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Articles 2671 - 2700 of 3949
Full-Text Articles in Chemistry
Pitfalls With The Use Of Enhancement Ratios Or Normalized Excess Mixing Ratios Measured In Plumes To Characterize Pollution Sources And Aging, Robert J. Yokelson, Meinrat O. Andreae, S. K. Akagi
Pitfalls With The Use Of Enhancement Ratios Or Normalized Excess Mixing Ratios Measured In Plumes To Characterize Pollution Sources And Aging, Robert J. Yokelson, Meinrat O. Andreae, S. K. Akagi
Chemistry and Biochemistry Faculty Publications
Normalized excess mixing ratios (NEMRs), also known as enhancement ratios, are a common way to characterize plumes of pollution in atmospheric research. As single-source pollutant plumes disperse in the atmosphere, they are diluted by mixing with the adjacent background air. Changes in the composition of this background air can cause large changes to the NEMR that is subsequently measured by remote-sensing, airborne, or ground-based instruments. This scenario is common when boundary layer plumes enter the free troposphere and could also impact long-range transport or plumes near the top of the troposphere. We provide a context for these issues and an …
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
Faculty Publications
Using a one-pot approach driven by the supramolecular interaction between β-cyclodextrin and adamantyl moieties, multifunctional viral nanoparticles can be facilely formulated for biomedical applications.
Synthesis And Evaluation Of Thermally-Responsive Coatings Based Upon Diels–Alder Chemistry And Renewable Materials, Dahlia N. Amato, Gregory A. Strange, John P. Swanson, Anton D. Chavez, Suzanne E. Roy, Kim L. Varney, Craig A. Machado, Douglas V. Amato, Philip Costanzo
Synthesis And Evaluation Of Thermally-Responsive Coatings Based Upon Diels–Alder Chemistry And Renewable Materials, Dahlia N. Amato, Gregory A. Strange, John P. Swanson, Anton D. Chavez, Suzanne E. Roy, Kim L. Varney, Craig A. Machado, Douglas V. Amato, Philip Costanzo
Chemistry and Biochemistry
A soybean based coating with thermally responsive Diels–Alder linkages has been prepared following an automotive 2-component formulation. The resulting coatings displayed the capability to be healed following physical deformation by a thermal stimulus, and such a material has significant potential for end users. Various curing agents were employed, and resulted in variation of scratch resistance and re-healablity. Different thermally responsive soybean resins were synthesized to have varying amounts reversible and nonreversible linkages when incorporated into the coating. Additionally, different isocyanates were added at differing ratios of NCO:OH in search of the optimum coating. It was found through the analysis of …
Mechanism Of Ubiquitin Ligation And Lysine Prioritization By A Hect E3, Hari B. Kamadurai, Yu Qiu, Alan Deng, Joseph S. Harrison, Chris Macdonald, Marcelo Actis, Patrick Rodrigues, Darcie J. Miller, Judith Souphron, Steven M. Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A. Schulman
Mechanism Of Ubiquitin Ligation And Lysine Prioritization By A Hect E3, Hari B. Kamadurai, Yu Qiu, Alan Deng, Joseph S. Harrison, Chris Macdonald, Marcelo Actis, Patrick Rodrigues, Darcie J. Miller, Judith Souphron, Steven M. Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A. Schulman
College of the Pacific Faculty Articles
Ubiquitination by HECT E3 enzymes regulates myriad processes, including tumor suppression, transcription, protein trafficking, and degradation. HECT E3s use a two-step mechanism to ligate ubiquitin to target proteins. The first step is guided by interactions between the catalytic HECT domain and the E2∼ubiquitin intermediate, which promote formation of a transient, thioester-bonded HECT∼ubiquitin intermediate. Here we report that the second step of ligation is mediated by a distinct catalytic architecture established by both the HECT E3 and its covalently linked ubiquitin. The structure of a chemically trapped proxy for an E3∼ubiquitin-substrate intermediate reveals three-way interactions between ubiquitin and the bilobal HECT …
2013 Annual Meeting Program
Journal of the South Carolina Academy of Science
No abstract provided.
