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Articles 31 - 60 of 249
Full-Text Articles in Chemistry
Pet And Polyolefin Plastics Supply Chains In Michigan: Present And Future Systems Analysis Of Environmental And Socio-Economic Impacts, Utkarsh S. Chaudhari, Kamand Sedaghatnia, Barbara K. Reck, Kate Maguire, Anne T. Johnson, David Watkins, Robert M. Handler, Tasmin Hossain, Damon S. Hartley, Vicki S. Thompson, Alejandra Peralta, Jenny L. Apriesnig, David Shonnard
Pet And Polyolefin Plastics Supply Chains In Michigan: Present And Future Systems Analysis Of Environmental And Socio-Economic Impacts, Utkarsh S. Chaudhari, Kamand Sedaghatnia, Barbara K. Reck, Kate Maguire, Anne T. Johnson, David Watkins, Robert M. Handler, Tasmin Hossain, Damon S. Hartley, Vicki S. Thompson, Alejandra Peralta, Jenny L. Apriesnig, David Shonnard
Michigan Tech Publications
Many actions are underway at global, national, and local levels to increase plastics circularity. However, studies evaluating the environmental and socio-economic impacts of such a transition are lacking at regional levels in the United States. In this work, the existing polyethylene terephthalate and polyolefin plastics supply chains in Michigan were compared to a potential future (‘NextCycle’) scenario that looks at increasing Michigan’s overall recycling rate to 45%. Material flow analysis data was combined with environmental and socio-economic metrics to evaluate the sustainability of these supply chains for the modeled scenarios. Overall, the NextCycle scenario for these supply chains achieved a …
Cadmium Oxide Nanoparticles From New Organometallic Cd(Ii)-Schiff Base Complex And In Vitro Biological Potentials: Dual S. Aureus And E. Coli Dna Gyrase Inhibition By The Precursors Via In Silico Binding Modes’ Study, Ikechukwu P. Ejidike, Amani Direm, Cemal Parlak, Mercy O. Bamigboye, Olajumoke Oluade, Juliana B. Adetunji, Athar Ata, Michael O. Eze, Joshua W. Hollett, Hadley S. Clayton
Cadmium Oxide Nanoparticles From New Organometallic Cd(Ii)-Schiff Base Complex And In Vitro Biological Potentials: Dual S. Aureus And E. Coli Dna Gyrase Inhibition By The Precursors Via In Silico Binding Modes’ Study, Ikechukwu P. Ejidike, Amani Direm, Cemal Parlak, Mercy O. Bamigboye, Olajumoke Oluade, Juliana B. Adetunji, Athar Ata, Michael O. Eze, Joshua W. Hollett, Hadley S. Clayton
Michigan Tech Publications
At the nanoscale level, several biological processes take place, owing to the potential that engineered nanomaterials might interrelate with bio-molecules and cellular procedures. This study aimed to synthesize cadmium oxide nanoparticles via a one-step calcination process of tetradentate Schiff base-Cd(II) complex at different temperature ranges. The as-synthesized compounds were carried out via a viz UV–visible, elemental analysis, 1H NMR, molar conductivity, transmission electron microscopy (TEM), FT-IR spectroscopy, and X-ray diffraction (PXRD). The band gap energy and average particle sizes of the CdO particles are respectively (2.69 eV, 3.54 eV), 26.88 nm for CdO@250, and (3.20 eV, 3.57 eV), 25.67 nm …
Living Emission Abolish Filters (Leafs) For Methane Mitigation: Design And Operation, Richard Hamilton, Nicholas Griffith, Peter Salamon, Robert Handler, Marina G. Kalyuzhnaya
Living Emission Abolish Filters (Leafs) For Methane Mitigation: Design And Operation, Richard Hamilton, Nicholas Griffith, Peter Salamon, Robert Handler, Marina G. Kalyuzhnaya
Michigan Tech Publications
As one of the most potent greenhouse gases, methane is a critical target for the near-term mitigation of global warming. Efficient, scalable, easy-to-implement, and robust mitigation technologies are urgently needed to assist in reaching methane abolishment. The goal of this research was to test the applicability of active, extremophilic methanotrophic cells as a baseline concept for engineered systems aiming at methane capturing. The system, named living emission abolish filters (LEAFs), represents an array of immobilized biomaterials capable of capturing methane directly from vent streams. The biomaterials were made using cells of Methylotuvimicrobium alcaliphilum 20ZR, a robust halophilic methanotrophic bacterium with …
