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2024

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Full-Text Articles in Social and Behavioral Sciences

A Multiagency Approach To Animal Hoarding In Central Iowa, Gary W. Rasmussen Aug 2024

A Multiagency Approach To Animal Hoarding In Central Iowa, Gary W. Rasmussen

Walden Dissertations and Doctoral Studies

This research explored animal hoarding in Iowa using the qualitative method with the resource dependency theory and a case study approach. These cases were studied using multiple sources of information, from media reports in initial locating cases to court documents, to examine the results of each case. It examined how different sized law enforcement agencies’ investigations into these cases impacted the outcomes of the cases in sentencing and the use of mental health evaluations and treatments. It also explored the efficacy of how different sized law enforcement agencies investigated animal hoarding cases. The law enforcement agencies were divided into two …


Human Rights Violations Against Legal Immigrants In Minnesota, John Ewu Aug 2024

Human Rights Violations Against Legal Immigrants In Minnesota, John Ewu

Walden Dissertations and Doctoral Studies

Despite legal entitlements to protections under the International Bill of Human Rights, legal immigrants in Minnesota face human rights violations, including discrimination, harassment, and denial of essential services. These violations hinder their well-being, social integration, and economic stability, exacerbate existing disparities, and their ability to provide for their families and secure legal representation. The purpose of this study was to provide information that could be used in considering policy reforms to improve the treatment of immigrants in Minnesota. This was achieved by exploring how Mexican, Somali, and Hmong legal immigrants experienced human rights violations in Minnesota as a vulnerable population …


Remembering, Forgetting, And Artifact Deposition In Late Prehistoric Florida, Andrew Bowen Aug 2024

Remembering, Forgetting, And Artifact Deposition In Late Prehistoric Florida, Andrew Bowen

Master's Theses

Material culture plays a fundamental role in memory processes. Artifacts are an important means of both connecting with and cutting ties with a real or imagined past. They can be reminders or symbols of connection to other people, places, things, powers, or memories, making them key components within networks and relations. The way materials are deposited or destroyed often follows specific customs or responds to environmental factors. Specific situations, like interactions with outside groups or socio-political changes, prompt particular depositional events. During the Mississippi period, such circumstances were prevalent throughout the Southeast. By treating artifacts in specific ways during deposition, …


Legend Trips And Vernacular Film Theory: Spooky Encounters In Tiktok Mediated Legend Trips, Drew Holley Aug 2024

Legend Trips And Vernacular Film Theory: Spooky Encounters In Tiktok Mediated Legend Trips, Drew Holley

All Graduate Reports and Creative Projects, Fall 2023 to Present

In this thesis I looked at how legend tripping is mediated through the affordances of new social technologies and apps, specifically TikTok. Short video formats allowed for folk cinematography to spread legend narratives and at the same time create more visual online landscapes for people to interact with. I defined folk cinematography as the way in which people make videos based on a vernacular level. This has been based on people having more access to video making tools and learning from informal patterns such as trends on sites like TikTok. Because of this, I explored how audiences participate in a …


Working Together For Working Lands: Knowledge Braiding And Adaptive Capacity At The Confluence Of Rangelands, Climate Adaptation, And Watershed Stewardship, William Wesley Munger Aug 2024

Working Together For Working Lands: Knowledge Braiding And Adaptive Capacity At The Confluence Of Rangelands, Climate Adaptation, And Watershed Stewardship, William Wesley Munger

All Graduate Theses and Dissertations, Fall 2023 to Present

Working lands are a mosaic that hold critical opportunities for biodiversity, rural community wellbeing, and climate change adaptation. This landscape mosaic is made up of public lands, tribal lands, and private ranches, farms, and forests. The current era of ecological restoration and climate adaptation requires engaging in working lands conservation because the most promising strategies require working across multiple ownership boundaries. This dissertation argues that supporting working lands conservation, climate adaptation, and ecological restoration is a joint venture. Building adaptive capacity for climate change involves both social and ecological components. Adaptive capacity consists of building social collaborative capacity and ecological …


