muskaan Makkar

Independent Study Project (ISP) Collection

Suboptimal diets contribute significantly to poor health and chronic diseases, with excessive sodium intake and low consumption of whole grains, fruits, and vegetables being major risk factors. To address this global nutrition burden, various countries have implemented front-of-package labeling (FOPL) systems such as the Nutri-Score, Warning Signs, and Facts Up Front.

This paper aims to analyze the effectiveness of these systems – which vary in development, design, content, and implementation – in both theory and practice. The methodology involves a comparative analysis of three FOPL systems, assessing their theoretical effectiveness with international guidelines and practical effectiveness through expert interviews and …

Lac-Phe Mediates The Effects Of Metformin On Food Intake And Body Weight, Shuke Xiao, Veronica L Li, Xuchao Lyu, Xudong Chen, Wei Wei, Fahim Abbasi, Joshua W Knowles, Alan Sheng-Hwa Tung, Shuliang Deng, Gaurav Tiwari, Xu Shi, Shuning Zheng, Laurie Farrell, Zsu-Zsu Chen, Kent D Taylor, Xiuqing Guo, Mark O Goodarzi, Alexis C Wood, Yii-Der Ida Chen, Leslie A Lange, Stephen S Rich, Jerome I Rotter, Clary B Clish, Usman A Tahir, Robert E Gerszten, Mark D Benson, Jonathan Z Long

Children’s Nutrition Research Center Staff Publications

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalanine (Lac-Phe) in cells, in mice and two independent human cohorts. Metformin drives Lac-Phe biosynthesis through the inhibition of complex I, increased glycolytic flux and intracellular lactate mass action. Intestinal epithelial CNDP2+ cells, not macrophages, are the principal in vivo source of basal and metformin-inducible Lac-Phe. Genetic ablation of Lac-Phe biosynthesis in male mice renders animals resistant to the …

Nourishtank: An Innovative Program On Solving Hunger, Palak Gupta, Ashley Sullivan, Kristin Hoch, Lea Palmer, Jocelin Gibson, Mateja Savoie-Roskos, Heidi Leblanc

Outcomes and Impact Quarterly

NourishTank, a Shark Tank-style event, saw students propose food and nutrition insecurity solutions. Twenty-eight students formed 11 teams, promoting interdisciplinary collaboration. The winning idea, 'Farm2Fork Gone Mobile,' earned $1,000 toward their proposed project. NourishTank, through partnerships and media, highlights student-driven efforts combating food insecurity and raising awareness.

Total Syntheses Of Hosieines A-C, Jiayang Zhang, Xu Yan, Qing-Bao Zhang, Fang Wang, Bin Yang, Yang Yang

Children’s Nutrition Research Center Staff Publications

The collective total syntheses of (±)-hosieines A-C with a cage-like tetracyclic framework have been realized, which includes the first syntheses of hosieines B-C. The key strategy of the synthesis employs a one-pot domino reaction that involves Cu-catalyzed [3+2] cycloaddition, 1,6-enone formation, and 1,6-aza-Michael addition forming the 5/6/6-aza-tricyclic skeleton. Other salient synthetic tactics comprise a challenging double bond migration and a 1,4-aza-Michael addition reaction to afford the tetracyclic framework.

A Mindful And Sustainable Eating Intervention To Improve Attitudes Related To Mindfulness, Sustainability, And Fruit And Vegetable Consumption In Elementary Schools, Amy Schachtner-Appel, Heejung Song

Journal of Human Sciences and Extension

Excessive plate waste is generated in elementary school cafeterias. Adapting nutrition promotion strategies to target waste reduction and encouraging mindful and sustainable eating (MSE) are possible strategies to encourage students to reduce waste during school lunch. Farm to Tray, Tray to Farm is a 16-week intervention that aims to encourage elementary school students to develop mindful and sustainable eating behaviors. An educational curriculum was delivered to eight 5th-grade students, who served as peer leaders and disseminated messages throughout the school. Additional strategies included cafeteria reinforcements and opportunities for food recovery. A pilot test of the program was conducted in two …

Una Exploración Sobre La Alimentación Saludable. Percepciones De Mujeres Adultas Entre 31 Y 45 Años Según Su Nivel De Ingresos En La Ciudad Autónoma De Buenos Aires En 2024 / An Exploration Of Healthy Eating. Perceptions Of Adult Women Between 31 And 45 Years Old According To Their Income Level In The Autonomous City Of Buenos Aires In 2024, Anabelle Flaharty

Independent Study Project (ISP) Collection

En los últimos años, Argentina ha identificado los hábitos alimentarios como un área crítica que necesita análisis e intervención. Dado que la desnutrición es una de las principales causas de enfermedades no transmisibles (ENTs), organizaciones mundiales de salud han afirmado que practicar una “alimentación saludable” es una solución práctica a este problema. Entre la población argentina, la alimentación poco saludable ha provocado una epidemia de obesidad, sobrepeso y ENTs. Se sabe que hoy el 31,7 % de las mujeres argentinas adultas y el 30,2 % de los hombres argentinos adultos tienen sobrepeso. Además, la diabetes tiene una prevalencia del 10,5% …

Long-Term Health Related Quality Of Life Following Uterine Fibroid Embolization In A Predominantly Black African Population: A Retrospective Cohort Study, Michael Kioko, Marleen Temmerman, Timona Obura, Adelaide Lusambili

Obstetrics and Gynaecology, East Africa

Uterine Fibroid Embolization (UFE) is one of the effective options available for treatment of symptomatic uterine fibroids with documented improvement in the quality of life and reduction in symptoms. The study assessed long-term quality of life post-uterine fibroid embolization in a mostly black population, noting scanty local or African research on this topic despite evidence suggesting a higher fibroid burden among black women. This retrospective study examined patients who underwent UFE from 2009 to 2014. Participants completed online demographic and UFS-QOL surveys. Statistical tests included Wilcoxon signed rank tests for HRQOL score differences and Pearson correlation for associations between independent …

Design, Protocol And Baseline Data Of Nurturing Healthy Teachers, A Cluster Non-Randomized Controlled Trial To Improve The Health, Well-Being, And Food Security Of Preschool And Elementary School Teachers In Houston, Texas, Ru-Jye Chuang, Azar Gaminian, Jill Cox, Katherine French, Nalini Ranjit

Faculty, Staff and Student Publications

BACKGROUND: We present the conceptual framework, design, and study measures of Nurturing Healthy Teachers, a quasi-experimental study to examine the short- and long-term effectiveness of the Nurturing Healthy Teachers (NHT) nutrition intervention on food insecurity, dietary behaviors, mental health and cardiometabolic health among preschool and elementary school teachers.

METHODS: A convenience sample of 28 elementary schools with pre-kindergarten and elementary classrooms were recruited in Houston, Texas. Nurturing Healthy Teacher intervention includes Brighter Bites, an evidence-based coordinated school health program that combines access to fresh produce and nutrition education, and Create Healthy Futures, a web-based nutrition education program that targets nutrition …