Structural, Spectroscopic, And Computational Insights From Canavanine-Bound And Two Catalytically Compromised Variants Of The Ethylene-Forming Enzyme, Shramana Chatterjee, Matthias Fellner, Joel A. Rankin, Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee, Christo Christov, Jian Hu, Robert P. Hausinger
Structural, Spectroscopic, And Computational Insights From Canavanine-Bound And Two Catalytically Compromised Variants Of The Ethylene-Forming Enzyme, Shramana Chatterjee, Matthias Fellner, Joel A. Rankin, Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee, Christo Christov, Jian Hu, Robert P. Hausinger
Michigan Tech Publications
The ethylene-forming enzyme (EFE) is an Fe(II), 2-oxoglutarate (2OG), and l-arginine (l-Arg)-dependent oxygenase that either forms ethylene and three CO2/bicarbonate from 2OG or couples the decarboxylation of 2OG to C5 hydroxylation of l-Arg. l-Arg binds with C5 toward the metal center, causing 2OG to change from monodentate to chelate metal interaction and OD1 to OD2 switch of D191 metal coordination. We applied anaerobic UV-visible spectroscopy, X-ray crystallography, and computational approaches to three EFE systems with high-resolution structures. The ineffective l-Arg analogue l-canavanine binds to the EFE with O5 pointing away from the metal center while promoting chelate formation by 2OG …
Induction Of Neuroinflammation And Brain Oxidative Stress By Brain-Derived Extracellular Vesicles From Hypertensive Rats, Xinqian Chen, Xin Yan, Leah Gingerich, Qing Hui Chen, Lanrong Bi, Zhiying Shan
Induction Of Neuroinflammation And Brain Oxidative Stress By Brain-Derived Extracellular Vesicles From Hypertensive Rats, Xinqian Chen, Xin Yan, Leah Gingerich, Qing Hui Chen, Lanrong Bi, Zhiying Shan
Michigan Tech Publications
Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity could trigger neuroinflammation and oxidative stress during hypertension development. To test this hypothesis, we compared the impact of EVs isolated from the brains of hypertensive Dahl Salt-Sensitive rats (DSS) and normotensive Sprague Dawley (SD) rats on inflammatory factors and mitochondrial reactive oxygen species (mtROS) production in primary neuronal …
Sustainability Of Biogas Production From Anaerobic Digestion Of Food Waste And Animal Manure, Sharath Kumar Ankathi, Utkarsh S. Chaudhari, Robert Handler, David R. Shonnard
Sustainability Of Biogas Production From Anaerobic Digestion Of Food Waste And Animal Manure, Sharath Kumar Ankathi, Utkarsh S. Chaudhari, Robert Handler, David R. Shonnard
Michigan Tech Publications
Anaerobic digestion (AD) involves a set of microbiological reactions and physio-chemical processes to generate biogas, a mixture of predominantly CH4 and CO2. It is commercialized globally; however, AD has limited commercial applications in the U.S. compared to other regions of the world. The main objective of this article is to review different studies on socio-economic and environmental aspects and policies of biogas/biomethane production and to focus on resource availability. The key outcome from this review shows that the anaerobic digestion of food waste and animal manure has great potential to achieve economic and environmental benefits compared to other waste management …
Unusual Catalytic Strategy By Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase Asph, Anandhu Krishnan, Sodiq Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J. Schofield, Tatyana G. Karabencheva-Christova
Unusual Catalytic Strategy By Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase Asph, Anandhu Krishnan, Sodiq Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J. Schofield, Tatyana G. Karabencheva-Christova
Michigan Tech Publications
Biocatalytic C-H oxidation reactions are of important synthetic utility, provide a sustainable route for selective synthesis of important organic molecules, and are an integral part of fundamental cell processes. The multidomain non-heme Fe(ii)/2-oxoglutarate (2OG) dependent oxygenase AspH catalyzes stereoselective (3R)-hydroxylation of aspartyl- and asparaginyl-residues. Unusually, compared to other 2OG hydroxylases, crystallography has shown that AspH lacks the carboxylate residue of the characteristic two-His-one-Asp/Glu Fe-binding triad. Instead, AspH has a water molecule that coordinates Fe(ii) in the coordination position usually occupied by the Asp/Glu carboxylate. Molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) studies reveal that the iron coordinating water is …
