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Articles 961 - 990 of 3949

Full-Text Articles in Chemistry

Engineering Of A Multi-Epitope Subunit Vaccine Against Sasrs-Cov-2 Through The Viroinformatic Approach, Aamir Shehzada, Christijogo Sumartono, Jusak Nugraha, Helen Susilowatid, Andi Yasmin Wijayab, Hafiz Ishfaq Ahmad, Wiwiek Tyasningsih, Fedik Abdul Rantam May 2022

Engineering Of A Multi-Epitope Subunit Vaccine Against Sasrs-Cov-2 Through The Viroinformatic Approach, Aamir Shehzada, Christijogo Sumartono, Jusak Nugraha, Helen Susilowatid, Andi Yasmin Wijayab, Hafiz Ishfaq Ahmad, Wiwiek Tyasningsih, Fedik Abdul Rantam

Karbala International Journal of Modern Science

The COVID-19 outbreak has infected millions of people worldwide, but no vaccine has been discovered to combat it efficiently. This research aims to design a multi-epitope vaccine using highly efficient B- and T-cell epitopes from the SARS-CoV-2 Surabaya isolate through a viroinformatic approach. First, the putative epitopes were linked together to develop tertiary structures and then docked with toll-like receptor 4 (TLR-4) that demonstrated a robust interaction with a low eigenvalue of 4.816138 e-06. Furthermore, the structure's high immunogenic response was observed and successfully cloned into the expression vector pET28a (+). This implies that the designed vaccine can prove effective …

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Influence Of Citrate And Phosphate On The Adsorption Of Adenosine-5′-Monophosphate At The Hematite Water Interface, Sudipta Rakshit, Avedananda Ray, Ali Taheri, Michael E. Essington May 2022

Influence Of Citrate And Phosphate On The Adsorption Of Adenosine-5′-Monophosphate At The Hematite Water Interface, Sudipta Rakshit, Avedananda Ray, Ali Taheri, Michael E. Essington

Agricultural and Environmental Sciences Faculty Research

Nucleic acid derived organic phosphorus (Po) is an important source of plant available P when degraded to inorganic phosphate (P(V)i). It is known that when nucleic acids or components are adsorbed on mineral surfaces, the enzymatic degradation is hindered or delayed. Thus, understanding adsorption/desorption mechanisms of nucleic acids and their derivatives are key to assess the biogeochemical pathways of Po cycling. Here we report adsorption mechanisms of adenosine-5′-monophosphate (AMP) on hematite, a common iron oxide mineral, under various solution properties using macroscopic and in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic probes. The effects of citrate, mimicking organic …

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Analysis Of The Light Responsive Azobenzene Peptide Nucleic Acid Duplexes, Kat Nguyen May 2022

Analysis Of The Light Responsive Azobenzene Peptide Nucleic Acid Duplexes, Kat Nguyen

Honors College Theses

Peptide nucleic acids (PNAs) are oligonucleotide analogues in which the sugar-phosphate backbone has been replaced by a pseudopeptide skeleton. Since PNAs use the natural nucleobases (Adenine, Thymine, Cytosine, Uracil, and Guanine) found in either DNA and/or RNA, they are able to hybridize according to Watson-Crick base-pairing to form duplexes. PNA is a promising therapeutic agent because they can function as antigene or antisense chemical agents. To further enhance their utility, we aim to incorporate a photoswitchable moiety using azobenzene. Here, we report the results of the synthesis and purification of a photoswitchable 11 mer PNA along with initial characterization efforts.

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Climatic Influences On Summer Use Of Winter Precipitation By Trees, Gregory R. Goldsmith, Scott T. Allen, Sabine Braun, Rolf T. W. Siegwolf, James W. Kirchner May 2022

Climatic Influences On Summer Use Of Winter Precipitation By Trees, Gregory R. Goldsmith, Scott T. Allen, Sabine Braun, Rolf T. W. Siegwolf, James W. Kirchner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Trees in seasonal climates may use water originating from both winter and summer precipitation. However, the seasonal origins of water used by trees have not been systematically studied. We used stable isotopes of water to compare the seasonal origins of water found in three common tree species across 24 Swiss forest sites sampled in two different years. Water from winter precipitation was observed in trees at most sites, even at the peak of summer, although the relative representation of seasonal sources differed by species. However, the representation of winter precipitation in trees decreased with site mean annual precipitation in both …

