Physical Sciences and Mathematics Commons^™

Environmental Chemicals And Maternal Depression During And After Pregnancy: A Scoping Review, Pengfei Guo, Yunyue Shi, Cindy Nguyen, Haoran Zhuo, Tormod Rogne, Zeyan Liew

Faculty Publications

Purpose of Review

There is increasing evidence that several environmental exposures may pose a risk for depression, including maternal depression. We conducted a scoping review of epidemiological evidence regarding maternal exposure to environmental chemicals and perinatal depression.

Recent Findings

We searched PubMed, Embase, Web of Science, Dimensions, and Scopus, and summarized the findings from 27 articles that examined environmental chemical exposures and maternal depression. Studies of ambient air pollutants (N = 11) showed exposure to NO₂ and PM10 to be most consistently associated with antenatal or postnatal depression. Studies of endocrine-disrupting chemicals, including phthalates (n = 6), …

Limit Theorems For Andrews’ Restricted Overpartitions, Tapas Bhowmik, Alex Cao, Jack Frew, John Lehman, Wei-Lun Tsai

Faculty Publications

The study of overpartitions in recent years has been used to great effect in various fields, including hypergeometric series, q-series identities, and mathematical physics. We investigate the limiting distributions of the number of parts in a family of overpartitions of n,  introduced by Andrews, where parts are counted with two different weights. Using Andrews’ identities and the saddle-point method, we establish two central limit theorems (CLTs) for the number of parts as n → ∞, corresponding to these weightings. We also derive explicit formulas for the mean and variance in each case.

Vegetation Enhances Nitrogen Removal In Stormwater Ponds In Coastal South Carolina, Darcy Perin, Annie Bourbonnais

Faculty Publications

Coastal development and the increase in impervious surfaces lead to greater stormwater volumes, a key contributor to nonpoint source pollution. Stormwater ponds are generally highly efficient in eliminating particle-bound nutrients, such as phosphorus, but are often much less effective at removing dissolved nutrients, like nitrogen. Excess inorganic nitrogen can lead to coastal eutrophication, harmful cyanobacterial blooms, and coastal hypoxia. However, inorganic nitrogen can be removed from the environment through several different microbially facilitated processes. This research aims to estimate the rates of nitrogen removal (i.e., by denitrification), the net N₂ fluxes, and internal recycling (DNRA) across the sediment-water interface …

Assessing The Threat Of Southern Pine Beetle To Pitch Pine In Acadia National Park, Caroline R. Kanaskie, Mark J. Ducey, Jeff R. Garnas

Faculty Publications

Many of the mountain summits of Acadia National Park (ACAD) are dominated by Pinus rigida (Pitch Pine). The ACAD Pitch Pine population is particularly valuable due to its position at the northernmost edge of the species’ range, its association with unique animal and plant communities, and its contribution to the aesthetics of the park. Pitch Pine is host to Dendroctonus frontalis (Southern Pine Beetle [SPB]). As the name suggests, SPB is native to the southeastern US, and can kill large numbers of healthy pines via mass-attack. With warming winters, SPB can establish and persist further north than ever before, presenting …

The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang

Faculty Publications

The p53 tumor suppressor protein plays a central role in maintaining genomic stability by regulating cell cycle arrest, apoptosis, and DNA repair under cellular stress. Mouse double minute 2 (MDM2), an E3 ubiquitin ligase, negatively regulates p53 via direct binding and proteasomal degradation. Overexpression or amplification of MDM2 can disrupt this pathway and promote tumorigenesis, even in cancers with wild-type p53. This review outlines the structural features of MDM2, particularly its N-terminal hydrophobic pocket and C-terminal RING domain, and their roles in p53 regulation. We further examine the pathological effects of MDM2 dysregulation and SNPs linked to increased cancer risk. …

Understanding The 2016–2018 Freshening Dynamics Of The Beaufort Gyre Through Observations And Model Reanalysis, Christina Gregory, Ganesh Gopalakrishnan, Bulusu Subrahmanyam

Faculty Publications

The Beaufort Gyre (BG) in the Arctic Ocean has experienced rapid changes in losing extensive amounts of sea-ice and undergoing freshening over the past few decades. In this study, we highlight important recent changes in BG’s surface circulation, and its impact on freshwater (FW) fluxes and freshwater content (FWC) and draw attention to the critical importance of continuous monitoring of BG dynamics. Using satellite observations of the upper ocean state and ocean and atmospheric reanalysis, here we attempt to understand the anomalous behavior of BG dynamics over the past few decades. In recent years, atmospheric forcings increasingly influenced important judications …