Innovative Cyanine-Based Fluorescent Dye For Targeted Mitochondrial Imaging And Its Utility In Whole-Brain Visualization, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Innovative Cyanine-Based Fluorescent Dye For Targeted Mitochondrial Imaging And Its Utility In Whole-Brain Visualization, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Michigan Tech Publications
Conducting in vivo brain imaging can be a challenging task due to the complexity of brain tissue and the strict requirements for safe and effective imaging agents. However, a new fluorescent dye called Cy5-PEG2 has been developed that selectively accumulates in mitochondria, enabling the visualization of these essential organelles in various cell lines. This dye is versatile and can be used for the real-time monitoring of mitochondrial dynamics in living cells. Moreover, it can cross the blood-brain barrier, making it a promising tool for noninvasive in vivo brain imaging. Based on the assessment of glial cell responses in the hippocampus …
A Spectrophotometric Determination Of Strontium Complexation With Methylthymol Blue, Adebayo Comlan Djanman
A Spectrophotometric Determination Of Strontium Complexation With Methylthymol Blue, Adebayo Comlan Djanman
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This study examines the complexation behavior of methylthymol blue (MTB) with strontium, particularly focusing on its application in addressing environmental concerns related to radiotoxic 90Sr. Using spectrophotometric techniques, the binding interactions were analyzed at pH = 7.50, 9.60, and 12.20. Results indicate that MTB forms a 1:1 complex with strontium at pH = 7.50, while at pH = 9.60 and 12.20 were assumed to influence complexation due to changes in ligand deprotonation and electrostatic interactions. Equilibrium constants (K1) = 22 (± 2) and molar absorptivities, ε1 = 6.3 x 10^3 (± 0.0008) L·mol⁻¹·cm⁻¹, and ε2 = 9.73 x (± 0.2)10^3 …
Investigation Of Ion Pairing And Clustering Leading To The Nucleation Of Fluorite Using Ion Selective Electrode Potentiometry, Courtney L. Crone
Investigation Of Ion Pairing And Clustering Leading To The Nucleation Of Fluorite Using Ion Selective Electrode Potentiometry, Courtney L. Crone
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Previously, mineral nucleation was described by Classical Nucleation Theory (CNT), a theory based on the thermodynamic properties of bulk materials. However, an alternative model, known as the Prenucleation Cluster Pathway, has been increasingly used to describe nucleation of minerals. This model considers the presence of thermodynamically stable ion clusters known as “prenucleation clusters” (PNCs). In the present research, the nucleation mechanism of calcium fluoride was investigated to identify evidence of PNCs by means of the ion-selective electrode (ISE) method, where a CaCl2 solution was titrated into a NaF solution while investigating the effects of saturation level and the aqueous ratio …
Effects Of Geometric Isomerism On Benzothiazole-Carbazole Based Tadf Emitters In Poly(Arylene Ether)S, Grace Olive
Effects Of Geometric Isomerism On Benzothiazole-Carbazole Based Tadf Emitters In Poly(Arylene Ether)S, Grace Olive
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Thermally activated delayed fluorescence (TADF) small molecules have dominated the literature for their use in OLED devices. The use of TADF polymers has been employed to correct for processing issues that small molecules face, providing increased thermal stability and supportive electronic structures. A TADF chromophore based on a 2-(2,6-difluorophenyl)-benzothiazole-carbazole donor-acceptor pair was synthesized via a copper (I) catalyzed reaction. The chromophore exhibited peak absorption at 340 nm and emission at 477 nm. The resulting chromophore was incorporated into a poly(arylene ether) (PAE) backbone via nucleophilic aromatic substitution (NAS) with 4,4’-biphenol, 4,4’-difluorodiphenyl sulfone, and 2-(2,6-difluorophenyl)-benzothiazole as comonomers. UV/Vis analysis of the …
Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang
Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang
Michigan Tech Publications
Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …
Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Michigan Tech Publications
Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …
Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi
Michigan Tech Publications
Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …
Molecular And Physical Composition Of Tar Balls In Wildfire Smoke: An Investigation With Complementary Ionisation Methods And 15-Tesla Ft-Icr Mass Spectrometry, Amna Ijaz, William Kew, Zezhen Cheng, Susan Mathai, Nurun Nahar Lata, Libor Kovarik, Simeon Schum, Swarup China, Lynn Mazzoleni
Molecular And Physical Composition Of Tar Balls In Wildfire Smoke: An Investigation With Complementary Ionisation Methods And 15-Tesla Ft-Icr Mass Spectrometry, Amna Ijaz, William Kew, Zezhen Cheng, Susan Mathai, Nurun Nahar Lata, Libor Kovarik, Simeon Schum, Swarup China, Lynn Mazzoleni
Michigan Tech Publications
Tar balls (TBs) are a major carbonaceous product of wildfires and other biomass-burning events that often exceed soot or other elemental forms of carbon in number and mass. Being a recalcitrant fraction of organic carbon, TBs are capable of long-range atmospheric transport, and thus, exert influence not only in the vicinity of wildfires but also in remote regions. Here, we characterised ambient atmospheric aerosol samples with varying TB number fractions collected downwind of Pacific Northwest wildfires using a 15-Tesla Fourier transform-ion cyclotron resonance mass spectrometer (15-T FT-ICR MS). Relative to non-TB aerosol, we found 2006 and 851 molecular formulae exclusively …
From Random To Rational: Improving Enzyme Design Through Electric Fields, Second Coordination Sphere Interactions, And Conformational Dynamics, Shobhit S. Chaturvedi, Daniel Bím, Christo Christov, Anastassia N. Alexandrova
From Random To Rational: Improving Enzyme Design Through Electric Fields, Second Coordination Sphere Interactions, And Conformational Dynamics, Shobhit S. Chaturvedi, Daniel Bím, Christo Christov, Anastassia N. Alexandrova
Michigan Tech Publications
Enzymes are versatile and efficient biological catalysts that drive numerous cellular processes, motivating the development of enzyme design approaches to tailor catalysts for diverse applications. In this perspective, we investigate the unique properties of natural, evolved, and designed enzymes, recognizing their strengths and shortcomings. We highlight the challenges and limitations of current enzyme design protocols, with a particular focus on their limited consideration of long-range electrostatic and dynamic effects. We then delve deeper into the impact of the protein environment on enzyme catalysis and explore the roles of preorganized electric fields, second coordination sphere interactions, and protein dynamics for enzyme …
Biological Formation Of Ethylene, Robert P. Hausinger, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Shramana Chatterjee, Jian Hu, Christo Christov
Biological Formation Of Ethylene, Robert P. Hausinger, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Shramana Chatterjee, Jian Hu, Christo Christov
Michigan Tech Publications
This review summarizes the structures, biochemical properties, and mechanisms of two major biological sources of ethylene, the ethylene-forming enzyme (EFE) and 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase (ACCO). EFE is found in selected bacteria and fungi where it catalyzes two reactions: (1) the oxygen-dependent conversion of 2-oxoglutarate (2OG) to ethylene plus three molecules of CO2/bicarbonate and (2) the oxidative decarboxylation of 2OG while transforming l-arginine to guanidine and l-Δ1-pyrroline-5-carboxylic acid. ACCO is present in plants where it makes the plant hormone by transforming ACC, O2, and an external reductant to ethylene, HCN, CO2, and water. Despite catalyzing distinct chemical reactions, EFE and …
The Fierce Urgency Of Now: Integrating The Youth Voice At Cop, Gillian Bowser, Pamela H. Templer, Susie S. Ho, Sarah A. Green, Sarah Hautzinger, Isabelle Zhu-Maguire, Alyssa Connaughton, Leah Dundon, Diane Husic, Mark Urban
The Fierce Urgency Of Now: Integrating The Youth Voice At Cop, Gillian Bowser, Pamela H. Templer, Susie S. Ho, Sarah A. Green, Sarah Hautzinger, Isabelle Zhu-Maguire, Alyssa Connaughton, Leah Dundon, Diane Husic, Mark Urban
Michigan Tech Publications, Part 1
No abstract provided.