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Theoretical Aspects Of Calculation Of Photocurrent In Structures With Periodically Spaced Heterinclusions, R. Аyukhanov, A. Uteniyazov, S. Farmonov, N. Shernazarov May 2022

Theoretical Aspects Of Calculation Of Photocurrent In Structures With Periodically Spaced Heterinclusions, R. Аyukhanov, A. Uteniyazov, S. Farmonov, N. Shernazarov

Karakalpak Scientific Journal

The processes of excitation of photoconductivity in structures with heteroinclusions with a band gap greater than the band gap of the base material of the matrix have been studied. Structures are studied when such macroinclusions are located periodically and are located at distances equal to the size of the inclusions. A technique has been developed and analytical expressions have been derived for calculating the photocurrent and specific photoconductivity in such structures.

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Injection Depletion Effect In Semiconductors With Pair Impurity Complexes, A. Yu. Leyderman, A. Uteniyazov, R. Turmanova, M. Dauletbayev May 2022

Injection Depletion Effect In Semiconductors With Pair Impurity Complexes, A. Yu. Leyderman, A. Uteniyazov, R. Turmanova, M. Dauletbayev

Karakalpak Scientific Journal

The possibility of realizing the effect of injection depletion in a + -structure made on the basis of a semiconductor with paired donor-acceptor complexes is considered. It is shown that the appearance of this effect is possible under conditions of almost complete compensation of the shallow dopant donor impurity by the charge of the acceptor component of the pair complex. A necessary condition is also a strong asymmetry of the coefficients of capture of holes at the acceptor level in comparison with the coefficient of capture of electrons at the donor level.

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Nonlinear Photoelasticity Processes Near Resonances At The Frequency Of Electronic Transitions From Deep Levels To The Conduction Zone, R. Аyukhanov, A. Uteniyazov, S. Farmonov, N. Shernazarov May 2022

Nonlinear Photoelasticity Processes Near Resonances At The Frequency Of Electronic Transitions From Deep Levels To The Conduction Zone, R. Аyukhanov, A. Uteniyazov, S. Farmonov, N. Shernazarov

Karakalpak Scientific Journal

The phenomenon of nonlinear photoelasticity, which consists of the occurrence of nonlinear photoelasticity coefficients comparable in magnitude to linear ones near the electronic resonance between the deep impurity levels and the bottom of the conduction zone, is considered theoretically. Analytical expressions for the Fourier decomposition coefficients of the dielectric permittivity of the crystal in the phase of the sound wave, which are proportional to the photoelasticity coefficients, are obtained. A general criterion for the nonlinear photoelasticity effect in the investigated frequency region is found numerically. It is shown that high deformation potentials of deep levels stimulate the appearance of this …

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A Machine Learning Based Approach To Detect The Ethereum Fraud Transactions With Limited Attributes, Rabia Musheer Aziz, Mohammed Farhan Baluch, Sarthak Patel, Pavan Kumar May 2022

A Machine Learning Based Approach To Detect The Ethereum Fraud Transactions With Limited Attributes, Rabia Musheer Aziz, Mohammed Farhan Baluch, Sarthak Patel, Pavan Kumar

Karbala International Journal of Modern Science

Ethereum smart contracts have recently received new commercial applications and a lot of attention from the scientific community. Ethereum eliminates the requirement for a trusted third party by allowing untrusted parties to expose contract details in computer code. Nonetheless, as online commerce grows, plenty of fraudulent activities, such as money laundering, bribery, and phishing, emerge as major threats to trade security. For correctly recognizing fraudulent transactions, this paper developed a Light Gradient Boosting Machine (LGBM) technique-based model. The modified LGBM model optimized the parameters of Light GBM using the Euclidean distant structured estimation approach. This paper also examines the performance …

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A Bi-Level Data Lowering Method To Minimize Transferring Big Data In The Sensors Of Iot Applications, Ali Kadhum M. Al-Qurabat, Ali Kadhum Idrees, Abdallah Makhoul, Chady Abou Jaoude May 2022