Large Magnetoresistance And Quantum Oscillations Observed In Superconducting Β-Irsn4, Smita Speer, Yuriy V. Pershin, Joanna Blawat, John Singleton, Rongying Jin

Faculty Publications

Diverse quantum phenomena have been observed in TSn₄ transition metal (T) stannides, includ ing superconductivity, nontrivial topology, and large magnetoresistance (MR) at low temperat ures. Here, we report the experimental and theoretical investigation of tetragonal β-IrSn4 (space group I4₁/acd) with the lattice parameters a = 6.362(3) Å and c = 22.723(0) Å. The temperature dependence of the electrical resistivity indicates that β-IrSn₄ is a good metal with Fermi-liquid behavior above the superconducting transition at T_c ∼ 0.7 K. Magnetic susceptibility measure ments indicate it is non-magnetic. However, positive transverse MR with …

Ecologic Factors Contributing To West Nile Virus Hyperendemicity In Central South Carolina: An Integrated Vector–Human–Environmental Study, Elba S. Fridriksson, Ahayla Muraleedharan, Kyndall C. Dye-Braumuller, Madeleine M. Meyer, Kia Zellars, Hiuxuan Li, Melissa S. Nolan Ph.D., Mph

Faculty Publications

West Nile virus (WNV) is an endemic arboviral infection in the United States that has undergone phyloge-netic evolution since its introduction 25 years ago. An integrated vector–human–pathogen study was conducted in the summer of 2023 to unearth contemporary Culex quinquefasciatus habitat patterns and human transmission spillover foci in South Carolina, a state with historically little WNV data. A serosurvey revealed WNV seroprevalence 10 times the national average (22% versus 2%, respectively), with unusual epidemiologic risk factors. Female Culex quinquefas-ciatus WNV positivity was low (2.7%), with viral phylogenetics 100% homologous to the WN02 clade. Mosquito vectors clustered in affluent urban neighborhoods …

Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne

Faculty Publications

Conjugated thiophene-based diboronate esters, 1–4, were synthesized to investigate how substituents on catechol alter the Lewis acidity and accessibility to boron, and influence binding interactions with low molecular weight Lewis basic amines. Crystallographic analysis indicated that both boron centres bind analyte and that Lewis base coordination induces deplanarization of the conjugated system. Spectroscopic studies demonstrate that amine binding disrupts conjugation, producing distinct and reproducible optical responses that depend on analyte basicity and structure, with association constants in organic solvent ranging from 10³ to 10⁶ M⁻¹. Quantitative binding analyses indicate strong negative cooperativity between the two boron …

Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture

Faculty Publications

We report on the study of the immobilization process of non-radioactive rhenium (Re), a chemical analogue of technetium-99 (⁹⁹Tc), in compounds based on magnesium potassium phosphate (MKP), as well as the possibility of enhancing their properties with iron-bearing additives/fillers. Powdered Re2O7 was used as the initial Re-containing source. Because of the solubility and high leachability of Tc (VII), which is also volatile at high temperatures, its immobilization for long-term storage and disposal poses a serious challenge to researchers. Taking this into account, low-temperature stabilization technology based on MKP, a cementitious material, is currently considered promising. We prepared experimental …

Future Trends In Cybersecurity: A Meta-Review, Yara Mohammed, Manar Alsaid, Gahangir Hossain

Faculty Publications

The increasing importance of cybersecurity in protecting digital assets, data and infrastructures necessitates a reevaluation of research priorities within the discipline. As of today, numerous emerging cybersecurity topics are gaining significant importance in both academic research and industry applications. To identify recent trends in cybersecurity topics, this study extracts scholarly articles from two prestigious academic databases, the ACM Digital Library, and Google Scholar, covering the period from early 2015 to late 2024.Through a systematic identification of trends and focal points in cybersecurity research, a comprehensive analysis is facilitated, including Latent Dirichlet Allocation (LDA), Biterm Topic Modeling (BTM), keyword frequencies, and …

Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza

Faculty Publications

Purpose: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment—pressure–volume (PV) loop acquisition—is invasive and limited to specialized settings. This study aims to develop a patient-specific lumped-parameter model that quantifies vessel-specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data.