Addressing The Great Salt Lake Desiccation: Exploring Support For Alternative Frameworks On Rights Of Nature And Multispecies Justice, Sadie Braddock Aug 2024

Addressing The Great Salt Lake Desiccation: Exploring Support For Alternative Frameworks On Rights Of Nature And Multispecies Justice, Sadie Braddock

All Graduate Theses and Dissertations, Fall 2023 to Present

Currently, there is a lack of social science research on the Great Salt Lake – a shrinking lake that faces potential ecological collapse as more water is taken upstream for human uses before it can get to the lake. The drying lake has received national attention, as it will lead to a loss of wildlife habitat, contribute to public health concerns, and impact Utah’s economy. In response to this issue, environmental scientists and activists have pressured policymakers to prioritize actions to conserve water for the lake. However, while polices have been implemented, water saved from these efforts are not guaranteed …


The Credit Card Behaviors And Financial Satisfaction Among Emerging Adults During The Covid-19 Pandemic, Jessica Ralphs Aug 2024

The Credit Card Behaviors And Financial Satisfaction Among Emerging Adults During The Covid-19 Pandemic, Jessica Ralphs

All Graduate Theses and Dissertations, Fall 2023 to Present

Using data from the 2021 National Financial Capability Study (NFCS), this study focused on poor credit card behaviors and financial satisfaction of emerging adults ages between 18 and 29 (N=1,944). The descriptive results show that 45.8% reported carrying over a balance in the past 12 months and 51.3% reported paying the minimum payment some months. It was also found that 28.3% reported being charged a late fee for late payment some months in the past 12 months, whereas 21.7% reported being charged an over the limit fee for exceeding their credit limit some months.

The multivariate results indicated …


Identifying Sociodemographic Group Changes In A Blended Family Relationship Education Program, Takoma R. Lindsay Aug 2024

Identifying Sociodemographic Group Changes In A Blended Family Relationship Education Program, Takoma R. Lindsay

All Graduate Theses and Dissertations, Fall 2023 to Present

This study evaluated if levels of change in mental health, conflict resolution, support, and companionship differed between sociodemographic groups who participated in a blended family relationship education program. Regarding individual mental health, females who were students improved more than non-students and those who had a bachelor’s or advanced degree improved more than those with a high school education or less. Male mental health across sociodemographic groups tended to be worse at posttest than baseline. Among couples, conflict improved more for those who were married and the female partner had a bachelor’s or advanced degree, were low income and female partners …


Differences In Debt Holdings And Financial Satisfaction Across Age During Covid, Loryn Elaine Law Aug 2024

Differences In Debt Holdings And Financial Satisfaction Across Age During Covid, Loryn Elaine Law

All Graduate Theses and Dissertations, Fall 2023 to Present

Access to credit has allowed many individuals to reach their own version of the American dream as credit offers them resources to improve quality of life by buying homes, purchasing automobiles, funding higher education, and financing everyday needs. However, accumulating debt may have negative impacts on their financial satisfaction. Since the 2021 wave of the National Financial Capability Study (NFCS) was collected during the COVID-19 Pandemic, this study was able to look at how financial stressors (e.g., unexpected income drops, being laid-off, difficulty paying on-going bills), financial anxiety, and financial literacy variables (e.g., subjective financial knowledge, objective financial knowledge, perceived …


Birds, Bees, And The Babies: Study Of The Influence Of Self-Efficacy On Parent-Child Sex Communication, Cassandra M. Craig Aug 2024

Birds, Bees, And The Babies: Study Of The Influence Of Self-Efficacy On Parent-Child Sex Communication, Cassandra M. Craig