A Bi-Level Data Lowering Method To Minimize Transferring Big Data In The Sensors Of Iot Applications, Ali Kadhum M. Al-Qurabat, Ali Kadhum Idrees, Abdallah Makhoul, Chady Abou Jaoude

Karbala International Journal of Modern Science

In the IoT era, the number of devices connected to it continues to grow significantly. This can lead to an increase in the amount of reported data by these IoT devices. The reported data by the Sensor Nodes (SNs) to the Gateway (GW) drives these IoT sensors to consume their energy and storage. These problems can be solved by reducing the amount of data in the source nodes in order to reduce both the amount of energy consumed and the amount of storage required. Energy consumption represents one aspect of the Quality of Service (QoS) in the sensor nodes of …

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An Economical Source For Peroxidase: Maize Cobs, Hathama Razooki Hasan, Ali Waleed Al- Ani May 2022

An Economical Source For Peroxidase: Maize Cobs, Hathama Razooki Hasan, Ali Waleed Al- Ani

Karbala International Journal of Modern Science

According to the current situation of peroxidase (POD), the relevant studies on this enzyme indicated its importance as a tool in clinical biochemistry and different industrial fields. Most of these studies used the fruits and vegetables as source of this enzyme. So that in order to couple the growing requirements for POD with the recent demands for reduc-ing disposal volume by recycling the plant waste, the aim of the present study was to extract POD through management of municipal bio-waste of Iraqi maize species. A simple, green and economical method was used to extract this enzyme. Our results revealed that …

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Efficient Removal Of Common Organic Pollutants From Water By Zn-Doped Tio2 Nanoparticles With Different Applications, Khaled Elgendy, Ibrahim Elmehasseb, Saleh Kandil May 2022

Efficient Removal Of Common Organic Pollutants From Water By Zn-Doped Tio2 Nanoparticles With Different Applications, Khaled Elgendy, Ibrahim Elmehasseb, Saleh Kandil

Karbala International Journal of Modern Science

Water purification via adsorption without energy consumption was considered a green process. Zn-doped TiO2 nanoparticles were fabricated by the Sol-gel method and characterized by different analysis techniques. Zinc doping of TiO2 increases the surface area to 26.7m2g-1 with adsorption results, 75.1%, 71.1%, and 68.2% for methylene blue, ofloxacin, and SLS, respectively. Variable affecting factors on adsorption have been studied. The adsorption behavior fitted with Langmuir and Freundlich equations than Temkin isotherm, indicating the preferred heterogeneous adsorption at equivalent adsorbent sites. The application of nanoparticles in many synthetic specimens of pollutants gave excellent removal results, which exceeded 75% of detoxification.

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Synthesis Of Cuo/Zno And Mgo/Zno Core/Shell Nanoparticles With Plasma Jets And Study Of Their Structural And Optical Properties, Raghad S. Mohammed, Kadhim A. Aadim, Khalid A. Ahmed May 2022

Synthesis Of Cuo/Zno And Mgo/Zno Core/Shell Nanoparticles With Plasma Jets And Study Of Their Structural And Optical Properties, Raghad S. Mohammed, Kadhim A. Aadim, Khalid A. Ahmed

Karbala International Journal of Modern Science

This paper reports the synthesis of CuO/ZnO and MgO/ZnO core/shell nanoparticles using atmospheric plasma jets. The characterization of the synthesized CuO/ZnO and MgO/ZnO core/shell nanoparticles were confirmed by a series of techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray dispersive spectroscopy (EDS), transmission electron microscopy (TEM), and UV–Vis spectroscopy. The XRD analysis confirmed no other peaks related to the secondary phases for CuO, MgO, or ZnO, indicating the purity of these nanoparticles. Additionally, EDX analysis confirmed the formation of high purity CuO/ZnO and MgO/ZnO core/shell nanoparticles. The surface morphology, which represented the high agglomeration rate, was investigated using …

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Numerical Analysis Of A Silicon-Based Electro-Optic Modulator, Mario Alberto García-Ramírez, Orfil González-Reynoso, Everardo Vargas-Rodríguez, Miguel Angel Bello-Jiménez, Abel García-Barrientos May 2022

Numerical Analysis Of A Silicon-Based Electro-Optic Modulator, Mario Alberto García-Ramírez, Orfil González-Reynoso, Everardo Vargas-Rodríguez, Miguel Angel Bello-Jiménez, Abel García-Barrientos

