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Articles 31 - 60 of 2314

Full-Text Articles in Physical Sciences and Mathematics

Topological Robustness Revealed By Real-Time Longitudinal And Transverse Studies, Hoai Anh Ho Jan 2024

Topological Robustness Revealed By Real-Time Longitudinal And Transverse Studies, Hoai Anh Ho

Wayne State University Dissertations

For a long time, phases of matter were interpreted through order parameters based on specific symmetries, with phase transitions involving symmetry breaking. However, the discovery of Integer Quantum Hall Effect (IQHE) with the Hall quantized resistances h/(ne^2) (n is a filling factor) has reshaped our understanding of phases and transitions. The effectis characterized by dissipationless edge states and insulating bulk states. These exotic properties are determined by a nontrivial topological invariant rather than an order parameter, and unchanged in the presence of perturbations. However, when measuring IQHE, there are two variations that require explanation. First, it is precision level of …

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Efficient Sabre-Sheath Hyperpolarization Of Pyruvate And Other Alpha-Ketocarboxylates And Ultra-High-Qualityfactor Wireless Masing Magnetic Resonance Sensing Of Hyperpolarized Contrast Media, Isaiah Olabisi Adelabu Jan 2024

Efficient Sabre-Sheath Hyperpolarization Of Pyruvate And Other Alpha-Ketocarboxylates And Ultra-High-Qualityfactor Wireless Masing Magnetic Resonance Sensing Of Hyperpolarized Contrast Media, Isaiah Olabisi Adelabu

Wayne State University Dissertations

Over the years, there has been research geared towards mitigating disease conditions such as cancers and tumors by molecular sensing of their aberrant metabolism in humans and animal models of diseases. Some of these biomolecules of interest are pyruvate, α-ketoglutarate, and ketoisocaproate, that play a central role in eukaryotic and human metabolic pathways. Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) have become predominant in investigating and imaging cancers and tumors for early detection and treatment. Although conventional NMR spectroscopy is limited by low sensitivity, we overcame this barrier through the use of hyperpolarization techniques. NMR hyperpolarization improves …

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Development Of Microfluidic Thermal Gel Electrophoresis For Biological Analysis, Mario Ambrocio Cornejo Jan 2024

Development Of Microfluidic Thermal Gel Electrophoresis For Biological Analysis, Mario Ambrocio Cornejo

Wayne State University Dissertations

ABSTRACTDEVELOPMENT OF MICROFLUIDIC THERMAL GEL ELECTROPHORESIS FOR BIOLOGICAL ANALYSIS by MARIO AMBROCIO CORNEJO May 2024 Advisor: Dr. Thomas H. Linz Major: Chemistry (Analytical Chemistry) Degree: Doctor of Philosophy The molecular biology that takes place within cells is vital to the over function of an organism. Healthy cellular function is crucial to a wide web of interconnected processes that need to be balanced and regulated. When these processes become abnormal, disease states are developed. The mapping of biological networks has led to the development of gene therapy and more accurate diagnostic tests. However, there are still vital biomolecules that due to …

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The Cohomology Of The Extended Morava Stabilizer Group, With Trivial Coefficients, At Large Primes, Mohammad Behzad Kang Jan 2024

The Cohomology Of The Extended Morava Stabilizer Group, With Trivial Coefficients, At Large Primes, Mohammad Behzad Kang

Wayne State University Dissertations

The goal of this thesis is to calculate the cohomology of the extended height n Morava stabilizer group, with trivial coefficients, for all heights n and all primes p>>n. To do this, we construct a family of deformations – parametrized over an affine line and smooth away from a single point – of Ravenel's Lie algebra model for the Morava stabilizer group. The singular fiber of the resulting bundle of differential graded algebras is the Chevalley-Eilenberg DGA of Ravenel's Lie algebra model, while the smooth fibers have very understandable cohomology. From here, tools such as parallel transport, connections, and …

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Exploiting Light To Probe Biological Processes, Madeline Denison Jan 2024

