Physical Sciences and Mathematics Commons^™

Big Data Analytics Of Medical Data, Ashwin Rajasankar

Masters Projects

Data has become a huge part of modern decision making. With the improvements in computing performance and storage in the past two decades, storing large amounts of data has become much easier. Analyzing large amounts of data and creating data models with them can help organizations obtain insights and information which helps their decision making. Big data analytics has become an integral part of many fields such as retail, real estate, education, and medicine. In the project, the goal is to understand the working of Apache Spark and its different storage methods and create a data warehouse to analyze data. …

Docker Container Image – Vulnerability Scanning, Joseph U. Ohaeche

Masters Projects

The technology landscape for container adoption has greatly evolved over the years from the first known Unix U7 container concept introduced in 1979 to the most utilized docker container concept which emerged in 2013. Docker container image is essentially a lightweight, standalone executable software package with capabilities to run an application. It is important to know that container images become containers when deployed, and simultaneously docker container images become docker containers when deployed on Docker Engine. This project paper aims, evaluates, and presents a methodology useful in vulnerability scanning of docker container images and suggests possible fixes based on OWASP …

Exploring Coral Reefs With Interactive Geospatial Visualizations, David Nicolas Tonning

Masters Projects

This project uses geospatial data to generate custom polygons in an interactive setting to represent the size and location of coral reefs to extract insights from coral reef-centered data sets. Historically, the data used by the Reef Restoration Group Bonaire exists in disparate sources, making it difficult to track and analyze the outcomes of their restoration work. Additionally, this information is not available in a digestible format for other audiences who would be interested in this data, such as citizen scientists seeking coral reef health statistics, the general public wanting to better understand the coral reefs surrounding Bonaire or recreational …

Hybrid Life Cycles In Software Development, Eric Vincent Schoenborn

Masters Projects

This project applied software specification gathering, architecture, work planning, and development to a real-world development effort for a local business. This project began with a feasibility meeting with the owner of Zeal Aerial Fitness. After feasibility was assessed the intended users, needed functionality, and expected user restrictions were identified with the stakeholders. A hybrid software lifecycle was selected to allow a focus on base functionality up front followed by an iterative development of expectations of the stakeholders. I was able to create various specification diagrams that express the end projects goals to both developers and non-tech individuals using a standard …

Malware Detection And Analysis, Namratha Suraneni

Masters Projects

Malicious software poses a serious threat to the cybersecurity of network infrastructures and is a global pandemic in the form of computer viruses, Trojan horses, and Internet worms. Studies imply that the effects of malware are deteriorating. The main defense against malware is malware detectors. The methods that such a detector employ define its level of quality. Therefore, it is crucial that we research malware detection methods and comprehend their advantages and disadvantages. Attackers are creating malware that is polymorphic and metamorphic and has the capacity to modify their source code as they spread. Furthermore, existing defenses, which often utilize …

A Bayesian Susceptible-Infectious-Hospitalized-Ventilated-Recovered Model To Predict Demand For Covid-19 Inpatient Care In A Large Healthcare System, Stella Coker Watson Self Ph.D., Ms, Rongjie Huang, Shrujan Amin, Joseph Ewing, Caroline Rudisill, Alexander C. Mclain

Faculty Publications

The COVID-19 pandemic has strained healthcare systems in many parts of the United States. During the early months of the pandemic, there was substantial uncertainty about whether the large number of COVID-19 patients requiring hospitalization would exceed healthcare system capacity. This uncertainty created an urgent need to accurately predict the number of COVID-19 patients that would require inpatient and ventilator care at the local level. As the pandemic progressed, many healthcare systems relied on such predictions to prepare for COVID-19 surges and to make decisions regarding staffing, the discontinuation of elective procedures, and the amount of personal protective equipment (PPE) …

Survival Of Epithelial Ovarian Cancer In Black Women: A Society To Cell Approach In The African American Cancer Epidemiology Study (Aaces), Joellen M. Schildkraut, Courtney Johnson, Lauren F. Dempsey, Bo Qin, Paul Terry, Maxwell Akonde, Edward S. Peters, Hannah Mandle, Michele L. Cote, Lauren Peres, Patricia Moorman, Ann G. Schwartz, Micheal Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. Lawson, Anthony Alberg, Elisa V. Bandera

Faculty Publications

Purpose

The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC.

