Physical Sciences and Mathematics Commons^™

The Impact Of Meal Dietary Inflammatory Index On Exercise-Induced Changes In Airway Inflammation In Adults With Asthma, Katrina P. Mcdiarmid, Lisa G. Wood, John W. Upham, Lesley K. Macdonald-Wicks, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Hayley A. Scott

Faculty Publications

Research suggests exercise may reduce eosinophilic airway inflammation in adults with asthma. The Dietary Inflammatory Index (DII®) quantifies the inflammatory potential of the diet and has been associated with asthma outcomes. This study aimed to determine whether the DII of a meal consumed either before or after exercise influences exercise-induced changes in airway inflammation. A total of 56 adults with asthma were randomised to (1) 30–45 min moderate–vigorous exercise, or (2) a control group. Participants consumed self-selected meals, two hours pre- and two hours post-intervention. Energy-adjusted DII (E-DIITM) was determined for each meal, with meals then characterised as “anti-inflammatory” or …

Separation Of Track- And Shower-Like Energy Deposits In Protodune-Sp Using A Convolutional Neural Network, A. Abed Abud, B. Abi, R, Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, A. Aduszkiewicz, M. Andreotti, M. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, S. Antusch, Roberto Petti, Et. Al.

Faculty Publications

Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagetic …

Tau Neutrinos In The Next Decade: From Gev To Eev, Roshan Mammen Abraham, Jamie Alvarez-Muñiz, Carlos A. Argüelles, Akitaka Ariga, Tomoko Ariga, Adam Aurisano, Dario Autiero, Mary Bishai, Nilay Bostan, Mauricio Bustamante, Austin Cummings, Valentin Decoene, André De Gouvêa, Giovanni De Lellis, Albert De Roeck, Peter B. Denton, Antonia Di Crescenzo, Milind V. Diwan, Yasaman Farzan, Anatoli Fedynitch, Jonathan L. Feng, Laura J. Fields, Alfonso Garcia, Maria Vittoria Garzelli, Julia Gehrlein, Christian Glaser, Katarzyna Grzelak, Steffen Hallmann, Jeremy Hewes, D Indumathi, Ahmed Ismail, Sudip Jana, Yu Seon Jeong, Kevin J. Kelly, Spencer R. Klein, Felix Kling, Thomas Kosc, Umut Kose, D Jason Koskinen, John Krizmanic, Jeff Lazar, Yichen Li, Ivan Martinez-Soler, Irina Mocioiu, Jiwoo Nam, Valentin Niess, Nepomuk Otte, Sameer Patel, Roberto Petti, Et. Al.

Faculty Publications

Tau neutrinos are the least studied particle in the standard model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long-baseline, beam-dump, collider, and astrophysical experiments. This whitepaper was prepared as a part of the NuTau2021 Workshop.

Metabolome-Wide Associations Of Gestational Weight Gain In Pregnant Women With Overweight And Obesity, Jin Dai, Nansi S. Boghossian, Mark Sarzynski Ph.D., Faha, Facsm, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu Sc.D., Liwei Chen

Faculty Publications

Excessive gestational weight gain (GWG) is associated with adverse pregnancy outcomes. This metabolome-wide association study aimed to identify metabolomic markers for GWG. This longitudinal study included 39 Black and White pregnant women with a prepregnancy body mass index (BMI) of ≥ 25 kg/m². Untargeted metabolomic profiling was performed using fasting plasma samples collected at baseline (mean: 12.1 weeks) and 32 weeks of gestation. The associations of metabolites at each time point and changes between the two time points with GWG were examined by linear and least absolute shrinkage and selection operator (LASSO) regression analyses. Pearson correlations between the …

Solvation Of Large Polycyclic Aromatic Hydrocarbons In Helium: Cationic And Anionic Hexabenzocoronene, Miriam Kappe, Florent Calvo, Johannes Schöntag, Holger F. Bettinger, Serge Krasnokutski, Martin Kuhn, Elisabeth Gruber, Fabio Zappa, Paul Scheier, Olof E. Echt

Faculty Publications

The adsorption of helium on charged hexabenzocoronene (Hbc, C₄₂H₁₈), a planar polycyclic aromatic hydrocarbon (PAH) molecule of D_6h symmetry, is investigated by a combination of high-resolution mass spectrometry and classical and quantum computational methods. The ion abundance of He_nHbc⁺ complexes versus size n features prominent local anomalies at n = 14, 38, 68, 82, and a weak one at 26, indicating that for these “magic” sizes the helium evaporation energies are relatively large. Surprisingly, mass spectra of anionic He_nHbc^– complexes feature a different set of anomalies, namely at …