Methods: A lumped-parameter model was calibrated using right heart catheterization and echocardiography data. Model agreement was assessed by R2 values for pressure and flow goodness-of-fit, and model-derived hemodynamic metrics were comparedwith clinical values. A dimensionality reduction approach was …

Characterization Of Ru(Ii) Polypyridyl Photosensitizers Bound To Tio2 Supports Through A New Covalent Metal-Ester Bonding Motif, D. M. S. C. Dissanayake, Christopher T. Lebarron, Laura C. Maybach, Joseph J. Kuchta Iii, Seyyedamirhossein Hosseini, Aaron K. Vannucci

Faculty Publications

The development of photoelectrochemical (PEC) devices involves the attachment of molecular photosensitizers onto solid supports. Particularly significant to this work are PECs that rely on ruthenium-based photosensitizers on high band gap metal oxide (MOx) supports. In this study, we have explored a new ester binding motif (MOx-ester) to covalently attach a ruthenium polypyridyl photosensitizer to TiO₂. This new MOx-ester photoanode is compared to the traditional photoanodes that utilize acid/base binding groups to attach the molecular Ru sensitizers to TiO₂. The new MOx-ester binding motif is characterized by cyclic voltammetry UV-Vis, solid state ¹³C NMR, and …

The Age And Composition Of The Voyager Seamounts: Evidence For A Long-Lived Marquesas Mantle Source, Andrea Balbas, Hannah Paradis, Kevin Konrad, Valerie A. Finlayson, Michael Bizimis, Stephanie Anderson, Christopher Kelley, Nicole A. Raineault, Beth N. Orcutt

Faculty Publications

We present new observations on the dynamics and locations of deep mantle reservoirs derived from the ages and compositions of Voyager Seamount Chain lava flows. The previously unexplored Voyager Seamount Chain trends NW–SE between the Mid-Pacific Mountains and the Northwestern Hawaiian Ridge. Volcanic samples were recovered from the chain during the Ocean Exploration Trust expedition NA134. The lava flows are alkalic to highly alkalic in composition. Ages ranged from 81 to 86 Ma (n = 8), with the oldest ages in the NW and an age-progression toward the SE. The Voyager age-progression continues southward through the Northern Line Islands …

High Frobenius Pushforwards Generate The Bounded Derived Category, Matthew R. Ballard, Srikanth B. Iyengar, Pat Lank, Alapan Mukhopadhyay, Josh Pollitz

Faculty Publications

This work concerns generators for the bounded derived category of coherent sheaves over a noetherian scheme X of prime characteristic. The main result is that when the Frobenius map on X is finite, for any compact generator G of D(X) the Frobenius pushforward F^e_*G generates the bounded derived category whenever p^e is larger than the codepth of X, an invariant that is a measure of the singularity of X. The conclusion holds for all positive integers e when X is locally complete intersection. The question of when one can take G = …

Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group

Faculty Publications

Background/Objectives: Unhealthy lifestyles lead to chronic low-grade inflammation, increasing the risk of colorectal cancer. Few studies in East Asia have examined the association between the dietary inflammation potential and colorectal cancer incidence. Therefore, we aimed to investigate this association further in the Japanese population. Methods: This study included 38,807 men aged 45–74 years who participated in the Japan Public Health Center-based prospective study (JPHC Study). The energy-adjusted dietary inflammatory index (E-DII) was derived from a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Differences in risk due to a …

Crystal Structures, Optical Behavior, And Magnetic Properties In Hydrated Lanthanide Iron Sulfates, Chole Jones, Silu Huang, Tyler L. Spano, Eric A. Gabilondo, Mohammed Al-Fahdi, Kara Trim, Mary Douglas, Rongying Jin, Andrew Miskowiec, P. Shiv Halasyamani, Ming Hu, Jie Ling

