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Articles 61 - 90 of 249
Full-Text Articles in Chemistry
Fabrication And Characterization Of Novel Agnps Functionalized With Chlorothymol (C@Agnps), Lirim Sopaj
Fabrication And Characterization Of Novel Agnps Functionalized With Chlorothymol (C@Agnps), Lirim Sopaj
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In this study, novel silver nanoparticles (AgNPs) were successfully synthesized and functionalized with an antibacterial agent, namely chlorothymol (denoted C@AgNPs). The resulting colloid (C@AgNPs) was purified by two comparative methods: ultrafiltration and ultracentrifugation. Ultrafiltration proved to be more efficient in purifying and size selecting (10 kD filter) and concentrating the C@AgNPs than ultracentrifugation. The physicochemical properties of the filtered C@AgNPs were then characterized by UV-Vis absorption spectroscopy, inductively coupled plasma optical emission spectroscopy (ICP-OES), Raman spectroscopy, Cytoviva hyperspectral imaging, and Scanning electron microscopy. These measurements confirmed the functionalization of the core AgNPs with chlorothymol and suggest the proposed mechanism of …
Gene Vectors With Fluorescence Tracking Capabilities, Sophia Despina Angelopoulos
Gene Vectors With Fluorescence Tracking Capabilities, Sophia Despina Angelopoulos
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This project focuses on the optimization of benzothiazole-based chromophores to utilize them as fluorescent tags functionalized onto stimuli-responsive, or “smart,” polymers as non-viral gene delivery vectors for gene therapy applications. Blue-fluorescent emissive chromophores will allow tracking capabilities for the transfection pathway of the vector to be monitored as it delivers the DNA payload within intercellular space. The most appropriate chromophore must be covalently bound to a free amine within the vector, which is accomplished through NAS chemistry from fluorophenyl-benzothiazoles (F-BTZ-CBz) derivatives to amidated hyperbranched poly(ethyleneimine)(HPEI-IBAm0.61). HPEI is considered to be a synthetic polycation, which promotes tunable solubility through characteristics of …
Detection Of Benzotriazole And Related Analogues In Surface Samples Collected Near An Ohio Airpark, Clara Leedy
Detection Of Benzotriazole And Related Analogues In Surface Samples Collected Near An Ohio Airpark, Clara Leedy
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Benzotriazoles are a class of contaminant of emerging concern which are commonly used as anticorrosive agents in aircraft deicer and anti-icing fluids (ADAFs). The analogues 1H-benzotriazole (BTZ), 4-methyl-1H-benzotrizole (4m-BTZ), and 5-methyl-1H-benzotriazole (5m-BTZ) are commonly found in environmental occurrence together. The two methylated isomers, collectively known as tolytriazole (TTZ), have different toxicity and stability. These contaminants are highly water soluble and resistant to biodegradation, making them persistent through water treatment. Benzotriazoles have been detected worldwide; this investigation focuses on monitoring three sites near a small airpark in Wilmington, Ohio. Two sites that receive runoff from the airpark, Lytle Creek and Indian …
A Spectrophotometric Determination Of Barium Complexation With Methylthymol Blue, Wesley Alexander
A Spectrophotometric Determination Of Barium Complexation With Methylthymol Blue, Wesley Alexander
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In this work, a spectrophotometric titration of methylthymol blue (MTB) with barium chloride was performed at pH = 7.5, 9.6, and 12.2 to determine the stoichiometry of complexation between the two as well as formation constants and absorptivity coefficients. Complexes of 1:1, 2:1, and 3:1 Ba:MTB were suggested by the experimental data upon fitting with appropriate models using Beer’s Law. The molar absorptivities of free MTB species at 605 nm were determined to be ����2������4− = 5.0 (± 0.2) x 103 L·mol-1·cm-1, ����������5− = 7.3 (± 0.3) x 103 L·mol-1·cm-1, ��������6− = 1.3 (± 0.2) x 104 L·mol-1·cm-1. At pH …