Karbala International Journal of Modern Science

A phase shift electro-optic semiconductor structure that features a Mach-Zehnder Interferometer (MZI) is numerically analyzed. The interferometer structure considers a highly-doped Si-based waveguide that can control the phase shift by varying the refractive index through the carrier concentration while applying a control voltage. To analyze the structure, Kramers-Kronig dispersion relations, the effective index method and the Drude model are implemented within a finite element software. As a result, for an optical waveguide structure with a 9 mm length and 10 V, it is possible to obtain a phase shift by that allows, at the output of the MZI, total interference …

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Partial Pseudo-Random Hashing For Transactional Memory Read/Write Data Processing And Validation, G M Sridevi, Ashoka D V, B V Ajay Prakash May 2022

Partial Pseudo-Random Hashing For Transactional Memory Read/Write Data Processing And Validation, G M Sridevi, Ashoka D V, B V Ajay Prakash

Karbala International Journal of Modern Science

Development of a bypass parallel processing block is one of the emerging and interesting research areas in memory read/write application domain. Many Random Number Generation (RNG) techniques have been introduced for processing the data in storage memory. But the limitations include reduced efficiency, increased computational complexity, high area consumption and higher cost. This paper presents a novel dynamic memory register with optimal XOR design based on partial pseudo-random hashing to process transactional memory read/write data. Transfer characteristics of the current are analysed based on the pseudo differential pair for proficient memory utilization. A memory window is then created and adjusted …

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A Content-Based File Identification Dataset: Collection, Construction, And Evaluation, Saja Dheyaa Khudhur, Hassan Awheed Jeiad May 2022

A Content-Based File Identification Dataset: Collection, Construction, And Evaluation, Saja Dheyaa Khudhur, Hassan Awheed Jeiad

Karbala International Journal of Modern Science

File-Type Identification (FTI) is one of the essential functions that can be performed by examining the data blocks' magic numbers. However, this examination leads to a challenge when a file is corrupt, or these magic numbers are missing. Content-based analytics is the best way for file type identification when the magic numbers are not available. This paper prepares and presents a content-based dataset for eight common types of files based on twelve features. We designed our dataset to be used for supervised and unsupervised machine learning models. It provides the ability to classify and cluster these types into two levels, …

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Nigella Sativa Methanol Extract Inhibits Pc-3 Cell Line Colonization, Induced Apoptosis, And Modulated Lc3-Based Autophagy, Yusuf Toy, Merve Kivrik, Marwa H. Alkhafaji, Aryan M. Faraj, Ibrahim H. Gecibesler, Can A. Ağca May 2022

Nigella Sativa Methanol Extract Inhibits Pc-3 Cell Line Colonization, Induced Apoptosis, And Modulated Lc3-Based Autophagy, Yusuf Toy, Merve Kivrik, Marwa H. Alkhafaji, Aryan M. Faraj, Ibrahim H. Gecibesler, Can A. Ağca

Karbala International Journal of Modern Science

Nigella sativa has various pharmacological properties and has been used throughout history for a variety of reasons. However, there is limited data about the effects of Nigella sativa (NS) on human cancer cells. This study aimed at observing the roles of methanolic extract of N. sativa on apoptosis and autophagy pathway in the Human PC3 (prostate cancer) cell line. The cell viability was checked by MTT assay. Clonogenic assay was performed to demonstrate clonogenicity and Western blot was used to check caspase-3, TIGAR, p53, and LC3 protein expression. The results demonstrated that PC3 cell proliferation was inhibited, caspase-3 and p53 …

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Ultrasound-Assisted Dibutyl Phthalate Nanocapsules Preparation And Its Application As Corrosion Inhibition Coatings, Uday Bagale, Ammar Kadi, Irina Potoroko, Vinay Rangari, Minakshi Mahale May 2022

Ultrasound-Assisted Dibutyl Phthalate Nanocapsules Preparation And Its Application As Corrosion Inhibition Coatings, Uday Bagale, Ammar Kadi, Irina Potoroko, Vinay Rangari, Minakshi Mahale