Faculty Publications

Single crystals of LnFe(SO₄)₃(H₂O)₂ (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm; compounds 1–11) and LnFe(SO₄)₃(H₂O) (Ln = Tm, Yb, Lu; compounds 12–14) were synthesized under hydrothermal conditions. Single-crystal X-ray diffraction (SCXRD) analysis revealed that the dihydrated compounds (1–11) crystallize in centrosymmetric (CS) structures, with the lanthanide ions adopting eight-coordinate geometries. In contrast, the monohydrated compounds (12–14) exhibit noncentrosymmetric (NCS) structures, where the lanthanide ions are seven-coordinated. Vibrating sample magnetometry (VSM) confirmed that compounds 2, …

Gatos – Xi. Excess Dust Heating In The Narrow-Line Regions Of Nearby Agn Revealed With Jwst/Miri, Houda Haidar, David J. Rosario, Ismael García-Bernete, Almudena Alonso-Herrero, Anelise Audibert, Steph Campbell, Chris M. Harrison, Tiago Costa, Laura Hermosa Muñoz, Françoise Combes, Dimitra Rigopoulou, Claudio Ricci, Cristina Ramos Almeida, Enrica Bellocchi, Peter Boorman, Andrew Bunker, Richard Davies, Daniel Delaney, Tanio Díaz Santos, Federico Esposito, Enrique Lopez Rodriguez, Et. Al.

Faculty Publications

We present James Webb Space Telescope/Mid-Infrared Instrument imaging of eight nearby active galactic nuclei (AGN) from the GATOS (Galactic Activity, Torus, and Outflow Survey) survey to investigate the physical conditions of extended dust in their narrow-line regions (NLRs). In four galaxies (ESO 428–G14, NGC 4388, NGC 3081, and NGC 5728), we detect spatially resolved dust structures extending ∼100–200 pc along the NLR. In these systems, we find a strong link between the morphology of the dust, the radio ejecta, and the coronal [Si VI] emission, implying that dust carries imprints of the processes shaping the NLR. Using spatially resolved …

Pdr-Stgcn: An Enhanced Stgcn With Multi-Scale Periodic Fusion And A Dynamic Relational Graph For Traffic Forecasting, Jie Hu, Bingbing Tang, Langsha Zhu, Yiting Li, Jianjun Hu, Guanci Yang

Faculty Publications

Accurate traffic flow prediction is a core component of intelligent transportation systems, supporting proactive traffic management, resource optimization, and sustainable urban mobility. However, urban traffic networks exhibit heterogeneous multi-scale periodic patterns and time-varying spatial interactions among road segments, which are not sufficiently captured by many existing spatio-temporal forecasting models. To address this limitation, this paper proposes PDR-STGCN (Periodicity-Aware Dynamic Relational Spatio-Temporal Graph Convolutional Network), an enhanced STGCN framework that jointly models multi-scale periodicity and dynamically evolving spatial dependencies for traffic flow prediction. Specifically, a periodicity-aware embedding module is designed to capture heterogeneous temporal cycles (e.g., daily and weekly patterns) and …

Proposed Methodology For Correcting Fourier-Transform Infrared Spectroscopy Field-Of-View Scene-Change Artifacts, Kody A. Wilson, Michael L. Dexter, Benjamin F. Akers, Anthony L. Franz

Faculty Publications

Fourier-transform spectrometers are widely used for spectral measurements. Changes in the field of view during measurement introduce oscillations into the measured spectra known as scene-change artifacts. Field-of-view changes also introduce uncertainty about which target the measured spectrum represents. Though scene-change artifacts are often present in dynamic data, their significance is disputed in the current literature. This work presents a theoretical framework and experimental validation for scene-change artifacts. Field-of-view changes introduce variable interferogram offsets, which standard processing techniques assume are constant. The error between the interferogram offset and its estimate is Fourier-transformed, yielding scene-change artifacts, often confused with noise, in the …

First Results On The Search For Lepton Number Violating Neutrinoless Double-Β Decay With The Legend-200 Experiment, H. Acharya, N. Ackermann, M. Agostini, A. Alexander, C. Andreoiu, G. R. Araujo, Frank Avignone Iii, M. Babicz, W. Bae, A. M. Bakalyarov, M. Balata, A. S. Barabash, C. J. Barton, L. Baudis, C. Bauer, E. Bernieri, L. Bezrukov, K. H. Bhimani, V. Biancaccu, E. Blalock, Et. Al.