Direct Measurement Of Stokes–Einstein Diffusion Of Cowpea Mosaic Virus With 19 Μs-Resolved Xpcs, Kacper Switalski, Jingyu Fang, Luxi Li, Miaoqi Chu, Erik Sarnello, Pete Jemian, Tao Li, Qian Wang, Qingteng Zhang

Faculty Publications

Brownian motion of Cowpea mosaic virus (CPMV) in water was measured using small-angle X-ray photon correlation spectroscopy (SA-XPCS) at 19.2 mu s time resolution. It was found that the decorrelation time tau(Q) = 1/DQ(2) up to Q = 0.091 nm(-1). The hydrodynamic radius R-H determined from XPCS using Stokes-Einstein diffusion D = kT/(6 pi eta R-H) is 43% larger than the geometric radius R-0 determined from SAXS in the 0.007 M K3PO4 buffer solution, whereas it is 80% larger for CPMV in 0.5 M NaCl and 104% larger in 0.5 M (NH4)(2)SO4, a possible effect of aggregation as well as …

Latest Results From The Cuore Experiment, I. Nutini, D. Q. Adams, C. Alduino, K. Alfonso, F. T. Avignone Iii, O. Azzolini, G. Bari, F. Bellini, M. Beretta, M. Biassoni, A. Branca, C. Brofferio, C. Bucci, J. Camilleri, A. Caminata, L. Canonica, X. G. Cao, S. Capelli, L. Cappelli, L. Cardani, Carl Rosenfeld Jr., Carl Rosenfeld, Et. Al.

Faculty Publications

The Cryogenic Underground Observatory for Rare Events (CUORE) is the frst cryogenic experiment searching for 0vββ decay that has been able to reach the onetonne mass scale. The detector, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, consists of an array of 988 TeO₂ crystals arranged in a compact cylindrical structure of 19 towers. CUORE began its frst physics data run in 2017 at a base temperature of about 10 mK and in April 2021 released its 3rd result of the search for 0vββ, corresponding to a tonne-year of TeO₂ exposure. This is the …

Utilization Of 18s Ribosomal Rna Lamp For Detecting Plasmodium Falciparum In Microscopy And Rapid Diagnostic Test Negative Patients, Enoch Aninagyei, Adjoa Agyemang Boakye, Clement Okraku Tettey, Kofi Adjei Nitri, Samuel Ohene Ofori, Comfort Dede Tetteh, Thelma Teley Alphour, Tanko Rufai

Faculty Publications

In this study, Plasmodium falciparum was detected in patients that were declared negative for malaria microscopy and rapid diagnostic test kit (mRDT), using Plasmodium 18s rRNA loop-mediated isothermal amplification (LAMP) technique. The main aim of this study was to assess the usefulness of LAMP assay for detecting pre-clinical malaria, when microscopy and mRDT were less sensitive. DNA was obtained from 100 μL of whole blood using the boil and spin method. Subsequently, the Plasmodium 18s rRNA LAMP assay was performed to amplify the specific Plasmodium 18s rRNA gene. Microscopy and mRDT negative samples [697/2223 (31.2%)] were used for this study. …

Broadening Participation In Tos Through Honors Nominations And Awards, Frank Muller-Karger, Eeshan Bhatt, Erin L. Meyer-Gutbrod

Faculty Publications

No abstract provided.

Oxygen Vacancies In Lib3O5 Crystals And Their Role In Nonlinear Absorption, Brian C. Holloway, Christopher A. Lenyk, Timothy D. Gustafson, Nancy C. Giles

Faculty Publications

LiB₃O₅ (LBO) crystals are used to generate the second, third, and fourth harmonics of near-infrared solid-state lasers. At high power levels, the material’s performance is adversely affected by nonlinear absorption. We show that as-grown crystals contain oxygen and lithium vacancies. Transient absorption bands are formed when these intrinsic defects serve as traps for “free” electrons and holes created by x rays or by three- and four-photon absorption processes. Trapped electrons introduce a band near 300 nm and trapped holes produce bands in the 500-600 nm region. Electron paramagnetic resonance (EPR) is used to identify and characterize the …