Effects Of Composition And Separation Techniques On The Structure Of Aggregates In The Milk Fat Globular Membrane, Tristan Dilbeck, Jose Ibarra, Rafael Jimenez-Flores, Tracey Nguyen
Effects Of Composition And Separation Techniques On The Structure Of Aggregates In The Milk Fat Globular Membrane, Tristan Dilbeck, Jose Ibarra, Rafael Jimenez-Flores, Tracey Nguyen
STAR Program Research Presentations
The milk fat globular membrane (MFGM) is a complex structure composed mainly of phospholipids, sphingolipids, and membrane specific proteins. The composition and size of the MFGM differs based on the isolation, purification, and techniques used in analysis of the membrane as well as physiological, chemical, and mechanical factors present during its creation. The purpose of this experiment is to analyze the effects of separation techniques and composition of lipids and proteins on the structure of aggregates in the MFGM. The aggregates found in whey protein isolate (95% pure whey protein), whey buttermilk (whey protein and phospholipids), and sweet buttermilk (whey …
Single Step Synthesis Of Antibiotic Kanamycin Embedded Gold Nanoparticles For Efficient Antibacterial Activity, Shravan Gavva
Single Step Synthesis Of Antibiotic Kanamycin Embedded Gold Nanoparticles For Efficient Antibacterial Activity, Shravan Gavva
Masters Theses & Specialist Projects
Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Streptomyces kanamyceticus. These special antibiotic GNPs are further characterized using …
Effects Of Xanthan/Locust Bean Gum Mixtures On The Physicochemical Properties And Oxidative Stability Of Whey Protein Stabilized Oil-In-Water Emulsions, Goutham Puli
Masters Theses & Specialist Projects
Scientific evidence shows that dietary intake of the omega-3 polyunsaturated fatty acids is beneficial to human health. Fish oil is a rich source of omega-3 fatty acids. However, fish oil with high levels of omega-3 PUFA is very susceptible to oxidative deterioration during storage. The objective of this study was to investigate the effect of xanthan gum (XG)-locust bean gum (LBG) mixtures on the physicochemical properties of whey protein isolate (WPI) stabilized oil-in-water (O/W) emulsions containing 20% v/v menhaden oil. The O/W emulsions containing XG/LBG mixtures were compared to emulsions with either XG or LBG alone. The emulsions were prepared …
Studies Toward The Synthesis Of Lyconadin A And Cranomycin, Brad M. Loertscher
Studies Toward The Synthesis Of Lyconadin A And Cranomycin, Brad M. Loertscher
Theses and Dissertations
Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium companatum with anticancer activity. Our approach sought to incorporate a 7-exo–6-exo acyl radical cyclization cascade to access the bicyclo[5.4.0]undecane framework of lyconadin A. Our studies created methodology for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones and sterically demanding epoxide substrates. These epoxide substrates underwent an unanticipated Payne rearrangement.Cranomycin is a potent antibiotic with antiprotozoal activity. Structurally it is a cyclopentane ring system with substitution at each carbon in the ring. Another interesting structural aspect is the existence of three contiguous quaternary stereocenters including two tertiary alcohols and a …
Developmental Signaling Requires Inwardly Rectifying K+ Channels In Drosophila Melanogaster, Giri Raj Dahal
Developmental Signaling Requires Inwardly Rectifying K+ Channels In Drosophila Melanogaster, Giri Raj Dahal
Theses and Dissertations
Inwardly rectifying potassium (IRK/Kir) channels regulate intracellular K+ concentrations and membrane potential. Disruption of Kir2.1 causes dominantly inherited Andersen Tawil Syndrome (ATS). ATS patients suffer from cardiac arrhythmias, periodic paralysis, and cognitive impairment. These symptoms are consistent with current understanding of the role of ion channels in muscle cells and neurons. However, ATS symptoms also include craniofacial and digital deformities such as cleft palate, dental defects, wide set eyes, low set ears, and crooked or fused digits. These developmental defects were not consistent with current understanding of developmental signaling or previously described roles for ion channels. We found that phenotypes …
