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Full-Text Articles in Physics

Control Of Charged Particle Dynamics And Electron Power Absorption Dynamics Utilizing Voltage Waveform Tailoring In Capacitively Driven Radio-Frequency Plasmas, Steven W. Brandt Jan 2020

Control Of Charged Particle Dynamics And Electron Power Absorption Dynamics Utilizing Voltage Waveform Tailoring In Capacitively Driven Radio-Frequency Plasmas, Steven W. Brandt

Graduate Theses, Dissertations, and Problem Reports

In this work, experimental measurements and analysis of numerical simulations are performed for capacitively coupled plasmas driven by tailored voltage waveforms under conditions which examine complicating factors present in industrial processes, including the influence of resonance effects, electronegative gases or gas mixtures, and plasma-surface interactions at a changing plasma-surface interface. Furthermore, the influence of different tailored voltage waveforms on the spatio-temporal electron power absorption, the generation of a DC self-bias, and on process relevant plasma parameters like ion energy distribution functions is investigated to provide a more complete understanding of the underlying fundamental plasma physics responsible for sustaining the discharge ...


Investigation Of Phonon Polaritons In An Hbn Gan Heterostructure, Catherine G. O'Hearn Jan 2020

Investigation Of Phonon Polaritons In An Hbn Gan Heterostructure, Catherine G. O'Hearn

Graduate Theses, Dissertations, and Problem Reports

There have been many great advances in the generation and manipulation of optics in the visible and near infrared (IR) range over the past decade. This is largely due to plasmonic enhancement, which has led to new technology in biosensing and molecule detection, solid-state lighting, and solar energy harvesting. The field of plasmonics uses quanta of plasma oscillations, plasmons, formed from the interaction between electromagnetic radiation and free electrons to enhance optical near field magnitudes. However, there is still a large region of the electromagnetic spectrum, covering the mid-infrared (MIR) and terahertz (THz) regions, ranging from 3 μm to 1 ...


Ultrafast Optical Properties Of La0.7sr0.3mno3 Thin Films, Saeed Yousefi Sarraf Jan 2020

Ultrafast Optical Properties Of La0.7sr0.3mno3 Thin Films, Saeed Yousefi Sarraf

Graduate Theses, Dissertations, and Problem Reports

Thin film solids often exhibit different physical properties in the ultra-thin regime. Enhancement of surface to bulk ratio results in the domination of surface/interface related phenomena such as surface recombination. Moreover, in the ultra-thin regime, quantum size and quantum confinement effects can alter the band gap of the system and constrain the strain wave propagation in the thin film. Ultrafast properties of solids can also be drastically altered in the ultra-thin regime due to the aforementioned phenomena. Experimentally, observation of these phenomena is challenging due to the insufficient material to absorb and interact with the electromagnetic wave. This dissertation ...


Interpretations Of Bicoherence In Space & Lab Plasma Dynamics, Gregory Allen Riggs Jan 2020

Interpretations Of Bicoherence In Space & Lab Plasma Dynamics, Gregory Allen Riggs

Graduate Theses, Dissertations, and Problem Reports

The application of bicoherence analysis to plasma research, particularly in non-linear, coupled-wave regimes, has thus far been significantly belied by poor resolution in time, and/or outright destruction of frequency information. Though the typical power spectrum cloaks the phase-coherency between frequencies, Fourier transforms of higher-order convolutions provide an n-dimensional spectrum which is adept at elucidating n-wave phase coherence. As such, this investigation focuses on the utility of the normalized bispectrum for detection of wave-wave coupling in general, with emphasis on distinct implications within the scope of non-linear plasma physics. Interpretations of bicoherent features are given for time series ...


Synthesis Of Graphene Using Plasma Etching And Atmospheric Pressure Annealing: Process And Sensor Development, Andrew Robert Graves Jan 2020

Synthesis Of Graphene Using Plasma Etching And Atmospheric Pressure Annealing: Process And Sensor Development, Andrew Robert Graves

Graduate Theses, Dissertations, and Problem Reports

Having been theorized in 1947, it was not until 2004 that graphene was first isolated. In the years since its isolation, graphene has been the subject of intense, world-wide study due to its incredibly diverse array of useful properties. Even though many billions of dollars have been spent on its development, graphene has yet to break out of the laboratory and penetrate mainstream industrial applications markets. This is because graphene faces a ‘grand challenge.’ Simply put, there is currently no method of manufacturing high-quality graphene on the industrial scale. This grand challenge looms particularly large for electronic applications where the ...