Permafrost And Climate Change: Carbon Cycle Feedbacks From The Warming Arctic, Edward A. G. Schuur, Benjamin W. Abbott, Roisin Commane, Jessica G. Ernakovich, Eugenie Euskirchen, Gustaf Hugelius, Guido Grosse, Miriam Jones, Charlie Koven, Victor Leshyk, David Lawrence, Michael M. Loranty, Marguerite Mauritz, David Olefeldt, Susan Natali, Heidi Rodenhizer, Verity Salmon, Christina Schadel, Jens Strauss, Claire C. Treat, Merritt Turetsky

Faculty Publications

Rapid Arctic environmental change affects the entire Earth system as thawing permafrost ecosystems release greenhouse gases to the atmosphere. Understanding how much permafrost carbon will be released, over what time frame, and what the relative emissions of carbon dioxide and methane will be is key for understanding the impact on global climate. In addition, the response of vegetation in a warming climate has the potential to offset at least some of the accelerating feedback to the climate from permafrost carbon. Temperature, organic carbon, and ground ice are key regulators for determining the impact of permafrost ecosystems on the global carbon …

On The Spatial Variability Of The Mesoscale Sea Surface Height Wavenumber Spectra In The Atlantic Ocean, Xiaobiao Xu, Eric P. Chassignet, Alan J. Wallcraft, Brian K. Arbic, Maarten C. Buijsman, Miguel Solano

Faculty Publications

The wavenumber spectral slope of sea surface height (SSH) computed within the mesoscale range (70–250 km) from satellite altimetry exhibits a large spatial variability which, until now, has not been reproduced in numerical ocean models. This study documents the impacts of including internal tides, high-resolution bathymetry, and high-frequency atmospheric variability on the SSH wavenumber spectra in the Atlantic Ocean, using a series of 1/50° North and equatorial Atlantic simulations with a realistic representation of barotropic/baroclinic tides and mesoscale-to-submesoscale variability. The results show that the inclusion of internal tides does increase high frequency SSH variability (with clear peaks near 120 and …

Innovation Transition Success: Practice Doesn't Make Perfect, Kaitlyn Ryan, Amy M. Cox, Ethan Blake, Clay Koschnick, Alfred E. Thal Jr.

Faculty Publications

The authors of this research examine and evaluate organizational factors associated with commercialization under the Air Force Small Business Innovation Research (SBIR) program. Their objective is to improve return on investment. The data set used was the SBIR Phase II program data set, which contains information on 433 SBIR topics with closed contracts reported during Department of Defense (DoD) fiscal years (FYs) 2015 to 2018. Each data point contained characteristics of the topic, including commercialization. Military capability or topic areas were hypothesized to have varying commercialization rates. Incumbency was theorized to be a characteristic of successful programs, while increased company …

Dietary Inflammatory Index And Mortality From All Causes, Cardiovascular Disease, And Cancer: A Prospective Study, Zhen Lin, Yanfei Feng, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Xin Xu

Faculty Publications

The Energy-adjusted Dietary Inflammatory Index (E-DIITM) is a comprehensive, literature-derived index for assessing the effect of dietary constituents on inflammatory biomarkers and inflammation-related chronic diseases. Several studies have examined the association between E-DII scores and mortality, with results that vary across populations. Therefore, in the present study, we aimed to investigate the potential association between E-DII scores and all-cause, cardiovascular disease (CVD), and cancer mortality using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial. E-DII scores, calculated based on a food-frequency questionnaire, were analyzed both as a continuous variable and after categorization into quintiles. A multivariate Cox …

Using Whole-Brain Diffusion Tensor Analysis To Evaluate White Matter Structural Correlates Of Delayed Visuospatial Memory And One-Week Motor Skill Retention In Nondemented Older Adults: A Preliminary Study, Jennapher Lingo Vangilder, Maurizio Bergamino, Andrew Hooyman, Megan C. Fitzhugh, Corianne Rogalsky, Jill C. Stewart, Scott C. Beeman, Sydney Y. Schaefer

Faculty Publications

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory …

Availability Of Hospital-Based Cancer Services Before And After Rural Hospital Closure, 2008-2017, Whitney Zahnd Ph.D., Peiyin Hung Ph.D., Sylvia Kewei Shi, Anja Zgodic, Melinda A. Merrell Ph.D., Elizabeth L. Crouch, Janice C. Probst, Jan Eberth Ph.D.

