Biomechanics Commons^™

Identifying The Function Of The Calpain Small Subunit In The Mechanics Of Cell Migration, Bingqing Hao

Wayne State University Dissertations

Cell migration plays a vital role in many physiological events including: morphogenesis, wound healing, and immune response. Dysfunctional cell migration results in multiple disease states including chronic inflammation, vascular disease, and tumor metastasis, to name a few. Progress in understanding the mechanism of cell migration had been slow until the turn of the century when rapid technological advances in microscopy and omics burst to the forefront. These advances led to the realization that physical factors (dimensions, fluid shear stress, hydrostatic pressure, compression stress, environmental stiffness, and topography) have profound effects on cell migration. This study of cell mechanics has expanded …

Obesity And Obesity Shape Markedly Influence Spine Biomechanics: A Subject-Specific Risk Assessment Model, Farshid Ghezelbash, Aboulfazl Shirazi-Adl, André Plamondon, Navid Arjmand, Mohammad Parnianpour

Études primaires

Underlying mechanisms of obesity-related back pain remain unexplored. Thus, we aim to determine the effect of obesity and its shapes on the spinal loads and the associated risks of injury. Obesity shapes were initially constructed by principal component analysis based on datasets on 5852 obese individuals. Spinal loads, cycles to vertebral failure and trunk stability margin were estimated in a subject-specific trunk model taking account of personalized musculature, passive ligamentous spine, obesity shapes, segmental weights, spine kinematics and bone mineral density. Three obesity shapes (mean and extreme abdominal circumferences) at three body weights (BWs) of 86, 98 and 109 kg …

Comparison Of Lumbo-Pelvic Kinematics During Trunk Forward Bending And Backward Return Between Patients With Acute Low Back Pain And Asymptomatic Controls, Iman Shojaei, Elizabeth G. Salt, Quenten L. Hooker, Linda R. Van Dillen, Babak Bazrgari

Biomedical Engineering Faculty Publications

Background—Prior studies have reported differences in lumbo-pelvic kinematics during a trunk forward bending and backward return task between individuals with and without chronic low back pain; yet, the literature on lumbo-pelvic kinematics of patients with acute low back pain is scant. Therefore, the purpose of this study was set to investigate lumbo-pelvic kinematics in this cohort.

Methods—A case-control study was conducted to investigate the differences in pelvic and thoracic rotation along with lumbar flexion as well as their first and second time derivatives between females with and without acute low back pain. Participants in each group completed one …

The Effects Of A 12-Week Custom Foot Orthotic Intervention On The Intrinsic Muscles Of The Foot, And Dynamic Stability During Unexpected Gait Termination In Healthy Young Adults, Katrina Protopapas

Theses and Dissertations (Comprehensive)

Introduction: Custom-made foot orthotics (CFO’s) are a commonly prescribed intervention to help individuals that are suffering from foot pain and foot disorders. However, the mechanisms of CFO’s are still poorly understood and are not well known. With the plantar intrinsic muscles of the foot being in direct contact with the CFO, it puts these structures at risk for disuse muscle atrophy as a result of being offloaded. Therefore, the purpose of the current study was to determine the effect of a 12-week custom-made foot orthotic intervention on the intrinsic muscles of the foot and dynamic stability during unexpected gait termination. …

An Investigation Of The Relationship Between Intervertebral Disc Puncture, Inflammation, And Tissue Mechanics Using A Rat-Tail Model., Brigitte Laird

Theses and Dissertations (Comprehensive)

Introduction: The intervertebral disc (IVD) is composed of the annulus fibrosus (AF), which surrounds and contains the nucleus pulposus (NP). It is hypothesized that when the IVD becomes injured, in the case of IVD herniation, a localized innate immune response is initiated. Although the presence of pro-inflammatory cytokines in injured IVDs has been well documented, the extent to which inflammation affects the mechanical properties of the IVD remains poorly understood. The purpose of this study was to determine the effect of IVD damage (via puncture) and inflammation (via lipopolysaccharide (LPS) exposure) on the mechanical and structural properties of the IVD. …

The Acute Effect Vibrating Foam Rollers Have On The Lower Extremities' Ability To Produce Power, Jared L. Klingenberg

EWU Masters Thesis Collection

The purpose of this study was to examine the effect that vibration through self-myofascial release in combination with a dynamic stretch routine had on maximum power output. Twenty-one collegiate volleyball athletes agreed to participate in the study. The design was a randomized cross-over design in which all participants served as their own control by participating in all three interventions, which consisted of; a) dynamic stretch routine (DS), b) non-vibrating foam rolling combined with dynamic stretch routine (NVFR), and c) vibrating foam rolling combined with dynamic stretch routine (VFR). The foam rolling protocol consisted of rolling each limb bilaterally for 30 …

The Effects Of Orthotics And Increased Plantar Sole Mechanoreceptor Activation On Turning Performance In Individuals With Parkinson’S Disease, Kelly A. Robb