Experimental And Computational Exploration Of The Dilute Magnetic Delafossite Cual1-Xfexo2 Alloys, Mina Aziziha Jan 2020

Experimental And Computational Exploration Of The Dilute Magnetic Delafossite Cual1-Xfexo2 Alloys, Mina Aziziha

Graduate Theses, Dissertations, and Problem Reports

CuAlO2 is among several ternary delafossites, which is a rare p-type semiconductor with potential applications as a transparent conductive oxide, photocatalyst, and spintronics when doped with transition metal ions. Reported in this thesis are results from our investigations of CuAl1-xFexO2 (x = 0 to1) with a focus on the x-dependence of structural, magnetic, vibrational, optical properties, and the role of defects and impurities. Samples are prepared by solid-state reactions.

We performed a complete study of magnetic properties to investigate the possibility of room temperature ferromagnetic alloys, which are used in transparent ferromagnet ...


Effects Of Oxygen Modification On The Structural And Magnetic Properties Of Highly Epitaxial La0.7sr0.3mno3 (Lsmo) Thin Films, Shalini Kumari, Navid Mottaghi, Chih-Yeh Huang, Robbyn Trappen, Ghadendra Bhandari, Saeed Yousefi, Guerau Cabrera, Mohindar S. Seehra, Mikel B. Holcomb Jan 2020

Effects Of Oxygen Modification On The Structural And Magnetic Properties Of Highly Epitaxial La0.7sr0.3mno3 (Lsmo) Thin Films, Shalini Kumari, Navid Mottaghi, Chih-Yeh Huang, Robbyn Trappen, Ghadendra Bhandari, Saeed Yousefi, Guerau Cabrera, Mohindar S. Seehra, Mikel B. Holcomb

Faculty & Staff Scholarship

La0.7Sr0.3MnO3, a strong semi-metallic ferromagnet having robust spin polarization and magnetic transition temperature (TC) well above 300 K, has attracted significant attention as a possible candidate for a wide range of memory, spintronic, and multifunctional devices. Since varying the oxygen partial pressure during growth is likely to change the structural and other physical functionalities of La0.7Sr0.3MnO3 (LSMO) films, here we report detailed investigations on structure, along with magnetic behavior of LSMO films with same thickness (~30 nm) but synthesized at various oxygen partial pressures: 10, 30, 50, 100, 150, 200 and 250 mTorr. The observation ...


On Demand Nanoscale Phase Manipulation Of Vanadium Dioxide By Scanning Probe Lithography, Dustin Schrecongost Jan 2020

On Demand Nanoscale Phase Manipulation Of Vanadium Dioxide By Scanning Probe Lithography, Dustin Schrecongost

Graduate Theses, Dissertations, and Problem Reports

This dissertation focuses on nanoscale phase manipulations of Vanadium Dioxide. Nanoscale control of material properties is a current obstacle for the next generation of optoelectronic and photonic devices. Vanadium Dioxide is a strongly correlated material with an insulator-metal phase transition at approximately 345 K that generates dramatic electronic and optical property changes. However, the development of industry device application based on this phenomenon has been limited thus far due to the macroscopic scale and the volatile nature of the phase transition. In this work these limitations are assessed and circumvented.

A home-built, variable temperature, scanning near-field optical microscope was engineered ...


Depth Dependent Atomic Valence Determination In La0.7sr0.3mno3 Thin Films Using Synchrotron Techniques, Robbyn B. Trappen Jan 2019

Depth Dependent Atomic Valence Determination In La0.7sr0.3mno3 Thin Films Using Synchrotron Techniques, Robbyn B. Trappen

Graduate Theses, Dissertations, and Problem Reports

The valence of atoms often has a strong effect on the properties of materials, such as magnetism, conductivity, and superconductivity. The atomic valence is often perturbed at the surface and/or interface and this deviation may play a strong role in many physical phenomena such as interfacial coupling and dead layers, both magnetic and electric. In this dissertation, I present a non-destructive approach of combining two X-ray absorption detection modes, electron yield and fluorescence, with very different probing depths in conjunction with theory to map out the layer-by-layer valence of a thin film.

