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2019

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Articles 841 - 870 of 1773

Full-Text Articles in Chemistry

Hydrated Sulfate Clusters So42–(H2o)N (N = 1–40): Charge Distribution Through Solvation Shells And Stabilization, Maksim Kulichenko, Nikita Fedik, Konstantin V. Bozhenko, Alexander I. Boldyrev Apr 2019

Hydrated Sulfate Clusters So42–(H2o)N (N = 1–40): Charge Distribution Through Solvation Shells And Stabilization, Maksim Kulichenko, Nikita Fedik, Konstantin V. Bozhenko, Alexander I. Boldyrev

Chemistry and Biochemistry Faculty Publications

Investigations of inorganic anion SO42– interactions with water are crucial for understanding the chemistry of its aqueous solutions. It is known that the isolated SO42– dianion is unstable, and three H2O molecules are required for its stabilization. In the current work, we report our computational study of hydrated sulfate clusters SO42–(H2O)n (n = 1–40) in order to understand the nature of stabilization of this important anion by water molecules. We showed that the most significant charge transfer from dianion SO42– to H2O takes …

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On The Capability Of Metal-Halogen Groups To Participate In Halogen Bonds, Steve Scheiner Apr 2019

On The Capability Of Metal-Halogen Groups To Participate In Halogen Bonds, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

A number of halogen (X) atoms were covalently attached to a metal (M) and the ability of the X atom to act as electron acceptor in a halogen bond to nucleophile NCH was assessed. Both Cl and Br were considered as halogen atom, with NH3 and CO as other ligands attached to the metal. Metals tested were Ti, Mn, and Zn in various combinations of oxidation state, coordination, and overall charge. In the majority of cases, the strong electron-releasing power of the metal imbues the halogen atom with a high negative partial charge and minimizes the development of a σ-hole. …

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The Effects Of Climate Change And Forest Disturbances On Terpene Production Of White Pine (Pinus Strobus) And Red Pine (Pinus Resinosa) In Northern Michigan, Troy Dehagen Apr 2019

The Effects Of Climate Change And Forest Disturbances On Terpene Production Of White Pine (Pinus Strobus) And Red Pine (Pinus Resinosa) In Northern Michigan, Troy Dehagen

Honors Theses

The secondary impacts that climate change may have on the interactions between forests and the atmosphere through forest disturbances is of increasing interest as the climate continues to change. Anthropogenic climate change, which is a direct result of coal and fossil fuel emissions, is likely to impact forest ecology through increased temperatures and extreme precipitation events, thus increasing the frequency and severity of climate-induced forest disturbances. Forest disturbances may have a secondary impact on the production and emission of biogenic volatile organic compounds (BVOC) within forests. In the presence of oxides of nitrogen (NOx) produced from fossil fuel …

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Nanostructuring Organic/Inorganic Multicomponent Composites For Solution Processable Solar Cells, Brad W. Watson Apr 2019

Nanostructuring Organic/Inorganic Multicomponent Composites For Solution Processable Solar Cells, Brad W. Watson

Chemistry and Chemical Biology ETDs

The current state of organic photovoltaics is centered on systems of polymeric donors and some type of acceptor molecule (i.e. fullerene) formed into an active layer that adopts a bulk-heterojunction morphology. Although these devices have come a far way from where they were when they were first discovered in the 1980’s much work is still needed to make them a viable technology. Two of the limitations of this type of devices revolve around the relatively narrow absorption window of the components and lack of control over the morphology after the film is cast. To overcome these shortcomings there are several …

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50 Years Of Student Research At Governors State University, Shailendra Kumar Apr 2019

50 Years Of Student Research At Governors State University, Shailendra Kumar

Research Days

The three pillars that provide the foundations for the excellent education at GSU are teaching, research, and service. Faculty and students have engaged in myriad of research activities since the inception of GSU in 1969. This presentation highlights the efforts, successes, and triumphs of students research in the last fifty years. Prior to 1995, students engaged in research, published in journals, and presented their work in professional conferences. A formal forum in the form of an Annual GSU Student Research Conference was introduced in 1995 by the Provost Office to provide students to present their research work before an audience …

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The Method Of Analyses Of Juices And Fruits, Which Produced In Uzbekistan, A. Ibragimov, Yu Isaev, O. Yigitaliyeva,, A. Ibrohimov. Apr 2019

The Method Of Analyses Of Juices And Fruits, Which Produced In Uzbekistan, A. Ibragimov, Yu Isaev, O. Yigitaliyeva,, A. Ibrohimov.