Faculty Publications

Introduction

Rural populations have less access to cancer care services and experience higher cancer mortality rates than their urban counterparts, which may be exacerbated by hospital closures. Our objective was to examine the impact of hospital closures on access to cancer-relevant hospital services across hospital service areas (HSAs).

Methods

We used American Hospital Association survey data from 2008 to 2017 to examine the change in access to cancer-related screening and treatment services across rural HSAs that sustained hospitals over time, experienced any closures, or had all hospitals close. We performed a longitudinal analysis to assess the association between hospital closure …

Clustering Behavior In Solar Flare Dynamics, Elmer C. Rivera, Jay R. Johnson, Jonathan Homan, Simon Wing

Faculty Publications

The solar magnetic activity cycle provides energy input that is released in intense bursts of radiation known as solar flares. As such, the dynamics of the activity cycle is embedded in the sequence of times between the flare events. Recent analysis shows that solar flares exhibit memory on different timescales. These previous studies showed that the time ordering of flare events is not random, but rather there is dependence between successive flares. In the present work, the clustering of flares is demonstrated through a straightforward nonparametric method where the cumulative distribution function of successive flares is compared with the cumulative …

The Roles Of Flux Tube Entropy And Effective Gravity In The Inward Plasma Transport At Saturn, S. Wing, M. F. Thomsen, J. R. Johnson, D. G. Mitchell, R. C. Allen, X. Ma, P. A. Delamere

Faculty Publications

The inward plasma transport at the Saturnian magnetosphere is examined using the flux tube interchange stability formalism developed by Southwood & Kivelson. Seven events are selected. Three cases are considered: (1) the injected flux tube and ambient plasmas are nonisotropic, (2) the injected flux tube and ambient plasmas are isotropic, and (3) the injected flux tube plasma is isotropic, but the ambient plasma is nonisotropic. Case 1 may be relevant for fresh injections, while case 3 may be relevant for old injections. For cases 1 and 2, all but one event have negative stability conditions, suggesting that the flux tube …

Neighborhood Characteristics And Dementia Symptomology Among Community-Dwelling Older Adults With Alzheimer’S Disease, Dana M. Alhasan, Matthew C. Lohman Ph.D., Jana A. Hirsch, Margaret Chandlee Miller Ms, Ph.D., Bo Cai Ph.D., Chandra L. Jackson

Faculty Publications

Background: Neuropsychiatric symptoms (NPSs) lead to myriad poor health outcomes among individuals with Alzheimer’s disease (AD). Prior studies have observed associations between the various aspects of the home environment and NPSs, but macro-level environmental stressors (e.g., neighborhood income) may also disrupt the neuronal microenvironment and exacerbate NPSs. Yet, to our knowledge, no studies have investigated the relationship between the neighborhood environment and NPSs.

Methods: Using 2010 data among older adults with AD collected from a sample of the South Carolina Alzheimer’s Disease Registry, we estimated cross-sectional associations between neighborhood characteristics and NPSs in the overall population and by race/ethnicity. Neighborhood …

Yin And Yang Of Cannabinoid Cb1 Receptor: Cb1 Deletion In Immune Cells Causes Exacerbation While Deletion In Non-Immune Cells Attenuates Obesity, Kathryn Miranda, William Becker, Philip B. Busbee, Nicholas Dopkins, Osama A. Abdulla, Yin Zhong, Jiajia Zhang Ph.D., Mitzi Nagarkatti, Prakash S. Nagarkatti

Faculty Publications

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional CB1 in all cells except the immune cells or expressed CB1 only in immune cells. CB1^-/- recipient hosts were resistant to DIO, indicating that CB1 in non-immune cells is necessary for induction of DIO. Interestingly, chimeras with CB1^-/- in immune cells showed exacerbation in DIO combined with …

Applications Of The Harary-Sachs Theorem For Hypergraphs, Gregory J. Clark, Joshua N. Cooper

Faculty Publications

The Harary-Sachs theorem for k-uniform hypergraphs equates the codegree-d coefficient of the adjacency characteristic polynomial of a uniform hypergraph with a weighted sum of subgraph counts over certain multi-hypergraphs with d edges. We begin by showing that the classical Harary-Sachs theorem for graphs is indeed a special case of this general theorem. To this end we apply the generalized Harary-Sachs theorem to the leading coefficients of the characteristic polynomial of various hypergraphs. In particular, we provide explicit and asymptotic formulas for the contribution of the k-uniform simplex to the codegree-d coefficient. Moreover, we provide an explicit formula for the leading …