The weighted average Mn atomic valence as ...


Empirical Studies Related To Open Questions Regarding Geomagnetic Storms, Bruce Patrick Tepke Jan 2019

Empirical Studies Related To Open Questions Regarding Geomagnetic Storms, Bruce Patrick Tepke

Graduate Theses, Dissertations, and Problem Reports

Earth’s magnetosphere is subject to disturbances, as evidenced by variations of the geomagnetic field in space and on the ground. It is generally understood that most such disturbances are controlled by variations in the solar wind, with interplanetary magnetic field orientations directed southward opposite to Earth’s dipole magnetic axis being most conducive to energy transfers into the magnetosphere, thus resulting in more disturbed intervals. However, the exact functional form for solar wind driving of the magnetosphere has been widely studied, with proposed functional forms varying from the simple half-wave electric rectifier to expressions with a much more complicated ...


Novel Computational Methods For Catalytic Applications, Gihan Uthpala Panapitiya Jan 2019

Novel Computational Methods For Catalytic Applications, Gihan Uthpala Panapitiya

Graduate Theses, Dissertations, and Problem Reports

Thiolate protected nanoclusters gold nanoparticles are gaining interest of many researchers due to their promising applications in a variety of fields the development of synthesizing techniques capable of producing atomically precise nanoclusters with high purity. Au25(SR)18 is one of the widely studied nanoclsuters due its remarkable stability. In this first part of this study, we explore the structural, electronic and catalytic properties of bimetallic Au25−xAgx(SR)18 (for x = 6, 7, 8). Due to the combinatorial enormity of the total number of possible alloyed isomers, we choose a randomly selected subset corresponding to ...


The Structural Information Filtered Features Potential For Machine Learning Calculations Of Energies And Forces Of Atomic Systems., Jorge Arturo Hernandez Zeledon Jan 2019

The Structural Information Filtered Features Potential For Machine Learning Calculations Of Energies And Forces Of Atomic Systems., Jorge Arturo Hernandez Zeledon

Graduate Theses, Dissertations, and Problem Reports

In the last ten years, machine learning potentials have been successfully applied to the study of crystals, and molecules. However, more complex materials like clusters, macro-molecules, and glasses are out reach of current methods. The input of any machine learning system is a tensor of features (the most universal type are rank 1 tensors or vectors of features), the quality of any machine learning system is directly related to how well the feature space describes the original physical system. So far, the feature engineering process for machine learning potentials can not describe complex material. The current methods are highly inefficient ...


Application Of Global Search Methods To Materials Prediction And Design, Adam J. Payne Jan 2019

Application Of Global Search Methods To Materials Prediction And Design, Adam J. Payne

Graduate Theses, Dissertations, and Problem Reports

Due to increased availability and power of computational resources over the past few decades, prediction and design of novel materials using computational methods has become feasible. Simulation of material systems has become vital to the further realization of novel material systems. In order to ascertain physical properties, accurate determination and identification of stable crystalline structures is necessary. Additionally, further identification of novel properties, such as magnetic moments or orbital occupation, is necessary to further realize this goal. Global search methods provide a path to accurate prediction of these properties. In this dissertation, the Firefly algorithm and minima hopping methods are ...


Evaluation Of X-Ray Spectroscopic Techniques For Determining Temperature And Density In Plasmas, Theodore Scott Lane Jan 2019

Evaluation Of X-Ray Spectroscopic Techniques For Determining Temperature And Density In Plasmas, Theodore Scott Lane

Graduate Theses, Dissertations, and Problem Reports

Temperature and density measurements of plasmas are important for understanding various phenomena. For example, equations of state, most scaling arguments for Inertial Confinement Fusion and laboratory astrophysics all rely upon accurate knowledge of temperature and density. Spectroscopy is a non-invasive technique to measure these quantities. In this work we establish a new spectroscopic technique by using it to determine temperature. We also compare and contrast the capability of two codes, PrismSPECT and ATOMIC, to infer electron density from experimentally acquired spectra via Stark broadening.

We compare and contrast the capability of isoelectronic line ratios and inter-stage line ratios in an ...