All Graduate Theses and Dissertations, Fall 2023 to Present

Previous studies show that parents tend to be uncomfortable discussing sexual topics with their children, such as menstruation, masturbation, and/or condom use. This study offers a look at the part confidence plays in a parent's intentions to talk to their kids about such topics. The results indicated that the confidence parents feel about discussing sexual topics is not related to how much their own parents talked with them about sex. However, the confidence they feel that could be coming from other models, like social media or peers, is related to how much parents intend to talk with their own children …


Contrasting Management Styles And Differing Outcomes Of Capping And Orphaning Of Utah Oil And Gas Wells By Conditions And Land Types, Maxwell C. Parson Aug 2024

Contrasting Management Styles And Differing Outcomes Of Capping And Orphaning Of Utah Oil And Gas Wells By Conditions And Land Types, Maxwell C. Parson

All Graduate Theses and Dissertations, Fall 2023 to Present

The issue of public lands management and ownership in the West has long been contentious. This thesis takes a quantitative approach examining outcomes of the rates at which oil and gas wells in the state of Utah are orphaned and/or capped. Findings indicate that orphanings occur at a statistically significant higher rate on state owned land as opposed to federal and private, and wells on tribal land have no recorded orphaning. No other variables were significant in their relationship to orphaning. The proposed explanations for this disparity are two-fold: First the longer periods of inactivity permitted by the state simply …


Validating A Scale Of Psychological Flexibility And Inflexibility For Older Adolescents, Caleb Douglas Farley Aug 2024

Validating A Scale Of Psychological Flexibility And Inflexibility For Older Adolescents, Caleb Douglas Farley

All Graduate Theses and Dissertations, Fall 2023 to Present

Psychological flexibility (PF) is a skill that is related to various mental health experiences in adults. Higher levels of PF seem related to greater wellbeing. Given increases in mental health problems with youth, measuring PF and its inverse, psychological inflexibility (PI), might be useful for identifying those teenagers at risk for mental health challenges and referring them to appropriate interventions. To date, most measures of PF and PI are only available for adults older than 18, and, while theory suggests PF and PI are important for adolescent mental health, little research has examined the validity of these claims. This multipaper …


The Rise And Fall Of Elizabeth Holmes: Investigating Myths Within Media Coverage, Charlotte Emelia Williams Aug 2024

The Rise And Fall Of Elizabeth Holmes: Investigating Myths Within Media Coverage, Charlotte Emelia Williams

All Graduate Theses and Dissertations, Fall 2023 to Present

When Elizabeth Holmes became the youngest female billionaire in 2014, news media framed her as the next Steve Jobs due to her similarities as a dropout, a passionate industry disruptor, and a visionary. When she was discovered as a fraud in 2018, coverage framed her as a feminine, seductive monster who duped everyone. I analyzed the media coverage in both years to uncover myths that guided these narratives and argue that these news frames contributed to the large interest in her rise and fall while also reinforcing harmful ways of thinking toward success and female leadership.


An Xrf Elemental Analysis Of Prosser Molded Beads From Southwest Oregon, Michele Hoferitza Aug 2024

An Xrf Elemental Analysis Of Prosser Molded Beads From Southwest Oregon, Michele Hoferitza

All Graduate Theses and Dissertations, Fall 2023 to Present

Glass beads were brought to the North American continent by European explorers and traders beginning in the 17th century. Native Americans quickly adopted beads as trade commodities and personal ornaments. Prosser beads were made predominately in France and Bohemia from the 1860’s to the 1970’s and can be found in archaeological contexts from coast to coast. In this study, elemental analysis using X-Ray fluorescence (XRF) technology is used to determine if there is a way to chemically discern where and when the beads were made.

