Physical Sciences and Mathematics Commons^™

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Analogy2kg: An Automatic Pipeline For Deriving Knowledge Graphs From Long-Text Analogies, Kara Combs, Lance E. Champagne, Bruce A. Cox, Christine M. Schubert Kabban, Trevor Bihl, Grace Lemming

Faculty Publications

Analogical reasoning is an increasingly popular, lightweight solution to enable large language model (LLM)-level reasoning without computational complexity. Still, it has yet to be adopted due to its reliance on strictly hand-formatted data. Therefore, we propose Analogy2KG (“Analogy to Knowledge Graph”), as an automatic pipeline that transforms text into a KG format via a fine-tuned version of information extraction (IE) algorithms for long-text analogies. The need to verify that the complex underlying analogical structure of the data is maintained was done via paired samples tests in the creation and validation of this pipeline. Graph density was used to evaluate the …

New Avenues For |Δb=2| Processes Beyond Neutron-Antineutron Oscillations, Arnau Basi Beneito, Svjetlana Fajfer, Alexey A. Petrov

Faculty Publications

We explore baryon-number-violating (|∆B| = 2) processes beyond the well-known neutron-antineutron (n-n̄) oscillations, focusing on the Λ-Λ̄ system. The presence of a strange quark in the Λ baryon introduces a new set of six-quark operators roughly of the form (uds)², which are different from the (udd)² operators responsible for n-n̄ oscillations. Using the Standard Model Effective Field Theory (SMEFT), we classify all dimension-9 operators that cause |∆B| = 2  transitions and study their UV completions mediated by exotic scalar fields with trilinear interactions. We demonstrate that …

Efficient Energy-Stable Discontinuous Galerkin Schemefor The Non-Isothermal Cahn–Hilliard–Navier–Stokestwo-Phase Fluid Flow System, Guang-An Zou, Meiting Wang, Kejia Pan, Yin Yang, Xiaofeng Yang

Faculty Publications

In this article, we propose a novel numerical framework for the non-isothermal Cahn–Hilliard–Navier–Stokes two-phase flow system, which couples the incompressible Navier–Stokes equations, the Cahn–Hilliard phase-field equation, and the heat transport equation to capture temperature-dependent two-phase flow dynamics. The pro-posed scheme achieves three major advances: (i) unconditional energy stability through a combined scalar auxiliary variable (SAV) and zero-energy-contribution (ZEC) approach, (ii) linearity and full decoupling of all variables while using a second-order temporal discretization, and (iii) efficient implementation via discontinuous Galerkin (DG) spa-tial discretization together with a second-order projection method for the Navier–Stokes equations. We rigorously prove the unconditional energy stability …

Congruence Properties Modulo Prime Powers For A Class Of Partition Functions, Matthew Boylan, Swati .

Faculty Publications

Let p be prime, and let p_[1,p](n) denote the function whose generating function is

∏ _n≥1 (1 − qⁿ)⁻¹ (1 − q^pn)⁻¹.

This function and its generalizations p_[c^r,d^m](n) are the subject of study in several recent papers. Let ℓ ≥ 5, let j ≥ 1, and let p ∈ {2, 3, 5}. In this paper, we prove that the generating function for p_[1,p](n) in the progression β_{p,ℓ,j …}

Ulk4 And Cdkn2a Polymorphisms Influence The Risk Of Developing Monoclonal Gammopathy Of Undetermined Significance, José Manuuel Sánchez-Maldonado, Angelica Macauda, Antonio José Cabrera-Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany Van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz-Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero-Fernández, Elena Cabezudo, Fernando Reyes-Zurita, Alyssa I. Clay-Gilmour, Et. Al.