Theses and Dissertations (Comprehensive)

Locomotion and turning are complex movement patterns essential to activities of daily living. Individuals with Parkinson’s disease (PD) report difficulties turning, often coupled with impaired balance and increased fear of falling. The purpose of this within-subject study was to determine if orthotics, with and without a textured top cover, can improve gait stability and turning performance within Parkinson’s participants. Seven participants with a diagnosis of idiopathic Parkinson’s disease, aged 55-80 years old, participated in the study. Participants completed three testing sessions; baseline, 4 weeks post-baseline, and 5 weeks post-baseline. The ‘footwear only’ and ‘footwear + non-textured orthotic’ conditions were tested …

The Rim And The Ancient Mariner: The Nautical Horizon Affects Postural Sway In Older Adults, Justin Munafo, Michael G. Wade, Nick Stergiou, Thomas A. Stoffregen

Journal Articles

On land, the spatial magnitude of postural sway (i.e., the amount of sway) tends to be greater when participants look at the horizon than when they look at nearby targets. By contrast, on ships at sea, the spatial magnitude of postural sway in young adults has been greater when looking at nearby targets and less when looking at the horizon. Healthy aging is associated with changes in the movement patterns of the standing body sway, and these changes typically are interpreted in terms of age-related declines in the ability to control posture. To further elucidate the mechanisms associated with these …

Chapter 9: Biomechanics, Nicholas Stergiou, Daniel Blanke, Sara A. Myers, Ka-Chun Siu

Journal Articles

Biomechanics is a discipline. A discipline deals with understanding, predicting, and explaining phenomena within a content domain, and biomechanics is the study of the human body in motion. By applying

principles from mechanics and engineering, biomechanists are able to study the forces that act on the body and the effects they produce (Bates, 1991). Hay (1973) describes biomechanics as the science that examines forces acting on and within a biological structure and the effects produced by such forces, whereas Alt (1967) describes biomechanics as the science that investigates the effect of internal and external forces on human and animal bodies …

Time-Series Analysis Of Embodied Interaction: Movement Variability And Complexity Matching As Dyadic Properties, Leonardo Zapata-Fonseca, Dobromir Dotov, Ruben Fossion, Tom Froese

Journal Articles

There is a growing consensus that a fuller understanding of social cognition depends on more systematic studies of real-time social interaction. Such studies require methods that can deal with the complex dynamics taking place at multiple interdependent temporal and spatial scales, spanning sub-personal, personal, and dyadic levels of analysis. We demonstrate the value of adopting an extended multi-scale approach by re-analyzing movement time-series generated in a study of embodied dyadic interaction in a minimal virtual reality environment (a perceptual crossing experiment). Reduced movement variability revealed an interdependence between social awareness and social coordination that cannot be accounted for by either …

The Effects Of An Inclined And Declined Slope On Backward Locomotion: A Kinematic And Electromyographic Analysis Of Retrowalking, Song Dan Vo

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to investigate the effects of an inclined and declined slopeon kinematic properties and muscle activation magnitudes. This purpose was achieved by using a +10% grade for inclined backward walking (IBW) and -10% grade for declined backwardwalking (DBW) on a treadmill. Eleven participants (24.6 ± 4.1 yrs, 68.5 ± 14.6 kg, 1.7 ± 0.1 m) were recruited from the UNLV student body and were subject to a three day adaptation protocol to allow them to choose a preferred walking speed and to familiarize themselves with such a novel task. Two consecutive practice days included a …

Indifference To Chaotic Motion May Be Related To Social Disinterest In Children With Autism, Joshua L. Haworth, Anastasia Kyvelidou, Wayne Fisher, Nicholas Stergiou

Journal Articles

Children with autism spectrum disorder tend to have little interest in the presence, actions, and motives of other persons. In addition, these children tend to present with a limited and overly redundant movement repertoire, often expressing hyperfixation and aversion to novelty. We explore whether this is related to a more fundamental lack of appreciation for various temporal dynamics, including periodic, chaotic, and aperiodic motion structures. Seven children with ASD (age, gender, and height matched with children without ASD) were asked to stand and watch the motion of a visual stimulus displayed on a large (55") video monitor. Gaze and posture …

A Framework For Studying Meshfree Geometry And A Method For Explicit Boundary Determination, Joseph Bradley Alford

USF Tampa Graduate Theses and Dissertations

Patient-specific biomechanical analysis is an important tool used to understand the complex processes that occur in the body due to physical stimulation. Patient-specific models are generated by processing medical images; once an object from the image is identified via segmentation, a point cloud representation of the object is extracted. Generating an analysis suitable representation from the point cloud has traditionally required generating a finite element mesh, which often requires a well defined surface to accomplish. Point clouds lack a well defined geometry, meaning that the surface definition is incomplete at best. Point clouds that have been generated from images have …

Molybdenum Disulfide-Conducting Polymer Composite Structures For Electrochemical Biosensor Applications, Hongxiang Jia