Estimation Of The Amount Of Active Pharmaceutical Ingredient In Over-The-Counter Available Aspirin Formulations Using Titrimetry, Uv-Visible Spectrophotometry And Raman Spectroscopy, Harismranjeet K. Chahal
Estimation Of The Amount Of Active Pharmaceutical Ingredient In Over-The-Counter Available Aspirin Formulations Using Titrimetry, Uv-Visible Spectrophotometry And Raman Spectroscopy, Harismranjeet K. Chahal
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Counterfeit pharmaceuticals are a serious threat to public safety worldwide. Adverse health effects including resistance to treatment and death have resulted from the consumption of such medicines. Aspirin, which is a non-steroidal anti-inflammatory drug, has been counterfeited in the past due to its increasing demand. Rapid and easy analytical methods are needed to detect these counterfeit medicines and put a halt to the growing number of such incidents. In this study, quantitative estimation of active pharmaceutical ingredient (API) content in different over-the-counter available aspirin tablets was done using titrimetry and UV- Visible spectrophotometry. Qualitative analysis was done using Raman spectroscopy. …
Emissions, Shawn Urbanski, Susan O'Neill, Amara L. Holder, Sarah Green, Rick L. Graw
Emissions, Shawn Urbanski, Susan O'Neill, Amara L. Holder, Sarah Green, Rick L. Graw
Michigan Tech Publications, Part 1
This chapter assesses the current state of the science regarding the composition, intensity, and drivers of wildland fire emissions in the USA and Canada. Globally and in the USA wildland fires are a major source of gases and aerosols which have significant air quality impacts and climate interactions. Wildland fire smoke can trigger severe pollution episodes with substantial effects on public health. Fire emissions can degrade air quality at considerable distances downwind, hampering efforts by air regulators to meet air standards. Fires are a major global source of aerosols which affect the climate system by absorbing and scattering radiation and …
The Ion Pair Thermal Model Of Maldi Ms, Shiyue Fang
The Ion Pair Thermal Model Of Maldi Ms, Shiyue Fang
Michigan Tech Publications, Part 1
The ion pair thermal model for MALDI MS is described. Key elements of the model include thermal desorption and ionization, strong tendency to neutralization via ion pair formation and proton transfer in the gas phase, thermal equilibrium, overall charge neutral plume, and thermal energy assisted free ion generation via ion pair separation by ion extraction potential. The quantities of ions in the solid sample and in the gaseous plume are estimated. Ion yields of different classes of molecules including peptides, nucleic acids, permanent salts and neutral molecules are estimated at the macroscale and single ion pair levels. The estimated ion …
Hydrochloric Acid Modification And Lead Removal Studies On Naturally Occurring Zeolites From Nevada, New Mexico, And Arizona, Garven M. Huntley, Rudy Luck, Michael Mullins, Nick Newberry
Hydrochloric Acid Modification And Lead Removal Studies On Naturally Occurring Zeolites From Nevada, New Mexico, And Arizona, Garven M. Huntley, Rudy Luck, Michael Mullins, Nick Newberry
Michigan Tech Publications, Part 1
Four naturally occurring zeolites were examined to verify their assignments as chabazites AZLB-Ca and AZLB-Na (Bowie, Arizona) and clinoptilolites NM-Ca (Winston, New Mexico) and NV-Na (Ash Meadows, Nevada). Based on powder X-ray diffraction, NM-Ca was discovered to be mostly quartz with some clinoptilolite residues. Treatment with concentrated HCl (12.1 M) acid resulted in AZLB-Ca and AZLB-Na, the chabazite-like species, becoming amorphous, as confirmed by powder X-ray diffraction. In contrast, NM-Ca and NV-Na, which are clinoptilolite-like species, withstood boiling in concentrated HCl acid. This treatment removes calcium, magnesium, sodium, potassium, aluminum, and iron atoms or ions from the framework while leaving …