Multidimensional Item Response Theory And The Conceptual Survey Of Electricity And Magnetism, Cabot Zabriskie, John Stewart Jan 2019

Multidimensional Item Response Theory And The Conceptual Survey Of Electricity And Magnetism, Cabot Zabriskie, John Stewart

Faculty & Staff Scholarship

This paper is part of the Focused Collection on Quantitative Methods in PER: A Critical Examination.] While many studies have examined the structure, validity, and reliability of the Force Concept Inventory, far less research has been performed on other conceptual instruments in widespread use in physics education research. This study performs a confirmatory analysis of the Conceptual Survey of Electricity and Magnetism (CSEM) guided by a theoretical model of expert understanding of electricity and magnetism. Multidimensional Item Response Theory (MIRT) with the discrimination matrix constrained to the theoretical model was used to investigate two large datasets (N1=2014 and N2 ...


Application Of Wavelet Analysis On Transient Rlectivity In Ultra-Thin Films, S. Yousefi Saraf, R. Trappen, S. Kumari, G. Bhandari, N. Mottaghi, C. Y. Huang, G. B. Cabrera, A. D. Bristow, M. B. Holcomb Jan 2019

Application Of Wavelet Analysis On Transient Rlectivity In Ultra-Thin Films, S. Yousefi Saraf, R. Trappen, S. Kumari, G. Bhandari, N. Mottaghi, C. Y. Huang, G. B. Cabrera, A. D. Bristow, M. B. Holcomb

Faculty & Staff Scholarship

Applications of wavelet analysis in ultra-thin film transient reflectivity (TR) measurements have been investigated. Advantages of utilizing different localized wavelet bases, in position and time, have been addressed on the residual TR signals. Morse wavelets have been used to obtain information from the abrupt oscillatory modes in the signal, which are not distinguishable with conventional methods such as Fourier transforms. These abrupt oscillatory modes are caused by the surface, interface, or any short-lived oscillatory modes which are suppressed in the TR signal in ultra-thin films. It is demonstrated that by choosing different Morse wavelets, information regarding different oscillatory modes in ...


Partitioning The Gender Gap In Physics Conceptual Inventories: Force Concept Inventory, Force And Motion Conceptual Evaluation, And Conceptual Survey Of Electricity And Magnetism, Rachel Henderson, John Stewart, Adrienne Traxler Jan 2019

Partitioning The Gender Gap In Physics Conceptual Inventories: Force Concept Inventory, Force And Motion Conceptual Evaluation, And Conceptual Survey Of Electricity And Magnetism, Rachel Henderson, John Stewart, Adrienne Traxler

Faculty & Staff Scholarship

Over the last decade, the “gender gap” in physics conceptual inventory scores has been extensively studied by the physics education research community. Researchers have identified many factors that influence the overall differences in post-test scores between men and women. More recently, it has been shown that the Force Concept Inventory (FCI) contains eight items that are substantially unfair; six are unfair to women, two are unfair to men. The Force and Motion Conceptual Evaluation (FMCE) and the Conceptual Survey of Electricity and Magnetism (CSEM), however, contain fewer unfair items. In this work, results from prior studies are used to further ...


Electrical Detection Of Current Generated Spin In Topological Insulator Surface States: Role Of Interface Resistance, C. H. Li, O. M. J. Van ‘T Erve, C. Yan, L. Li., B. T. Jonker Jan 2019

Electrical Detection Of Current Generated Spin In Topological Insulator Surface States: Role Of Interface Resistance, C. H. Li, O. M. J. Van ‘T Erve, C. Yan, L. Li., B. T. Jonker

Faculty & Staff Scholarship

Current generated spin polarization in topological insulator (TI) surface states due to spin-momentum locking has been detected recently using ferromagnet/tunnel barrier contacts, where the projection of the TI spin onto the magnetization of the ferromagnet is measured as a voltage. However, opposing signs of the spin voltage have been reported, which had been tentatively attributed to the coexistence of trivial two-dimensional electron gas states on the TI surface which may exhibit opposite currentinduced polarization than that of the TI Dirac surface states. Models based on electrochemical potential have been presented to determine the sign of the spin voltage expected ...