Synthesis And Characterization Of Humic/Melanin-Like Compounds By Oxidative Polymerization Of Simple Aromatic Precursors, Nastaran Khademimoshgenani, Sarah A. Green
Synthesis And Characterization Of Humic/Melanin-Like Compounds By Oxidative Polymerization Of Simple Aromatic Precursors, Nastaran Khademimoshgenani, Sarah A. Green
Michigan Tech Publications, Part 1
Dissolved organic matter (DOM) is a complex mixture of naturally occurring organic molecules originating from multiple marine and terrestrial sources. DOM plays a significant role in water quality by affecting the photochemistry, trace metal transport, and acidity in aquatic systems. Understanding the chemical composition of DOM helps interpret the links between its optical properties and molecular structures. Currently, the molecular origins of the optical properties of DOM are not well-defined. In this study, we oxidize and initiate the polymerization of melanin precursors 1,8-dihydroxy naphthalene and 5,6-dihydroxy indole by the addition of hydrogen peroxide and/or with ultraviolet irradiation. Our goal is …
Kinetic Studies On The 2-Oxoglutarate/Fe(Ii)-Dependent Nucleic Acid Modifying Enzymes From The Alkb And Tet Families, Zhiyuan Peng, Jian Ma, Christo Christov, Tatyana Karabencheva-Christova, Nicolai Lehnert, Deyu Li
Kinetic Studies On The 2-Oxoglutarate/Fe(Ii)-Dependent Nucleic Acid Modifying Enzymes From The Alkb And Tet Families, Zhiyuan Peng, Jian Ma, Christo Christov, Tatyana Karabencheva-Christova, Nicolai Lehnert, Deyu Li
Michigan Tech Publications
Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation. In this review, we focus on the demethylation or oxidative modification that is mediated by the 2-oxoglutarate (2-OG)/Fe(II)-dependent AlkB/TET family enzymes. In the catalytic process, most enzymes oxidize 2-OG to succinate, in the meantime oxidizing methyl to hydroxymethyl, leaving formaldehyde and generating demethylated base. The AlkB enzyme from Escherichia coli has nine human homologs (ALKBH1-8 and FTO) and the TET family includes three members, TET1 to 3. Among them, some enzymes have been carefully studied, but for …
Selectively Modified Lactose And N-Acetyllactosamine Analogs At Three Key Positions To Afford Effective Galectin-3 Ligands †, Shuay Abdullayev, Priyanka Dipak Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy
Selectively Modified Lactose And N-Acetyllactosamine Analogs At Three Key Positions To Afford Effective Galectin-3 Ligands †, Shuay Abdullayev, Priyanka Dipak Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy
Michigan Tech Publications, Part 1
Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and N-Acetyllactosamine (2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose, LacNAc) have been widely exploited as ligands for a wide range of galectins, sometimes with modest selectivity. Even though several chemical modifications at single positions of the sugar rings have been applied to these ligands, very few examples combined the simultaneous modifications at key positions known to increase both affinity and selectivity. We report herein combined modifications at the anomeric position, C-2, and O-3′ of each of the two …
Green Synthesis Of Nanoparticles And Their Utilization In Electrochemical Detection Of Catechol- Or Phenol-Based Substances, Daniel Laurence Myers Iii
Green Synthesis Of Nanoparticles And Their Utilization In Electrochemical Detection Of Catechol- Or Phenol-Based Substances, Daniel Laurence Myers Iii
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PART A: GREEN SYNTHESIS OF COPPER NANOPARTICLES AND THEIR UTILIZATION IN THE DETECTION OF NEUROTRANSMITTERS Neurotransmitters, such as dopamine and epinephrine, are chemicals frequently found in the brain and are responsible for a number of human moods, needs, and emotions.1, 2 Detection of such neurotransmitters allows for a better judgement of a person’s physical and mental state, a utility that is vital in determining the presence of disease and mental illnesses.2 Electrochemical detectors used for such detections are often modified by materials such as metal nanoparticles.3 However, synthesizing nanoparticles can involve or produce chemicals, ammonium hydroxide among them, that are …
Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova
Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova
Michigan Tech Publications, Part 1
The targeting of facilitative sugar transporters (GLUTs) has been utilized in the development of tools for diagnostics and therapy. The interest in this area is promoted by the phenomenon of alterations in cellular metabolic processes that are linked to multitudes of metabolic disorders and diseases. However, nonspecific targeting (e.g., glucose-transporting GLUTs) leads to a lack of disease detection efficiency. Among GLUTs, GLUT5 stands out as a prominent target for developing specific molecular tools due to its association with metabolic diseases, including cancer. This work reports a non-radiolabeled fluoride (19F) coumarin-based glycoconjugate of 2,5-anhydro-D-mannitol as a potential PET imaging probe that …
Importance Of Glut Transporters In Disease Diagnosis And Treatment, Abdelrahman Ismail, Marina Tanasova
Importance Of Glut Transporters In Disease Diagnosis And Treatment, Abdelrahman Ismail, Marina Tanasova
Michigan Tech Publications, Part 1
Facilitative sugar transporters (GLUTs) are the primary method of sugar uptake in all mammalian cells. There are 14 different types of those transmembrane proteins, but they transport only a handful of substrates, mainly glucose and fructose. This overlap and redundancy contradict the natural tendency of cells to conserve energy and resources, and has led researchers to hypothesize that different GLUTs partake in more metabolic roles than just sugar transport into cells. Understanding those roles will lead to better therapeutics for a wide variety of diseases and disorders. In this review we highlight recent discoveries of the role GLUTs play in …
A Quantum Mechanical Description Of The Diffusion Properties Of C1-C2 Hydrocarbon Molecules In Mof-74-Mg, Gemechis Degaga, Amanda Studinger, Loredana Valenzano-Slough
A Quantum Mechanical Description Of The Diffusion Properties Of C1-C2 Hydrocarbon Molecules In Mof-74-Mg, Gemechis Degaga, Amanda Studinger, Loredana Valenzano-Slough
Michigan Tech Publications
Among the numerous metal organic framework (MOF) families, of significant importance is the MOF-74-M series (M = metal, -also known as CPO-27-M), characterized by a high density of not fully coordinated open metal site centers; this peculiarity has been demonstrated to translate into a higher hydrocarbons’ separation potential than other known MOFs and zeolites. To provide a more comprehensive description of the behavior of the hydrocarbon molecules within the MOF-74 cavity, diffusion processes and corresponding diffusion barriers of small hydrocarbons in the MOF-74-Mg were modeled. This work provides a description of the molecular transport processes of CH4, C2H2, C2H4 and …
Synthesis And Characterization Of Alkyne-Functionalized Photo-Cross-Linkable Polyesters, Warrick Ma, Xiaochu Ding, Ying Chen, Yadong Wang
Synthesis And Characterization Of Alkyne-Functionalized Photo-Cross-Linkable Polyesters, Warrick Ma, Xiaochu Ding, Ying Chen, Yadong Wang
Michigan Tech Publications, Part 1
An alkyne-functionalized elastomer derived from sebacic acid, 1,3-propanediol, and alkyne-functionalized serinol is synthesized via melt condensation. A low-power UV lamp triggers the cross-linking rapidly via thiol-yne click chemistry. The cross-linking behavior is studied by photorheology and NMR spectroscopy. The resultant elastomer possesses mechanical properties similar to those of human soft tissues and exhibits in vitro degradability and good cytocompatibility.