Methods

AACES phase 2 (enrolled 2020 onward) is a multi-site, population-based study focused on overall survival (OS) of EOC. Rapid case ascertainment is used in ongoing patient recruitment in eight U.S. states, both northern and southern. Data collection is composed of a survey, biospecimens, and medical record abstraction. Results characterizing the survival experience of the phase 1 study population (enrolled 2010–2015) are presented.

Results …

Torward Real-World Cross-View Image Geo-Localization, Sijie Zhu

Electronic Theses and Dissertations, 2020-2023

Cross-view image geo-localization aims to determine the locations of street-view query images by searching in a GPS-tagged reference image database from aerial view. One fundamental challenge is the dramatic view-point/domain difference between the street-view query images and aerial-view reference images. Recent works have made great progress on bridging the domain gap with advanced deep learning techniques and geometric prior knowledge, i.e. the query is aligned at the center of one aerial-view reference image (spatial alignment) and the orientation relationship between the two views is known (orientation alignment). However, such prior knowledge of the geometry correspondence of the two views is …

Investigation Of The Effect Of Corundum Layer On The Heat Transfer Of Sic Slab, Sri Elsa Fatmi, Donanta Dhaneswara, Muhammad Anis, Ahmad Ashari

Journal of Materials Exploration and Findings

Aluminum is the most widely used metal in industry. Aluminum smelting is one of the important steps that needs to be carried out to produce products made of aluminum metal with good quality. In the process of smelting aluminum there are several problems that occur, one of which is the growth of corundum in Si C refractories which affects the quality of aluminum melt and the durability of Si C refractories. This research was conducted to see the heat transfer in Si C and the effect of the presence of Corundum on heat transfer. This research was carried out by …

Dynamic Rbi With Central Difference Method Approach In Calculation Of Uniform Corrosion Rate: A Casestudy On Gas Pipelines, M.Riefqi Dwi Alviansyah, Fernanda Hartoyo, Zahra Nadia Nurullia, Ari Kurniawan

Journal of Materials Exploration and Findings

The oil and gas industry generally uses a piping system to drain fluids. Even though the pipes used have been well designed, the use of pipes as a means of fluid transportation still provides the possibility of failure that can occur at any time, one of which is due to uniform corrosion. The use of standard Risk Based Inspection (RBI) according to the API RBI 581 document has been widely used to anticipate potential failures to pipe components. The use of standard RBI can reduce the risk of failure significantly. Because the standard RBI considers the component risk value to …

2022 December 15 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Preferential Stiffness And The Crack-Tip Fields Of An Elastic Porous Solid Based On The Density-Dependent Moduli Model, Hyun C. Yoon, S. M. Mallikarjunaiah, Dambaru Bhatta

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we study the preferential stiffness and the crack-tip fields for an elastic porous solid of which material properties are dependent upon the density. Such a description is necessary to describe the failure that can be caused by damaged pores in many porous bodies such as ceramics, concrete and human bones. To that end, we revisit a new class of implicit constitutive relations under the assumption of small deformation. Although the constitutive relationship \textit{appears linear} in both the Cauchy stress and linearized strain, the governing equation bestowed from the balance of linear momentum results in a quasi-linear partial …

Local Spectroscopy Data Infrastructure: Solid State Nmr Crystallography With Experiment, First-Principal Analysis And Machine Learning, He Sun

Arts & Sciences Graduate Student Theses and Dissertations

Solid-state magnetic resonance (SSNMR) spectroscopy is a powerful tool for obtaining precise information about the local bonding and morphology of materials. The detailed local structure of crystalline materials cannot be easily solved by traditional experimental methods such as X-ray diffraction (XRD). SSNMR combined with first principal calculation methods such as density functional theory (DFT) can be of great use in this research area. The methodology that is called “NMR crystallography” today has been widely applied to the determination of a wide range of solid materials with an increasing amount of computationally simulated NMR spectra. The construction of a well-established computational …

Development Of Redox-Responsive Phenazine-Based Foldamers. Acylative Kinetic Resolution Of Hydroxamic Acids, Jingwei Yin