Faculty Publications

Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six independent cohorts, five from Europe and one from North America, comprising 2317 MGUS cases and 282,358 controls. We also assessed their impact on immune parameters, including absolute counts of 91 blood-derived immune cell subsets and 103 circulating immunological proteins. Meta-analysis revealed a genome-wide significant association between the ULK4 …

Impact Of Medicaid Enrollment Timing On Tumor Stage At Diagnosis And Survival In Breast, Colorectal, And Lung Cancer, Gabriel A. Benavidez, Stella Coker Watson Self Ph.D., Ms, Anthony Alberg Ph.D., M.P.H., Janice Probst, Jan Marie Eberth

Faculty Publications

Background: Medicaid-insured patients experience higher rates of late-stage cancer diagnosis and worse survival than non-Medicaid patients. The impact of Medicaid enrollment timing on cancer outcomes is less clear. This study examines the association between Medicaid enrollment and timing with tumor stage and cancer-specific survival for breast, colorectal, and lung cancers. Methods: We analyzed SEER-Medicaid linked data for 276,755 breast, 104,784 colorectal, and 101,058 lung cancer patients < 65 years of age. Patients were categorized as non-Medicaid enrollees, pre-diagnosis enrollees (≥12 months before), or post-diagnosis enrollees (≤12 months after). Multivariable logistic regression estimated odds ratios of late-stage diagnosis, and cause-specific Cox proportional hazards models were used to assess cancer-specific survival, adjusting for demographic and socioeconomic factors. Results: Compared to non-Medicaid enrollees, post-diagnosis enrollees had the highest odds of late-stage diagnosis (breast cancer: OR: 3.41; colorectal cancer: OR: 3.78; lung cancer: OR: 1.87). Pre-diagnosis enrollees also had increased odds, but the …

Characterizing Atmospheric Turbulence With The Lunar Step Response Method, Patrick D. Carattini, Caleb J. Stilp, Katelyn M. Atkinson, Stephen C. Cain

Faculty Publications

Most methods that astronomers use to characterize the strength of atmospheric turbulence in and around their observatories use differential image motion monitors observing a star to provide the necessary data for the measurement. With the Moon becoming a greater national priority, the need to characterize atmospheric paths between observatories on Earth and the Moon is potentially going to grow in the future. To this end, the differential image motion monitor is not an ideal instrument for characterizing turbulence along paths between observatories and the Moon as the bright Moon makes it difficult to detect and locate stars in its vicinity. …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Rural–Urban Differences In Cognitive Outcomes Among Older Adults: The Roles Of Falls And Depressive Symptoms, Ayse Malatyali, Tom Cidav, Lisa A.K. Wiese, Jian Zou, Monique J. Brown Ph.D., Mph, Junfeng Ma, Breno S. Diniz, Ladda Thiamwong

Faculty Publications

Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the association of falls and depressive symptoms with cognitive impairment and dementia in a nationally representative sample. Methods: We analyzed data from 6221 participants (age ≥ 65) in the Health and Retirement Study (HRS) from the 2018–2020 waves, using Multinomial logistic regression models. Measures included the HRS health status questionnaire, HRS cognition scale, and the Center for Epidemiological Studies Depression scale. Results: Prevalence of fall exposure across …

Main-Chain Ion-Pair Polybenzimidazole Membranes Enabling Reduced-Temperature Ht-Pemfc Operation (Down To 120°C), Huina Lin, Brian C. Benicewicz

Faculty Publications

Proton exchange membrane (PEM) fuel cells are promising for clean and efficient energy conversion across diverse applications. High-temperature PEM fuel cells (HT-PEMFCs) using phosphoric acid (PA)-doped polybenzimidazole (PBI) can operate up to 200°C, but at lower temperatures, water-induced PA loss often leads to performance degradation and reduced durability. In this work, we present a new class of main-chain ion-pair PBI membranes by integrating the imidazolium-biphosphate ion-pair units directly into the PBI backbone. This design results in membranes with high acid content, stronger acid-polymer interactions and stabilized acid retention. In single-cell tests, the Im⁺-PBI15-3 wt.% exhibits peak power densities …

Generation Of Inner Core Anisotropy By Anisotropic Thermal Conductivity Of Iron Crystals, Prajna Paramita Das, Bruce Buffett, Daniel A. Frost

