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Factors Influencing Glycogen Branching Enzyme Activity In Mouse Liver, Scott Fuller 2013 Louisiana State University and Agricultural and Mechanical College

Factors Influencing Glycogen Branching Enzyme Activity In Mouse Liver, Scott Fuller

LSU Doctoral Dissertations

Glycogen is the storage polysaccharide in a spectrum of organisms ranging from yeast to humans. Glycogen has a highly branched structure somewhat resembling a tree or shrub, with the branch points formed by glucose molecules being joined by α 1,6-glycosidic linkages. These linkages are formed by the action of branching enzyme. Branching of glycogen is critical to health, with a lack of branching causing glycogen storage disease type IV, which is fatal in humans by age 2. While glycogen branching enzyme has been studied in clinical medicine, modulation of the enzyme has received comparatively little attention. This dissertation undertook three …


College Of Education And Human Services 2012-2013 Annual Report, College of Education and Human Services, Wright State University 2013 Wright State University

College Of Education And Human Services 2012-2013 Annual Report, College Of Education And Human Services, Wright State University

College of Education and Human Services Annual Reports

This annual report by the Wright State University College of Education and Human Services details the news and events of CEHS's organizations and departments in the 2012-2013 school year.


Modulation Of Cell-Matrix Interaction For Cryopreservation Of Engineered Tissue, Angela Christine Seawright 2013 Purdue University

Modulation Of Cell-Matrix Interaction For Cryopreservation Of Engineered Tissue, Angela Christine Seawright

Open Access Theses

Long term preservation of functional engineered tissues can significantly advance tissue engineering industry and regenerative medicine. Several preservation techniques have been proposed and investigated for this purpose, and cryopreservation is a leading candidate. While tissues are cryopreserved, ice forms in both the extracellular and intracellular spaces and causes freezing-induced spatiotemporal deformation of the tissue. During this process the cells undergo dehydration by the freezing-induced osmotic pressure difference and mechanical deformation, transmitted through cell-extracellular matrix adhesions. However, the significance and interaction of these cellular level transport and mechanics processes are not well understood. Therefore, this study aims to establish mechanistic understanding …


Modeling Of Legged Locomotion With A Suspended Load In The Sagittal Plane, Karna P. Potwar 2013 Purdue University

Modeling Of Legged Locomotion With A Suspended Load In The Sagittal Plane, Karna P. Potwar

Open Access Theses

Walking or running while carrying loads has always been a tedious task, more so when the loads are heavy. Such a task of carrying loads not only requires extra effort but also leads to physical pain and in some cases injury. Prior studies on human locomotion with a suspended load have used models that are restricted in their DOFs and so are not able to take into account the fore aft movement in human beings. The objective of this thesis is to model the dynamics of sagittal plane center-of-mass locomotion with a suspended load and apply findings to carrying loads …


Role Of Satellite Cells In Long Term Fiber Type Shifts, Honglu Liu 2013 University of Kentucky

Role Of Satellite Cells In Long Term Fiber Type Shifts, Honglu Liu

Lewis Honors College Capstone Collection

Muscle fiber type shifts in respect to satellite cells, muscle stem cells, are not well understood currently. The Peterson Lab has generated a mouse model (PAX7-DTA) that ablates satellite cells to determine if these muscle stem cells contribute to mouse muscle fiber type changes over an eight week period. In the study, control and satellite-cell-ablated mouse groups were split into control and overload groups (via synergist ablation surgery) and placed under similar environmental conditions. Eight weeks post-experiment, muscles were dissected to obtain the plantaris muscles of animals from all groups. Muscle cross-sections obtained were immunohistochemically stained, imaged, quantified by fiber …


Developing Youth's Positive View Of Physical Activity, E. Whitney G. Moore 2013 University of North Texas

Developing Youth's Positive View Of Physical Activity, E. Whitney G. Moore

Kinesiology, Health and Sport Studies

Many youth start withdrawing from voluntary physical activity and physical education programs as they approach adolescence. Developmentally, this is also when youth can become more aware of their ability compared to others, and the amount of work it may take to improve their ability level. This focus on comparative performance standards can be affected by our coaching emphasis. This article highlights the characteristics and impacts of two coaching approaches. Particular emphasis is given to the specific behaviors adolescents have reported as fostering their effort, enjoyment, sportspersonship, and interest in continuing to be active.