Arts & Sciences Graduate Student Theses and Dissertations

Two different research directions have been presented in this thesis. The first project is about phenazine-based foldamers as molecular actuators. Researchers have been interested in the design and synthesis of foldamers and molecular actuators for years. We began our exploration by demonstrating that phenazine-1,6-dicarboxamides can function as redox-responsive molecular switches. We then designed and synthesized two generations of phenazine-based interleafed foldamers and studied their stability and redox behaviors under chemical and electrochemical conditions. In the second project, we have developed the first acylative kinetic resolution on hydroxamic acids. Although chiral hydroxamic acids have extensive applications, synthetic methods towards them are …

Tracking Reducing Equivalents Between Cellular Compartments To Understand The Metabolic Demands Of Proliferation, Yahui Wang

Arts & Sciences Graduate Student Theses and Dissertations

Proliferating cancer cells compartmentalize metabolic reactions, many of which require reducing equivalents. This compartmentalization is functionally important, but it is challenging to study with current technologies. As a consequence, our understanding of proliferating metabolism has been limited. Here, I developed an approach to track reducing equivalents between cellular compartments. By applying this method to a panel of different cell lines under various conditions, I investigated a dysregulated metabolic phenotype in proliferating cells known as “aerobic glycolysis”. Aerobic glycolysis is characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen availability. Using the NCI-60 cell lines, I first …

Non-Canonical Beta-Lactam Antibiotics, Brett Wesley Virgin-Downey

Arts & Sciences Graduate Student Theses and Dissertations

In canonical β-Lactam antibiotics, such as penicillin, the strained nature of the β-Lactam ring leads to acylation of the catalytic serine in the active site of transpeptidases. In 2018, our lab reported a novel mechanism for monocyclic β-lactam antibiotics in the inhibition of glutamine synthetase (GS) by a natural product, tabtoxinine-β-lactam (TβL) using a 3-hydroxy-β-lactam pharmacophore. This work aims to generalize the β-lactam scaffold from TβL to act as a warhead against ATP-dependent carboxylate-amine ligase enzymes, with dihydrofolate synthetase (DHFS) as the test case. A pure 3-hydroxy-β-lactam warhead was synthesized and ligated both chemically and chemoenzymatically to different pteridine mimics. …

Systems Level Analysis Of Organelle Biogenesis In Saccharomyces Cerevisiae, Kiandokht Panjtan Amiri

Arts & Sciences Graduate Student Theses and Dissertations

Eukaryotic cells contain hundreds of subcellular structures that serve different functions to maintain cellular homeostasis. A hallmark of Eukaryotic cells is its compartmentalization into membrane-bound organelles. One of the grand challenges in quantitative cell biology is understanding the precision with which cells assemble and maintain subcellular organelles. Despite identification of numerous molecular factors that regulate organelle sizes we lack insight into the quantitative principles underlying organelle size control. We examine organelle sizes from Saccharomyces cerevisiae and human iPS cells with mathematical theory to show that cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey …

Truncated Realized Variations Of Lévy Models: Optimality, Debiasing, And Implementation Approaches, Yuchen Han

Arts & Sciences Graduate Student Theses and Dissertations

Statistical inference for stochastic processes under high-frequency observations has been an active research area in econometrics and financial statistics for over twenty years. In this thesis, we consider some aspects related to the estimation of the volatility of an Itô semimartingale in the presence of Lévy-type jumps, which is of fundamental importance in derivatives pricing evaluation, risk management and portfolio allocation. The main technique we use is the Truncated Realized Variation (TRV) that is both rate- and variance-efficient, in the Cramer-Rao lower bound sense, when jumps are of bounded variation.Motivated by recent results that state that the optimal threshold parameter, …

Effects Of Surface Ligation On Charge Extraction From Wurtzite Cadmium Selenide Quantum Platelets And Quantum Belts, Hailey Meyer

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation presents the synthesis of flat, colloidal wurtzite CdSe quantum platelets and quantum belts for ligand exchange to novel and existing organic and inorganic L-, X-, and Z- type ligands. Use of these ligands in conjunction with the semiconductor nanocrystals allows for examination of their ligand exchange abilities, photoluminescence quenching efficiencies, and charge transfer properties.First, zinc and cadmium dithiocarbamate compounds [M(S2CNR1R2)2] are used as ligands on wurtzite CdSe quantum belts. Complete ligand exchange is achieved when the belts are initially ligated with Cd(oleate)2, a Z-type ligand, prior to the exchange, as opposed to n-octylamine or ammonia, which are both …

