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2016

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Articles 10471 - 10500 of 10847

Full-Text Articles in Physical Sciences and Mathematics

A Study On Singapore Haze, Bingtian Dai, Kasthuri Jayarajah, Ee-Peng Lim, Archan Misra, Shriguru Nayak Jan 2016

A Study On Singapore Haze, Bingtian Dai, Kasthuri Jayarajah, Ee-Peng Lim, Archan Misra, Shriguru Nayak

Research Collection School Of Computing and Information Systems

In 2015, Singaporean have experienced one of the worse air pollution crises in history. With datasets from a well-known photo sharing social network, we analyze how this haze affects Singaporean's daily life. We will share our preliminary results in this paper.


Salient Pairwise Spatio-Temporal Interest Points For Real-Time Activity Recognition, Mengyuan Liu, Hong Liu, Qianru Sun, Tianwei Zhang, Runwei Ding Jan 2016

Salient Pairwise Spatio-Temporal Interest Points For Real-Time Activity Recognition, Mengyuan Liu, Hong Liu, Qianru Sun, Tianwei Zhang, Runwei Ding

Research Collection School Of Computing and Information Systems

Real-time Human action classification in complex scenes has applications in various domains such as visual surveillance, video retrieval and human robot interaction. While, the task is challenging due to computation efficiency, cluttered backgrounds and intro-variability among same type of actions. Spatio-temporal interest point (STIP) based methods have shown promising results to tackle human action classification in complex scenes efficiently. However, the state-of-the-art works typically utilize bag-of-visual words (BoVW) model which only focuses on the word distribution of STIPs and ignore the distinctive character of word structure. In this paper, the distribution of STIPs is organized into a salient directed graph, …


An Extended Study On Addressing Defender Teamwork While Accounting For Uncertainty In Attacker Defender Games Using Iterative Dec-Mdps, Eric Shieh, Albert Xin Jiang, Amulya Yadav, Pradeep Varakantham, Milind Tambe Jan 2016

An Extended Study On Addressing Defender Teamwork While Accounting For Uncertainty In Attacker Defender Games Using Iterative Dec-Mdps, Eric Shieh, Albert Xin Jiang, Amulya Yadav, Pradeep Varakantham, Milind Tambe

Research Collection School Of Computing and Information Systems

Multi-agent teamwork and defender-attacker security games are two areas that are currently receiving significant attention within multi-agent systems research. Unfortunately, despite the need for effective teamwork among multiple defenders, little has been done to harness the teamwork research in security games. The problem that this paper seeks to solve is the coordination of decentralized defender agents in the presence of uncertainty while securing targets against an observing adversary. To address this problem, we offer the following novel contributions in this paper: (i) New model of security games with defender teams that coordinate under uncertainty; (ii) New algorithm based on column …


Investigating The Influence Of Offline Friendship On Twitter Networking Behaviors, Young Soo Kim, Felicia Natali, Feida Zhu, Ee-Peng Lim Jan 2016

Investigating The Influence Of Offline Friendship On Twitter Networking Behaviors, Young Soo Kim, Felicia Natali, Feida Zhu, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

We investigate the influence of offline friendship in three specific areas of Twitter networking behaviors: (a) network structure, (b) Twitter content and (c) interaction on Twitter. We observe some interesting findings through the empirical analysis of 2193 pairs of users who are online friends. When these pairs of users know each other offline, they are more likely to (1) respond to the online gesture of friendship from their friend, (2) share mutual online friends, (3) distribute and gather information in their friend’s Twitter network, (4) pay attention to their friend’s tweets, (5) post tweets that might be of interest to …


Posting Topics ≠ Reading Topics: On Discovering Posting And Reading Topics In Social Media, Wei Gong, Ee-Peng Lim, Feida Zhu Jan 2016

Posting Topics ≠ Reading Topics: On Discovering Posting And Reading Topics In Social Media, Wei Gong, Ee-Peng Lim, Feida Zhu

Research Collection School Of Computing and Information Systems

Social media users make decisions about what content to post and read. As posted content is often visible to others, users are likely to impose self-censorship when deciding what content to post. On the other hand, such a concern may not apply to reading social media content. As a result, the topics of content that a user posted and read can be different and this has major implications to the applications that require personalization. To better determine and profile social media users’ topic interests, we conduct a user survey in Twitter. In this survey, participants chose the topics they like …