Scientific journal of the Fergana State University

The article presents and discusses the requirements of state standards of the Republic of Uzbekistan for fruit juices, as well as the results of determining the amount of ascorbic acid in various sorts of apples grown in the Fergana region.

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The Synthesis Of Glytsirizin Acid With Components Of Urea Syclization, Yu. Isayev, S. Rustamov, I. Asqarov, N Tu’Laqov Apr 2019

The Synthesis Of Glytsirizin Acid With Components Of Urea Syclization, Yu. Isayev, S. Rustamov, I. Asqarov, N Tu’Laqov

Scientific journal of the Fergana State University

The article presents the work on the synthesis of a complex compound of glycyrrhizin acid and urea, as well as some physicochemical parameters of the compounds are obtained

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Pyscan: Interfacing Laboratory Instruments With Python, Julian N. Payne, Peter E. Timperman Apr 2019

Pyscan: Interfacing Laboratory Instruments With Python, Julian N. Payne, Peter E. Timperman

18th Annual Celebration of Undergraduate Research and Creative Activity (2019)

Laboratory instruments can be interfaced with and controlled from personal computers. Several programs to scan lasers and acquire data have been written by students in the Polik Lab. However, computer hardware and software change more rapidly (3-5 years) than instrument lifetime (20 years). Thus, programs must be replaced to run on modern computers and operating systems. This can be done to minimize dependence on specific hardware and software. PyScan is a laser instrument interface program intended to replace the Polik Lab’s current software. It allows the user to control the laser, setup a scan, acquire data, and store the data …

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Mechanistic Studies And Derivative Effects In 1, 3, 4- Oxadiazole Synthesis Via Cyclodehydration Reactions, Evan Huggins Apr 2019

Mechanistic Studies And Derivative Effects In 1, 3, 4- Oxadiazole Synthesis Via Cyclodehydration Reactions, Evan Huggins

Undergraduate Honors Thesis Projects

In the world of pharmaceutical synthesis, research to combat foreign pathogens is always necessary. Scientists have been exploring different methods in order to synthesize the most effective compounds in antibacterial, anticancer, anti-inflammatory, and many other treatments. A key component within these versatile compounds are 1,3,4-oxadiazoles. Current methods to synthesize these compounds are inefficient. This research seeks to improve oxadiazole synthesis; however, the mechanism of this reaction is unknown. The goal of this project was to study the mechanistic pathway in the discovered, one-pot cyclodehydration synthesis of 1,3,4-oxadiazoles. In the first part of this study, a diacylhydrazine intermediate was proposed. This …

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The Lowest-Energy Isomer Of C2Si2H4 Is A Bridged Ring: Reinterpretation Of The Spectroscopic Data Based On Dft And Coupled-Cluster Calculations, Jesse J. Lutz, Larry W. Burggraf Apr 2019

The Lowest-Energy Isomer Of C2Si2H4 Is A Bridged Ring: Reinterpretation Of The Spectroscopic Data Based On Dft And Coupled-Cluster Calculations, Jesse J. Lutz, Larry W. Burggraf

Faculty Publications

The lowest-energy isomer of C2Si2H4 is determined by high-accuracy ab initio calculations to be the bridged four-membered ring 1,2-didehydro-1,3-disilabicyclo[1.1.0]butane (1), contrary to prior theoretical and experimental studies favoring the three-member ring silylsilacyclopropenylidene (2). These and eight other low-lying minima on the potential energy surface are characterized and ordered by energy using the CCSD(T) method with complete basis set extrapolation, and the resulting benchmark-quality set of relative isomer energies is used to evaluate the performance of several comparatively inexpensive approaches based on many-body perturbation theory and density functional theory (DFT). Double-hybrid DFT methods are found to …

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Quantitative Analysis Of Iron In Beer Using Cloud Point Extraction, Joshua Rempfer Apr 2019

Quantitative Analysis Of Iron In Beer Using Cloud Point Extraction, Joshua Rempfer

Student Scholar Showcase

Determination of Iron concentration in Apocalypse Ale beer using a preconcentration method coupled with UV-Vis spectroscopy. Samples will be cross checked with MP-AES to ensure precise and accurate results.