Karbala International Journal of Modern Science

The current research employs an encapsulation of dibutyl phthalate (DBP) as a corrosion inhibitor in situ polymerization using a sonochemical method to form nanocapsules. The prepared nanocapsules were characterization by using Malvern particle size, Fouri-er transforms infrared spectroscopy (FTIR), Scanning electron microscope (SEM) and Transmission electron microscope (TEM), and thermal and mechanical test to check particle size, morphology, and stability of nanocapsules. Later prepared DBP nanocapsules were incorporated in standard epoxy coating to check its corrosion inhibition resistance. The results show that nanocapsules are spherical, with an average particle size of 337 nm. Scratch nanocapsules epoxy coating shows improves coating …

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Heterogeneous Catalytic Degradation Of Dye By Fenton-Like Oxidation Over A Continuous System Based On Box–Behnken Design And Traditional Batch Experiments, Imad M. Luaibi, Mohammed A. Atiya, Ahmed K. Hassan, Zainab A. Mahmoud May 2022

Heterogeneous Catalytic Degradation Of Dye By Fenton-Like Oxidation Over A Continuous System Based On Box–Behnken Design And Traditional Batch Experiments, Imad M. Luaibi, Mohammed A. Atiya, Ahmed K. Hassan, Zainab A. Mahmoud

Karbala International Journal of Modern Science

In this study, iron was coupled with copper to form a bimetallic compound through a biosynthetic method, which was then used as a catalyst in the Fenton-like processes for removing direct Blue 15 dye (DB15) from aqueous solution. Characterization techniques were applied on the resultant nanoparticles such as SEM, BET, EDAX, FT-IR, XRD, and zeta potential. Specifically, the rounded and shaped as spherical nanoparticles were found for green synthesized iron/copper nanoparticles (G-Fe/Cu NPs) with the size ranging from 32-59 nm, and the surface area was 4.452 m2/g. The effect of different experimental factors was studied in both batch and continuous …

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Optical Measurement And Performance Prediction Of Solar Pv System In Al-Khidhir Zone/Iraq, Faten Sh. Zainulabdeen, Jaber O. Dahloos, Ahmed F. Atwan, Naseer K. Kasim May 2022

Optical Measurement And Performance Prediction Of Solar Pv System In Al-Khidhir Zone/Iraq, Faten Sh. Zainulabdeen, Jaber O. Dahloos, Ahmed F. Atwan, Naseer K. Kasim

Karbala International Journal of Modern Science

People have tended for investing the sources of renewable energy, especially solar energy, as they are clean and environmentally friendly sources. The present work aims to invest the measured data of solar irradiance, maximum ambient temperatures and wind speed provided by Al Khidhir Meteorological Station to predict the minimum performance of photovoltaic solar systems (NT-R0E3E-SHARP) for electric power generation. The single diode model is used to calculate the minimum output power produced by solar module and its minimum conversion efficiency based on soalr irradiance, maximum ambient temperatures and wind speed throughout 2020. The results indicate that the annual solar irradiance …

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Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas May 2022

Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas

Faculty Publications

Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm2) and nanoparticle radius (8 nm). While the moduli follow a rule of mixtures (Wood’s law) for long chains, they display enhanced elasticity and anomalous dissipation for graft chains <1⁢0⁢0  kDa. GNP melts with long polymers at high 𝜎 have a dry zone near the GNP core, surrounded by a region where the grafts can interpenetrate with chain fragments from adjacent GNPs. We propose that the departures from Wood’s law for short chains are due to the effectively larger silica volume fraction in the region where sound propagates—this is caused by the short, interpenetrated chain fragments being pushed out of the way. We thus conclude that transport mechanisms (of gas, ions, sound, thermal phonons) in GNP melts are radically different if interpenetrated chain segments can be “pushed out of the way” or not. This provides a facile new means for manipulating the properties of these materials.