Statistical analysis of three categories of elements was done to determine whether the creation …


Gpr171 Modulates Mood, Consummatory Behaviors, And Morphine Antinociception In A Sexually Dimorphic Pattern In Mice, Megan C. Raddatz Aug 2024

Gpr171 Modulates Mood, Consummatory Behaviors, And Morphine Antinociception In A Sexually Dimorphic Pattern In Mice, Megan C. Raddatz

All Graduate Theses and Dissertations, Fall 2023 to Present

Receptors in the brain influence everything from complex behaviors related to mood, all the way to simple physiological functions like the way a person moves. Receptors are activated or inactivated by chemicals or hormones that the body produces or that are created to mimic the body’s natural chemicals. Of the hundreds of receptors in the brain, GPR171 is particularly interesting because new drugs have been created to activate or block the receptor, and are being proposed for the treatment of different disorders, particularly disorders related to pain. GPR171 has been shown to affect pain behaviors, eating, and mood-related behaviors, but …


Do Older Siblings Differentiate From Their Younger Siblings? Predictors And Longitudinal Correlates, Iliana Wilkinson Aug 2024

Do Older Siblings Differentiate From Their Younger Siblings? Predictors And Longitudinal Correlates, Iliana Wilkinson

All Graduate Theses and Dissertations, Fall 2023 to Present

Families are a critical part of an individual's development, yet sibling influences on development are rarely studied. Siblings often share the same genetics and live in the same environment, yet many remark that they are nothing like their brothers or sisters. One proposed reason for these differences is sibling differentiation, a process by which individuals become different from their sibling in order to reduce conflict and rivalry as well as increase intimacy in the sibling relationship. To date, this process has been studied from the perspective of the younger sibling; the current study focused on older siblings. Using longitudinal data …


Healing Through Caring And Knowledge-Making In Everyday Food Practices Among Lgbtq+ Black, Indigenous, People Of Colour, Elizabeth Grace Wong Aug 2024

Healing Through Caring And Knowledge-Making In Everyday Food Practices Among Lgbtq+ Black, Indigenous, People Of Colour, Elizabeth Grace Wong

All Graduate Theses and Dissertations, Fall 2023 to Present

Three different models are used in this study to understand how everyday food practices carry healing potential through the interwoven process of caring and knowledge-making. Daily food practices reflect a mixture of tradition and modernity— borne out of our roots and our contexts. Anzaldúa’s (1987) Borderland Theory helps us understand how this mixture is made by people who straddle two borders or worlds and contest those confines. Chavez-Dueñas et al.’s (2019) HEART model names strengthening our cultural and familial traditions and roots as part of the broader processes of building cultural consciousness and connection, and engaging in collective healing. Finally, …


Online Act For Caregivers: A Longitudinal Mixed Methods Study, Jacob D. Gossner Aug 2024

Online Act For Caregivers: A Longitudinal Mixed Methods Study, Jacob D. Gossner

All Graduate Theses and Dissertations, Fall 2023 to Present

Family caregivers for people with dementia are a resilient population operating under stressful circumstances that can put them at risk of multiple negative outcomes. Existing interventions may be difficult for family caregivers to access due to time and transportation constraints; an alternative is online, self-guided interventions that caregivers can access from their own homes. The purpose of this dissertation is to evaluate the impact of ACT for Caregivers, a six session online, self-guided program based on the principles of Acceptance and Commitment Therapy. Participants had an average age of 61.93 (SD = 13.69), had been caregiving for an average …


Managing Public Land Outdoor Recreation For Improved Visitor Experience And Resource Protection: Comparing Direct And Indirect Visitor Use Management Tools, Iree Wheeler Aug 2024

Managing Public Land Outdoor Recreation For Improved Visitor Experience And Resource Protection: Comparing Direct And Indirect Visitor Use Management Tools, Iree Wheeler

All Graduate Theses and Dissertations, Fall 2023 to Present

Public land managers incorporate a variety of tools to manage visitors to Parks and Protected Areas (PPAs). The intention of these management actions is to mitigate visitor impacts on natural resources, and facilitate high quality visitor experiences by minimizing depreciative behavior or spreading out visitation to reduce congestion. Approaches such as interpretation and educational information which indirectly influence visitor behavior by encouraging people to participate in minimum impact behavior or to visit during a different time, are referred to as indirect management actions. Other approaches use enforcement or regulations to mandate changes in behavior, or direct management actions. While these …