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The Relationship Between Insect Visitors And Chemical Fragrance Composition Of Cypripedium Parviflorum Var. Pubescens In Central Virginia., Ruth Elkins Apr 2019

The Relationship Between Insect Visitors And Chemical Fragrance Composition Of Cypripedium Parviflorum Var. Pubescens In Central Virginia., Ruth Elkins

Student Scholar Showcase

Due to its rarity, little is known regarding which insects pollinate Cypripedium parviflorum var. pubescens, large yellow lady slipper orchids, and why they do so when offered no reward. Insect identification and fragrance composition data have been collected from two populations of large yellow lady slippers in Central Virginia for more than a decade. This research analyzed data in order to determine potential relationships between visiting insects and fragrance compositions of the orchid. The results of this research can be used to establish and protect populations of Cypripedium parviflorum var. pubescens.

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Elemental Analysis Of Legacy Sediments At College Lake, Amelia Dalton Apr 2019

Elemental Analysis Of Legacy Sediments At College Lake, Amelia Dalton

Student Scholar Showcase

College Lake is a large reservoir located on the campus of the University of Lynchburg. College Lake’s ecosystem has degraded over the years due to the buildup of sediment, nutrients, and raw sewage. Increased urbanization in the area has also most likely contributed to the contaminants present within the system. Because of flooding issues during the summer of 2018, Lynchburg CIty officials drained College Lake, which caused sediment to be released downstream. To better understand the transport of heavy metals in the sediments released from College Lake, sediment core samples were taken from College Lake, Hollins Mill Park, and Sandusky …

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Abiotic Stress And Anthocyanins Biosynthesis In Arabidopsis Thaliana, Carolanne Bekus Apr 2019

Abiotic Stress And Anthocyanins Biosynthesis In Arabidopsis Thaliana, Carolanne Bekus

Student Scholar Showcase

Crops and farmers today are facing unprecedented challenges due to the changing environment. The plants of the future need to be hardy to survive harsh environmental conditions such as increased temperature, and prolonged droughts. It is imperative to understand the mechanisms plants employ to protect themselves under these types of stresses. Anthocyanins are pigments of the flavonoid subclass produced by plants. They impart red to purple color to flowers, fruits, and seeds. They also have antioxidant properties and they contribute to stress tolerance in plants. They are understood to be produced under abiotic stresses in order to protect the plant. …

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Mobilization Of Calcium Across Mineralized Tissues In Yellow Perch, Perca Flavescens, Taylor Bopp Apr 2019

Mobilization Of Calcium Across Mineralized Tissues In Yellow Perch, Perca Flavescens, Taylor Bopp

Student Scholar Showcase

Bones in many higher teleost fish, such as percids and centrarchids, lack osteocytes that function as both chemo- and mechano-sensors, and thus, are not actively involved in homeostasis of blood calcium level. Nonetheless, the vertebrae of yellow perch, Perca flavescens (P. flavescens), living in darker and low calcium (Ca) water, have demonstrated adaptive modeling and remodeling of vertebrae to be more mineralized and thus enhance transmission of the axial muscle torque into the thrust force for the C-start predator escape behavior. The prey-predator interaction is expected to occur at closer range between prey fish and predator fish in …

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A Chemical In Filter Paper Interferes With Trail Following Behavior In The Termite Reticulitermes Hesperus (Banks), Kathryn Vest Apr 2019

A Chemical In Filter Paper Interferes With Trail Following Behavior In The Termite Reticulitermes Hesperus (Banks), Kathryn Vest

Student Scholar Showcase

Termites follow chemical trails. In previous experiments we dissolved and diluted chemicals in acetone to test if they elicited trail following. Each trail was a straight line across the arena drawn with 10 µl using a glass capillary (Microcaps). We noticed a minor but stable response to trails laid with pure acetone. The response could be caused by contaminated acetone or by a chemical in the filter paper (Watman #5) that lined our arena (petri dish, 10cm diameter). We could confirm that the termites respond to acetone alone. Soxkhlet extraction for 8 hours removed the signal from the filter paper. …

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Age Status Effects On Female Silk Production And Male Courtship Response In Dolomedes Scriptus, Joseph Osborne Apr 2019