Targeting Of Glut5 For Transporter-Mediated Drug-Delivery Is Contingent Upon Substrate Hydrophilicity, Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Targeting Of Glut5 For Transporter-Mediated Drug-Delivery Is Contingent Upon Substrate Hydrophilicity, Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Michigan Tech Publications, Part 1
Specific link between high fructose uptake and cancer development and progression highlighted fructose transporters as potential means to achieve GLUT-mediated discrimination between normal and cancer cells. The gained expression of fructose-specific transporter GLUT5 in various cancers offers a possibility for developing cancer-specific imaging and bioactive agents. Herein, we explore the feasibility of delivering a bioactive agent through cancer-relevant fructose-specific transporter GLUT5. We employed specific targeting of GLUT5 by 2,5-anhydro-D-mannitol and investigated several drug conjugates for their ability to induce cancer-specific cytotoxicity. The proof-of-concept analysis was carried out for conjugates of chlorambucil (CLB) in GLUT5-positive breast cancer cells and normal breast …
Ratiometric Near-Infrared Fluorescent Probes Based On Hemicyanine Dyes Bearing Dithioacetal And Formal Residues For Ph Detection In Mitochondria, Yunnan Yan, Yibin Zhang, Shuai Xia, Shulin Wan, Tara Vohs, Marina Tanasova, Rudy Luck, Haiying Lui
Ratiometric Near-Infrared Fluorescent Probes Based On Hemicyanine Dyes Bearing Dithioacetal And Formal Residues For Ph Detection In Mitochondria, Yunnan Yan, Yibin Zhang, Shuai Xia, Shulin Wan, Tara Vohs, Marina Tanasova, Rudy Luck, Haiying Lui
Michigan Tech Publications, Part 1
Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses to pH changes through the protonation and deprotonaton of a hydroxy group in hemicyanine dyes with experimentally determined pKa values of 6.85 and 6.49, respectively. Calculated pKa values from a variety of theoretical methods indicated that …
The Formation Of Prenucleation Clusters For Calcium Fluoride, Taylor M. Muterspaw
The Formation Of Prenucleation Clusters For Calcium Fluoride, Taylor M. Muterspaw
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There have been limited studies on the analysis of the nucleation and precipitation behind calcium fluoride. Earlier studies support a nucleation mechanism in agreement to classical nucleation theory (CNT) in which a surface nucleation mechanism is required for calcium fluoride. This experiment devised using the ISE method to calcium fluoride to find evidence of a nucleation mechanism like that of calcium carbonate (prenucleation cluster pathway). The potential and pH were recorded versus time and the potential data was converted to nCa2+ data of free calcium ions. It was determined that there was evidence of a similar nucleation mechanism for calcium …
Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke
Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke
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This investigative research was carried out with the purpose of determining the source of contaminants present in the surface waters flowing through the Wright State University woods. Five sample sites going from upstream to downstream namely; Inflow to Nutter Center Pond (INNCP), Nutter Center Pond (NCP), Outfall 21 (OTF 21), Burley, and Outfall 15 (OTF 15), were sampled over a time period spanning from June 2020 to January 2021. Samples collected were analyzed for Escherichia coli (E. coli) using 3M™ Petrifilm™ E. coli/Coliform Count (EC) plates, select anions (Phosphate PO43-, Nitrate NO3-, Sulfate SO42-, Fluoride F- and Chloride Cl-) using …
Cytoviva Hyperspectral Imaging For Comparing The Uptake And Transformation Of Agnps And Ag+ In Mitochondria, Kristina Steingass
Cytoviva Hyperspectral Imaging For Comparing The Uptake And Transformation Of Agnps And Ag+ In Mitochondria, Kristina Steingass