Examining Administrative Attitudes Regarding The Determinants For The Expansion And Eliminations Of Intercollegiate Athletic Programs, Matthew A. Martin 2013 Eastern Washington University

Examining Administrative Attitudes Regarding The Determinants For The Expansion And Eliminations Of Intercollegiate Athletic Programs, Matthew A. Martin

EWU Masters Thesis Collection

No abstract provided.


Psychosocial And Cognitive Function In Children With Nephrotic Syndrome: Association With Disease And Treatment Variables, Panagiota Manti, George Giannakopoulos, Elena Giouroukou, Helen Georgaki-Angelaki, Constantinos J. Stefanidis, Andromahi Mitsioni, Nikolaos Stergiou, Constantinos Mihas, George P. Chrousos, Maria Alexandra Magiakou, Gerasimos Kolaitis 2013 Technological Educational Institution of Athens

Psychosocial And Cognitive Function In Children With Nephrotic Syndrome: Association With Disease And Treatment Variables, Panagiota Manti, George Giannakopoulos, Elena Giouroukou, Helen Georgaki-Angelaki, Constantinos J. Stefanidis, Andromahi Mitsioni, Nikolaos Stergiou, Constantinos Mihas, George P. Chrousos, Maria Alexandra Magiakou, Gerasimos Kolaitis

Journal Articles

Background
To investigate possible differences in emotional/behavioral problems and cognitive function in children with nephrotic syndrome compared to healthy controls and to examine the effect of disease-specific and steroid treatment-specific characteristics on the abovementioned variables.

Methods
Forty-one patients with nephrotic syndrome (23 boys, age range: 4.4-15.2 years) and 42 sex- and age-matched healthy control subjects (20 boys, age range: 4.1-13.4 years) were enrolled in the study. Disease (severity, age of diagnosis, duration) and steroid treatment (total duration, present methylprednisolone dose and duration of present dose) data were collected. In order to assess children’s emotional/behavioral problems, the Child Behavior Checklist was …


The Effect Of A Short Duration, High Intensity Exercise Intervention On Gait Biomechanics In Patients With Copd: Findings From A Pilot Study, Jenna M. Yentes, Daniel Blanke, Stephen I. Rennard, Nikolaos Stergiou 2013 University of Nebraska at Omaha

The Effect Of A Short Duration, High Intensity Exercise Intervention On Gait Biomechanics In Patients With Copd: Findings From A Pilot Study, Jenna M. Yentes, Daniel Blanke, Stephen I. Rennard, Nikolaos Stergiou

Journal Articles

Previous work has shown that patients with chronic obstructive pulmonary disease (COPD) demonstrate changes in their gait biomechanics as compared to controls. This pilot study was designed to explore the possibility that biomechanical alterations present in COPD patients might be amenable to treatment by exercise training of skeletal muscle. This study investigated the effect of a 6-week exercise intervention on gait biomechanics in patients with COPD under both a rest and a non-rested condition. Seven patients with COPD underwent a supervised cardio-respiratory and strength training protocol 2-3 times per week for 6-weeks for a total of 16-sessions. Spatiotemporal, kinematic and …


A Perspective On Human Movement Variability With Applications In Infancy Motor Development, Nikolaos Stergiou, Yawen Yu, Anastasia Kyvelidou 2013 University of Nebraska at Omaha

A Perspective On Human Movement Variability With Applications In Infancy Motor Development, Nikolaos Stergiou, Yawen Yu, Anastasia Kyvelidou

Journal Articles

Movement variability is considered essential to typical motor development. However, multiple theoretical perspectives and measurement tools have limited interpretation of the importance of movement variability in biological systems. The complementary use of linear and nonlinear measures have recently allowed for the evaluation of not only the magnitude of variability but also the temporal structure of variability. As a result, the theoretical model of optimal movement variability was introduced. The model suggests that the development of healthy and highly adaptable systems relies on the achievement of an optimal state of variability. Alternatively, abnormal development may be characterized by a narrow range …


Prosthesis Preference Is Related To Stride-To-Stride Fluctuations At The Prosthetic Ankle, Shane R. Wurdeman, Sara A. Myers, Adam L. Jacobsen, Nikolaos Stergiou 2013 University of Nebraska at Omaha

Prosthesis Preference Is Related To Stride-To-Stride Fluctuations At The Prosthetic Ankle, Shane R. Wurdeman, Sara A. Myers, Adam L. Jacobsen, Nikolaos Stergiou