Faculty Publications

Seismic anisotropy in the Earth’s inner core refers to the observation that seismic waves travel faster along the Earth’s rotation axis than in the equatorial plane, a feature inferred from decades of global seismological observations. This directional dependence of wave speeds provides important clues about the structure, composition and dynamics of the inner core. Here we explore a coupled thermo-mechanical mechanism for the generation of inner core anisotropy, focusing on the effects of anisotropic thermal conductivity in iron crystals as the inner core cools. We propose that the higher thermal conductivity of iron along the crystallographic c-axis compared with …

Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta

Faculty Publications

Introduction: 

Stated aims for digital healthcare transformation frequently cite goals for better coordinated patient-centric systems. However, despite advances in medical science, digital technologies, health policies, and billions of dollars invested over the past 25 years, most healthcare providers are far from fully realizing the demonstrated benefits of today's digital technologies for improving patient care. Sharing information across healthcare systems remains challenging. Problems with fragmentation, quality, inequities, and rising costs of care delivery persist. A recent study of 1,026 U.S. hospital systems found that only 15.8 percent achieved a digital maturity level needed to provide digitally enabled healthcare services to better …

Complex Spin Structure In Co-Trimer-Chain Li2Co3Se4O12, Jie Xing, Feng Ye, Daniel Duong, Sai Mu, Max T. Pan, Rongying Jin

Faculty Publications

Complex magnetic materials are extremely attractive for revealing unconventional spin states and novel magnetic excitations. Here, we report the structural, thermodynamic, and magnetic properties of a novel magnetic material Li₂Co₃Se₄O₁₂based on x-ray and neutron diffraction, specific heat, magnetization, and x-ray photoelectron spectroscopy measurements. X-ray and neutron diffraction refinements reveal two Co sites Co (1) and Co (2) even though both are in the octahedral environment. While they are not connected along the b and c directions, these octahedra are edge-shared forming the Co (2) – Co (1) – Co (2) trimer chain …

Ecology And Life History Of Baleen Whales Inform Climate Change Vulnerabilities And Priorities For Future Monitoring, Lesley H. Thorne, Erin L. Meyer-Gutbrod

Faculty Publications

Baleen whales are key consumers in marine habitats that serve as vectors of nutrients, but their populations have been slow to recover from past commercial whaling due to their low reproductive rates and ongoing anthropogenic threats. Climate impacts have become central to the demography and habitat use of baleen whales, and conservation efforts must account for these impacts to be effective. However, knowledge of baleen whale climate responses is lacking, and current survey effort is insufficient to capture changes in migration and habitat use for many species. Due to their unique combination of ecological and life history characteristics, baleen whales …

Transfer Learning Neural Networks For Nuclear Forensic Image Morphology Using Image Splitting Techniques, Niko A. Petrocelli, Lee C. Lambert, Brett J. Borghetti, Abigail A. Bickley

Faculty Publications

Manual morphological analysis of actinide particles from scanning electron microscope (SEM) imagery is a critical component of nuclear forensics but is prone to significant inter-analyst variability. To address this challenge, this work develops and evaluates an automated classification method using deep learning. We introduce a methodology based on partitioning 1906 SEM images, representing 13 classes of uranium compounds, into smaller patches for analysis. Three convolutional neural network (CNN) architectures of increasing complexity were compared: a custom baseline CNN, a simple transfer learning model using ResNet50v1, and a complex model featuring hierarchical feature extraction and a spatial attention mechanism built upon …

Dynamic Magnetic Null Behavior In Planar Ion Diodes: Particle-In-Cell Analysis Of Field Oscillations And Ion Beam Dynamics, Jesse C. Foster, Stephen B. Swanekamp, Paul F. Ottinger

Faculty Publications

Particle-in-cell simulations of a 1.75 MV, 375 kA, and 50 ns planar pinched-beam diode reveal that the strongest gigahertz-frequency oscillations in electric field and ion current arise from the dynamic motion of the magnetic null near the anode tip. These oscillations, which appear when the ion transit time becomes comparable to the local field-variation timescale, periodically expand the effective anode–cathode gap and generate bursts of over-accelerated ions. The resulting ion energy spectrum broadens substantially near the null while maintaining excellent beam uniformity along the anode. The simulations, therefore, demonstrate a direct physical linkage between ion transit time instability and magnetic …