Synergy Of Physics-Based Reasoning And Machine Learning In Biomedical Applications: Towards Unlimited Deep Learning With Limited Data, Valeriy Gavrishchaka, Olga Senyukova, Mark Koepke Jan 2019

Synergy Of Physics-Based Reasoning And Machine Learning In Biomedical Applications: Towards Unlimited Deep Learning With Limited Data, Valeriy Gavrishchaka, Olga Senyukova, Mark Koepke

Faculty & Staff Scholarship

Technological advancements enable collecting vast data, i.e., Big Data, in science and industry including biomedical field. Increased computational power allows expedient analysis of collected data using statistical and machine-learning approaches. Historical data incompleteness problem and curse of dimensionality diminish practical value of pure data-driven approaches, especially in biomedicine. Advancements in deep learning (DL) frameworks based on deep neural networks (DNN) improved accuracy in image recognition, natural language processing, and other applications yet severe data limitations and/or absence of transfer-learning-relevant problems drastically reduce advantages of DNN-based DL. Our earlier works demonstrate that hierarchical data representation can be alternatively implemented ...


Exploring The Structure Of Misconceptions In The Force Concept Inventory With Modified Module Analysis, James Wells, Rachel Henderson, John Stewart, Gay Stewart, Jie Yang, Adrienne Traxler Jan 2019

Exploring The Structure Of Misconceptions In The Force Concept Inventory With Modified Module Analysis, James Wells, Rachel Henderson, John Stewart, Gay Stewart, Jie Yang, Adrienne Traxler

Faculty & Staff Scholarship

Module analysis for multiple-choice responses (MAMCR) was applied to a large sample of Force Concept Inventory (FCI) pretest and post-test responses (Npre ¼ 4509 and Npost ¼ 4716) to replicate the results of the original MAMCR study and to understand the origins of the gender differences reported in a previous study of this dataset. When the results of MAMCR could not be replicated, a modification of the method was introduced, modified module analysis (MMA). MMA was productive in understanding the structure of the incorrect answers in the FCI, identifying 9 groups of incorrect answers on the pretest and 11 groups ...


Multidimensional Item Response Theory And The Force And Motion Conceptual Evaluation, Jie Yang, Cabot Zabriskie, John Stewart Jan 2019

Multidimensional Item Response Theory And The Force And Motion Conceptual Evaluation, Jie Yang, Cabot Zabriskie, John Stewart

Faculty & Staff Scholarship

Many studies have examined the structure and properties of the Force Concept Inventory (FCI); however, far less research has investigated the Force and Motion Conceptual Evaluation (FMCE). This study applied Multidimensional Item Response Theory (MIRT) to a sample of N ¼ 4528 FMCE post-test responses. Exploratory factor analysis showed that 5, 9, and 10-factor models optimized some fit statistics. The FMCE uses extensive blocking of items into groups with a common stem; these blocks factored together in most models. A confirmatory analysis, which constrained the MIRT models to a theoretical model constructed from expert solutions, produced a model requiring only ...


Interface Engineered Room‐Temperature Ferromagnetic Insulating State In Ultrathin Manganite Films, Weiwei Li, Bonan Zhu, Qian He, Albina Y. Borisevich, Chao Yun, Rui Wu, Ping Lu, Zhimin Qi, Qiang Wang, Aiping Chen, Haiyan Wang, Stuart A. Cavill, Kelvin H.L. Zhang, Judith L. Macmanus-Driscoll Jan 2019

Interface Engineered Room‐Temperature Ferromagnetic Insulating State In Ultrathin Manganite Films, Weiwei Li, Bonan Zhu, Qian He, Albina Y. Borisevich, Chao Yun, Rui Wu, Ping Lu, Zhimin Qi, Qiang Wang, Aiping Chen, Haiyan Wang, Stuart A. Cavill, Kelvin H.L. Zhang, Judith L. Macmanus-Driscoll

Faculty & Staff Scholarship

emperatures near room temperature are critically needed for use in dissipationless quantum computation and spintronic devices. However, such materials are extremely rare. Here, a room‐temperature FMI is achieved in ultrathin La0.9Ba0.1MnO3 films grown on SrTiO3 substrates via an interface proximity effect. Detailed scanning transmission electron microscopy images clearly demonstrate that MnO6 octahedral rotations in La0.9Ba0.1MnO3 close to the interface are strongly suppressed. As determined from in situ X‐ray photoemission spectroscopy, O K‐edge X‐ray absorption spectroscopy, and density functional theory, the realization of the FMI state arises from a reduction of Mn eg ...