Righting Reproductive Wrongs: A Rhetorical Analysis Of Special Topoi In Alberto Fernández’S Pro-Voluntary Interruption Of Pregnancy Speeches, Kymberlie Crosby Aug 2024

Righting Reproductive Wrongs: A Rhetorical Analysis Of Special Topoi In Alberto Fernández’S Pro-Voluntary Interruption Of Pregnancy Speeches, Kymberlie Crosby

All Graduate Theses and Dissertations, Fall 2023 to Present

The reproductive rights movement argues that abortion rights are fundamental and necessary for women to enjoy their human rights. Politicians opposed to abortion rights around the world have made it clear that they plan to ban abortion both statewide and nationwide. A country that has proven to be successful in defending its reproductive rights is Argentina. In 2020, the Voluntary Interruption of Pregnancy Bill (Interrupción Voluntaria del Embarazo; IVE) democratically passed and legalized abortion throughout Argentina. Argentine President, Alberto Fernández, supported IVE and delivered a series of speeches over four years highlighting IVE and the progress that has succeeded each …


Trip Production Models For Persons With Disabilities, Pouyan Saeidian Aug 2024

Trip Production Models For Persons With Disabilities, Pouyan Saeidian

All Graduate Theses and Dissertations, Fall 2023 to Present

Nearly 13% of the US population consists of people with disabilities, yet finding an equitable and comprehensive approach to meet their travel needs remains a challenge. Our research delves into the mobility patterns of people with disabilities to understand how their daily travel—both the frequency of trips and the distance covered—compares to those without disabilities. We also explore the factors influencing their travel behaviors and how these insights can guide policymakers in improving accessibility and mobility for this community. Utilizing data from the 2022 US National Household Travel Survey, we applied a blend of statistical analysis and machine learning methods. …


Sparks, Belonging, And Relationships: High School Teachers' Use Of Developmental Context To Engage Students In Career Pathways, Dave Francis Aug 2024

Sparks, Belonging, And Relationships: High School Teachers' Use Of Developmental Context To Engage Students In Career Pathways, Dave Francis

All Graduate Theses and Dissertations, Fall 2023 to Present

The 4-H Thriving Model outlines how a foundation for youth sparks, belonging, and relationships can lead to short and long-term outcomes. This study explored how high school teachers in Utah integrate the elements of the foundation of the 4-H Thriving Model in environmental science and natural resources management classroom teaching. A mixed method of interviews and surveys was used to understand teaching practices. Teachers described helping students discover their interests (sparks), nurturing these interests, and linking them to careers using methods like guest speakers, field trips, contests, and student presentations. They also worked on creating a sense of belonging in …


To Pot Or Not To Pot: Understanding Technological Investment In Ceramics And Marine Mammal Oil Rendering In Kodiak, Alaska, Elizabeth Groat Aug 2024

To Pot Or Not To Pot: Understanding Technological Investment In Ceramics And Marine Mammal Oil Rendering In Kodiak, Alaska, Elizabeth Groat

All Graduate Theses and Dissertations, Fall 2023 to Present

Why do groups choose to use certain technologies, but not others? This study focuses on an especially confusing instance of this question: the adoption of pottery in Kodiak, Alaska. This event was strange for two reasons. First, by AD 1500, when Alutiiq ancestors in the Kodiak Archipelago began making pottery, their neighbors on the mainland had already been doing it for centuries—so why did they wait so long? Second, pottery is also only found in the south of the islands—so why did some people use it, but not others? Whale and seal are more abundant in southern Kodiak, so one …


Linking Community-Level Food Sovereignty To Subjective Wellbeing: Framing Perspectives On Food Systems In The Upper Yakima River Basin, Alexander W. Theophilus Aug 2024