Age Status Effects On Female Silk Production And Male Courtship Response In Dolomedes Scriptus, Joseph Osborne

Student Scholar Showcase

Female Dolomedes scriptus, the striped fishing spider, serve as model organisms exhibiting pheromone production as a means of chemical signaling. Previous work has shown that male fishing spiders are responsive to female silk, and preferentially court in the presence of silk from mature virgins. In our research, we hypothesized that mature females produced larger quantities of silk than penultimate females in an attempt to elicit greater male mating response. Female spiders of both age statuses were kept for two days in a gridded tank. Sub-sampling of silk lines that crossed a random portion of the grid produced results signifying …

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Robust Chromium Precursors For Catalysis: Isolation And Structure Of A Single-Component Ethylene Tetramerization Precatalyst, Nathanael A. Hirscher, Danny Perez Sierra, Theodor Agapie Apr 2019

Robust Chromium Precursors For Catalysis: Isolation And Structure Of A Single-Component Ethylene Tetramerization Precatalyst, Nathanael A. Hirscher, Danny Perez Sierra, Theodor Agapie

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

We have introduced a new class of stable organometallic Cr reagents (compounds 1-4) that are readily prepared, yet reactive enough to serve as precursors. They were used for ethylene tetramerization catalysis following stoichiometric activation by in situ protonation. This study highlights the importance of balancing stability with reactivity in generating an organometallic precursor that is useful in catalysis. Moreover, precursor 4 allowed for the isolation and crystallographic characterization of a room-temperature stable cationic species, (PNP)CrR2+ (R = o-C6H4(CH2)2OMe, PNP = iPrN(PPh2)2). This complex (5) may …

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Method Development To Quantify The Reinforcing Properties Of Silica Fillers, Hamid Reza Givehchi Apr 2019

Method Development To Quantify The Reinforcing Properties Of Silica Fillers, Hamid Reza Givehchi

Electronic Theses & Dissertations

Polysiloxane polymers are widely used as a high-temperature resistant materials with the ability to maintain flexibility at extremely low temperatures. Unfortunately, polysiloxane elastomers generally exhibit low strength and poor mechanical properties and have no practical use unless they are reinforced. These elastomers can be mechanically improved through the use of reinforcing silica-based fillers. It is known that silanol groups on the surface of silica filler particles can interact with the polysiloxane backbone. Interactions of silanol groups on the fillers’ surfaces with the polysiloxane backbone through hydrogen bonding may hinder the mobility of the polymer chain and can improve thermal, physical, …

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Reduction Of Amine Emissions From An Aqueous Amine Carbon Dioxide Capture System Using Charged Colloidal Gas Aphrons, Xiaobing Li, Jesse G. Thompson, Kunlei Liu Apr 2019

Reduction Of Amine Emissions From An Aqueous Amine Carbon Dioxide Capture System Using Charged Colloidal Gas Aphrons, Xiaobing Li, Jesse G. Thompson, Kunlei Liu

Center for Applied Energy Research Faculty Patents

The present invention includes a system and process to reduce amine mist emissions (or MEA) from carbon capture systems using colloidal gas aphrons (CGA), and includes a method for separating and recovering an amine solvent (e.g., in the form of entrained droplets/mist and/or fine aerosol particles) from a carbon dioxide scrubbed flue gas stream exiting a carbon capture system (e.g., oil-fired power plants, coal-fired power plants, and/or natural gas combined cycle plants).

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Evidence For A Bind-Then-Bend Mechanism For Architectural Dna Binding Protein Ynhp6a, Manas Kumar Sarangi, Viktoriya Zvoda, Molly Nelson Holte, Nicole A. Becker, Justin Peters, L. James Maher Iii, Anjum Ansari Apr 2019

Evidence For A Bind-Then-Bend Mechanism For Architectural Dna Binding Protein Ynhp6a, Manas Kumar Sarangi, Viktoriya Zvoda, Molly Nelson Holte, Nicole A. Becker, Justin Peters, L. James Maher Iii, Anjum Ansari

