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Full-Text Articles in Chemistry

1,4-Di-9-Anthrylbutane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker May 2007

1,4-Di-9-Anthrylbutane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

In the title compound, C32H26, the molecule has an inversion centre at the mid-point of the central C—C bond. Weak intermolecular C—H...π interactions help to stabilize the crystal structure.


A Tandem Enol Silane Formation-Mukaiyama Aldol Reaction Mediated By Tmsotf, C. Wade Downey, Miles W. Johnson May 2007

A Tandem Enol Silane Formation-Mukaiyama Aldol Reaction Mediated By Tmsotf, C. Wade Downey, Miles W. Johnson

Chemistry Faculty Publications

A slight excess of silyl trifluoromethanesulfonate mediates a tandem enol silane formation-Mukaiyama aldol reaction in the presence of Hunig’s base. Preformation of the enol silane is unnecessary for efficient reactions, which proceed in 75–97% yield for the addition of aryl methyl ketones and acetate esters to non-enolizable aldehydes. Mechanistic data suggests that free amine is crucial for full conversion.


Novel Synthetic Routes Toward The Alkaline-Earth Metal Amides, Eli S. Mekhlin May 2007

Novel Synthetic Routes Toward The Alkaline-Earth Metal Amides, Eli S. Mekhlin

Renée Crown University Honors Thesis Projects - All

Metal organic chemical vapor deposition is a process used in the production of thin, crystalline films. The method involves the transportation of volatile, organometallic precursors to a heated substrate, where it undergoes chemical reactions to produce a thin, metallic layer on the substrate surface. Strontium and barium films of this nature are used as components in semi-conductor device fabrication, including among other things, the cell capacitors in Dynamic Random Access Memory computer chips. Additionally, organoalkaline-earth metal compounds are also desired for their potential to serve as polymerization initiators and reagents to modify polymers. Organocalcium derivatives are currently being explored as …


Functionalized Nanomaterials: Synthesis, Characterization, And Applications, Liangwei Qu May 2007

Functionalized Nanomaterials: Synthesis, Characterization, And Applications, Liangwei Qu

All Dissertations

Due to their unique electronic, optical, catalytic and mechanical properties, nanomaterials (nanoparticles and nanotubes) have been attracting much attention over the past decades. In this dissertation, polymeric nanoparticles bearing derivatized D-mannose and galactose molecules were prepared via dispersion polymerization and their interactions with various bacterial cells were studied. The results show that there are strong adhesin-specific interactions of the nanoparticles with E. coli cells, resulting significant nanoparticles-madiated cell agglutination.
Poly(ethylene glycol)-coated magnetic polymer nanoparticles were synthesized through miniemulsion polymerization by using macromonomer as both a comonomer and a surfactant. The resulting magnetic polymer nanoparticles were successfully used for bio-detection and …


1,3-Bi-9-Anthrylpropane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker Apr 2007

1,3-Bi-9-Anthrylpropane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

The title compound, C31H24, with three molecules in the asymmetric unit. The crystal packing is mainly stabilized by weak C—H⋯π inter­actions in addition to van der Waals forces.


Nontraditional Synthesis Of Organometallic Compounds And Allylic Alcohols, Andrew J. Hesse Mar 2007

Nontraditional Synthesis Of Organometallic Compounds And Allylic Alcohols, Andrew J. Hesse

Undergraduate Honors Thesis Collection

One of the central dogmas of chemistry is the use of convection heating to increase rate and yields of reactions. However, other methods for the impartation of energy do exist. Microwave irradiation uses high power waves to directly excite molecule into higher energy states. This speeds up the kinetics of the reaction and thermodynamically favorable products are formed at a higher rate. This project successfully uses microwave irradiation to perform organometallic syntheses of iron based compounds such as ferrocene and iron diene tricarbonyls. Another alternative method involves using mechanical energy as a substitute for thermal energy. By rapidly colliding reactants …


