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Wayne State University

Corticosterone

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Full-Text Articles in Biological Psychology

The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber Jan 2018

The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber

Wayne State University Dissertations

In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …


Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante Jan 2013

Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante

Wayne State University Dissertations

Stress and affiliative social relationships are bi-directionally related. It is well understood that social relationships can buffer the physiological response to a stressor. Conversely, there is some evidence to suggest that stress can affect the propensity to form a pair bond. Data from humans and prairie voles, monogamous rodents, suggest that activation of the hypothalamic-pituitary-adrenal axis (HPA) in males increases attraction for females. Across species, females are understudied, but evidence from the prairie vole suggests HPA activation impairs formation of partner preference, the first step in establishing a pair bond. Across taxa there is evidence that formation and maintenance of …