Utilizing An Α,Β-Unsaturated Dicarboxylic Acid For A Defect Initiated Residue Removal During Cu Post-Chemical Mechanical Planarization Cleaning, Abigail L. Dudek, Kiana A. Cahue, Adam T. Caridi, Tatiana R. Cahue, Jason J. Keleher

Chemistry Department Faculty Articles

The development of post-Chemical Mechanical Planarization (p-CMP) cleaning processes is critical for the continued miniaturization of Integrated Circuit (IC) and logic device architecture. In order for further extension of Moore’s Law the minimization of critical defects is essential. This work focuses on the development of surface-active cleaning chemistries via the implementation of an α, β-unsaturated dicarboxylic acid additive to create synergy at the liquid-brush-wafer interface. More specifically, the implementation of Itaconic Acid (ItA) will chemically activate an organic residue (i.e., Cu(I)-BTA film) resulting in effective removal at significantly reduced CoF. This work demonstrates that the conjugated structure present in ItA …

Cloud Container Security’ Next Move, Vishakha Sadhwani

Dissertations and Theses

In the last few years, it is apparent to cybersecurity experts everywhere that the proverbial container tech genie is out of the bottle, and has been widely embraced across multiple organizations. To achieve the flexibility of building and deploying applications anywhere and everywhere, cloud native environments have gained great momentum and made the development lifecycle simpler than ever. However, container environments brings with them a range of cybersecurity issues that includes images, containers, hosts, runtimes, registries, and orchestration platforms, which needs the necessity to focus on investing in securing your container stack.

According to this report[1], released by cloud-native …

Uv-Light-Tunable P-/N-Type Chemiresistive Gas Sensors Based On Quasi-1d Tis3 Nanoribbons: Detection Of Isopropanol At Ppm Concentrations, Victor V. Sysoev, Andrey V. Lashkov, Alexey Lipatov, Ilya A. Plugin, Michael Bruns, Dirk Fuchs, Alexey S. Varezhnikov, Mustahsin Adib, Martin Sommer, Alexander Sinitskii

Department of Chemistry: Faculty Publications

The growing demand of society for gas sensors for energy-efficient environmental sensing stimulates studies of new electronic materials. Here, we investigated quasi-one-dimensional titanium trisulfide (TiS₃) crystals for possible applications in chemiresistors and on-chip multisensor arrays. TiS₃ nanoribbons were placed as a mat over a multielectrode chip to form an array of chemiresistive gas sensors. These sensors were exposed to isopropanol as a model analyte, which was mixed with air at low concentrations of 1–100 ppm that are below the Occupational Safety and Health Administration (OSHA) permissible exposure limit. The tests were performed at room temperature (RT), as …

Predicted Episode Of Submarine Groundwater Discharge Onto The South Carolina, Usa, Continental Shelf And Its Effect On Dissolved Oxygen, Wilson S. Moore, Jacob Vincent, James L. Pickney, Alicia M. Wilson

Faculty Publications

Submarine groundwater discharge (SGD) may directly influence the dissolved oxygen (DO) content of coastal bottom waters. Here, we report a predicted episode of enhanced SGD that caused low DO concentrations on the South Carolina continental shelf. The prediction model linked episodes of SGD to upwelling-favorable winds. The data revealed these waters were a factor of 2–6 higher in ²²⁶Ra and ²²⁸Ra compared to typical bottom water values and were significantly depleted in DO (<130 μM). The tight ²²⁸Ra:²²⁶Ra correlation of these data was similar to values during a strong hypoxic event off SC in 2012. Water ages from …

Observation Of The Ξ_B^-→Λ_B^0 Π^- Decay And Measurement Of B(Ξ_B^-→Λ_B^0 Π^-), Zhuoming Li

Dissertations - ALL

We present the first observation of the weak decay Ξ−b → Λ0b π−, which is mediated by an s → u ̄ud transitionwithin the Ξ_b^- baryon. The analysis uses a pp collision data sample at a center-of-mass energy of 13 TeV corresponding to 5.5 fb^(−1) of integrated luminosity. The sample of Λb0 baryons used in this analysis are reconstructed through their decays to Λ+c π− and Λ+c π−π+π−. From a fit to the Ξ−b → Λ0b π− mass spectrum, the Ξ−b → Λ0b π− decay is observed with a significance of 11.3 standard deviations, thus establishing observation of this decay. …

Uniqueness Of Steady State Positive Solutions To A General Elliptic System With Dirichlet Boundary Conditions, Joon Hyuk Kang

Faculty Publications

The purpose of this paper is to give conditions for the uniqueness of positive solution to a rather general type of elliptic system of the Dirichlet problem on a bounded domain Ω in Rⁿ. Also considered are the effects of perturbations on the coexistence state and uniqueness.