Linking Community-Level Food Sovereignty To Subjective Wellbeing: Framing Perspectives On Food Systems In The Upper Yakima River Basin, Alexander W. Theophilus

All Graduate Theses and Dissertations, Fall 2023 to Present

Food sovereignty is a framework focused on achieving a wide range of changes in food systems that yield more equitable outcomes for consumers, workers, farmers, and future generations. Food sovereignty is also believed to be an important driver of community wellbeing. However, there is limited research linking perceptions of community-level food sovereignty to subjective wellbeing. Additionally, the complex determinants of food sovereignty are not fully understood. Through two papers linking community-level food sovereignty and subjective wellbeing, I discuss the factors that influence food sovereignty and the impact of food systems on wellbeing in Washington’s upper Yakima River Basin.

In the …


Exploring The Role Of Whiteness In Sociopolitical Development: Predictive Contexts And Trajectories, Jesiah P. Salazar Aug 2024

Exploring The Role Of Whiteness In Sociopolitical Development: Predictive Contexts And Trajectories, Jesiah P. Salazar

All Graduate Theses and Dissertations, Fall 2023 to Present

Critical consciousness is the ability to understand and challenge oppressive social systems, believe in one's power to create positive social change, and take actions toward making those changes. Sociopolitical development theory suggests that this awareness grows through a mix of social influences, opportunities for activism, and personal identity. Historically, this concept has been viewed as a way to empower youth of color to challenge systemic oppression, rather than just cope with it. Therefore, most research has focused on critical consciousness in youth of color. Recently, however, researchers have begun to explore critical consciousness among White adolescents. Using a person-centered approach, …


Cyclical Patterns Of Self-Regulated Learning In College Students, David N. Longhurst Aug 2024

Cyclical Patterns Of Self-Regulated Learning In College Students, David N. Longhurst

All Graduate Theses and Dissertations, Fall 2023 to Present

Zimmerman’s self-regulated learning (SRL) model is a cyclical approach to learning where learners use several processes to facilitate learning or to perform a skill within many domains. Zimmerman’s model describes three phases including forethought, performance, and self-reflection, which occur respectively before, during, and after a task. Theoretically, these phases interact in a cyclical feedback loop in which a person cognitively interacts with a task before, during, and after the activity and continuously do so independently. This model has been the basis for several school-based intervention programs. Those programs have been studied regarding academic outcomes and efficacy; however, less research has …


Mind-Body Bridging (Mbb) Techniques And Emotional Regulation In Political Discourse And Confidence In Political Talk, Joseph Ofori Acheampong Aug 2024

Mind-Body Bridging (Mbb) Techniques And Emotional Regulation In Political Discourse And Confidence In Political Talk, Joseph Ofori Acheampong

All Graduate Theses and Dissertations, Fall 2023 to Present

In today's politically divided landscape, conversations across political lines can often provoke intense feelings of anger and anxiety, making productive dialogue difficult. This polarization not only dampens the quality of public discourse but also affects individual emotional well-being and the broader societal cohesion. This study explores a novel approach to alleviating the negative emotional effects caused by political polarization, using Mind-Body Bridging (MBB) techniques. It specifically targets emotional regulation- how we control and manage our feelings- during political discussions, without attempting to change participants' political beliefs. The study involved participants from Utah State University setting who engaged in MBB training. …


Governing With Public Engagement: An Anticipatory Approach To Human Genome Editing, Dorit Barlevy, Eric Juengst, Jeffrey Kahn, Jonathan Moreno, Lauren Lambert, Alta Charo, Hervé Chneiweiss, Mahmud Farooque, David H Guston, Insoo Hyun, Paul S Knoepfler, Cynthia Selin, Rebecca Wilbanks, Manar Zaghlula, Christopher Thomas Scott Aug 2024