Information Source Detection Via Maximum A Posteriori Estimation, Biao Chang, Feida Zhu, Enhong Chen, Qi. Liu Jan 2016

Information Source Detection Via Maximum A Posteriori Estimation, Biao Chang, Feida Zhu, Enhong Chen, Qi. Liu

Research Collection School Of Computing and Information Systems

The problem of information source detection, whose goal is to identify the source of a piece of information from a diffusion process (e.g., computer virus, rumor, epidemic, and so on), has attracted ever-increasing attention from research community in recent years. Although various methods have been proposed, such as those based on centrality, spectral and belief propagation, the existing solutions still suffer from high time complexity and inadequate effectiveness. To this end, we revisit this problem in the paper and present a comprehensive study from the perspective of likelihood approximation. Different from many previous works, we consider both infected and uninfected …


Demo: Real-World Deployment Of Seat Occupancy Detectors, Nguyen Huy Hoang Nguyen, Gihan Hettiarachchi, Youngki Lee, Rajesh Krishna Balan Jan 2016

Demo: Real-World Deployment Of Seat Occupancy Detectors, Nguyen Huy Hoang Nguyen, Gihan Hettiarachchi, Youngki Lee, Rajesh Krishna Balan

Research Collection School Of Computing and Information Systems

Detecting occupancy of seats in library is important for librarians to check seats’ usage, and for students to find available seats in crowded time. In our prior work [1], we presented in-lab micro benchmarks to show feasibility of capacitive sensing for seat occupancy detection. In this demo paper, we present larger scale real-world deployment of occupancy detection system and its performance.


Demo: Sound Localization Using Smartphone, Amit Sharma, Youngki Lee Jan 2016

Demo: Sound Localization Using Smartphone, Amit Sharma, Youngki Lee

Research Collection School Of Computing and Information Systems

Smartphones based sound direction estimation can be helpful in many situations. For example, a deaf person in a meeting room can look at the smartphone to find out which direction the speaker is in and then he can look in appropriate direction to read lips/gestures of the speaker. Many smartphones today come with two built-in microphones located at physically different positions. This difference in position can cause time difference of arrival (TDOA) of sound on both microphones. Value of TDOA for two microphones may vary depending on the location of sound source with respect to the smartphone. This time difference …


Friendship Maintenance And Prediction In Multiple Social Networks, Roy Ka-Wei Lee, Ee-Peng Lim Jan 2016

Friendship Maintenance And Prediction In Multiple Social Networks, Roy Ka-Wei Lee, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Due to the proliferation of online social networks (OSNs), users find themselves participating in multiple OSNs. These users leave their activity traces as they maintain friendships and interact with other users in these OSNs. In this work, we analyze how users maintain friendship in multiple OSNs by studying users who have accounts in both Twitter and Instagram. Specifically, we study the similarity of a user's friendship and the evenness of friendship distribution in multiple OSNs. Our study shows that most users in Twitter and Instagram prefer to maintain different friendships in the two OSNs, keeping only a small clique of …


Powerforecaster: Predicting Power Impact Of Mobile Sensing Applications At Pre-Installation Time, Chulhong Min, Youngki Lee, Chungkuk Yoo, Seungwoo Kang, Inseok Hwang, Junehwa Song Jan 2016

Powerforecaster: Predicting Power Impact Of Mobile Sensing Applications At Pre-Installation Time, Chulhong Min, Youngki Lee, Chungkuk Yoo, Seungwoo Kang, Inseok Hwang, Junehwa Song

Research Collection School Of Computing and Information Systems

Today's smartphone application (hereinafter 'app') markets miss a key piece of information, power consumption of apps. This causes a severe problem for continuous sensing apps as they consume significant power without users' awareness. Users have no choice but to repeatedly install one app after another and experience their power use. To break such an exhaustive cycle, we propose PowerForecaster, a system that provides users with power use of sensing apps at pre-installation time. Such advanced power estimation is extremely challenging since the power cost of a sensing app largely varies with users' physical activities and phone use patterns. We observe …


Smart Ambient Sound Analysis Via Structured Statistical Modeling, Jialie Shen, Liqiang Nie, Tat Seng Chua Jan 2016

Smart Ambient Sound Analysis Via Structured Statistical Modeling, Jialie Shen, Liqiang Nie, Tat Seng Chua