Journal Articles

The purpose of this study was to determine the relationship between stride-to-stride fluctuations and prosthesis preference. Thirteen individuals with unilateral, transtibial amputation consented to participate. Individuals walked on a treadmill for 3 min with their prescribed and an alternate prosthesis. Stride-to-stride fluctuations were quantified with the largest Lyapunov exponent (LyE) of each joint flexion/extension time series. The change in the LyE was calculated for each major lower-limb joint for both conditions. Participants indicated preference between the prostheses on a continuous visual analog scale. The change in the LyE was correlated with the degree of preference between the two prostheses at …


Cardiorespiratory Responses In Healthy-Weight And Obese Women And Children, Elizabeth Ann Easley 2013 University of Kentucky

Cardiorespiratory Responses In Healthy-Weight And Obese Women And Children, Elizabeth Ann Easley

Theses and Dissertations--Kinesiology and Health Promotion

A criterion method to evaluate cardiorespiratory health is measuring peak oxygen consumption (VO2 peak) from a maximal graded exercise test (GXT). While VO2 peak is a valuable measure, heart rate recovery (HRRec) and endothelial function (EF) also describe cardiorespiratory health and fitness. The purpose of this study was to investigate whether differences exist in VO2 peak, HRRec, and EF between healthy-weight (HW) and obese (OB) women and children and to determine if there were significant correlations among these variables. A total of 60 women and children participated in this study. Anthropometric, body composition, resting heart rate and …


The Effect Of Acute Beetroot Juice Supplementation On Muscle Fatigue In Knee Extensor Exercise, SEUNGYONG LEE 2013 University of Kentucky

The Effect Of Acute Beetroot Juice Supplementation On Muscle Fatigue In Knee Extensor Exercise, Seungyong Lee

Theses and Dissertations--Kinesiology and Health Promotion

To examine the effect of acute beetroot juice supplementation on the rate of fatigue as measured by changes in peak torque.

Placebo-controlled, double-blind, cross-over study, 35 recreationally active subjects consumed beetroot (BR) juice or black currant juice (PL) 12 and 2.5 hours before the exercise procedure. Peak torque was measured on the BIODEX dynamometer by performing 50, maximal effort, concentric knee extensions at 90°/s. Blood pressure (BP) was recorded before and after exercise.

No significant difference between BR and PL in the rate of fatigue measured by change in peak torque. By stage 3, subjects retained 87.6±6.9% of strength with …


Physical Activity For African American Females : Salience Of Race, Gender-Role, And Exercise Identities, Jasmine M. Hamilton 2013 Louisiana State University and Agricultural and Mechanical College

Physical Activity For African American Females : Salience Of Race, Gender-Role, And Exercise Identities, Jasmine M. Hamilton

LSU Doctoral Dissertations

Social identity theory explores the process of self-identifications based upon perceived shared commonalities with others in order to positively affiliate with group membership and accounts for inter-group and intra-group behaviors (Deaux, 2001; Hogg & Abrams, 1999; Tajfel, 1982). Social identity is also dependent upon environment and situation dynamics (Turner, 1982). African American females are at risk for high levels of physical inactivity. Researchers have suggested the use of frameworks that move investigations beyond assessing social aggregates such as race and gender to understand why this is true. Racial identity, gender-role identity, and exercise identity (derived from social identity theory) provide …


Oxygen Consumption During Exercise: The Role Of Venous Occlusion, Tiffany Noel Saltzman 2013 Louisiana State University and Agricultural and Mechanical College

Oxygen Consumption During Exercise: The Role Of Venous Occlusion, Tiffany Noel Saltzman

LSU Master's Theses

Abstract Oxygen consumption during exercise is typically used to advance performance, determine fitness level, and make clinical diagnoses. The rate at which VO2 adjusts to and recovers from (i.e. on- and off- kinetics) a bout of exercise is typically associated with certain metabolic processes such as stores of PCr, ATP, replenishing myoglobin, hemoglobin, and removing metabolic waste. The ability of an individual to utilize these processes can determine the speed at which oxygen consumption rises and falls, and thus is associated with the health of the individual (i.e. faster=fitter; slower=unhealthy). The use of circulatory occlusion training has recently become a …


Perceptions Of The Motivational Climate And Gender Class Structure In Physical Education, Lauren E. Delgado 2013 Louisiana State University and Agricultural and Mechanical College