The Role Of Smpb In Licensing Tmrna Entry Into Stalled Ribosomes, Mickey R. Miller
The Role Of Smpb In Licensing Tmrna Entry Into Stalled Ribosomes, Mickey R. Miller
Theses and Dissertations
Ribosomes translate the genetic information contained in mRNAs into protein by linking together amino acids with the help of aminoacyl-tRNAs. In bacteria, protein synthesis stalls when the ribosome reaches the 3'-end of truncated mRNA transcripts lacking a stop codon. Trans-translation is a conserved bacterial quality control process that rescues stalled ribosomes. Transfer-messenger RNA (tmRNA) and its protein partner SmpB mimic a tRNA by entering the A site of the ribosome and accepting the growing peptide chain. The ribosome releases the truncated mRNA and resumes translation on the tmRNA template. The open reading frame found on tmRNA encodes a peptide tag …
Analisis Variasi Genetik Varian Jati Arboretum Dengan Penanda Mikrosatelit, Imas Cintamulya
Analisis Variasi Genetik Varian Jati Arboretum Dengan Penanda Mikrosatelit, Imas Cintamulya
Jurnal Pendidikan Sains
Seleksi tanaman jati untuk memperoleh sifat unggul tidak cukup hanya melalui penanda morfologi, tetapi juga perlu menggunakan penanda molekuler berdasarkan polimorfisme DNA. Oleh karena itu, perlu dilakukan kajian tanaman jati dari segi genetik pada level DNA untuk melihat variasi genetik. Informasi tentang variasi genetik jati diperlukan dalam pengadaan bibit untuk pembangunan hutan tanaman industri, dengan tujuan mencegah inbreeding dan mendukung upaya konservasi. Penelitian ini bertujuan untuk menganalisis variasi genetik varian jati arboretum menggunakan penanda molekuler mikrosatelit serta menyusun buku pengayaan kajian dasar-dasar molekuler tumbuhan, khususnya penanda mikrosatelit, dalam menganalisis variasi genetik varian jati arboretum yang berkualitas. Langkah-langkah penelitian meliputi isolasi …
Pembelajaran Kooperatif Tai Dan Game Puzzle Dalam Meningkatkan Motivasi Belajar Dan Pemahaman Konsep Matematika, Any Herawati
Pembelajaran Kooperatif Tai Dan Game Puzzle Dalam Meningkatkan Motivasi Belajar Dan Pemahaman Konsep Matematika, Any Herawati
Jurnal Pendidikan Sains
Penelitian ini mendeskripsikan rancangan dan pelaksanaan pembelajaran kooperatif Team Assisted Individualized (TAI) dan game puzzle dalam meningkatkan motivasi belajar serta pemahaman konsep fungsi komposisi dan fungsi invers di SMA Negeri 3 Malang. Penelitian ini merupakan penelitian tindakan kelas dengan pendekatan mix research, yang dilaksanakan dalam tiga siklus. Subjek penelitian adalah siswa kelas XI IPA 1 semester genap tahun pelajaran 2011/2012 sebanyak 33 siswa, terdiri atas 13 siswa laki-laki dan 20 siswa perempuan. Data yang dikumpulkan meliputi motivasi belajar dan pemahaman konsep matematika siswa. Hasil penelitian menunjukkan bahwa pembelajaran kooperatif TAI dan game puzzle mampu meningkatkan motivasi belajar dan pemahaman konsep. …
Penggunaan Pita Melalui Pembelajaran Missouri Mathematics Project Untuk Memahamkan Siswa Tentang Luas Permukaan Bola, Pentri Arfia Dewi
Penggunaan Pita Melalui Pembelajaran Missouri Mathematics Project Untuk Memahamkan Siswa Tentang Luas Permukaan Bola, Pentri Arfia Dewi
Jurnal Pendidikan Sains
Penelitian ini akan mendeskripsikan penggunaan pita melalui pembelajaran Missouri Mathematics Project untuk memahamkan siswa tentang luas permukaan bola. Pembelajaran yang dilaksanakan berdasarkan pada tahapan pembelajaran Missouri Mathematics Project yang dipadukan dengan bahan manipulatif. Penelitian ini merupakan penelitian tindakan kelas. Setiap siklus terdiri dari tiga kali pertemuan. Dalam penelitian ini juga dilakukan kajian dari jawaban siswa. Hasil penelitian ini menunjukkan bahwa penerapan pembelajaran menggunakan bahan manipulatif bola dan pita dapat memahamkan siswa tentang luas permukaan bola.