Research Collection School Of Computing and Information Systems

In this paper, we introduce a novel framework called SASA (Smart Ambient Sound Analyser) to support different ambient audio mining tasks (e.g., audio classification and location estimation). To gain comprehensive ambient sound modelling, SASA extracts a variety of acoustic features from different sound components (e.g., music, voice and background), and translates them into structured information. This significantly enhances quality of audio content representation. Further, distinguished from existing approaches, SASA’s multilayered architecture seamlessly integrates mixture models and aPEGASOS (adaptive PEGASOS) SVM algorithm into a unified classification framework. The approach can leverage complimentary strengths of both models. Experimental results based on three …


Iot+Small Data: Transforming In-Store Shopping Analytics And Services, Meera Radhakrishnan, Sougata Sen, Vigneshwaran Subbaraju, Archan Misra, Rajesh Balan Jan 2016

Iot+Small Data: Transforming In-Store Shopping Analytics And Services, Meera Radhakrishnan, Sougata Sen, Vigneshwaran Subbaraju, Archan Misra, Rajesh Balan

Research Collection School Of Computing and Information Systems

We espouse a vision of small data-based immersive retail analytics, where a combination of sensor data, from personal wearable-devices and store-deployed sensors & IoT devices, is used to create real-time, individualized services for in-store shoppers. Key challenges include (a) appropriate joint mining of sensor & wearable data to capture a shopper’s product level interactions, and (b) judicious triggering of power-hungry wearable sensors (e.g., camera) to capture only relevant portions of a shopper’s in-store activities. To explore the feasibility of our vision, we conducted experiments with 5 smartwatch-wearing users who interacted with objects placed on cupboard racks in our lab (to …


Press: Personalized Event Scheduling Recommender System (Demonstration), Hoong Chuin Lau, Aldy Gunawan, Pradeep Varakantham, Wenjie Wang Jan 2016

Press: Personalized Event Scheduling Recommender System (Demonstration), Hoong Chuin Lau, Aldy Gunawan, Pradeep Varakantham, Wenjie Wang

Research Collection School Of Computing and Information Systems

This paper presents a personalized event scheduling recom-mender system, PRESS, for a large conference setting with multiple parallel tracks. PRESS is a mobile application that gathers personalized information from a user and recommends talks/demos to be attend. The input from a user include a list of keyword preferences and (optionally) preferred talks. We use the MALLET topic model package to analyze the set of conference papers and classify them based on automatically identified topics. We propose an algorithm to generate a list of recommended papers based on the user keywords and the MALLET topics. An optimization model is then applied …


Data Analytics On Consumer Behavior In Omni-Channel Retail Banking, Card And Payment Services, Geng Dan Jan 2016

Data Analytics On Consumer Behavior In Omni-Channel Retail Banking, Card And Payment Services, Geng Dan

Research Collection School Of Computing and Information Systems

Innovations in financial services have created challenges for banks that Information Systems (IS) research can address. My interests involve transaction cost theory, substitution and complementarity theory, and consumer informedness theory to understand consumer behavior and firm performance in the omni-channel world of digital banking. At a high level, my research inquiry asks: How can financial institutions take advantage of the deep insights that data analytics and management science modeling create on consumer behavior and channel management decision-making? And how can changes in payments and services in retail banking be understood in spatial and temporal terms? I am working on three …


Online Arima Algorithms For Time Series Prediction, Chenghao Liu, Hoi, Steven C. H., Peilin Zhao, Jianling Sun Jan 2016

Online Arima Algorithms For Time Series Prediction, Chenghao Liu, Hoi, Steven C. H., Peilin Zhao, Jianling Sun

Research Collection School Of Computing and Information Systems

Autoregressive integrated moving average (ARIMA) is one of the most popular linear models for time series forecasting due to its nice statistical properties and great flexibility. However, its parameters are estimated in a batch manner and its noise terms are often assumed to be strictly bounded, which restricts its applications and makes it inefficient for handling large-scale real data. In this paper, we propose online learning algorithms for estimating ARIMA models under relaxed assumptions on the noise terms, which is suitable to a wider range of applications and enjoys high computational efficiency. The idea of our ARIMA method is to …


Object Pooling For Multimedia Event Detection And Evidence Localization, Ho Zhang, Chong-Wah Ngo, Chong-Wah Ngo Jan 2016

Object Pooling For Multimedia Event Detection And Evidence Localization, Ho Zhang, Chong-Wah Ngo, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