Cost-Effective Engineering Of A Small-Scale Bioreactor, John Tansey, Sadie R. Bartholomew Feb 2007

Cost-Effective Engineering Of A Small-Scale Bioreactor, John Tansey, Sadie R. Bartholomew

Chemistry Faculty Scholarship

Several methods exist for increasing the scale of cell culture in the laboratory. While these methods provide significant increases in biomass, they are often prohibitively expensive for many laboratories. We have engineered a small-scale bioreactor with a novel means of introducing oxygen through the catalytic breakdown of hydrogen peroxide using a manganese oxide catalyst. We have also adapted and modified an existing assay for dissolved oxygen to be compatible with culture conditions. In this system we have been able to culture CHO cells at densities of up to 107 cells/mL without the use of automated feedback systems.


Selective Synthesis Of Oxacalix[6]Arenes And Mixed Oxacalix[4]Arenes, Christian Crannell Jan 2007

Selective Synthesis Of Oxacalix[6]Arenes And Mixed Oxacalix[4]Arenes, Christian Crannell

Undergraduate Research Symposium (UGRS)

Calixarenesare macrocycles composed of benzene rings meta linked to each other by one carbon atom. These exotic compounds can be used for a variety of purposes including metalleaching for environmental cleanup, surface technology, luminescent probes, nuclear waste treatment, among others. A variety of calixarenesexist, including azacalix[n]arenesthiocalix[n]arenes(where n = the number of benzene rings) and oxacalix[n]arenes; these macrocycles use nitrogen, sulfur and oxygen, respectively, as the atom whichlinks the benzene rings together. My research has focused on synthesizing oxacalix[6]arenes (“hexamer”) in high yield, which is a synthetic challenge because it is generally accepted that oxacalix[n>4]arenes will thermodynamically decompose to the …


2-Aminopyrimidine-3,3,3-Triphenyl- Propanoic Acid (1/1), Mateusz F. Serafin, Kraig A. Wheeler Jan 2007

2-Aminopyrimidine-3,3,3-Triphenyl- Propanoic Acid (1/1), Mateusz F. Serafin, Kraig A. Wheeler

Faculty Research and Creative Activity

The title bimolecular compound, C4H5N3·C21H18O2, constructed from 2-aminopyrimidine and 3,3,3-triphenylpropanoic acid, forms a tetramolecular hydrogen-bonded motif via O—H...N, N—H...O and N—H...N contacts. This aggregate organizes to give crystal-packing motifs with hydrophilic and hydrophobic regions.


Hydromination Of Alkynes, Enynes, And Dienes Using Titanium Catalysts, Taryn Palluccio Jan 2007

Hydromination Of Alkynes, Enynes, And Dienes Using Titanium Catalysts, Taryn Palluccio

Undergraduate Review

No abstract provided.


Elliptical Micro-Ring Organic Lasers, P. R. Korade, John Ballato, R, V. Gregory Jan 2007

Elliptical Micro-Ring Organic Lasers, P. R. Korade, John Ballato, R, V. Gregory

Chemistry & Biochemistry Faculty Publications

Multimode laser action was observed from optically excited 2,5-dioctyloxy poly(para-phenylene-vinylene), DOO-PPV, micro-rings coaxially deposited around glass optical fibres of elliptical cross-section. The laser emission was found to be dependent upon the incident angle of the excitation and exhibited linewidths of approximately 1.2 Å, quality factors (Q) exceeding 5000, and thresholds below 0.3 μJ pulse. Such elliptical organic micro-ring lasers offer increased tailorability in emission properties over more conventional analogues of circular cross-section. Also discussed is the potential for such low-threshold lasers to serve as integrated sources for fibre lasers and amplifiers.