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Nanomaterials have attracted significant attention in the last decade, with applications in everyday products. Amongst all known nanomaterials in use, silver is the leading metal, present in 531 different types of products, owing to their unique optical, electrical, antimicrobial, and thermal properties. Though silver nanoparticles (AgNPs) come in contact regularly with the general population, there is little known about their toxicity mechanism due to limited techniques for thorough analysis. CytoViva Hyperspectral Imaging (HSI) shows potential for filling these gaps. In this study, borohydride-capped AgNPs with an approximate diameter of 10 nm were synthesized using the modified Creighton method and characterized …
Benzotriazole And Tolytriazole Analysis In Select Surface Waters Near Wilmington Air Park, Lee A. Raska
Benzotriazole And Tolytriazole Analysis In Select Surface Waters Near Wilmington Air Park, Lee A. Raska
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Previous investigations into the presence of benzotriazole (BTZ) and corresponding analogs done in early 2019 found elevated levels near the Wilmington Air Park in Wilmington, Ohio. The analogs detected were 4-methyl-1H-benzotriazole and 5-methyl-1H-benzotriazole: known together as tolytriazole (TTZ). BTZ and TTZ are emerging environmental contaminants of concern that are often found in aircraft de-icing solutions, anti-icing solutions and detergents. The Wilmington Air Park has two facilities used to pre-treat runoff water before its subsequent release into surrounding streams. Three sites were chosen: Lytle Creek, Indian Run, and Cowan Creek. For the 2019 and 2019/2020 investigative projects, Cowan Creek was designated …
Insights On Dissolved Organic Matter Production Revealed By Removal Of Charge-Transfer Interactions In Senescent Leaf Leachates, Karl M. Meingast, Brice K. Grunert, Sarah A. Green, Evan S. Kane, Nastaran Khademimoshgenani
Insights On Dissolved Organic Matter Production Revealed By Removal Of Charge-Transfer Interactions In Senescent Leaf Leachates, Karl M. Meingast, Brice K. Grunert, Sarah A. Green, Evan S. Kane, Nastaran Khademimoshgenani
Michigan Tech Publications, Part 1
Dissolved organic matter (DOM) is a critical part of the global carbon cycle. Currently, it is understood that at least a portion of the chromophoric DOM (CDOM) character can be described through an electronic interaction of charge transfer (CT) complexes. While much work has been done to understand the influence of CT on soil and aquatic reference standard DOM, little is known about the influence of CT in fresh terrestrially derived DOM. In this study, leaf litter leachates from three tree species were treated (reduced) with sodium borohydride to determine the contribution of CT on a source of fresh terrestrial …
An International Laboratory Comparison Of Dissolved Organic Matter Composition By High Resolution Mass Spectrometry: Are We Getting The Same Answer?, Jeffrey A. Hawkes, Juliana D'Andrilli, Jeffrey N. Agar, Mark P. Barrow, Stephanie M. Berg, Núria Catalán, Hongmei Chen, Rosalie K. Chu, Richard B. Cole, Thorsten Dittmar, Rémy Gavard, Gerd Gleixner, Patrick G. Hatcher, Chen He, Nancy J. Hess, Ryan H.S. Hutchins, Amna Ijaz, Hugh E. Jones, William Kew, Maryam Khaksari, Diana Catalina Palacio Lozano, Jitao Lv, Lynn Mazzoleni, Beatriz E. Noriega-Ortega, Helena Osterholz, Nikola Radoman, Shuzhen Zhang, Phoebe Zito, David C. Podgorski
An International Laboratory Comparison Of Dissolved Organic Matter Composition By High Resolution Mass Spectrometry: Are We Getting The Same Answer?, Jeffrey A. Hawkes, Juliana D'Andrilli, Jeffrey N. Agar, Mark P. Barrow, Stephanie M. Berg, Núria Catalán, Hongmei Chen, Rosalie K. Chu, Richard B. Cole, Thorsten Dittmar, Rémy Gavard, Gerd Gleixner, Patrick G. Hatcher, Chen He, Nancy J. Hess, Ryan H.S. Hutchins, Amna Ijaz, Hugh E. Jones, William Kew, Maryam Khaksari, Diana Catalina Palacio Lozano, Jitao Lv, Lynn Mazzoleni, Beatriz E. Noriega-Ortega, Helena Osterholz, Nikola Radoman, Shuzhen Zhang, Phoebe Zito, David C. Podgorski
Michigan Tech Publications, Part 1