Multimedia event detection (MED) and evidence hunting are two primary topics in the area of multimedia event search. The former serves to retrieve a list of relevant videos given an event query, whereas, the latter reasons why and how much the degree a retrieved video answers that query. Common practices deal with these two topics in separate methods, however, in this paper, we combine MED and evidence hunting into a joint framework. We propose a refined semantical representation named object pooling which can dynamically extract visual snippets corresponding to the location of when and where evidences might appear. The main …


We Can Hear You With Wi-Fi!, Guanhua Wang, Yongpan Zou, Zimu Zhou, Kaishun Wu, Lionel M. Ni Jan 2016

We Can Hear You With Wi-Fi!, Guanhua Wang, Yongpan Zou, Zimu Zhou, Kaishun Wu, Lionel M. Ni

Research Collection School Of Computing and Information Systems

Recent literature advances Wi-Fi signals to “see” people’s motions and locations. This paper asks the following question: Can Wi-Fi “hear” our talks? We present WiHear, which enables Wi-Fi signals to “hear” our talks without deploying any devices. To achieve this, WiHear needs to detect and analyze fine-grained radio reflections from mouth movements. WiHear solves this micro-movement detection problem by introducing Mouth Motion Profile that leverages partial multipath effects and wavelet packet transformation. Since Wi-Fi signals do not require line-of-sight, WiHear can “hear” people talks within the radio range. Further, WiHear can simultaneously “hear” multiple people’s talks leveraging MIMO technology. We …


Top-K Dominating Queries On Incomplete Data, Xiaoye Miao, Yunjun Gao, Baihua Zheng, Gang Chen, Huiyong Cui Jan 2016

Top-K Dominating Queries On Incomplete Data, Xiaoye Miao, Yunjun Gao, Baihua Zheng, Gang Chen, Huiyong Cui

Research Collection School Of Computing and Information Systems

The top-k dominating (TKD) query returns the k objects that dominate the maximum number of objects in a given dataset. It combines the advantages of skyline and top-k queries, and plays an important role in many decision support applications. Incomplete data exists in a wide spectrum of real datasets, due to device failure, privacy preservation, data loss, and so on. In this paper, for the first time, we carry out a systematic study of TKD queries on incomplete data, which involves the data having some missing dimensional value(s). We formalize this problem, and propose a suite of efficient algorithms for …


Ambiguityvis: Visualization Of Ambiguity In Graph Layouts, Yong Wang, Qiaomu Shen, Zhiguang Zhou, Min Zhu, Sixiao Yang, Qu Huamin Jan 2016

Ambiguityvis: Visualization Of Ambiguity In Graph Layouts, Yong Wang, Qiaomu Shen, Zhiguang Zhou, Min Zhu, Sixiao Yang, Qu Huamin

Research Collection School Of Computing and Information Systems

Node-link diagrams provide an intuitive way to explore networks and have inspired a large number of automated graph layout strategies that optimize aesthetic criteria. However, any particular drawing approach cannot fully satisfy all these criteria simultaneously, producing drawings with visual ambiguities that can impede the understanding of network structure. To bring attention to these potentially problematic areas present in the drawing. this paper presents a technique that highlights common types of visual ambiguities: ambiguous spatial relationships between nodes and edges, visual overlap between community structures, and ambiguity in edge bundling and metanodes. Metrics, including newly proposed metrics for abnormal edge …


The Bou Dahar Jurassic Carbonate-Hosted Pb–Zn–Ba Deposits (Oriental High Atlas, Morocco): Fluid-Inclusion And C–O–S–Pb Isotope Studies, Larbi Rddad, Salah Bouhlel Jan 2016

The Bou Dahar Jurassic Carbonate-Hosted Pb–Zn–Ba Deposits (Oriental High Atlas, Morocco): Fluid-Inclusion And C–O–S–Pb Isotope Studies, Larbi Rddad, Salah Bouhlel

Publications and Research

The Bou Dahar Pb–Zn–Ba (±Sr) is hosted in the Lower and Middle Liassic carbonate platform in the oriental High Atlas of Morocco. The paragenetic sequence includes quartz–pyrite–melnicovite–sphalerite–galena– calcite–barite ± fluorite– ± celestite. Fluid-inclusion studies were conducted on sphalerite (early mineralizing stage) and barite, and celestite (late mineralizing stage). These studies reveal two end-member fluids, a hot (~143 °C) and saline fluid (~23 wt.% NaCl eq.) and a cooler (b50 °C) and diluted fluid (~5 wt.% NaCl eq.). Based on fluid-inclusion and C–O–S isotope studies, a conclusion is reached that the Bou Dahar ore deposits were formed by the mixing of …