Governing With Public Engagement: An Anticipatory Approach To Human Genome Editing, Dorit Barlevy, Eric Juengst, Jeffrey Kahn, Jonathan Moreno, Lauren Lambert, Alta Charo, Hervé Chneiweiss, Mahmud Farooque, David H Guston, Insoo Hyun, Paul S Knoepfler, Cynthia Selin, Rebecca Wilbanks, Manar Zaghlula, Christopher Thomas Scott

Center for Medical Ethics and Health Policy Staff Publications

In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we detail an anticipatory approach to the governance of HGE. By soliciting multidisciplinary experts’ input on the drivers and uncertainties of HGE development, we developed a set of plausible future scenarios to ascertain publics values—specifically, their hopes and concerns regarding the novel technology and its applications. In turn, we gathered a subset of multidisciplinary experts to propose governance recommendations for HGE that incorporate identified publics’ values. These recommendations include: (1) continued …


Staying Fresh: Unconventional Approaches Towards Advancing Energy Sustainability, Water Resources, And Community Resiliency In The Southwestern United States, Judith Hoyt Aug 2024

Staying Fresh: Unconventional Approaches Towards Advancing Energy Sustainability, Water Resources, And Community Resiliency In The Southwestern United States, Judith Hoyt

Open Access Theses & Dissertations

This dissertation addresses critical challenges in urban heat management, sustainable energy resource utilization, and water quality communication through three studies. Study 1 investigates the impact of roof color on urban heat islands in Tucson, Arizona where approximately 70% of roofs display high albedo (i.e., light) colors. Energy consumption simulations conducted indicate that converting dark- to light-colored roofs could save Tucson approximately $1,400,000 annually in energy costs, highlighting the potential of cool roofs for energy savings and improved thermal comfort. Study 2 assesses the sources of lithium in subsurface waters in West Texas and South Central New Mexico. Water chemistry data …


Generating Clinical-Grade Gene-Disease Validity Classifications Through The Clingen Data Platforms, Matt W Wright, Courtney L Thaxton, Tristan Nelson, Marina T Distefano, Juliann M Savatt, Matthew H Brush, Gloria Cheung, Mark E Mandell, Bryan Wulf, T J Ward, Scott Goehringer, Terry O'Neill, Phil Weller, Christine G Preston, Ingrid M Keseler, Jennifer L Goldstein, Natasha T Strande, Jennifer Mcglaughon, Danielle R Azzariti, Ineke Cordova, Hannah Dziadzio, Lawrence Babb, Kevin Riehle, Aleksandar Milosavljevic, Christa Lese Martin, Heidi L Rehm, Sharon E Plon, Jonathan S Berg, Erin R Riggs, Teri E Klein Aug 2024

Generating Clinical-Grade Gene-Disease Validity Classifications Through The Clingen Data Platforms, Matt W Wright, Courtney L Thaxton, Tristan Nelson, Marina T Distefano, Juliann M Savatt, Matthew H Brush, Gloria Cheung, Mark E Mandell, Bryan Wulf, T J Ward, Scott Goehringer, Terry O'Neill, Phil Weller, Christine G Preston, Ingrid M Keseler, Jennifer L Goldstein, Natasha T Strande, Jennifer Mcglaughon, Danielle R Azzariti, Ineke Cordova, Hannah Dziadzio, Lawrence Babb, Kevin Riehle, Aleksandar Milosavljevic, Christa Lese Martin, Heidi L Rehm, Sharon E Plon, Jonathan S Berg, Erin R Riggs, Teri E Klein

Center for Medical Ethics and Health Policy Staff Publications

Clinical genetic laboratories must have access to clinically validated biomedical data for precision medicine. A lack of accessibility, normalized structure, and consistency in evaluation complicates interpretation of disease causality, resulting in confusion in assessing the clinical validity of genes and genetic variants for diagnosis. A key goal of the Clinical Genome Resource (ClinGen) is to fill the knowledge gap concerning the strength of evidence supporting the role of a gene in a monogenic disease, which is achieved through a process known as Gene-Disease Validity curation. Here we review the work of ClinGen in developing a curation infrastructure that supports the …