Exploiting Light To Probe Biological Processes, Madeline Denison

Wayne State University Dissertations

Metal complexes have many advantages as biochemical tools due to their rich photophysical properties and unique geometry. Metal-based complexes are commonly reported as emissive probes or photoactivatable biological agents. Long emission lifetimes of metal complexes allow for the use of lifetime gating which eliminates autofluorescence found in assays, a distinct advantage over short-lived organic fluorophores. This work utilizes this powerful technique to generate reversible, emissive probes for monitoring CYP3A4 active site occupancy. In addition to the emissive properties of metals, metals can also be used as photodynamic therapy (PDT) and photochemotherapy (PCT) agents. These light-activated strategies provide important spatiotemporal control …

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Visible Light Photocatalysis With Quantum Dot Gel For Organic Synthesis, Daohua Liu Jan 2024

Visible Light Photocatalysis With Quantum Dot Gel For Organic Synthesis, Daohua Liu

Wayne State University Dissertations

This dissertation presents metal chalcogenide quantum dots (QDs), a group of emerging visible light photocatalysts, for unique organic chemical transformations that are impossible using conventional molecular photocatalysts. The first part of this dissertation focuses on the comparison between ligand-capped CdS QD and CdS gel. CdS QD gel is a three-dimensional network of interconnected QD. CdS gels were found to show more facile charge transfer with substrates than QDs, due to the partial removal of ligands from its surface during gelation. Our study showed that the photocatalytic activity of CdS gels was indeed superior to trioctylphosphine (TOP)- and thioglycolic acid (TGA)-capped …

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Thermosensitive Phosphors As Optical Temperature Sensors In Extreme Environments, Marcos Ramon Imer Rocha Pita Jan 2024

Thermosensitive Phosphors As Optical Temperature Sensors In Extreme Environments, Marcos Ramon Imer Rocha Pita

Wayne State University Dissertations

Luminescent temperature sensors offer unique advantages over thermocouples and pyrometers for applications in extreme environments such as operando wall temperature mapping of combustion engines. A refractory oxide host doped with an optically active ion has the potential to afford a thermosensitive phosphor with a well-defined temperature response in such extreme environments. However, the design of thermosensitive phosphors with targeted temperature sensitivity and spatial resolution in the operational temperature range of interest has been hindered by the inability to rationally select host–activator pairs. A major scientific question is what crystal-chemistry features a low thermal conductivity oxide must possess to afford a …

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Verifying And Analyzing Ultra-Compact X-Ray Binaries Via Reflection Spectroscopy, David Louis Moutard Jan 2024

Verifying And Analyzing Ultra-Compact X-Ray Binaries Via Reflection Spectroscopy, David Louis Moutard

Wayne State University Dissertations

A low-mass X-ray binary (LMXB) is a compact object, such as a neutron star (NS) or black hole (BH), which is accreting material from a stellar companion via a process called Roche-lobe overflow. An ultra-compact X-ray binary (UCXB) is a subset of these systems defined by a shorter orbital period (< 80 minutes, compared to the hours to days seen in LMXBs). This shorter orbital period implies that the companion is more compact than a main sequence type star, often being a white dwarf (WD). These systems are important to study, as the compact nature of both objects in a tight orbit produces low frequency gravitational waves that will affect the next generation of multi-messenger astronomy. By observing UCXBs we can help to understand every facet of these unique systems before such missions begin. Over the course of this dissertation, we study a NS-WD UCXB called 4U 0614+091 and a NS UCXB candidate called SLX 1735-269. The primary method used to study these systems is a process called reflection modeling. This process involves collecting X-ray spectra, and modeling various components; a thermal contribution from the NS, non-thermal contribution from an X-ray corona surrounding the compact object, and sometimes thermal contributions from the accretion disk itself when necessary. These make up the standard continuum for an LMXB, but an additional component is applied which accounts for photons from the corona illuminating the disk and being reprocessed by the elements therein. These elements differ between UCXBs and LMXBs, as UCXBs tend to have an overabundance of oxygen with respect to solar, while being nearly devoid of hydrogen, resulting in a unique feature in the low-energy band. We use this fact to attempt to verify the UCXB nature of SLX 1735-269 by comparing reflection models applied to the data. These models contain different chemical abundances, with some designed for standard LMXBs with a main sequence companion and another designed specifically for UCXBs with a WD companion. We find that it is more likely that the source is ultra-compact in nature, but our timing analysis yields no orbital period, so we can not verify this beyond the indirect evidence of abundances. We also use this method to analyzea series of observations of 4U0614+091, which is a confirmed UCXB. This source varies in flux quasi-periodically over the course of a few days. By capturing the source at various stages along this flux evolution and modeling the reflection, we find that the inner disk appears to move away from the NS at the lowest flux state. This is analogous to what is seen in BH LMXB systems, and explains an apparent anti-correlation in the flux of the illuminating corona and that of the reflected emission, as the accretion disk is physically further from the illuminating source. Finally, we focus on a long term analysis of the same source, taking 51 archival spectra and modeling them with a UCXB reflection abundances. We find the source in different states throughout the course of these observations, which allows us to study how certain reflection parameters change as the source varies overall. We find that our results are consistent with the X-ray corona moving closer to the NS during high flux states, where the bulk of the emission is at low energies. This unique subset of sources can help us understand accretion at various scales by drawing comparisons to more massive black hole counterparts.