Faculty Publications

The LEGEND Collaboration is searching for neutrinoless double-beta (0νββ) decay by operating high-purity germanium detectors enriched in ⁷⁶Ge in a low-background liquid argon environment. Building on key technological innovations from the GERmanium Detector Array (GERDA) experiment and the MAJORANA DEMONSTRATOR experiment, LEGEND-200 has performed a first 0νββ decay search based on 61.0 kg yr of data. Over half of this exposure comes from our highest performing detectors, including newly developed inverted-coaxial detectors, and is characterized by an estimated background level of 0.5^+0.3_−0.2 cts/(keV ton yr) in the 0νββ decay signal region. A combined …

Chasing Disinfection Byproducts Through The Pipes: How 66 Dbps Change Over Time In Chlorinated Vs. Chloraminated Distribution Systems, Erik Niehaves, Patrick T. Justen, Ashley A. Perkins, Alexandria L.B. Forster, Caroline O. Granger, Susan D. Richardson

Faculty Publications

While disinfection byproducts (DBPs) are typically measured at drinking water treatment plants, levels can change dramatically within the distribution system before reaching the consumer. In this study, the spatio-temporal trends of 66 DBPs across 9 different classes were examined in two drinking water distribution systems with similar source waters, but different pretreatments and residual disinfectants. One system uses residual chlorine in the distribution system, and the other uses chloramine, allowing for examination of how DBP concentrations change over time in distribution systems with different residual disinfectants. Four routes were sampled for each system with six time points over three days …

Protocol For The Development Of The Who Gestational Weight Gain Charts, Thais Rangel Bousquet Carrilho, Olufemi Taiwo Oladapo, Jennifer A. Hutcheon, Giovanna Gatica-Domínquez, Kathleen M. Rasmussen, Monica C. Flores-Urrutia, Richard Kumapley, Ӧzge Tunçalp, Dang Bahya-Batinda, Amel A. Fayed, Annick Bogaerts, Aris T. Papageorghiou, Cinthya Muñoz-Manrique, Dayana Rodrigues Farias, Eric Ohuma, Harshpal Sachdev, Hayfaa A. Wahabi, Helena J. Teede, Molin Wang, Nandita Perumal Phd

Faculty Publications

Introduction Gestational weight gain (GWG) is an important indicator of maternal nutrition to be monitored during pregnancy. However, there is no evidence-based tool that can be used to monitor it across all geographic locations and pre-pregnancy body mass index (BMI) categories. The WHO is undertaking a project to develop GWG charts by pre-pregnancy BMI category, and to identify GWG ranges associated with the lowest risks of adverse maternal and infant outcomes. This protocol describes all the steps that will be used to accomplish the development of these GWG charts.

Methods and analysis This project will involve the analysis of individual …

Optimized Photoemission From Organic Molecules In 2d Layered Halide Perovskites, Muhammad S. Muhammad, Dilruba A. Popy, Hamza Shoukat, John M. Lane, Neeraj Rai, Vojtěch Vaněček, Zdeněk Remeš, Romana Kučerková, Vladimir Babin, Chenjia Mi, Yitong Dong, Mark D. Smith, Novruz G. Akhmedov, Daniel T. Glatzhofer, Bayram Saparov

Faculty Publications

In recent years, hybrid organic–inorganic metal halides have been at the forefront of materials research. Typically, the functional (e.g., optoelectronic) properties of hybrid halides are derived from the inorganic structural part, whereas the organic structural units can add extra advantages in terms of stability, rigidity, and processability. Here, we report the design, synthesis, and characterization of two new hybrid materials in which the outstanding photophysical properties originate from the organic structural part. The new compounds, (C₁₅H16N)₂CdCl₄ and((Br)C₁₅H₁₅N)₂CdCl₄, have 2D layered Ruddlesden–Popper-type perovskite structures. These hybrids are blue-white …

Jwst Interferometric Imaging Reveals The Dusty Torus Obscuring The Supermassive Black Hole Of Circinus Galaxy, Enrique Lopez Rodriguez, Joel Sanchez-Bermudez, Omaira González-Martín, Robert Nikutta, Ryan M. Lau, Deepashri Thatte, Julien H. Girard, Ismael García-Bernete, Matthew J. Hankins