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Covalent Modification Of Recombinant Protein With Reactive Thiols, Sawyer Dulaney, Bailey Taylor May 2022

Covalent Modification Of Recombinant Protein With Reactive Thiols, Sawyer Dulaney, Bailey Taylor

Honors Theses

Many diseases cause chronic and painful inflammation in different body systems. One of the front-line drug classes to treat such inflammation is Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Despite the benefits of oral administration of NSAIDs, there are drawbacks to their long-term usage because they can cause detrimental effects on off-target systems in the body such as the liver, kidney, or the lining of the intestinal tract. An alternative to NSAIDs is the usage of hydrogels for targeted drug delivery. Hydrogels can provide drug delivery in a specific portion of the site of inflammation, thus allowing higher doses of medication to be …

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Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry, Pallavi Ragi May 2022

Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry, Pallavi Ragi

Masters Theses & Specialist Projects

Steroidal hormones are naturally produced as a part of many physiological processes and are excreted in the urine and feces of animals and humans. Farm animals in concentrated animal feeding operations (CAFOs) are routinely implanted with synthetic and natural hormones to enhance growth and production, contributing significantly to environmental steroid hormone contamination. Every year around 49 tons of estrogens are generated by livestock waste in the United States alone. Due to rainfall and runoff, these steroid hormones reach the environment when animal waste is applied as manure. Studies show that estrogens and other steroidal hormones present in the surface waters …

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Liquid Chromatography With Tandem Mass Spectrometry Method Development For The Determination Of Β–Defensins In Bovine Milk, Symone T. Whalin May 2022

Liquid Chromatography With Tandem Mass Spectrometry Method Development For The Determination Of Β–Defensins In Bovine Milk, Symone T. Whalin

Masters Theses & Specialist Projects

Bovine mastitis, caused by a wide array of pathogens, results in a substantial economic loss for the dairy cattle livestock industry. β-defensins are a part of the bovine’s innate immune system and act as the first line of defense against mastitis. Only foundational research has been done on β-defensins’ ability to treat and prevent mastitis. There have been no analytical methods reported in the literature for analyzing β-defensins in bovine milk. This research aims to create an analytical approach to determine β-defensins in bovine milk. It is challenging to determine an analyte in a complex sample matrix, and milk is …

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Investigation Of The Binding Domain Interfaces Of The C-Terminus Of The Albino3 Insertase And The 43kda Chloroplast Signal Recognition Particle Subunit Via Single Molecule Förster Resonance Energy Transfer, Amanda Tomanek May 2022

Investigation Of The Binding Domain Interfaces Of The C-Terminus Of The Albino3 Insertase And The 43kda Chloroplast Signal Recognition Particle Subunit Via Single Molecule Förster Resonance Energy Transfer, Amanda Tomanek

Chemistry & Biochemistry Undergraduate Honors Theses

Fluorescent labeling is a technique used for visualizing functional groups contained in biomolecules by fluorescence imaging. This technique was used in this project to analyze post-translational targeting of light-harvesting chlorophyll-binding proteins (LHCP), which are the core complexes that harvest sunlight to drive photosynthetic electron transfer. This protein is synthesized in the cytosol and post-translationally targeted to the stroma of chloroplasts. CpSRP43 is a signal recognition particle (SRP) subunit unique to chloroplasts, which has been shown to interact with the stroma-soluble C-terminus of the thylakoid-bound Albino3 insertase (Alb3-Cterm). In the chloroplast stroma, targeting to thylakoids is performed via the cpSRP pathway …

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The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen May 2022

The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen

Honors College Theses

The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in …

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Role Of E168d In M. Tuberculosis Igps Catalysis, Hedda Booter May 2022

Role Of E168d In M. Tuberculosis Igps Catalysis, Hedda Booter

Theses, Dissertations and Culminating Projects

Mycobacterium tuberculosis is a bacterium that affects the lungs and causes tuberculosis, infecting over 10 million people worldwide each year. Owing to the organism’s evolving drug resistance, existing antibiotics no longer combat the disease. The need to discover new drug targets has never been greater. Previous findings suggest that the protein IGPS (indole-3-glycerol phosphate synthase) in M. tuberculosis (MtIGPS) may be a target in the treatment of the disease. MtIGPS catalyzes the fourth step in the tryptophan biosynthetic process. The ability to create their own tryptophan is a major advantage that many bacteria have. The role of E168, in the …

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Lipid Rafts, Exosomal Vesicles And Anti-Giardial Therapies, Brian Ivan Grajeda May 2022