Persepsi Pengelola Terhadap Peran Sistem Informasi Manajemen (Sim) Berbasis Teknologi Informasi (Ti) Dalam Pengelolaan Administrasi Sekolah Menengah Kejuruan Kota Mojokerto, Tri Wahjoedi Hidajat
Persepsi Pengelola Terhadap Peran Sistem Informasi Manajemen (Sim) Berbasis Teknologi Informasi (Ti) Dalam Pengelolaan Administrasi Sekolah Menengah Kejuruan Kota Mojokerto, Tri Wahjoedi Hidajat
Jurnal Pendidikan Sains
Peran sistem informasi manajemen (SIM) berbasis teknologi informasi sangat penting dalam pengelolaan sekolah untuk meningkatkan kualitas pelayanan, proses, dan prestasi belajar siswa. Oleh karena itu, penelitian ini bertujuan untuk mengungkap dan mendeskripsikan persepsi pengelola terhadap peran SIM berbasis TI dalam pengelolaan administrasi SMK di Kota Mojokerto. Penelitian ini menggunakan rancangan deskriptif kuantitatif dan dilaksanakan pada sembilan SMK di Kota Mojokerto dengan 45 pengelola administrasi akademik sebagai populasi. Teknik pengambilan sampel yang digunakan adalah sampel jenuh, yaitu seluruh populasi dijadikan sampel. Hasil penelitian menunjukkan bahwa: (1) secara umum, persepsi pengelola terhadap peran SIM berbasis TI dalam pengelolaan administrasi SMK tergolong penting, …
Integrasi Pendidikan Karakter Melalui Inkuiri Dengan Lesson Study Dalam Pembelajaran Biologi Untuk Meningkatkan Sikap Ilmiah Dan Hasil Belajar Kognitif Siswa Kelas Vii Smpn I Singosari, Elly Lailatul Budur
Integrasi Pendidikan Karakter Melalui Inkuiri Dengan Lesson Study Dalam Pembelajaran Biologi Untuk Meningkatkan Sikap Ilmiah Dan Hasil Belajar Kognitif Siswa Kelas Vii Smpn I Singosari, Elly Lailatul Budur
Jurnal Pendidikan Sains
Pembelajaran inkuiri memungkinkan siswa terlibat secara aktif dalam proses berpikir dan menemukan konsep yang dipelajarinya. Pengetahuan dan keterampilan yang diperoleh siswa diharapkan bukan sekadar hasil menghafal fakta, melainkan hasil dari proses penemuan secara mandiri. Hasil pengamatan awal menunjukkan bahwa siswa SMP Negeri 1 Singosari masih cenderung menghafal materi pembelajaran sehingga keterampilan proses dan sikap ilmiah belum berkembang secara optimal. Selain itu, karakter siswa sebagaimana diamanatkan dalam tujuan pendidikan nasional belum sepenuhnya tercapai. Penelitian ini bertujuan untuk meningkatkan sikap ilmiah dan hasil belajar kognitif siswa melalui integrasi pendidikan karakter dengan metode inkuiri terbimbing berbasis lesson study pada siswa kelas VII SMP …
Pengaruh Model Siklus Belajar Berbantuan Mind Map Terhadap Prestasi Belajar Fisika Ditinjau Dari Kinerja Laboratorium Siswa Kelas Viii Smpn 1 Rejoso Kabupaten Pasuruan, Ary Analisa Rahma
Pengaruh Model Siklus Belajar Berbantuan Mind Map Terhadap Prestasi Belajar Fisika Ditinjau Dari Kinerja Laboratorium Siswa Kelas Viii Smpn 1 Rejoso Kabupaten Pasuruan, Ary Analisa Rahma
Jurnal Pendidikan Sains
Penelitian ini bertujuan untuk menguji pengaruh model siklus belajar berbantuan mind map terhadap prestasi belajar fisika ditinjau dari kinerja laboratorium siswa kelas VIII pada materi cahaya di SMP Negeri 1 Rejoso, Kabupaten Pasuruan. Penelitian ini merupakan penelitian eksperimen semu dengan rancangan faktorial 2 × 2. Subjek penelitian berjumlah 204 siswa. Instrumen penelitian terdiri atas instrumen perlakuan yang meliputi silabus, RPP, dan LKS, serta instrumen pengukuran berupa instrumen kinerja laboratorium dan tes prestasi belajar fisika. Hasil penelitian menunjukkan bahwa prestasi belajar fisika siswa yang belajar menggunakan model siklus belajar berbantuan mind map lebih tinggi dibandingkan dengan siswa yang belajar melalui pembelajaran …