An Extremal Problem For Finite Lattices, John Goldwasser, Brendan Nagle, Andres Saez Jan 2016

An Extremal Problem For Finite Lattices, John Goldwasser, Brendan Nagle, Andres Saez

Theory & Applications of Graphs

For a fixed M x N integer lattice L(M,N), we consider the maximum size of a subset A of L(M,N) which contains no squares of prescribed side lengths k(1),...,k(t). We denote this size by ex(L(M,N), {k(1),...,k(t)}), and when t = 1, we abbreviate this parameter to ex(L(M,N), k), where k = k(1).

Our first result gives an exact formula for ex(L( …


Towards An In-Vehicle Sonically-Enhanced Gesture Control Interface: A Pilot Study, Jason Sterkenburg, Steven Landry, Myounghoon Jeon, Joshua Johnson Jan 2016

Towards An In-Vehicle Sonically-Enhanced Gesture Control Interface: A Pilot Study, Jason Sterkenburg, Steven Landry, Myounghoon Jeon, Joshua Johnson

Department of Psychology and Human Factors Publications

A pilot study was conducted to explore the potential of sonically-enhanced gestures as controls for future in-vehicle information systems (IVIS). Four concept menu systems were developed using a LEAP Motion and Pure Data: (1) 2x2 with auditory feedback, (2) 2x2 without auditory feedback, (3) 4x4 with auditory feedback, and (4) 4x4 without auditory feedback. Seven participants drove in a simulator while completing simple target-acquisition tasks using each of the four prototype systems. Driving performance and eye glance behavior were collected as well as subjective ratings of workload and system preference. Results from driving performance and eye tracking measures strongly indicate …


Lifemusic: Reflection Of Life Memories By Data Sonification, Ridwan Ahmed Khan, Ram K. Avvari, Katherine Wiykovics, Pooja Ranay, Myounghoon Jeon Jan 2016

Lifemusic: Reflection Of Life Memories By Data Sonification, Ridwan Ahmed Khan, Ram K. Avvari, Katherine Wiykovics, Pooja Ranay, Myounghoon Jeon

Department of Psychology and Human Factors Publications

Memorable life events are important to form the present selfimage. Looking back on these memories provides an opportunity to ruminate meaning of life and envision future. Integrating the life-log concept and auditory graphs, we have implemented a mobile application, "LifeMusic", which helps people reflect their memories by listening to their life event sonifcation that is synchronous to these memories. Reflecting the life events through LifeMusic can relieve users of the present and have them journey to the past moments and thus, they can keep balance of emotions in the present life. In the current paper, we describe the implementation and …


The Optimization Of The Synthesis And Characterization Of Vapor-Liquid-Solid Grown Zno Nanowires, Silas R. Fiefhaus Jan 2016

The Optimization Of The Synthesis And Characterization Of Vapor-Liquid-Solid Grown Zno Nanowires, Silas R. Fiefhaus

Theses and Dissertations--Chemistry

ZnO nanowires are a promising material with great semiconductor properties. ZnO nanowires were prepared by carbothermal reduction and vapor-liquid-solid growth mechanism. Altering a variety of parameters ranging from mole to mole ratio of ZnO to C all the way to gas flow rate was examined. The nanowires were then characterized and their morphology examined under a SEM to observe what effect the parameter had on the morphology of the nanowires. From the experiments and the parameters tested it was observed that in order to produce the highest quality straight nanowires one should use a mole to mole ratio of ZnO …


Towards An Understanding Of The Role Of Cation Packaging On Dna Protection From Oxidative Damage, Cody E. Gay Jan 2016

Towards An Understanding Of The Role Of Cation Packaging On Dna Protection From Oxidative Damage, Cody E. Gay

Theses and Dissertations--Chemistry

In sperm chromatin, DNA exists in a highly condensed state reaching a final volume roughly twenty times that of a somatic nucleus. For the vast majority (>90%) of sperm DNA in mammals, somatic-like histones are first replaced by transition proteins which in turn are replaced by arginine-rich protamines. This near crystalline organization of the DNA in mature sperm is thought crucial for both the transport and protection of genetic information since all DNA repair mechanisms are shut down. Recent studies show that increased DNA damage is linked to dysfunctions in replacing histones with protamines resulting in mispackaged DNA. This …