Does Genetic Testing Influence Outcomes: Early Experience In Melanoma Case Series, Ryan Reyes, George Skenteris, Stella Coker Watson Self Ph.D., Ms, Christine Marie-Gilligan Schammel, Steven D. Trocha

Faculty Publications

Background:

The treatment and prognosis of melanoma have historically been based on histologic stage and Breslow depth; however, due to the increase in surveillance, melanomas are being identified at an earlier stage and lower Breslow depth. Advances in genetic testing, such as Decision Dx®, mean that melanoma diagnostic decisions and prognosis can now be directed by genetics. The purpose of this project was to assess the influence of a Decision Dx® high-grade (Class 2A/B) classification on the treatment of melanoma patients at a regional medical center, particularly those not deemed high risk by conventional classification methods, including Breslow depth and …

Experiments Towards A Neutron Target For Measurements In Inverse Kinematics, S. F. Dellmann, Caroline M. Harrington, O. R. Cantrell, A. L. Cooper, A. Couture, D, V, Gorelov, I Knapová, S. M. Mosby, R. Reifarth, A. Alvarez, A. Aprahamian, J. Butz, I. J. Bos, Michael T. Febbraro, T. Hankins, B. M. Harvey, T. Heftrich, M. Le, Juan J. Manfredi, A. B. Mcintosh, K. V. Manukyan, M. Matney, S. Regener, D. Robertson, A. Simon, D. Sokolovic, E. Stech, G. Tabacaru, W. Tan, M. Wiescher, S. Yennello

Faculty Publications

Neutron-induced reactions play an important role in fundamental nuclear physics, nuclear astrophysics, and applications. In the case of reactions on rare isotopes, there are limited options for direct experimental measurements. The Neutron Target Demonstrator project at Los Alamos National Laboratory seeks to test the feasibility of moderating spallation neutrons within a 1 m³graphite cube to create a standing neutron target for neutron-induced reaction measurements in inverse kinematics. This paper presents the results of experimental neutron flux distribution tests using neutron sources (ranging from 1 keV to 50 MeV) created by accelerators at the University of Notre Dame and …

Exosome Engineering For Blocking Gut Dysbiosis And Inducing Cell Death Mechanisms In Glioblastoma Multiforme, Ahalya Muraleedharan, Karthik Rangavajhula, Swapan K. Ray

Faculty Publications

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults. Emerging evidence endorses that gut dysbiosis contributes to GBM progression through the gut–brain axis (GBA), promoting inflammation and therapeutic resistance via abnormal short-chain fatty acid production and cytokine dysregulation. Exosomes, naturally occurring nanovesicles (30–150 nm), offer promising therapeutic potential due to their blood–brain barrier permeability, biocompatibility, and versatile cargo capacity. This review examines exosome engineering strategies for dual targeting: inhibiting alterations in gut microbiome and inducing regulated cell death mechanisms such as apoptosis and ferroptosis in GBM. We describe exosome engineering with detailed focus on cargo loading approaches …

Egain Tube Memristors Offering Reliable Switching On A Biological Time Scale, Yuriy V. Pershin, Liya Patel, Bapi Bera, Doug Aaron, Stephen A. Sarles

Faculty Publications

Memristive devices have been considered promising candidates for nature-inspired computing and in-memory information processing. However, experimental devices developed to date typically show significant variability and function at different time scales than biological neurons and synapses. This study presents a memristive device comprised of liquid-metal eutectic gallium indium (EGaIn) contained within a mm-scale tube that operates via a bulk, voltage-dependent switching mechanism and exhibits distinct unipolar resistive switching characteristics that occur on a biological time scale (tens of milliseconds). The switching mechanism involves voltage-controlled growth and dissolution of an oxide layer on the surface of the liquid metal in contact with …

Discovery Of Dynamical Structures Mapping Chaotic Transport Pathways In The Earth–Moon Cr3bp, Tyler J. Kapolka, Christina E. Paljug, Robert A. Bettinger, Rachel Oliver, Bruce A. Cox, Jeremiah A. Specht