High-resolution mass spectrometry (HRMS) has become a vital tool for dissolved organic matter (DOM) characterization. The upward trend in HRMS analysis of DOM presents challenges in data comparison and interpretation among laboratories operating instruments with differing performance and user operating conditions. It is therefore essential that the community establishes metric ranges and compositional trends for data comparison with reference samples so that data can be robustly compared among research groups. To this end, four identically prepared DOM samples were each measured by 16 laboratories, using 17 commercially purchased instruments, using positive-ion and negative-ion mode electrospray ionization (ESI) HRMS analyses. The …
Role Of Structural Dynamics In Selectivity And Mechanism Of Non-Heme Fe(Ii) And 2-Oxoglutarate-Dependent Oxygenases Involved In Dna Repair, Sodiq Waheed, Rajeev Ramanan, Shobhit Chaturvedi, Nicolai Lehnert, Christopher J. Schofield, Christo Z. Christov, Tatyana Karabencheva-Christova
Role Of Structural Dynamics In Selectivity And Mechanism Of Non-Heme Fe(Ii) And 2-Oxoglutarate-Dependent Oxygenases Involved In Dna Repair, Sodiq Waheed, Rajeev Ramanan, Shobhit Chaturvedi, Nicolai Lehnert, Christopher J. Schofield, Christo Z. Christov, Tatyana Karabencheva-Christova
Michigan Tech Publications, Part 1
AlkB and its human homologue AlkBH2 are Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with mutagenic agents. We used molecular dynamics (MD) and combined quantum mechanics/molecular mechanics (QM/MM) methods to investigate how structural dynamics influences the selectivity and mechanisms of the AlkB- and AlkBH2-catalyzed demethylation of 3-methylcytosine (m3C) in single (ssDNA) and double (dsDNA) stranded DNA. Dynamics studies reveal the importance of the flexibility in both the protein and DNA components in determining the preferences of AlkB for ssDNA and of AlkBH2 for dsDNA. Correlated motions, including of a …
Richardsite, Zn2cugas4, A New Gallium-Essential Member Of The Stannite Group From The Gem Mines Near Merelani, Tanzania, Luca Bindi, John A. Jaszczak
Richardsite, Zn2cugas4, A New Gallium-Essential Member Of The Stannite Group From The Gem Mines Near Merelani, Tanzania, Luca Bindi, John A. Jaszczak
Michigan Tech Publications, Part 1
The new mineral richardsite occurs as overgrowths of small (50–400 μm) dark gray, disphenoidal crystals with no evident twinning, but epitaxically oriented on wurtzite–sphalerite crystals from the gem mines near Merelani, Lelatema Mountains, Simanjiro District, Manyara Region, Tanzania. Associated minerals also include graphite, diopside, and Ge,Ga-rich wurtzite. It is brittle, dark gray in color, and has a metallic luster. It appears dark bluish gray in reflected plane-polarized light, and is moderately bireflectant. It is distinctly anisotropic with violet to light-blue rotation tints with crossed polarizers. Reflectance percentages for Rmin and Rmax in air at the respective wavelengths are 23.5, 25.0 …
Organic Blue Tadf Chromophore Tag For Monitoring Transfection Studies, Brandon G. Bresler
Organic Blue Tadf Chromophore Tag For Monitoring Transfection Studies, Brandon G. Bresler
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A novel organic TADF chromophore was synthesized via a 3-step process to emit a blue fluorescent light upon excitation. The chromophore was covalently attached to a 61% isobutyryl amidated poly(ethyleneimine) (PEI-IBAm0.61) non-viral gene vector utilized in gene transfection experiments. The gene vectors are loaded with a green fluorescent protein (GFP) and are monitored via fluorescence microscopy. The addition of the blue chromophore therefore allows for the monitoring of the movements of the PEI-IBAm0.61 through the full delivery mechanism of the GFP inside the cells. This can give vital information about the overall toxicity of these non-viral gene vectors to biological …
Exploring The Multiplex Detection Capabilities Of Raman Spectroscopy On Mock Street Samples Containing Illicitly Manufactured Fentanyls, Mia Laverne Williams Burnett