USF Tampa Graduate Theses and Dissertations

Lactic acid is widely existing in human bodies, animals and microorganisms. Recently, using biosensor to detect the concentration of lactic acid and diagnose disease have attracted great research and development interests. Nanocomposites is one of the best material used for biosensor because their wonderful conductivity, optical and electrochemical properties. In the study, MoS₂ and polypyrrole (PPY) are used for the composite material electrode. To determine whether lactate oxidase (LOD) was helpful for the biosensor’s detective properties, both PPY-MoS₂ film with LOD and PPY-MoS₂ film without LOD are being tested. The fourier transform infrared spectroscopy (FTIR) and Raman …

Hydrodynamic Properties Of Fin Whale Flippers Predict Maximum Rolling Performance, Paolo S. Segre, David E. Cade, Frank E. Fish, Jean Potvin, Ann N. Allen, John Calambokidis, Ari S. Friedlaender, Jeremy A. Goldbogen

Biology Faculty Publications

Maneuverability is one of the most important and least understood aspects of animal locomotion. The hydrofoil-like flippers of cetaceans are thought to function as control surfaces that effect maneuvers, but quantitative tests of this hypothesis have been lacking. Here, we constructed a simple hydrodynamic model to predict the longitudinal-axis roll performance of fin whales, and we tested its predictions against kinematic data recorded by on-board movement sensors from 27 free-swimming fin whales. We found that for a given swimming speed and roll excursion, the roll velocity of fin whales calculated from our field data agrees well with that predicted by …

Dynamic Perception Of Dynamic Affordances: Walking On A Ship At Sea, Hannah Walter, Jeffrey B. Wagman, Nicholas Stergiou, Nurtekin Erkmen, Thomas A. Stoffregen

Journal Articles

Motion of the surface of the sea (waves, and swell) causes oscillatory motion of ships at sea. Generally, ships are longer than they are wide. One consequence of this structural difference is that oscillatory ship motion typically will be greater in roll (i.e., the ship rolling from side to side) than in pitch (i.e., the bow and stern rising and falling). For persons on ships at sea, affordances for walking on the open deck should be differentially influenced by ship motion in roll and pitch. Specifically, the minimum width of a walkable path should be greater when walking along the …

Hallux Valgus Surgery Affects Kinematic Parameters During Gait, Jitka Klugarova, Miroslav Janura, Zdenek Svoboda, Zdenek Sos, Nicholas Stergiou, Miloslav Klugar

Journal Articles

Background

The aim of our study was to compare spatiotemporal parameters and lower limb and pelvis kinematics during the walking in patients with hallux valgus before and after surgery and in relation to a control group.

Methods

Seventeen females with hallux valgus, who underwent first metatarsal osteotomy, constituted our experimental group. The control group consisted of thirteen females. Kinematic data during walking were obtained using the Vicon MX system.

Findings

Our results showed that hallux valgus before surgery affects spatiotemporal parameters and lower limb and pelvis kinematics during walking. Hallux valgus surgery further increased the differences that were present before …

Speed And Rhythm Affect Temporal Structure Of Variability In Reaching Poststroke: A Pilot Study, Amit Sethi, Nicholas Stergiou, Tara Patterson, Carolynn Patten, Lorie G. Richards

Journal Articles

Temporal structure reveals the potential adaptive strategies employed during upper extremity movements. The authors compared the temporal structure of upper extremity joints under 3 different reaching conditions: preferred speed, fast speed, and reaching with rhythmic auditory cues in 10 individuals poststroke. They also investigated the temporal structure of these 3 reaching conditions in 8 healthy controls to aid in the interpretation of the observed patterns in the poststroke cohort. Approximate entropy (ApEn) was used to measure the temporal structure of the upper extremity joints. ApEn was similar between conditions in controls. After stroke, ApEn was significantly higher for shoulder, elbow, …

Biologically-Variable Rhythmic Auditory Cues Are Superior To Isochronous Cues In Fostering Natural Gait Variability In Parkinson’S Disease, Dobromir Dotov, S. Bayard, Valérie Cochen De Cock, Christian Geny, Valérie Driss, G. Garrigue, Benoit G. Bardy, Simone Dalla Bella

Journal Articles

Introduction

Method

Effect Of Timing Of Hip Extension Assistance During Loaded Walking With A Soft Exosuit, Ye Ding, Fausto A. Panizzolo, Christopher Siviy, Philippe Malcolm, Ignacio Galiana, Kenneth G. Holt, Conor J. Walsh

Journal Articles

Background

Recent advances in wearable robotic devices have demonstrated the ability to reduce the metabolic cost of walking by assisting the ankle joint. To achieve greater gains in the future it will be important to determine optimal actuation parameters and explore the effect of assisting other joints. The aim of the present work is to investigate how the timing of hip extension assistance affects the positive mechanical power delivered by an exosuit and its effect on biological joint power and metabolic cost during loaded walking. In this study, we evaluated 4 different hip assistive profiles with different actuation timings: early-start-early-peak …