Micro/Nanofabrication And Characterization Of Advanced Materials And Devices, Yanxi Li, Liang He, Mengyu Yan, Zhengjun Wang Jan 2019

Micro/Nanofabrication And Characterization Of Advanced Materials And Devices, Yanxi Li, Liang He, Mengyu Yan, Zhengjun Wang

Faculty & Staff Scholarship

No abstract provided.


Reply To: “On The Understanding Of Current-Induced Spin Polarization Of Three-Dimensional Topological Insulators”, C. H. Li, O. M. J. Van ‘T Erve, S. Rajput, L. Li, B. T. Jonker Jan 2019

Reply To: “On The Understanding Of Current-Induced Spin Polarization Of Three-Dimensional Topological Insulators”, C. H. Li, O. M. J. Van ‘T Erve, S. Rajput, L. Li, B. T. Jonker

Faculty & Staff Scholarship

No abstract provided.


Automated Polarization-Dependent Multidimensional Coherent Spectroscopy Phased Using Transient Absorption, J. K. Wahlstrand, G. M. Wernsing, J. Paul, A. D. Bristow Jan 2019

Automated Polarization-Dependent Multidimensional Coherent Spectroscopy Phased Using Transient Absorption, J. K. Wahlstrand, G. M. Wernsing, J. Paul, A. D. Bristow

Faculty & Staff Scholarship

: An experimental apparatus is described for multidimensional optical spectroscopy with fully automated polarization control, based on liquid crystal variable retarders. Polarization dependence of rephasing two-dimensional coherent spectra are measured in a single scan, with absolute phasing performed for all polarization configurations through a single automated auxiliary measurement at the beginning of the scan. A factor of three improvement in acquisition time is demonstrated, compared to the apparatus without automated polarization control. Results are presented for a GaAs quantum well sample and an InGaAs quantum well embedded in a microcavity


Learning Local, Quenched Disorder In Plasticity And Other Crackling Noise Phenomena, Stefanos Papanikolaou Jan 2018

Learning Local, Quenched Disorder In Plasticity And Other Crackling Noise Phenomena, Stefanos Papanikolaou

Faculty & Staff Scholarship

When far from equilibrium, many-body systems display behavior that strongly depends on the initial conditions. A characteristic such example is the phenomenon of plasticity of crystalline and amorphous materials that strongly depends on the material history. In plasticity modeling, the history is captured by a quenched, local and disordered flow stress distribution. While it is this disorder that causes avalanches that are commonly observed during nanoscale plastic deformation, the functional form and scaling properties have remained elusive. In this paper, a generic formalism is developed for deriving local disorder distributions from field- response (e.g., stress/strain) timeseries in models ...


Insights Into The Magnetic Dead Layer In La0.7sr0.3mno3 Thin Films From Temperature, Magnetic Field And Thickness Dependence Of Their Magnetization, N. Mottaghi, M.S. Seehra, R. Trappen, S. Kumari, Chih-Yeh Huang, S. Yousefi, G.B. Cabrera, A.H. Romero, M.B. Holcomb Jan 2018

Insights Into The Magnetic Dead Layer In La0.7sr0.3mno3 Thin Films From Temperature, Magnetic Field And Thickness Dependence Of Their Magnetization, N. Mottaghi, M.S. Seehra, R. Trappen, S. Kumari, Chih-Yeh Huang, S. Yousefi, G.B. Cabrera, A.H. Romero, M.B. Holcomb

Faculty & Staff Scholarship

Experimental investigations of the magnetic dead layer in 7.6 nm thick film of La0.7Sr0.3MnO3 (LSMO) are reported. The dc magnetization (M) measurements for a sample cooled to T = 5 K in applied field H = 0 reveal the presence of negative remanent magnetization (NRM) in the M vs. H (magnetic field) measurements as well as in the M vs. T measurements in H = 50 Oe and 100 Oe. The M vs. T data in ZFC (zero-field-cooled) and FC (field-cooled) protocols are used to determine the blocking temperature TB in different H. Isothermal hysteresis loops at differ- ent T ...