Exploring The Multiplex Detection Capabilities Of Raman Spectroscopy On Mock Street Samples Containing Illicitly Manufactured Fentanyls, Mia Laverne Williams Burnett
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Illicitly manufactured fentanyls (IMFs) have become a global and local epidemic and have recently caused an increase in the number of accidental exposures and overdoses in first responders and the community. The aim of the research is to explore a method to discriminate between IMFs and cutting agents in mock street samples using Raman Spectroscopy. Predominant Raman bands corresponding to the structural moieties of each individual illicit, licit drugs, and cutting agents were tracked, then used to discriminate between varying components in a mock street sample. In conclusion, discrimination between the components in the mixture was obtained using Raman Spectroscopy. …
Investigating Heterogeneous Nucleation Of Barite Using Hydrothermal Atomic Force Microscopy And Optical Microscopy, Ankita B. Gurav
Investigating Heterogeneous Nucleation Of Barite Using Hydrothermal Atomic Force Microscopy And Optical Microscopy, Ankita B. Gurav
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In order to develop a better understanding heterogeneous nucleation of barite, barite precipitation was studied under varying experimental parameters. Hydrothermal atomic force microscopy (HAFM) and optical microscopy were used to investigate the effect of change in temperature, supersaturation and varying ratios of ions on heterogeneous nucleation of barite. In the experiments conducted at higher temperatures, the particles thus nucleated were found to display characteristic hexagonal and rhomboidal shapes. In comparing results of particle densities among different ion ratios, there is evidence suggesting that barium to sulfate ratio plays a role of promoter. Wherein, the ratios with higher [Ba2+] concentration were …
Quantum Chemical Pka Estimation Of Carbon Acids, Saturated Alcohols, And Ketones Via Quantitative Structure-Activity Relationships, Corey Adam Baldasare
Quantum Chemical Pka Estimation Of Carbon Acids, Saturated Alcohols, And Ketones Via Quantitative Structure-Activity Relationships, Corey Adam Baldasare
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Acid dissociation constants, often expressed as pKa values, afford vital information with regards to molecular behavior in various environments and are of significance in fields of organic, inorganic, and medicinal chemistry. Several quantitative structure-activity relationships (QSARs) were developed that correlate experimental pKas for a given class of compounds with a descriptor(s) calculated using density functional theory at the B3LYP/6-31+G** level utilizing the CPCM solvent model. A set of carbon acids provided a good final QSAR model of experimental aqueous pKas versus ΔEH2O (R2 = 0.9647) upon removal of three aldehydes as outliers. A study of saturated alcohols offered a final …
Introducing Functionality To Poly(Arylene Ether)S Via Modification Of Diphenyl Sulfone – Type Monomers, Zahida Humayun
Introducing Functionality To Poly(Arylene Ether)S Via Modification Of Diphenyl Sulfone – Type Monomers, Zahida Humayun
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The synthesis of poly(arylene ether)s, with a pendent aryl iodide, was achieved via nucleophilic aromatic substitution (NAS) polycondensation of DI-DFDPS monomer. The platform diiodo-difluorodiphenyl sulfone monomer, DFDPS-DI (3), was prepared in one-step, via EAS chemistry. Structural characterization was provided by NMR spectroscopy, GC/MS, and elemental analysis. As “pre” approach didn’t work here, so “post” approach was used to synthesize N-heterocycle functionalized copolymers. The DI-copolymers were subjected to copper-catalyzed C-N coupling reaction with carbazole, phenoxazine, and indole and the syntheses of chromophore based copolymer were successfully carried out. A series of PAEs containing carbazole, phenoxazine, and indole substituents were synthesized and …