Penerapan Pembelajaran Inkuiri Terbimbing Berbasis Laboratorium Untuk Meningkatkan Keterampilan Proses Dan Hasil Belajar Ipa Siswa Kelas Viii-4 Di Smpn 1 Probolinggo, Karyatin Karyatin
Penerapan Pembelajaran Inkuiri Terbimbing Berbasis Laboratorium Untuk Meningkatkan Keterampilan Proses Dan Hasil Belajar Ipa Siswa Kelas Viii-4 Di Smpn 1 Probolinggo, Karyatin Karyatin
Jurnal Pendidikan Sains
Penelitian ini bertujuan untuk mendeskripsikan keterlaksanaan pembelajaran inkuiri terbimbing berbasis kegiatan laboratorium dalam meningkatkan keterampilan proses sains dan hasil belajar kognitif IPA (biologi) siswa. Deskripsi keterlaksanaan pembelajaran diperoleh melalui identifikasi permasalahan yang muncul selama proses pembelajaran di kelas, yang selanjutnya dianalisis untuk menemukan solusi berdasarkan data empiris di lapangan. Penelitian ini juga berupaya mengungkap permasalahan pembelajaran secara menyeluruh dan kontekstual dengan menempatkan peneliti sebagai instrumen kunci. Pendekatan yang digunakan adalah kualitatif dengan jenis penelitian tindakan kelas (PTK) yang dilaksanakan dalam dua siklus. Setiap siklus terdiri atas empat pertemuan dengan alokasi waktu 2 × 40 menit per pertemuan. Teknik pengumpulan data …
Kajian Morfologi, Anatomi, Dan Agronomi Antara Kedelai Sehat Dengan Kedelai Terserang Cowpea Mild Mottle Virus Serta Pemanfaatannya Sebagai Bahan Ajar Di Sekolah Menengah Kejuruan, As’Ad Syamsul Arifin
Kajian Morfologi, Anatomi, Dan Agronomi Antara Kedelai Sehat Dengan Kedelai Terserang Cowpea Mild Mottle Virus Serta Pemanfaatannya Sebagai Bahan Ajar Di Sekolah Menengah Kejuruan, As’Ad Syamsul Arifin
Jurnal Pendidikan Sains
Salah satu penyebab rendahnya produktivitas kedelai di Indonesia adalah serangan virus belang samar kacang tunggak, Cowpea mild mottle virus (CPMMV). Penelitian ini merupakan penelitian survei yang bertujuan untuk menggambarkan dan mengumpulkan informasi mengenai kajian morfologi, anatomi, dan agronomi terhadap infeksi CPMMV pada varietas yang terinfeksi dan yang tidak terinfeksi. Data dianalisis secara deskriptif dan inferensial menggunakan ANAVA melalui program SPSS for Windows versi 16. Hasil penelitian menunjukkan bahwa varietas Gumitir sehat, Anjosmoro sehat, Mahameru sehat, MLGG 0021, dan MLGG 0268 memiliki ukuran daun, panjang petiol, serta nisbah daun (L/W dan L/PL) lebih besar dibandingkan varietas yang sakit. Varietas Argopuro sakit …
Pembelajaran Berbantuan Multimedia Berdasarkan Teori Beban Kognitif Untuk Meningkatkan Kemampuan Menyelesaikan Masalah Program Linear Siswa X Tkr 1 Smkn 1 Doko, Fifi Damayanti
Jurnal Pendidikan Sains
Berdasarkan teori beban kognitif, pembelajaran efektif terjadi apabila beban intrinsic dikelola dengan baik, beban germane ditingkatkan, dan beban extraneous dikurangi. Penerapan multimedia merupakan salah satu upaya untuk mencapai pembelajaran yang efektif. Penelitian ini mengkaji penerapan pembelajaran matematika berbantuan multimedia dalam meningkatkan kemampuan siswa menyelesaikan masalah program linear. Penelitian ini menggunakan pendekatan penelitian tindakan kelas yang dilaksanakan dalam dua siklus. Hasil penelitian menunjukkan bahwa penggunaan multimedia dapat mengelola beban intrinsic, meningkatkan beban germane, dan mengurangi beban extraneous, sehingga kemampuan siswa dalam menyelesaikan masalah program linear meningkat.