Faculty Work

The yeast Nhp6A protein (yNhp6A) is a member of the eukaryotic HMGB family of chromatin factors that enhance apparent DNA flexibility. yNhp6A binds DNA nonspecifically with nM affinity, sharply bending DNA by >60◦. It is not known whether the protein binds to unbent DNA and then deforms it, or if bent DNA conformations are ‘captured’ by protein binding. The former mechanism would be supported by discovery of conditions where unbent DNA is bound by yNhp6A. Here, we employed an array of conformational probes (FRET, fluorescence anisotropy, and circular dichroism) to reveal solution conditions in which an 18- base-pair DNA oligomer …

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Design And Synthesis Of A Novel Lsoxazoline As A Potential Pam-Agonist, Josselyn Roosenberg Apr 2019

Design And Synthesis Of A Novel Lsoxazoline As A Potential Pam-Agonist, Josselyn Roosenberg

Honors Theses

Progression of Alzheimer's disease is associated with a loss of Ml receptor activation in the brain. However, a lack of clinical success following attempts to activate the Ml receptor at the orthosteric site has contributed to a transition towards the allosteric pocket of the receptor. Here, positive allosteric modulators (PAMs) interact to potentiate the acetylcholine response. Recent research proposes that optimization of PAM activity at the expense of intrinsic agonism may posit a means to limit adverse side effects. Therefore, this project proposes a design and synthesis of a novel isoxazoline as a potent PAM agent with weak intrinsic agonism.

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Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova Apr 2019

Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova

Honors Theses

HPLC methodology was developed to determine the concentrations and ratios of D to L amino acids in emu and ostrich eggshells treated with heat at different temperatures . We aimed to determine an internal standard and how ratios were affected under different conditions. An HPLC method was determined that gave consistent retention times and satisfactory enantioseparation . Calibration curves for each amino acid were developed from single and multi-amino acid containing dilution series producing a model that most closely replicates the eggshell-extracted amino acids.

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Application Of The Picoloyl Group In Carbohydrate Chemistry, Michael Mannino Apr 2019

Application Of The Picoloyl Group In Carbohydrate Chemistry, Michael Mannino

Dissertations

Stereocontrol of glycosylation reactions is a constant struggle in the field of synthetic carbohydrate chemistry. The application of the picoloyl (Pico) substituent can offer numerous stereocontrolling avenues. The most popular application is the Hydrogen-bond-mediated Aglycone Delivery (HAD) method that provides excellent selectivity in the glycosylation of a variety of sugar substrates. The HAD method relies on the formation of an intermolecular hydrogen bond between the nitrogen atom of the Pico substituent on the glycosyl donor with the hydroxyl group of the glycosyl acceptor. This interaction provides a facial preference for the nucleophilic attack and hence provides powerful stereocontrol for the …

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A Non-Natural Nucleotide Uses A Specific Pocket To Selectively Inhibit Telomerase Activity, Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J. Robinson, William P. Schiemann, Anthony J. Berdis, Emmanuel Skordalakes, Derek J. Taylor Apr 2019

A Non-Natural Nucleotide Uses A Specific Pocket To Selectively Inhibit Telomerase Activity, Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J. Robinson, William P. Schiemann, Anthony J. Berdis, Emmanuel Skordalakes, Derek J. Taylor

Chemistry Faculty Publications

Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2′-deoxyriboside 5′-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activity. The crystal structure of 5-MeCITP bound to the Tribolium castaneum telomerase reverse transcriptase reveals an atypical interaction, in which the nucleobase is flipped in the active site. In this orientation, the methoxy group of 5-MeCITP extends out of the canonical active site to interact with a telomerase-specific hydrophobic pocket formed by motifs 1 and 2 in the fingers domain and …

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Semi-Quantitative Characterization Of Secondary Science Teachers’ Use Of Three-Dimensional Instruction, Senetta F. Bancroft, Deborah Herrington, Roxana Dumitrache Apr 2019

Semi-Quantitative Characterization Of Secondary Science Teachers’ Use Of Three-Dimensional Instruction, Senetta F. Bancroft, Deborah Herrington, Roxana Dumitrache

Peer Reviewed Articles

This quasi-experimental study evaluated middle- and high-school science teachers’ implementation of three-dimensional (3D) instruction as defined by the Next Generation Science Standards. Teachers participated in a long-term professional development (PD) program designed to increase their use of inquiry-based science instruction. We describe our semi-quantitative adaptation of the Educators Evaluating the Quality of Instructional Products: Science rubric version 2 (SQ-EQuIP) to facilitate the longitudinal evaluation of teacher practices with 3D instruction. SQ-EQuIP evaluations revealed that after two years, 80% of PD teachers implemented lessons where students were explicitly and coherently engaged in 3D learning, compared with 22% of comparison teachers. …