Targeting Oncogenic K-Ras And Monoamine Oxidase B Utilizing Chalcones Bearing The 3,4,5-Trimethoxyphenyl Motif, Cody Fourman
Targeting Oncogenic K-Ras And Monoamine Oxidase B Utilizing Chalcones Bearing The 3,4,5-Trimethoxyphenyl Motif, Cody Fourman
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Oncogenic K-Ras is a driver protein found in specific cancers and was once thought to be “undruggable.” However, recent advances have suggested that mislocalizing K-Ras from the plasma membrane could be a viable strategy to target these cancers. The objective of this project was to identify a lead compound and determine a structure-activity relationship from chalcones bearing the 3,4,5-trimethoxy motif towards oncogenic K-Ras and MAO-B. This was accomplished by keeping the trimethoxy group consistent on one ring while varying the electron-donating or -withdrawing groups on the opposite ring. Previous work showed chalcones of this specific archetype exhibiting indiscriminate MAO inhibition, …
Development Of Tetrathiafulvalene Fused N-Heterocyclic Carbene Compounds, William J. Robinson Iii
Development Of Tetrathiafulvalene Fused N-Heterocyclic Carbene Compounds, William J. Robinson Iii
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Separately, N-Heterocyclic carbene and Tetrathiafulvalene compounds show great promise for a variety of applications. N-heterocyclic carbenes exhibit desirable metal bonding characteristics which allow for modulation of the metal center via back-bonding interactions. Additionally, this creates a system of increased bonding strength creating stable complexes. Tetrathiafulvalene exhibits strong redox-active and optical characteristics. These are owed to an increased aromaticity as oxidation of the compound occurs and thus, is stable through a multitude of oxidative states. The marriage of these two functionalization creates a unique opportunity for a “cure-all” compound, able to address many problems the world faces today including, but not …
The Development Of Pet Imaging Agents For Neurodegenerative Disorders, Christine Morgan Kinstedt
The Development Of Pet Imaging Agents For Neurodegenerative Disorders, Christine Morgan Kinstedt
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With the intent to synthesize a potent and viable PET imaging agent for Alzheimer’s disease and/or Parkinson’s disease utilizing tau protein aggregates or alpha-synuclein aggregates as the ailments’ respective targets, researchers in this investigation synthesized derivatives of the chalcone scaffold in order to determine a lead molecule for further drug development. This molecular structure, which due to its ability to cross the blood brain barrier (BBB), has demonstrated efficiency in a number of neurodegenerative diseases and constitutes a convenient starting point for the development of potential imaging agents for Alzheimer’s and Parkinson’s diseases. Since simple chalcones have been demonstrated to …
Antibacterial Properties Of Mussel-Inspired Polydopamine Coatings Prepared By A Simple Two-Step Shaking-Assisted Method, Pegah Kord Fooroshani, Elizabeth Polega, Kevin Thomson, Mohammad Saleh Akram Bhuiyan, Rattapol Pinnaratip, Mikhail Trought, Chito E. Kendrick, Yuesheng Gao, Kathryn Perrine, Lei Pan, Bruce P. Lee
Antibacterial Properties Of Mussel-Inspired Polydopamine Coatings Prepared By A Simple Two-Step Shaking-Assisted Method, Pegah Kord Fooroshani, Elizabeth Polega, Kevin Thomson, Mohammad Saleh Akram Bhuiyan, Rattapol Pinnaratip, Mikhail Trought, Chito E. Kendrick, Yuesheng Gao, Kathryn Perrine, Lei Pan, Bruce P. Lee
Michigan Tech Publications, Part 1
A simple two-step, shaking-assisted polydopamine (PDA) coating technique was used to impart polypropylene (PP) mesh with antimicrobial properties. In this modified method, a relatively large concentration of dopamine (20 mg ml−1) was first used to create a stable PDA primer layer, while the second step utilized a significantly lower concentration of dopamine (2 mg ml−1) to promote the formation and deposition of large aggregates of PDA nanoparticles. Gentle shaking (70 rpm) was employed to increase the deposition of PDA nanoparticle aggregates and the formation of a thicker PDA coating with nano-scaled surface roughness (RMS = 110 …