Pengembangan Profesionalitas Berkelanjutan/Continuing Professional Development (Cpd) Guru Bersertifikat Pendidik Di Smk Rumpun Teknologi Se-Malang Raya, Sujianto Sujianto
Pengembangan Profesionalitas Berkelanjutan/Continuing Professional Development (Cpd) Guru Bersertifikat Pendidik Di Smk Rumpun Teknologi Se-Malang Raya, Sujianto Sujianto
Jurnal Pendidikan Sains
Penelitian ini bertujuan untuk mendeskripsikan pengembangan profesionalitas berkelanjutan guru bersertifikat pendidik melalui investasi pengembangan diri, publikasi ilmiah, dan karya inovatif, baik secara mandiri, berkelompok, maupun melembaga. Penelitian menggunakan rancangan deskriptif kuantitatif dengan subjek guru kejuruan bersertifikat pendidik di wilayah Malang Raya. Instrumen penelitian meliputi kuesioner (angket) dan pedoman wawancara. Hasil penelitian menunjukkan bahwa pemberlakuan Undang-Undang Guru dan Dosen (UU Nomor 14 Tahun 2005) yang disertai pemberian tunjangan profesi sejatinya memberikan harapan besar dalam mendorong minat guru untuk terus mengembangkan profesionalitasnya. Namun, temuan penelitian menunjukkan kondisi yang berbeda. Tingkat pengembangan profesionalitas berkelanjutan guru bersertifikat pendidik di SMK rumpun teknologi se-Malang Raya …
Carcinogenic Adducts Induce Distinct Dna Polymerase Binding Orientations, Kyle B. Vrtis, Radoslaw P. Markiewicz, Louis J. Romano, David Rueda
Carcinogenic Adducts Induce Distinct Dna Polymerase Binding Orientations, Kyle B. Vrtis, Radoslaw P. Markiewicz, Louis J. Romano, David Rueda
Chemistry Faculty Research Publications
DNA polymerases must accurately replicate DNA to maintain genome integrity. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), covalently bind DNA bases and promote mutagenesis near the adduct site. The mechanism by which carcinogenic adducts inhibit DNA synthesis and cause mutagenesis remains unclear. Here, we measure interactions between a DNA polymerase and carcinogenic DNA adducts in real-time by single-molecule fluorescence. We find the degree to which an adduct affects polymerase binding to the DNA depends on the adduct location with respect to the primer terminus, the adduct structure and the nucleotides present in the solution. Not only do the …
Investigation Of Water-Molecule Complexes And Their Catalytic Effect On Important Atmospheric Reactions, Taylor Scott Cline
Investigation Of Water-Molecule Complexes And Their Catalytic Effect On Important Atmospheric Reactions, Taylor Scott Cline
Theses and Dissertations
This dissertation is a collection of works that investigates issues related to environmental chemistry. The first portion of this research explores the role of water vapor on the kinetics of important atmospheric reactions. Work is presented on the self-reaction of β-hydroxyethyl peroxy radical (β-HEP) and the catalytic increase in reaction rate by water vapor. β-HEP serves as a model system for investigating the possible role of water vapor in perturbing the kinetics and product branching ratio of atmospheric reactions of other alkyl peroxy radicals. The self-reaction rate coefficient of β-HEP was investigated between 276-296 K with 1.0 × 10^15 to …
Miniaturized Electrostatic Ion Beam Trap Mass Analyzer, Junting Wang
Miniaturized Electrostatic Ion Beam Trap Mass Analyzer, Junting Wang
Theses and Dissertations
The electrostatic ion beam trap (EIBT) was designed by D. Zajfman during the previous decade. This ion trap combines many properties of the Fourier-transform ion cyclotron resonance (FTICR) mass analyzer and time-of-flight (TOF) mass analyzer. There are several advantages for the electrostatic ion beam trap. First, large mass-to-charge particles in an electrostatic field could be easier to analyze. Second, there is a folded flight path, which could make the mass analyzer smaller compared to conventional TOF mass analyzer. This principle of operation of this ion trap is analogous to an optical resonator. The ions are trapped in a voltage valley …
Identification And Differentiation Of Tier 1 Bacterial Agents Using Gas Chromatography-Mass Spectrometry, Dan Li
Theses and Dissertations
A simple method was developed for detection and differentiation of five Tier 1 bacterial agents, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, Burkholderia pseudomallei and Burkholderia mallei as well as their closely related near neighbors by gas chromatography-mass spectrometry (GC-MS). Generally, different classes of compounds can be used as biomarkers for biowarfare agent detection, including nucleic acids (i.e., DNA or RNA), proteins (i.e., antibodies), carbohydrates (i.e., sugars), lipopolysaccharides, lipids (i.e., fatty acids) and small molecules. One-step thermochemolysis (TCM) was developed to provide GC-MS detectable biomarker signatures, including sugars, fatty acids and small molecules. Solid phase micro-extraction (SPME) was used for …
Overview Of The Recent Fda Process Validation Guidance For Medicinal Product Development And Manufacture, Nuala Calnan (Editor)
Overview Of The Recent Fda Process Validation Guidance For Medicinal Product Development And Manufacture, Nuala Calnan (Editor)
Conference Papers
This conference paper presents an overview of the recently published FDA Process Validation Guideline for the development and manufacture of medicinal drug products. It discusses the impacts of conducting life cycle based validation activities and highlights the future challenges in meeting the ongoing 'Continued Process Validation' (CPV) expectations of the regulator. It also presents the latest information on the EU draft Process Validation Guidance - due for publication in late 2013 / 2014.