Coupling Coherence Distinguishes Structure Sensitivity In Protein Electron Transfer, Tatiana Prytkova, Igor V. Kurnikov, David Beratan Jan 2007

Coupling Coherence Distinguishes Structure Sensitivity In Protein Electron Transfer, Tatiana Prytkova, Igor V. Kurnikov, David Beratan

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Quantum mechanical analysis of electron tunneling in nine thermally fluctuating cytochrome b562 derivatives reveals two distinct protein-mediated coupling limits. A structure-insensitive regime arises for redox partners coupled through dynamically averaged multiple-coupling pathways (in seven of the nine derivatives) where heme-edge coupling leads to the multiple-pathway regime. A structure-dependent limit governs redox partners coupled through a dominant pathway (in two of the nine derivatives) where axial-ligand coupling generates the single-pathway limit and slower rates. This two-regime paradigm provides a unified description of electron transfer rates in 26 ruthenium-modified heme and blue-copper proteins, as well as in numerous photosynthetic proteins.


Use Of The Mitsunobu Reaction In The Synthesis Of Orthogonally Protected A,B-Diaminopropionic Acids, Fintan Kelleher, Keith Ó Proinsias Jan 2007

Use Of The Mitsunobu Reaction In The Synthesis Of Orthogonally Protected A,B-Diaminopropionic Acids, Fintan Kelleher, Keith Ó Proinsias

Articles

Orthogonally protected a,b-diaminopropionic acids have been synthesised in good yields by the reaction of N-trityl L-serine esters with N-substituted sulfonamides under Mitsunobu reaction conditions (DEAD, PPh3, THF). The best isolated yields were obtained when N-Boc p-toluenesulfonamide was used as the nitrogen nucleophile precursor in the Mitsunobu reaction. Subsequently, the N-trityl group was efficiently replaced with the more stable allyloxycarbonyl (alloc) group.


Iron(Iii) P-Toluenesulfonate Catalyzed Synthesis Of Homoallyl Ethers From Acetals And Aldehydes, Ram Mohan, Matthew Spafford, Erin Anderson, Joshua Lacey, Ann Palma Jan 2007

Iron(Iii) P-Toluenesulfonate Catalyzed Synthesis Of Homoallyl Ethers From Acetals And Aldehydes, Ram Mohan, Matthew Spafford, Erin Anderson, Joshua Lacey, Ann Palma

Scholarship

Iron(III) p-toluenesulfonate, Fe(OTs)3.6H20, is an inexpensive, versatile and commercially available catalyst for the allylation of acetals using allyltrimethylsilane to yield homoallyl ethers in moderate to good yields. The one-pot conversion of aldehydes to homoallyl ethers using alkoxysilanes has also been accomplished using Fe(OTs)3.6H20 as a catalyst. The use of mild reaction conditions and a relatively non-corrosive catalyst make this method an attractive option for the synthesis of a range of homoallyl ethers.


Reactivity Of Ionic Liquids, Ram Mohan, Shahana Chowdhury, Janet Scott Jan 2007

Reactivity Of Ionic Liquids, Ram Mohan, Shahana Chowdhury, Janet Scott

Scholarship

Ionic liquids are becoming widely used in synthetic organic chemistry and yet relatively little attention has been paid to the intrinsic reactivity of these low temperature molten salts. Clues to the non-innocent nature of many ionic liquids are contained in the reports of altered reactivity of dissolved substrates, unexpected catalytic activity and unforeseen by-product formation. In this review, we focus on the reactivity of ionic liquids, as opposed to reactivity in ionic liquids (although discussion of the latter is often included where it aids understanding of the former).