Computational Studies Of Dinuclear Catalytic Reaction Mechanisms, James Curtis Coombs Iii

Theses and Dissertations

Heterodinuclear and homodinuclear metal complexes with a direct metal-metal interaction offer the potential for unique catalysis due to cooperativity effects that impact reaction mechanisms, reactivity, and selectivity. Quantum-chemical density functional theory (DFT) calculations can directly examine the origin of dinuclear reactivity and selectivity effects. Chapter 1 provides a short overview of heterodinuclear and homodinuclear catalysts that have been experimentally and computationally examined. Chapter 2 reports our study using DFT methods to understand the mechanism and reactivity of a heterodinuclear Co-Zr catalyst with phosphinoamide ligands that catalyzes a Kumada coupling between alkyl halides and alkyl Grignards. Chapter 3 reports DFT calculations …

Does Science Need Intersubjectivity? The Problem Of Confirmation In Orthodox Interpretations Of Quantum Mechanics, Emily Adlam

Mathematics, Physics, and Computer Science Faculty Articles and Research

Any successful interpretation of quantum mechanics must explain how our empirical evidence allows us to come to know about quantum mechanics. In this article, we argue that this vital criterion is not met by the class of ‘orthodox interpretations,’ which includes QBism, neo-Copenhagen interpretations, and some versions of relational quantum mechanics. We demonstrate that intersubjectivity fails in radical ways in these approaches, and we explain why intersubjectivity matters for empirical confirmation. We take a detailed look at the way in which belief-updating might work in the kind of universe postulated by an orthodox interpretation, and argue that observers in such …

Wildfire Modeling With Data Assimilation, Andrew Johnston

Theses and Dissertations

Wildfire modeling is a complex, computationally costly endeavor, but with droughts worsening and fires burning across the western United States, obtaining accurate wildfire predictions is more important than ever. In this paper, we present a novel approach to wildfire modeling using data assimiliation. We model wildfire spread with a modification of the partial differential equation model described by Mandel et al. in their 2008 paper. Specifically, we replace some constant parameter values with geospatial functions of fuel type. We combine deep learning and remote sensing to obtain real-time data for the model and employ the Nelder-Mead method to recover optimal …

Powerful Yet Lonely: Is 3c 297 A High-Redshift Fossil Group?, Valentina Missaglia, Juan P. Madrid, Mischa Schirmer, Francesco Massaro, Alberto Rodríguez-Ardila, Carlos J. Donzelli, Martell Valencia, Alessandro Paggi, Ralph P. Kraft, Chiara Stuardi, Belinda J. Wilkes

Physics & Astronomy Faculty Publications

The environment of the high-redshift (z = 1.408), powerful radio-loud galaxy 3C 297 has several distinctive features of a galaxy cluster. Among them, a characteristic halo of hot gas revealed by Chandra X-ray observations. In addition, a radio map obtained with the Very Large Array shows a bright hotspot in the northwestern direction, created by the interaction of the active galactic nucleus (AGN) jet arising from 3C 297 with its environment. In the X-ray images, emission cospatial with the northwestern radio lobe is detected, and peaks at the position of the radio hotspot. The extended, complex X-ray emission observed …

Future Colorado River Basin Drought And Surplus, Rama Bedri, Thomas Piechota

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Historical and future drought and surplus periods in the Colorado River basin are evaluated based on eight climate scenarios. Unimpaired streamflow from 17 stations in the Colorado River are evaluated based on U.S. Geological Survey, Bureau of Reclamation, and Coupled Modeled Intercomparison Projection 5 downscaled data from 1950–2099. Representative Concentration Pathway (RCP) 4.5 and 8.5 emission scenarios are considered for four climate models (HadGEM2-ES, CNRM-CM5, CanESM2, MI-ROC5). Drought (surplus) quantities, magnitudes, severities, and water year flows are compared for the historical and future periods. Results indicate that there is a significant difference between the historical record and future projections. The …