Bacterial Spores Remain Viable After Electrospray Charging And Desolvation, Sara Nielson Pratt
Bacterial Spores Remain Viable After Electrospray Charging And Desolvation, Sara Nielson Pratt
Theses and Dissertations
The electrospray survivability of B. subtilis spores and E. coli was tested in atmospheric mobility experiments. E. coli did not survive electrospray charging and desolvation, but B. subtilis did. Experimental conditions ensured that any surviving bacteria were charged, desolvated, and de-agglomerated. B. subtilis was also found to survive both positive and negative electrospray and subsequent introduction into vacuum conditions. Attempts were made to measure the charge distribution of viable B. subtilis spores using electrostatic deflection. From those experiments, it was found that either the spores do not become highly charged under the electrospray conditions used or only spores in a …
Interactions Of Zn2+ On Insulin Oligomer Formation, Stability, And Fragmentation: Analysis Using Esi-Im-Ms, Tiffany Culver
Interactions Of Zn2+ On Insulin Oligomer Formation, Stability, And Fragmentation: Analysis Using Esi-Im-Ms, Tiffany Culver
Honors Theses
Insulin is a hormone protein essential to the regulation of blood sugar levels. Although it is active as a hormone in the monomer (single insulin unit) form, it is stored in the pancreas as a hexamer – a coordination of six insulin units and zinc ions. This research analyzes the effects of zinc ions on the formation, stability, and fragmentation of the hexamer and other oligomer species in varying solution and instrument conditions, including the ability of the higher oligomers to transfer from crystallization to solution to a gas phase for analysis using electrospray ionization ion mobility mass spectrometry (ESI-IM-MS). …
The Mathematics Of A Successful Deconvolution: A Quantitative Assessment Of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
The Mathematics Of A Successful Deconvolution: A Quantitative Assessment Of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
Mathematics Faculty Articles
In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution combine two approaches for the rapid identification of specific scaffolds and active ligands. Here we present a quantitative assessment of the screening of 32 positional scanning libraries in the identification of highly specific and selective ligands for two formylpeptide receptors. We also compare and contrast two mixture-based library approaches using a mathematical model to facilitate the selection of active scaffolds and libraries to be pursued for further …
Isolation, Characterization And Synthesis Of Asthma Inducing Fungal Glycolipid And Analytical Method Development For Novel Antimicrobial Peptide Mimics, Vinod Chaudhary
Isolation, Characterization And Synthesis Of Asthma Inducing Fungal Glycolipid And Analytical Method Development For Novel Antimicrobial Peptide Mimics, Vinod Chaudhary
Theses and Dissertations
NKT cells are an important part of human immune system and recognize a specific set of antigens called glycolipids. Only a handful of "natural" NKT cell antigens are known till date. Although NKT cells play a protective role against pathogenic organisms, imbalances in NKT cell functions are implicated in many diseases including asthma. Allergic asthma, a Th2 driven inflammation of airways, is primarily caused by inhalation of environmental allergens. In the last decade, inhaled allergen Aspergillus fumigatus has been under scrutiny for the presence of NKT cell antigens that might trigger asthma. We successfully isolated, characterized and synthesized a "natural" …