Lipid Rafts, Exosomal Vesicles And Anti-Giardial Therapies, Brian Ivan Grajeda

Open Access Theses & Dissertations

Giardia lamblia, a protozoan parasite, is a major cause of waterborne infection, worldwide. While the trophozoite form of this parasite induces pathological symptoms in the gut, the cyst forms transmit the infection via contaminated water. Since Giardia is a non-invasive parasite, the actual mechanism by which it causes infection remains elusive. We have previously reported that Giardia assembles cholesterol and GM1 glycolipid-enriched lipid rafts (LRs) that participate in encystation and cyst production. To further delineate the role of LRs in pathogenesis, we isolated LRs from Giardia and subjected them to proteomic analysis. Various cellular proteins including the virulent proteins—e.g., giardins, …

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Design, Synthesis, And Analysis Of Paired Coiled-Coil Peptidic Molecular Building Blocks Used For Linearly Controlled Self-Assembly Of Α-Helical Coiled-Coil Heterodimer Peptide Pairs, Jason Distefano Apr 2022

Design, Synthesis, And Analysis Of Paired Coiled-Coil Peptidic Molecular Building Blocks Used For Linearly Controlled Self-Assembly Of Α-Helical Coiled-Coil Heterodimer Peptide Pairs, Jason Distefano

Chemistry Theses

Molecular building blocks are fundamental to biological synthesis and processes and have been utilized in advanced materials, drugs and drug delivery systems, and biotechnology. Proteins have been used as molecular building blocks for the construction of complex, well-ordered structures. Coiled-coil protein domains are essential subunits used for the oligomerization of protein complexes, gene expression, and structural elements of biological materials. The synthesis and assembly of proteins utilizing coiled-coil motifs are of great scientific interest due to their potential applications in disease treatment, biomechanical motors, nanoscale delivery systems, etc. However, assembling protein complexes with specific morphology is still challenging because …

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Foldamers Reveal And Validate Therapeutic Targets Associated With Toxic Α-Synuclein Self-Assembly, Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar Apr 2022

Foldamers Reveal And Validate Therapeutic Targets Associated With Toxic Α-Synuclein Self-Assembly, Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar

Chemistry and Biochemistry: Faculty Scholarship

Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no successful prevention or intervention. The pathological hallmark for PD involves the self-assembly of functional Alpha-Synuclein (αS) into non-functional amyloid structures. One of the potential therapeutic interventions against PD is the effective inhibition of αS aggregation. However, the bottleneck towards achieving this goal is the identification of αS domains/sequences that are essential for aggregation. Using a protein mimetic approach, we have identified αS sequences-based targets that are essential for aggregation and will have significant therapeutic implications. An extensive array of in vitro, ex vivo, and in vivo assays …

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Evaluating Alternative Ebullition Models For Predicting Peatland Methane Emission And Its Pathways Via Data–Model Fusion, Shuang Ma, Lifen Jiang, Rachel M. Wilson, Jeff P. Chanton, Scott Bridgham, Shuli Niu, Colleen M. Iversen, Avni Malhotra, Jiang Jiang, Xingjie Lu, Yuanyuan Huang, Jason Keller, Xiaofeng Xu, Daniel M. Ricciuto, Paul J. Hanson, Yiqi Luo Apr 2022

Evaluating Alternative Ebullition Models For Predicting Peatland Methane Emission And Its Pathways Via Data–Model Fusion, Shuang Ma, Lifen Jiang, Rachel M. Wilson, Jeff P. Chanton, Scott Bridgham, Shuli Niu, Colleen M. Iversen, Avni Malhotra, Jiang Jiang, Xingjie Lu, Yuanyuan Huang, Jason Keller, Xiaofeng Xu, Daniel M. Ricciuto, Paul J. Hanson, Yiqi Luo

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Understanding the dynamics of peatland methane (CH4) emissions and quantifying sources of uncertainty in estimating peatland CH4 emissions are critical for mitigating climate change. The relative contributions of CH4 emission pathways through ebullition, plant-mediated transport, and diffusion, together with their different transport rates and vulnerability to oxidation, determine the quantity of CH4 to be oxidized before leaving the soil. Notwithstanding their importance, the relative contributions of the emission pathways are highly uncertain. In particular, the ebullition process is more uncertain and can lead to large uncertainties in modeled CH4 emissions. To improve model simulations of CH4 emission and its pathways, …

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