Synthesis And Characterization Of Arylmethyl Sulfone Dendrimers And Hyperbranched Poly (Phenylene Sulfide) / Poly (Sulfone), Qiuxia Zhao Jan 2007

Synthesis And Characterization Of Arylmethyl Sulfone Dendrimers And Hyperbranched Poly (Phenylene Sulfide) / Poly (Sulfone), Qiuxia Zhao

Seton Hall University Dissertations and Theses (ETDs)

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Studies Toward Improving The Reactivity And Chemoselectivity Of Chloroarenes In Palladium-Catalyzed Cross-Coupling Processes, Joseph P. Simeone Jan 2007

Studies Toward Improving The Reactivity And Chemoselectivity Of Chloroarenes In Palladium-Catalyzed Cross-Coupling Processes, Joseph P. Simeone

Seton Hall University Dissertations and Theses (ETDs)

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Flavin Charge Transfer Transitions Assist Dna Photolyase Electron Transfer, Spiros S. Skourtis, Tatiana Prytkova, David Beratan Jan 2007

Flavin Charge Transfer Transitions Assist Dna Photolyase Electron Transfer, Spiros S. Skourtis, Tatiana Prytkova, David Beratan

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

This contribution describes molecular dynamics, semi-empirical and ab-initio studies of the primary photo-induced electron transfer reaction in DNA photolyase. DNA photolyases are FADH−-containing proteins that repair UV-damaged DNA by photo-induced electron transfer. A DNA photolyase recognizes and binds to cyclobutatne pyrimidine dimer lesions of DNA. The protein repairs a bound lesion by transferring an electron to the lesion from FADH−, upon photo-excitation of FADH− with 350–450 nm light. We compute the lowest singlet excited states of FADH− in DNA photolyase using INDO/S configuration interaction, time-dependent density-functional, and time-dependent Hartree-Fock methods. The calculations identify the lowest singlet excited state of FADH− …


Improved Nitrate Sensing Using Ion Selective Electrodes Based On Urea–Calixarene Ionophores, Benjamin Schazmann, Dermot Diamond Jan 2007

Improved Nitrate Sensing Using Ion Selective Electrodes Based On Urea–Calixarene Ionophores, Benjamin Schazmann, Dermot Diamond

Articles

Urea–calix[4]arenes 1 and 2 were synthesised and incorporated into ISE membranes for assessment as sensors for inorganic anions in water. 1 revealed a strong response to all anions following the Hofmeister selectivity order. For ISEs of 2, the response to a portion of the anion series was suppressed, increasing the margin of selectivity of nitrate over chloride, a common interferant of nitrate in fresh and marine water samples. The performance of ISEs containing 2 was compared to commercially available alkylammonium nitrate ion-exchange salts used for nitrate sensing. Our ISEs performed favourably in terms of sensitivity, linear range and LOD performing …


Identification And Characterization Of A New Tubulin-Binding, Susan L. Mooberry, Kimberly N. Weiderhold, Sivanesan Dakshanamurthy, Ernest Hamel, Edith J. Banner, Anastasia Kharlamova, Jonathan Hempel, John T. Gupton, Milton L. Brown Jan 2007

Identification And Characterization Of A New Tubulin-Binding, Susan L. Mooberry, Kimberly N. Weiderhold, Sivanesan Dakshanamurthy, Ernest Hamel, Edith J. Banner, Anastasia Kharlamova, Jonathan Hempel, John T. Gupton, Milton L. Brown

Chemistry Faculty Publications

We studied the mechanism of action of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (JG-03-14) and found that it is a potent microtubule depolymerizer. JG-03-14 caused a dose-dependent loss of cellular microtubules, formation of aberrant mitotic spindles, accumulation of cells in the G2/M phase of the cell cycle, and Bcl-2 phosphorylation. These events culminated in the initiation of apoptosis, as evidenced by the caspase 3-dependent cleavage of poly(ADP-ribose) polymerase (PARP). JG-03-14 has antiproliferative activity against a wide range of cancer cell lines, with an average IC50 value of 62 nM, and it is a poor substrate for transport …


Evaluation And Characterization Of Some Biologically Active Coumarin Derived Sulfonamides, Harish Gosike Jan 2007

Evaluation And Characterization Of Some Biologically Active Coumarin Derived Sulfonamides, Harish Gosike