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The Potential Of Marine Microbes, Flora And Fauna In Drug Discovery, Santana Alexa Lavonia Thomas Apr 2019

The Potential Of Marine Microbes, Flora And Fauna In Drug Discovery, Santana Alexa Lavonia Thomas

USF Tampa Graduate Theses and Dissertations

Natural products are chemical compounds synthesized by a living organism. These compounds have been utilized by humans from ancient times to the present for their pharmacological and biological activities. Terrestrial organisms are considered a lucrative source of bioactive compounds and chemical diversity. Within the past 60 years, the marine environment has presented its potential as a validated source for structural diversity and biologically active compounds. Technology has given access from shallow waters down to the abyssal plane for exploration and investigation of the inhabitants. Marine organisms have displayed their benefits in the pharmaceutical industry with the approval of several marine-derived …

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Isolation And Characterization Of Novel Arginine-Derived Heterocyclic Amines, Nathaniel Srikureja Apr 2019

Isolation And Characterization Of Novel Arginine-Derived Heterocyclic Amines, Nathaniel Srikureja

Honors Theses

Most known heterocyclic amines (HCAs) are potent mutagens present at significant concentrations in cooked meats, and can be synthesized from burned mixtures of L-creatin(in)e with various amino acids. We hypothesize that novel mutagenic HCAs may be synthesized from a heated plant-based food simulating binary amino acid mL'\:ture: L-arginine and L-threonine. A two-part solid phase extraction was used to separate nitrogen heterocycles from byproducts followed by prep­ HPLC and the Ames mutagenicity assay using Salmonella TA98 to determine the mutagenicity of various isolates. The results indicate that this binary amino acid mixture does not yield a mutagenic sample.

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Hour-Level Resolution On Consumption Pattern Of Substance Abuse, Jarrett Mauk, Rhiannon Huffines, Brittney Nelson, Tara Croft, Bikram Subedi Apr 2019

Hour-Level Resolution On Consumption Pattern Of Substance Abuse, Jarrett Mauk, Rhiannon Huffines, Brittney Nelson, Tara Croft, Bikram Subedi

Scholars Week

Conventional survey-based approaches of determining the consumption statistics of drugs in communities are suffered from non-response biases, and typically underestimate the actual consumption. Time and cost-intensive conventional approaches, therefore, can’t be utilized to determine high-resolution temporal variability in drug consumption. In this study, the temporal trend of consumption of 10 illicit and 26 prescribed neuropsychiatric drugs was determined at hour-level resolution utilizing wastewater-based epidemiology. The hourly composite raw wastewater (every 10 minutes) samples were collected for three consecutive days in a typical week (total of 72 samples), analyzed for target drug residues using UPLC-MS/MS, and back-calculated the consumption rate of …

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Uncertainties Treatment For Wastewater-Based Epidemiological Estimation Of The Consumption Of Illicit And Prescribed Neuropsychiatric Drugs In Two Urban Communities In Kentucky Using Ammonium Normalized Population And Monte Carlo Simulation, Rhinannon Huffines, Tara Croft, Manoj Pathak, Bikram Subedi Apr 2019

Uncertainties Treatment For Wastewater-Based Epidemiological Estimation Of The Consumption Of Illicit And Prescribed Neuropsychiatric Drugs In Two Urban Communities In Kentucky Using Ammonium Normalized Population And Monte Carlo Simulation, Rhinannon Huffines, Tara Croft, Manoj Pathak, Bikram Subedi

Scholars Week

The conventional estimation of the prevalence of substance use in a community based on self-reported surveys typically underestimates the actual consumption. Drug’s residues in raw wastewater collected from the centralized wastewater treatment plants were utilized – Wastewater-Based Epidemiology (WBE) – to determine the consumption rate of illicit and prescribed neuropsychiatric residues in two urban communities in eastern Kentucky and two rural communities in western Kentucky. The ammonical nitrogen content in raw wastewater samples was used to minimize the uncertainty associated with the population dynamicity. Uncertainties associated with the several WBE parameters to back-calculate the consumption rate of drugs such as …

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