Pulse-Quality Metric For Nonstationary Partially Coherent Fields, Milo W. Hyde Iv, Olga Korotkova, Mark F. Spencer

Faculty Publications

This paper generalizes a pulse-quality metric referred to as P², i.e., the time analogue of Siegman’s beam quality factor M², to include pulsed (nonstationary) random fields of any state of coherence. The analysis begins with the derivation of a general P² relation, which we then specialize to the important cases of coherent and Schell-model pulsed beams. As examples, we derive the P² for two stochastic sources: (1) a cosine Gaussian-correlated Schell-model pulsed beam and (2) a nonuniformly correlated pulsed beam. For both of these sources, we generate (in simulation) random instances of each and …

Deep-Turbulence Phase Compensation Using Tiled Arrays, Mark F. Spencer, Terry J. Brennan

Faculty Publications

Tiled arrays use modulo-2π phase compensation and coherent beam combination to correct for the effects of deep turbulence. As such, this paper uses wave-optics simulations to compare the closed-loop performance of tiled arrays to a branch-point-tolerant phase reconstructor known as LSPV+7 [Appl. Opt. 53, 3821 (2014) [CrossRef] ]. The wave-optics simulations make use of a point-source beacon and are setup with weak-to-strong scintillation conditions. This setup enables a trade-space exploration in support of a power-in-the-bucket comparison with LSPV+7. In turn, the results show that tiled arrays outperform LSPV+7 when transitioning from weak-to-strong scintillation conditions. These results are both …

Resonant Plasmonic–Biomolecular Chiral Interactions In The Far-Ultraviolet: Enantiomeric Discrimination Of Sub-10 Nm Amino Acid Films, Tiago Ramos Leite, Lin Zschiedrich, Orhan Kizilkaya, Kevin M. Mcpeak

Faculty Publications

Resonant plasmonic–molecular chiral interactions are a promising route to enhanced biosensing. However, biomolecular optical activity primarily exists in the far-ultraviolet regime, posing significant challenges for spectral overlap with current nano-optical platforms. We demonstrate experimentally and computationally the enhanced chiral sensing of a resonant plasmonic–biomolecular system operating in the far-UV. We develop a full-wave model of biomolecular films on Al gammadion arrays using experimentally derived chirality parameters. Our calculations show that detectable enhancements in the chiroptical signals from small amounts of biomolecules are possible only when tight spectral overlap exists between the plasmonic and biomolecular chiral responses. We support this conclusion …

Quantifying Dds-Cerberus Network Control Overhead, Andrew T. Park, Nathaniel R. Peck, Richard Dill, Douglas D. Hodson, Michael R. Grimaila, Wayne C. Henry

Faculty Publications

Securing distributed device communication is critical because the private industry and the military depend on these resources. One area that adversaries target is the middleware, which is the medium that connects different systems. This paper evaluates a novel security layer, DDS-Cerberus (DDS-C), that protects in-transit data and improves communication efficiency on data-first distribution systems. This research contributes a distributed robotics operating system testbed and designs a multifactorial performance-based experiment to evaluate DDS-C efficiency and security by assessing total packet traffic generated in a robotics network. The performance experiment follows a 2:1 publisher to subscriber node ratio, varying the number of …

Design Of Pd–Zn Bimetal Mof Nanosheets And Mof-Derived Pd3.9zn6.1/Cns Catalyst For Selective Hydrogenation Of Acetylene Under Simulated Front-End Conditions, Xinxiang Cao, Ruijian Tong, Siye Tang, Ben W.-L. Jang

Faculty Publications

Novel zinc–palladium–porphyrin bimetal metal–organic framework (MOF) nanosheets were directly synthesized by coordination chelation between Zn(II) and Pd(II) tetra(4-carboxyphenyl) porphin (TCPP(Pd)) using a solvothermal method. Furthermore, a serial of carbon nanosheets supported Pd–Zn intermetallics (Pd–Zn-ins/CNS) with different Pd: Zn atomic ratios were obtained by one-step carbonization under different temperature using the prepared Zn-TCPP(Pd) MOF nanosheets as precursor. In the carbonization process, Pd–Zn-ins went through the transformation from PdZn (650 C) to Pd3.9Zn6.1 (~950 C) then to Pd3.9Zn6.1/Pd (1000 C) with the temperature increasing. The synthesized Pd–Zn-ins/CNS were further employed as catalysts for selective hydrogenation of acetylene. Pd3.9Zn6.1 showed the best catalytic …