Theses and Dissertations

Sulfonamide drugs discovered in the 1930's were the first effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infections in humans. Bacterial resistance to these drugs over the years has led to the development of new variety of sulfonamide derivatives. Recently Chohan et al. synthesized a series of coumarin derived sulfonamides and their chemical structures have been established. In this report, we present some microbiological studies to establish the antibacterial characters of these compounds. In order to establish their chemical structure-biological activity relationship, electrochemical and spectroscopic studies have been conducted. Antibacterial studies conducted on these compounds …


Perfluoroalkyl (Aryl) Sulfonimide Zwitterions, Hua Mei Dec 2006

Perfluoroalkyl (Aryl) Sulfonimide Zwitterions, Hua Mei

All Dissertations

This research focuses on superacid perfluoroalkyl(aryl) sulfonimides and their derivatives as a source of stable zwitterionic salts. The strong resonance stabilization of sulfonimides imparts unexpected stability to the zwitterions.
Two types of zwitterions were investigated. The first are symmetrical diaryliodonium zwitterions (DZs) as potential photo acid generators (PAGs) for microlithography. Driven by the demand for smaller feature sizes in the microelectronics industry, microlithography using shorter wavelength light has evolved and new PAGs are of interest. New DZs are potentially useful because they have good thermal stability and may be structurally modified to alter their spectral absorption characteristics. As an extension …


Bis(1,2-Dihydroxy­Benzene) Hexa­Methyl­Ene­Tetra­Mine, Philias Daka, Kraig A. Wheeler Nov 2006

Bis(1,2-Dihydroxy­Benzene) Hexa­Methyl­Ene­Tetra­Mine, Philias Daka, Kraig A. Wheeler

Faculty Research and Creative Activity

The title binary complex, 2C6H6O2·C6H12N4, is constructed from hexa­methyl­ene­tetra­mine, positioned about a twofold symmetry operator, and 1,2-dihydroxy­benzene. Each of the four tertiary amine N atoms participates in O—H⋯N contacts that produce mol­ecular strands that propagate along the c axis.


(Acetonitrile-Κn){2-[Bis­(2-Pyridylethyl)­Amino]Ethanol-Κ4n,N′,N′′,O}Zinc(Ii) Bis­(Perchlorate) Monohydrate, Hong-Chang Liang, Marcel M. Hetu, Kraig A. Wheeler, Lev N. Zakharov, Arnold L. Rheingold Nov 2006

(Acetonitrile-Κn){2-[Bis­(2-Pyridylethyl)­Amino]Ethanol-Κ4n,N′,N′′,O}Zinc(Ii) Bis­(Perchlorate) Monohydrate, Hong-Chang Liang, Marcel M. Hetu, Kraig A. Wheeler, Lev N. Zakharov, Arnold L. Rheingold

Faculty Research and Creative Activity

In the title compound, [Zn(C2H3N)(C16H21N3O)](ClO4)2·H2O, the ZnII ion is coordinated by two pyridyl N atoms, one amine N atom, and an ethanol O atom from the N,N′,N′′,O-tetra­dentate 2-[bis­(2-pyridylethyl)amino]­ethanol donor ligand. The fifth coordination site is filled by an acetonitrile N atom, and there is one solvent water mol­ecule in the asymmetric unit. The 2+ charge of the cationic portion of the complex is balanced by two perchlorate counter-anions.


(E,E)-1,3-Bis[9,10-Dihydro-9-Nitro-10-(Trinitro­Meth­Yl)-9-Anthr­Yl]Propane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker Sep 2006

(E,E)-1,3-Bis[9,10-Dihydro-9-Nitro-10-(Trinitro­Meth­Yl)-9-Anthr­Yl]Propane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

The title compound, C33H24N8O16, was obtained as a product of the photoreaction between 1,3-di-9-anthrylpropane and tetra­nitro­methane. The mol­ecule occupies a special position on a twofold axis. The trinitro­methyl and nitro substituents on the 9,10-dihydro­acridine system are E oriented.