Determination Of Optical Density (Od) Of Oligodeoxynucleotide From Hplc Peak Area, Komal Chillar, Yipeng Yin, Dhananjani Eriyagama, Shiyue Fang
Determination Of Optical Density (Od) Of Oligodeoxynucleotide From Hplc Peak Area, Komal Chillar, Yipeng Yin, Dhananjani Eriyagama, Shiyue Fang
Michigan Tech Publications, Part 1
Oligodeoxynucleotides (ODNs) are typically purified and analysed with HPLC equipped with a UV-Vis detector. Quantities of ODNs are usually determined using a UV-Vis spectrometer separately after HPLC, and are reported as optical density at 260 nm (OD260). Here, we describe a method for direct determination of OD260 of ODNs using the area of the peaks in HPLC profiles.
Harmful Algal Blooms In Caesar Creek Lake And Their Relationship To Riparian Cover, Morgan C. Grunden
Harmful Algal Blooms In Caesar Creek Lake And Their Relationship To Riparian Cover, Morgan C. Grunden
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Caesar Creek Lake (CCL) in Warren County, OH has recently been experiencing harmful algal blooms (HABs) which are most likely attributed to an excess of phosphorus (P) from fertilizers and manures applied to surrounding fields. Sediments act as a sink for P later supplying a source of P in lakes for HABs when waters become thermally stratified and anoxic. This study seeks to determine the relationship between HABs in CCL and riparian cover at the main tributaries, Anderson Fork and Caesar Creek. In order to do this, sediment samples were collected from four sample sites along Anderson Fork and three …
Covalent Attachment Of Tadf Chromophores To Thermally Stable Poly(Arylene Ether)S, Samuel Farrar
Covalent Attachment Of Tadf Chromophores To Thermally Stable Poly(Arylene Ether)S, Samuel Farrar
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The covalent attachment of a blue emitting, benzothiazole based TADF chromophore into poly(arylene ether) backbone polymers was explored. A benzothiazole derivative, 2-(2,4-difluorophenyl)-benzothiazole (2,4-diF-BTZ), was synthesized to form the electrophilic component of the host polymer. Two polymers were synthesized to have chromophore incorporated, using 2,4-diFBTZ and 4,4-dihydroxydiphenyl ether (DPE) or 4,4’-biphenol (BP). The chromophore was covalently incorporated at a 10% molar ratio into the polymer backbone by copolymerization with 2,4-diF-BTZ and BP, utilizing nucleophilic aromatic substitution (NAS). Structural characterization was provided via NMR spectroscopy and GC/MS analysis. The polymer syntheses provided high molecular weight materials that were able to be cast …
Detection And Identification Of Prevalent Cutting Agents In 'Street' Samples Utilizing Handheld And Benchtop Raman Spectroscopy And Surface-Enhanced Raman Spectroscopy (Sers), Nicole Kenny
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Illicit and licit drugs continue to have a negative impact on the public’s health even with new regulations and laws. At local, state, and federal levels, crime laboratories analyze samples in a variety of mixtures and concentrations. Raman spectroscopy is a molecular fingerprinting, multiplex technique, which is considered a category A forensic characterization tool by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). The sensitivity of the Raman technique can be further enhanced down to the single-molecule detection level when analytes of interest are located at the interstitial sites of aggregated silver nanoparticles (i.e., the “hot spots” …