Distribution Of Dds-Cerberus Authenticated Facial Recognition Streams, Andrew T. Park, Nathaniel Peck, Richard Dill, Douglas D. Hodson, Michael R. Grimaila, Wayne C. Henry

Faculty Publications

Successful missions in the field often rely upon communication technologies for tactics and coordination. One middleware used in securing these communication channels is Data Distribution Service (DDS) which employs a publish-subscribe model. However, researchers have found several security vulnerabilities in DDS implementations. DDS-Cerberus (DDS-C) is a security layer implemented into DDS to mitigate impersonation attacks using Kerberos authentication and ticketing. Even with the addition of DDS-C, the real-time message sending of DDS also needs to be upheld. This paper extends our previous work to analyze DDS-C’s impact on performance in a use case implementation. The use case covers an artificial …

Cardiorespiratory Fitness And The Risk Of All-Cause, Cardiovascular And Cancer Mortality In Men With Hypercholesterolemia, Xuemei Sui M.D., M.P.H., Ph.D., Mark A. Sarzynski Facsm, Nicole Gribben, Jiajia Zhang Ph.D., Carl J. Lavie

Faculty Publications

Background: Whether higher cardiorespiratory fitness (CRF) confers protection against cardiovascular disease (CVD) in individuals with manifest hypercholesterolemia is poorly understood. Methods: Participants were 8920 men aged 20–82 years with hypercholesterolemia but no history of CVD and/or cancer and who received a preventive examination at the Cooper Clinic in Dallas, TX, USA, during 1974–2001. CRF was quantified as maximal treadmill test duration and was grouped for analysis as low, moderate, or high based on the traditional Aerobics Center Longitudinal Study cutpoints. Using Cox regression analyses, we computed hazard ratios and 95% confidence intervals for risk of mortality based on CRF. Results: …

Processed Food As A Risk Factor For The Development And Perpetuation Of Crohn's Disease-The Enigma Study, Gina L. Trakman, Winnie Y.Y. Lin, Amy L. Hamilton, Amy L. Wilson-O'Brien, Annalise Stanley, Jessica Y. Ching, Jun Yu, Joyce W.Y. Mak, Yang Sun, Junkin Niu, Yinglei Miao, Xiaoqing Lin, Rui Feng, Minhu Chen, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Mark Morrison, Siew C, Ng, Michael A. Kamm

Faculty Publications

(1) Background: Developing countries have experienced a rapid recent rise in Inflammatory Bowel Disease (IBD) incidence and emerging evidence suggests processed foods and food additives may predispose one to the development and perpetuation of Crohn’s disease (CD). The aim of this study was to evaluate processed food and food additive intake in CD patients and controls, in Australia (high CD incidence), Hong Kong (intermediate incidence) and mainland China (emerging incidence). (2) Methods: In 274 CD patients (CD), 82 first-degree relatives (FDR), 83 household members (HM) and 92 healthy unrelated controls (HC) from Australia (n = 180), Hong Kong (HK) (n …

Evidence Of Likely Autochthonous Chagas Disease In The Southwestern United States: A Case Series Of Trypanosoma Cruzi Seropositive Blood Donors, Mary K. Lynn, Kyndall C. Dye-Braumuller, Norman L. Beatty, Patricia L. Dorn, Stephen A. Klotz, Susan L. Stramer, Rebecca L. Townsend, Hany Kamel, Jacquelyn M. Vannoy, Patrick Sadler, Susan P. Montgomery, Hilda N. Rivera, Melissa Nolan Ph.D., Mph

Faculty Publications

Background Chagas disease is a parasitic infection that can insidiously cause non-ischemic cardiomyopathy. Given the largely silent nature of this progressive disease, asymptomatic blood donors pose potential blood transfusion risk. Blood donation screening has become an unintentional form of Chagas disease surveillance, with thousands of new cases identified since national surveillance was initiated in 2007.

Study Design and Methods We recruited T. cruzi-positive blood donors identified from California and Arizona blood centers for confirmatory blood screening and assessment of lifetime infection risk.

Results Among eight suspected cases, we identified four confirmed US autochthonous infections. The current manuscript details the …