A 2:1 Complex Of 1,3-Bis­(9h-Carbazol-9-Yl)Propane And Tetra­Chloro-P-Benzoquinone (P-Chloranil), Mustafa Arslan, Randolph B. Krafcik, John Masnovi, Ronald J. Baker Sep 2006

A 2:1 Complex Of 1,3-Bis­(9h-Carbazol-9-Yl)Propane And Tetra­Chloro-P-Benzoquinone (P-Chloranil), Mustafa Arslan, Randolph B. Krafcik, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

In the title electron donor–acceptor complex, C27H22N2·0.5C6Cl4O2, the p-chloranil mol­ecule lies on a crystallographic inversion center, which is located at the center of the benzene ring. In the crystal structure, one p-chloranil mol­ecule lies above and below the central rings of each donor group of two neighboring 1,3-bis­(9H-carbazol-9-yl)propane mol­ecules, with a ring-centroid separation of 3.444 (1) Å. The angle between the planes of the stacking rings of the carbazole and p-chloranil mol­ecules is 3.4 (2)°.


N-(2-Aminobenzyl)-N,N-Bis(Quinolin- 2-Ylmethyl)Amine, Abhijit Mitra, Pamela J. Seaton, Kraig A. Wheeler Sep 2006

N-(2-Aminobenzyl)-N,N-Bis(Quinolin- 2-Ylmethyl)Amine, Abhijit Mitra, Pamela J. Seaton, Kraig A. Wheeler

Faculty Research and Creative Activity

The title new diquinaldine derivative, C27H24N4, forms mol­ecular assemblies organized by inter­molecular quinoline π–π stacking [3.356 (3) and 3.440 (3) Å] and both inter- and intra­molecular N—H⋯N hydrogen bonds [3.039 (3)–3.104 (3) Å and 129 (2)–172 (2)°]. The combination of such inter­actions provides readily definable contacts that propagate along each crystallographic axis.


Strychninium (S)-2-(2-Bromo­Phen­Oxy)Propanoate 1.4-Hydrate, Kraig A. Wheeler, Aaron M. Lineberry Aug 2006

Strychninium (S)-2-(2-Bromo­Phen­Oxy)Propanoate 1.4-Hydrate, Kraig A. Wheeler, Aaron M. Lineberry

Faculty Research and Creative Activity

In the title mol­ecular salt, C21H23N2O2+·C9H8BrO3−·1.4H2O, the components are linked by inter­molecular C—O−⋯H—+N and OW—H⋯O inter­actions.


10,10′-Dinitro-10,10′-(Butane-1,4-Di­Yl)Dianthracen-9(10h)-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker Jul 2006

10,10′-Dinitro-10,10′-(Butane-1,4-Di­Yl)Dianthracen-9(10h)-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

The title compound, C32H24N2O6, was obtained as the decomposition product of (E,E)-1,4-bis­[9,10-dihydro-9-nitro-10-(trinitro­meth­yl)-9-anthr­yl]butane, which was synthesized via a photochemical reaction of 1,4-bis­(9-anthr­yl)butane with tetra­nitro­methane. The asymmetric unit contains one half-mol­ecule; the complete mol­ecule is generated by a center of inversion. The crystal packing is determined mainly by inter­molecular C—H⋯O inter­actions.


10,10′-Dinitro-10,10′-(Propane-1,3-Di­Yl)Di-10h-Anthracen-9-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker May 2006

10,10′-Dinitro-10,10′-(Propane-1,3-Di­Yl)Di-10h-Anthracen-9-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker

Chemistry Faculty Publications

The title compound, C31H22N2O6, was obtained as the decomposition product of (E,E)-1,3-bis­[9,10-dihydro-9-nitro-10-(trinitro­meth­yl)-9-anthr­yl]propane, which was synthesized via a photochemical reaction of 1,3-di-9-anthrylpropane with tetra­nitro­methane. Inter­molecular C—H⋯O inter­actions are the most prominent features of the crystal packing; no indications of any inter­molecular π–π stacking were found.