Perceptions Of The Motivational Climate And Gender Class Structure In Physical Education, Lauren E. Delgado

LSU Master's Theses

Many children do not engage in the recommended levels of physical activity, and they ten to become even less active during adolescence. Girls are less active then boys, and it is important to explore ways that physical education teachers can foster girls’ motivation to be more physically active. The specific research questions for this study were: (a) How does gender class structure affect girls’ perception of the motivational climate?; and (b) How do girls’ views of the motivation climate in different gender class structures relate to intentions to participate in physical activity outside of physical education? A phenomenological framework guided …


Outsmarting The Brain: Augmenting Motor Training With Non-Invasive Brain Stimulation In Order To Facilitate Plasticity-Dependent, Functional Improvement Within The Motor Cortex, Raymond Joseph Butts 2013 University of South Carolina

Outsmarting The Brain: Augmenting Motor Training With Non-Invasive Brain Stimulation In Order To Facilitate Plasticity-Dependent, Functional Improvement Within The Motor Cortex, Raymond Joseph Butts

Theses and Dissertations

Brain stimulation techniques capable of optimizing cortical plasticity may provide the key to improved therapeutic techniques and functional outcomes. The primary aim of this dissertation was to examine the potential of motor training (MT) augmented with intermittent theta burst stimulation (iTBS) and anodal transcranial direct current stimulation (a-tDCS). The secondary aim was to investigate whether the training would also be advantageous to older-adults. We hypothesized that right-handed, college-age students exposed to the treatment (n=17) would perform better short-term (directly following MT) and long-term (24 hours and 7 days following MT) on motor-skill retention tests than students receiving sham stimulation (n=14). …


The Effects Of A High Fat Diet On Mitochondrial Biogenesis And Inflammation In The Brain., Lauren Suzanne Vervaecke 2013 University of South Carolina

The Effects Of A High Fat Diet On Mitochondrial Biogenesis And Inflammation In The Brain., Lauren Suzanne Vervaecke

Theses and Dissertations

INTRO: High fat diets (HFD) ingested over long periods of time have been shown to cause diet induced obesity leading to excessive adiposity and chronic low grade inflammation. Here we have shown how differing levels of saturated fats (SF), which are common storage fats, affect markers of inflammation and mitochondrial biogenesis. IL-1â and TNF-alpha are pro-inflammatory cytokines that have been shown to increase with a HFD, while molecular signalers, PGC-1alpha, cyt c, and SIRT1, related to mitochondrial biogenesis have been shown to decrease. Despite the risks of consuming a diet high in SF's, consumers continue to buy energy dense foods …


Integrating Movement And Science To Promote Physical Activity And Academic Performance In Middle School Children, Kevin E. Finn, Kyle McInnis 2013 Merrimack College

Integrating Movement And Science To Promote Physical Activity And Academic Performance In Middle School Children, Kevin E. Finn, Kyle Mcinnis

Health Sciences Faculty Publications

Background: Recommendations from leading U.S. health agencies concerned with reducing childhood obesity call for increased physical activity during school and afterschool environments. Methods: We developed the Active Science curriculum, which is a variety of activity-based lessons (e.g., nature hike, dance class, walk at local park, treadmill at local YMCA) and incorporated them into traditional science classes and after school programs for middle school children in a low-income, ethnically diverse community. Following the activity experiments, students and teachers uploaded data from devices to an interactive website that provided inquiry-based exploratory learning of science content. Results: Physical activity results showed that the …


Acute Effects Of Exercise On Cognitive Performances Of Older Adults, R. Pennington, S. Hanna 2013 Arkansas Tech University

Acute Effects Of Exercise On Cognitive Performances Of Older Adults, R. Pennington, S. Hanna

Journal of the Arkansas Academy of Science

Accelerating rates of structural decline become evident during the third and fourth decades of human life, with disproportionate degeneration occurring in the frontal, parietal, and temporal brain lobes. As the structure of the brain declines, a broad array of cognitive processes involving memory, decision making, and selective attention are reduced as well (Raz 2000, Park et al. 2001). Cardiovascular exercise has been associated with improved cognitive functioning in aging humans, suggesting that increased vascular supply enhances availability of oxygen, nutrients, and other physical entities to nourish the brain. Previous experimentation on older adults revealed significant positive effects of exercise on …


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