Faculty Publications

Chaos; Deterministic chaos; Earth–Moon system; Poincaré map; Quasi-chaotic; Surface of section /// For the Circular Restricted 3-Body Problem (CR3BP), the topologies present within a Poincaré map enable the extraction of useful information regarding periodic, quasi-periodic, and chaotic trajectory behavior. Aside from the prominent topologies that follow distinct concentric patterns around fixed points, indicative of the periodic and quasi-periodic motion that is often the central focus of CR3BP research, there are also many “dusty” regions on the Poincaré map that appear random without an apparent structure and are indicative of chaotic motion. This paper, for the first time in literature, identifies …

The Detection Of Marine Microseismic Activity With The Cuore Tonne-Scale Cryogenic Experiment, D. Q. Adams, C. Aldunio, K. Alfonso, A. Armatol, Frank Avignone Iii, O. Azzolini, G. Bari, F. Bellini, G. Benato, M. Beretta, C. Bucci, J. Camilleri, A. Caminata, A. Campani, J. Cao, C. Capelli, S. Capelli, L. Capelli, J. Capelli, A. Caminata, Et. Al.

Faculty Publications

Vibrations from experimental setups and the environment are a persistent source of noise for low-temperature calorimeters searching for rare events, including neutrinoless double beta (0νββ) decay or dark matter interactions. Such noise can significantly limit experimental sensitivity to the physics case under investigation. Here, we report the detection of marine microseismic vibrations using mK-scale calorimeters. This study employs a multi-device analysis correlating data from CUORE, the leading experiment in the search for 0νββ decay with mK-scale calorimeters, and the Copernicus Earth Observation program, revealing the seasonal impact of Mediterranean Sea activity on CUORE’s …

Rapid Single-Cell Measurement Of Transient Transmembrane Water Flow Under Osmotic Gradient, Hong Jiang, Jinnawat Jongkhumkrong, Y. J. Chao, Qian Wang, Guiren Wang

Faculty Publications

Aquaporins (AQPs) are critical for transmembrane water transport in response to osmotic gradients, but their gating and regulatory mechanisms remain poorly understood. A central challenge is the lack of methods to measure water flow across AQPs from individual cells with the spatiotemporal resolution and sensitivity equivalent to patch-clamp recordings of ion fluxes—a limitation stemming from the electrically silent nature of water flow. Here, we present a novel optical technique—Flow-Induced Fluorescence Increase Velocimetry (FIFIV) based on Laser-Induced Fluorescence Photobleaching Anemometry (LIFPA)—that enables direct, real-time monitoring of cytoplasmic flow induced by transmembrane water transport under osmotic pressure gradients. Using small molecular fluorescent …

Association Between Dietary Folate And Prostate Cancer Aggressiveness Among African Americans And European Americans, Lihchyun Joseph Su, Sarah O'Connor, Daniela Ramirez Aguilar, Minjae Lee, Harrison Wong, Hui-Yi Lin, Jeannette T. Bensen, James L. Mohler, Lenore Arab, Longgang Zhao, Ebonee N. Butler, Laura Farnan, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Background: Despite the confirmed beneficial effects on preventing neural tube defects, concerns about high intakes of synthetic folate, or folic acid, in promoting cancer progression have been raised. This study evaluated the association between folate intake and prostate cancer (PCa) aggressiveness among African-American (AA) and European-American (EA) males. Methods: This study included 722 AA and 775 EA men with prostate cancer. Folate intake (dietary folate equivalent (DFE), synthetic folate, natural folate) was estimated using the National Cancer Institute Dietary History Questionnaire and detailed dietary supplement use questionnaire. Analyses included univariable comparisons of demographic and clinical characteristics of the two racial …

A New Highly Oxygen-Deficient And Cubic Pr3Zro8-Δ For Intermediate-Temperature Thermochemical Production Of Oxygen And Hydrogen, Jiaxin Lu, Yongliang Zhang, Luhong Chen, Yan Chen, Ke An, Yasser Shoukry, Xinfang Jin, Zhi-Hao Wang, Sai Mu, Kevin Huang