Three-Dimensional Imaging Of Kndy Neurons In The Mammalian Brain Using Optical Tissue Clearing And Multiple-Label Immunocytochemistry, Aleisha M. Moore, Kathryn A. Lucas, Robert L. Goodman, Lique M. Coolen, Michael N. Lehman Jan 2018

Three-Dimensional Imaging Of Kndy Neurons In The Mammalian Brain Using Optical Tissue Clearing And Multiple-Label Immunocytochemistry, Aleisha M. Moore, Kathryn A. Lucas, Robert L. Goodman, Lique M. Coolen, Michael N. Lehman

Faculty & Staff Scholarship

Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in the regulation of fertility. The ability to detect features of KNDy neurons that are essential for fertility may require three-dimensional (3D) imaging of the complete population. Recently developed protocols for optical tissue clearing permits 3D imaging of neuronal populations in un-sectioned brains. However, these techniques have largely been described in the mouse brain. We report 3D imaging of the KNDy cell population in the whole rat brain and sheep hypothalamus using immunolabelling and modification of a solvent-based clearing protocol, iDISCO. This study expands the ...


Macrophage Sensing Of Single- Walled Carbon Nanotubes Via Toll- Like Receptors, Sourav P. Mukherjee, Olesja Bondarenko, Pekka Kohonen, Fernando T. Andon, Tana Brzicova, Isabel Gessner, Sanjay Mathur, Massimo Bottini, Paolo Calligari, Lorenzo Stella, Elena Kisin, Anna Shvedova, Reija Autio, Heli Salminen-Mankonen, Ritta Lahesmaa, Bengt Fadeel Jan 2018

Macrophage Sensing Of Single- Walled Carbon Nanotubes Via Toll- Like Receptors, Sourav P. Mukherjee, Olesja Bondarenko, Pekka Kohonen, Fernando T. Andon, Tana Brzicova, Isabel Gessner, Sanjay Mathur, Massimo Bottini, Paolo Calligari, Lorenzo Stella, Elena Kisin, Anna Shvedova, Reija Autio, Heli Salminen-Mankonen, Ritta Lahesmaa, Bengt Fadeel

Faculty & Staff Scholarship

Carbon-based nanomaterials including carbon nanotubes (CNTs) have been shown to trigger

inflammation. However, how these materials are ‘sensed’ by immune cells is not known. Here we compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages. Genome-wide transcriptomics assessment was performed at sub-cytotoxic doses. Pathway analysis of the microarray data revealed pronounced effects on chemokine-encoding genes in macrophages exposed to SWCNTs, but not in response to GO, and these results were validated by multiplex array-based cytokine and chemokine profiling. Conditioned medium from SWCNT-exposed cells acted as a chemoattractant for dendritic cells ...


Graphene Nanoplatelets-Sericin Surface-Modified Gum Alloy For Improved Biological Response, Valentina Mitran, Valentina Dinca, Raluca Ion, Vasile D. Cojocaru, Patricia Neacsu, Cerasela Zoica Dinu, Laurentiu Rusen, Simona Brajnicov, Anca Bonciu, Maria Dinescu, Doina Raducanu, Ioan Dan Jan 2018

Graphene Nanoplatelets-Sericin Surface-Modified Gum Alloy For Improved Biological Response, Valentina Mitran, Valentina Dinca, Raluca Ion, Vasile D. Cojocaru, Patricia Neacsu, Cerasela Zoica Dinu, Laurentiu Rusen, Simona Brajnicov, Anca Bonciu, Maria Dinescu, Doina Raducanu, Ioan Dan

Faculty & Staff Scholarship

In this study a “Gum Metal” titanium-based alloy, Ti-31.7Nb-6.21Zr-1.4Fe-0.16O, was synthesized by melting and characterized in order to evaluate its potential for biomedical applications. The results showed that the newly developed alloy presents a very high strength, high plasticity and a low Young's modulus relative to titanium alloys currently used in medicine. For further bone implant applications, the newly synthesized alloy was surface modified with graphene nanoplatelets (GNP), sericin (SS) and graphene nanoplatelets/sericine (GNP–SS) composite films via Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The characterization of each specimen was monitored by scanning ...