Towards An Understanding Of Pharmacologically Induced Intracellular Changes In Nicotinic Acetylcholine Receptors: A Fluorescence Microscopy Approach, Ashley M. Loe Jan 2016

Towards An Understanding Of Pharmacologically Induced Intracellular Changes In Nicotinic Acetylcholine Receptors: A Fluorescence Microscopy Approach, Ashley M. Loe

Theses and Dissertations--Chemistry

Upregulation of nicotinic acetylcholine receptors (nAChRs) is a well-documented response to chronic nicotine exposure. Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels consisting of alpha (α2-10) and beta (β2-4) subunits. Nicotine, an agonist of nAChRs, alters trafficking and assembly of some subtypes of nAChRs, leading to an increase in expression of high sensitivity receptors on the plasma membrane. These physiological changes in nAChRs are believed to contribute to nicotine addiction, although the mechanism of these processes has not been resolved. Recently, many studies have converged on the idea that nicotine induces upregulation by an intracellular mechanism. In this dissertation, expression …


Organometallic Materials: Ferroceno[C]Thiophenes And 1,2-Bisthienylmetallocenes, Surya R. Banks Jan 2016

Organometallic Materials: Ferroceno[C]Thiophenes And 1,2-Bisthienylmetallocenes, Surya R. Banks

Theses and Dissertations--Chemistry

Development of synthetic routes toward two general organometallic frameworks was undertaken. The first project involved synthetic attempts of substituted and unsubstituted ferroceno[c]thiophene while the second one was the synthesis of 1,2-dithienylmetallocenes. The long-term goal of this work is to lay the foundations for study of electronic, electrochromic, redox, and optical properties of thiophene-based materials integrated with organometallic systems such as ferrocene, ruthenocene and cymantrene. The synthetic pathway for the target molecule in the first project involved converting 1,2-bis(hydroxymethyl)ferrocene to 1,2-bis(thiouroniummethyl)ferrocene with thiourea under acidic conditions. Refluxing the salt in base followed by acidification resulted in 1,2-bis(mercaptomethyl)ferrocene, which is …


Green Infrastructure In The Community Ratings System: A Proposed Path To National Flood Insurance Program Recognition, Kevin Macwhorter, Kathleen Zaratzian Jan 2016

Green Infrastructure In The Community Ratings System: A Proposed Path To National Flood Insurance Program Recognition, Kevin Macwhorter, Kathleen Zaratzian

Virginia Coastal Policy Center

No abstract provided.


Understanding Electrical Conduction In Lithium Ion Batteries Through Multi-Scale Modeling, Jie Pan Jan 2016

Understanding Electrical Conduction In Lithium Ion Batteries Through Multi-Scale Modeling, Jie Pan

Theses and Dissertations--Chemical and Materials Engineering

Silicon (Si) has been considered as a promising negative electrode material for lithium ion batteries (LIBs) because of its high theoretical capacity, low discharge voltage, and low cost. However, the utilization of Si electrode has been hampered by problems such as slow ionic transport, large stress/strain generation, and unstable solid electrolyte interphase (SEI). These problems severely influence the performance and cycle life of Si electrodes. In general, ionic conduction determines the rate performance of the electrode, while electron leakage through the SEI causes electrolyte decomposition and, thus, causes capacity loss. The goal of this thesis research is to design Si …


Design, Synthesis And Physicochemical Analysis Of Ruthenium(Ii) Polypyridyl Complexes For Application In Phototherapy And Nucleic Acid Sensing, Erin Melissa Wachter Jan 2016

Design, Synthesis And Physicochemical Analysis Of Ruthenium(Ii) Polypyridyl Complexes For Application In Phototherapy And Nucleic Acid Sensing, Erin Melissa Wachter

Theses and Dissertations--Chemistry

Current chemotherapeutics exhibit debilitating side effects as a result of their toxicity to healthy tissues. Reducing these side effects by developing chemotherapeutics with selectivity for cancer cells is an active area of research. Phototherapy is one promising modality for selective treatment, where drug molecules are “turned on” when irradiated with light, reducing damage to healthy tissues by spatially restricting the areas exposed to irradiation. A second approach to improve selectivity is to exploit the differences in cancerous versus healthy cells, such as increased metabolism and/or upregulation of cell surface receptors. Ruthenium(II) polypyridyl complexes are candidates for phototherapy due to their …