Faculty Publications

The dusty and molecular torus is an elusive structure surrounding supermassive black holes, yet its importance is unequivocal for understanding feedback and accretion mechanisms. The torus and accretion disk feed the inspiraling gas onto the active nucleus, launching outflows that fundamentally connect the active nucleus’s activity to the host galaxy. In this work, we utilize the aperture-masking interferometric mode onboard the JWST to achieve a resolution of 0.08" at 4.3 μm and bring out the fainter features in the central 10 pc of the Circinus galaxy. We show that most of the dust mass is located along the equatorial …

A Comparison Of Modeled Daytime E Regions From E-Probed And Pyiri With Ionosonde Observations, Daniel J. Emmons, Cornelius C. J. H. Salinas, Dong L. Wu, Nimalan Swarnalingam, Eugene V. Dao, Jorge L. Chau, Yosuke Yamazaki, Kyle E. Fitch, Victoriya V. Forsythe

Faculty Publications

While the F region is the primary focus of many ionospheric models because it contains the peak electron density, the E region is an important region for ionospheric conductivities and high-frequency radio propagation. This study analyzes modeled E regions from the newly developed PyIRI and E-PROBED models. A long-term comparison of E region predictions from E-PROBED and PyIRI with ionosonde observations is performed for three sites spanning low- (Fortaleza, Brazil), mid- (El Arenosillo, Spain), and high-latitudes (Gakona, Alaska). Modeled foE and hmE trends are compared against a combination of manually-scaled and automatically-scaled ionograms using ARTIST-5 for the period 2009–2024 for …

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …

Sociodemographic And Hiv-Related Characteristics Associated With Mental Health Diagnoses Among People Living With Hiv, Monique J. Brown Ph.D., Mph, Jiayang Xiao, Xueying Yang Ph.D., Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Mental health diagnoses have been linked to poor HIV treatment outcomes and poorer quality of life among people living with HIV (PLWH). Therefore, this study aimed to investigate the association between sociodemographic and HIV-related characteristics, and common and serious mental health disorders among PLWH in South Carolina (SC). Data were obtained from the integrated system of statewide electronic health record (EHR) data in SC (2006–2019; N = 8,124). Multivariable logistic regression models were used to determine the associations between sociodemographic and HIV-related characteristics, and common mental health disorders and serious mental health disorders. Among the study population, 4% were 60 …

Tectonic Implications Of Transitional Melting Regimes From Petrological, Geochronological, And Compositional Characterization Of The Ophiolitic Seventymile Terrane, Alaska, Usa, Erin Todd, Johnathan Saul Caine, Michael Bizimis, Andrew R.C. Kylander-Clark, Robert Reece Hammond, Alicja Wypych

Faculty Publications

New geochemical, U-Pb geochronology, and Sr-Nd-Hf isotope data provide evidence for the tectonic evolution of the Seventymile terrane in interior Alaska, USA. Ultramafic and mafic rocks of the Seventymile terrane are thought to represent components of a dismembered ophiolite and provide unique constraints on regional terrane evolution and accretion. The Seventymile ophiolite represents fragments of the Devonian to Permian Slide Mountain Ocean (SMO) that separated allochthonous and parautochthonous continental fragments of western North America. It now occurs as multiple thrust sheets containing Permian mafic and ultramafic rocks overlying and/or possibly imbricated with amphibolite-facies supracrustal rocks of allochthonous Yukon-Tanana terrane and …

Multiple Myeloma Risk Linked To Dna Damage Response Genes, Michael Conry, Irina Ostrovnaya, Yelena Kemel, Saloni Sinha, Linda B. Baughn, Brian Avery, Kylee Maclachlan, Victoria Groner, Lauren Banaszak, Aaron Norman, Nicholas J. Boddicker, Alyssa I. Clay-Gilmour Ph.D., Shaji Kumar, Ellen Kim, Sita Dandiker, Mitul Waghmare, Susan Slager, Douglas Sborov, Judy Garber, Elizabeth E. Brown, Michelle Hildebrandt, Et. Al.

Faculty Publications

Background DNA damage response genes (DDRG), implicated in several cancers as both predisposing risk factors as well as biomarkers for aggressiveness, have not been fully explored in multiple myeloma (MM).

Methods Herein, we analyzed disease associations of pathogenic variations in nine putative candidate genes using 3 446 MM cases and 323 233 cancer-free controls.

Results Increased MM risk was found to be associated with inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A, with an enrichment of these variants among individuals with early onset or family history of MM. Individuals with TP53 or ATM germline mutations are also …