Faculty Publications

Two-step thermochemical cycles offer a clean route for hydrogen and oxygen production but are typically limited to high temperatures exceeding 1500 °C. Lowering operating temperatures would enable the use of alternative heat sources such as industrial waste heat. Here, we report Pr₃ZrO₈ as a new enabling material for efficient intermediate-temperature redox cycling, with thermal reduction at 900 °C in argon and steam oxidation at 400 °C. Pr₃ZrO₈ adopts a face-centered cubic structure similar to CeO₂ but exhibits significantly greater oxygen deficiency, achieving average oxygen and hydrogen fluxes of 331.7 and 70.3 µmol·g-1, respectively, …

Trends In Self-Reported Responses To Nutrition Facts Labels Before And After Nutrition Labeling Policy Implementation: A Comparison Of Adults In The United States And Mexico, Jim Thrasher Ph.D., Ma, Ms, Victor Vilalobos, Dai Fang, Alejandra Jáuregui, Alejandra Contreras-Manzano, Rachel Davis Ph.D., Lana Vanderlee, Christine M. White, Rachel B. Acton, James W. Hardin, Edward A. Frongillo Jr. Ph.D., Simón Barquera, David Hammond

Faculty Publications

Background

Objectives

Methods

Uranium Chemical Compound Classification Using Sub-Images And Statistical Machine Learning For Nuclear Forensics, Lee C. Lambert, Brett J. Borghetti, Abigail A. Bickley

Faculty Publications

Uranium particle analysis from Scanning Electron Microscope (SEM) imagery is a crucial tool in nuclear forensics. The particle morphology lexicon proposed by Tamasi et al. in J Radioanal Nucl Chem 307, 1611–1619 (2016) follows a standardized, manual identification process to identify particle morphology features. The present work seeks to mirror this methodology using computer feature selection from the scikit-image Python library rather than human classification. Using a random forest classifier, a 56% overall uranium true positive classification accuracy (a 39.6% balanced classification accuracy) was achieved on a test set outperforming a naïve (chance) model by 48%. The methodology introduced splits …

A Transcriptional Program Associated With Neurotransmission In The Living Human Brain, Alexander W. Charney, Lora E. Liharska, Eric Vornholt, Alissa Valentine, Anina Lund, Alice Hashemi, Ryan C. Thompson, Terry Lohrenz, Jessica S. Johnson, Nicole Bussola, Esther Cheng, You Jeong Park, Salman Qasim, Alisha Aristel, Lillian Wilkins, Kimia Ziafat, Hannah Silk, Lisa M. Linares, Brendan Sullivan, Claudia Feng, Beniamino Hadj-Amar Ph.D.

Faculty Publications

At the foundation of neurotransmission, and by extension at the foundation of brain function, are coordinated programs of gene expression involving many thousands of genes. These programs are poorly defined in humans because most modern studies that characterize human brain gene expression use tissue obtained in the postmortem state when neurotransmission and brain function have ceased. Here, to advance knowledge of the gene expression programs at the foundation of neurotransmission in the human brain, gene expression was characterized in 130 prefrontal cortex (PFC) samples obtained from participants of the Living Brain Project (LBP) during neurosurgical procedures in conjunction with intracranial …

Survival On Image Regression With Application To Partially Functional Distributional Representation Of Physical Activity, Rahul Ghosal, Sunwoo Emma Cho, Marcos Matabuena

Faculty Publications

Technological advancements in wearable devices and medical imaging often lead to high-dimensional physiological signals in the form of images or surfaces. To address these data structures, we develop a novel survival on image regression model with a specific focus on partially functional distributional representation of wearable data. The existing approaches for functional data and survival outcomes have been primarily developed for uni-dimensional functional predictors. Drawing on recent developments in distributional data analysis, we model temporally varying distributional patterns of physical activity (PA) as a partially functional distributional predictor within a semiparametric Cox model framework. We use tensor product splines to …