Extensive Soot Compaction By Cloud Processing From Laboratory And Field Observations, Janarjan Bhandari, Swarup China, Kamal Kant Chandrakar, Greg Kinney, Will Cantrell, Raymond Shaw, Lynn Mazzoleni, Giulia Girotto, Noopur Sharma, Kyle Gorkowski, Stefania Gilardoni, Stefano Decesari, Maria Cristina Facchini, Nicola Zanca, Giulia Pavese, Francesco Esposito, Manvendra K Dubey, Allison C Aiken, Rajan K Chakrabarty, Hans Moosmüller, Timothy B Onasch, Rahul A Zaveri, Barbara V Scarnato, Paulo Fialho, Claudio Mazzoleni
Extensive Soot Compaction By Cloud Processing From Laboratory And Field Observations, Janarjan Bhandari, Swarup China, Kamal Kant Chandrakar, Greg Kinney, Will Cantrell, Raymond Shaw, Lynn Mazzoleni, Giulia Girotto, Noopur Sharma, Kyle Gorkowski, Stefania Gilardoni, Stefano Decesari, Maria Cristina Facchini, Nicola Zanca, Giulia Pavese, Francesco Esposito, Manvendra K Dubey, Allison C Aiken, Rajan K Chakrabarty, Hans Moosmüller, Timothy B Onasch, Rahul A Zaveri, Barbara V Scarnato, Paulo Fialho, Claudio Mazzoleni
Michigan Tech Publications, Part 1
Soot particles form during combustion of carbonaceous materials and impact climate and air quality. When freshly emitted, they are typically fractal-like aggregates. After atmospheric aging, they can act as cloud condensation nuclei, and water condensation or evaporation restructure them to more compact aggregates, affecting their optical, aerodynamic, and surface properties. Here we survey the morphology of ambient soot particles from various locations and different environmental and aging conditions. We used electron microscopy and show extensive soot compaction after cloud processing. We further performed laboratory experiments to simulate atmospheric cloud processing under controlled conditions. We find that soot particles sampled after …
Spontaneous Selective Deposition Of Iron Oxide Nanoparticles On Graphite As Model Catalysts, Chathura De Alwis, Timothy Leftwich, Pinaki Mukherjee, Alex Denofre, Kathryn Perrine
Spontaneous Selective Deposition Of Iron Oxide Nanoparticles On Graphite As Model Catalysts, Chathura De Alwis, Timothy Leftwich, Pinaki Mukherjee, Alex Denofre, Kathryn Perrine
Michigan Tech Publications, Part 1
Iron oxide nanomaterials participate in redox processes that give them ideal properties for their use as earth-abundant catalysts. Fabricating nanocatalysts for such applications requires detailed knowledge of the deposition and growth. We report the spontaneous deposition of iron oxide nanoparticles on HOPG in defect areas and on step edges from a metal precursor solution. To study the nucleation and growth of iron oxide nanoparticles, tailored defects were created on the surface of HOPG using various ion sources that serve as the target sites for iron oxide nucleation. After solution deposition and annealing, the iron oxide nanoparticles were found to nucleate …
Detecting Zn(Ii) Ions In Live Cells With Near-Infrared Fluorescent Probes., Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Marina Tanasova, Rudy Luck, Haiying Liu
Detecting Zn(Ii) Ions In Live Cells With Near-Infrared Fluorescent Probes., Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Marina Tanasova, Rudy Luck, Haiying Liu
Michigan Tech Publications, Part 1
Two near-infrared fluorescent probes (A and B) containing hemicyanine structures appended to dipicolylamine (DPA), and a dipicolylamine derivative where one pyridine was substituted with pyrazine, respectively, were synthesized and tested for the identification of Zn(II) ions in live cells. In both probes, an acetyl group is attached to the phenolic oxygen atom of the hemicyanine platform to decrease the probe fluorescence background. Probe A displays sensitive fluorescence responses and binds preferentially to Zn(II) ions over other metal ions such as Cd2+ ions with a low detection limit of 0.45 nM. In contrast, the emission spectra of probe B is …