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Density Functional Studies Of Molecular Separation And Charge Transport, Timothy Quainoo Jan 2024

Density Functional Studies Of Molecular Separation And Charge Transport, Timothy Quainoo

Wayne State University Dissertations

This thesis presents a series of studies which can be grouped majorly into two sections both focusing on the utilization of density functional theory techniques; Molecular electronics and Molecular separation. Molecular electronics has been anticipated to hold a great future as it seeks to apply molecular building blocks in the creation of electronic components. On the other hand, the utilization of mild conditions in chemical processes is geared toward the major goals of green chemistry as it produces less waste and is cost-effective. Thus, this dissertation tackles and answers some of the unanswered questions in literature by using theoretical methods …

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Design And Synthesis Of Aminoglycoside-Based Heparan Sulfate Mimetics For Structure-Activity Relationship Studies Of Heparan-Binding Proteins, Joseph Wakpal Jan 2024

Design And Synthesis Of Aminoglycoside-Based Heparan Sulfate Mimetics For Structure-Activity Relationship Studies Of Heparan-Binding Proteins, Joseph Wakpal

Wayne State University Dissertations

Cancer remains a formidable challenge in modern medicine, demanding innovative approaches and treatments. Among the emerging strategies, inhibiting heparanase and fibroblast growth factor 2 (FGF2) has garnered considerable attention in recent years. This dissertation presents a novel approach to designing and synthesizing a diverse library of heparan sulfate (HS) mimetics derived from aminoglycosides to study their binding to two heparin-binding proteins involved in cancer development and metastasis. Heparanase cleaves HS polysaccharide chains in the extracellular matrix (ECM) and is a regulator of aggressive tumor behavior. Clinical studies have illustrated that aberrant heparanase expression correlates with increased tumor size, amplified tumor …

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Studies Towards High Surface Area Porous Polymers Via Cross-Coupling Methodology, Anthony Lybrand Jan 2024

Studies Towards High Surface Area Porous Polymers Via Cross-Coupling Methodology, Anthony Lybrand

Wayne State University Theses

Porous polymers, known for their high internal surface area and robust chemical stability, are promising candidates for applications in gas storage, water purification, energy storage, and catalysis. The Yamamoto-type Ullmann reaction, known for yielding high porosity polymers, serves as a benchmark in this study. However, its limitations as a homocoupling reaction restricts the synthesis of ordered A-B type copolymers. This research addresses this challenge by investigating the use of cross-coupling reactions, particularly the Negishi reaction, to synthesize A-B type copolymers with reduced defectivity and enhanced surface area. The synthesis of fully-metalated intermediates and their subsequent polymerization are discussed in detail. …

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Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry Jan 2024

Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry

Open Data at Wayne State

Contaminated urban soil is one of the major contributors to child Pb exposure. To gain a better understanding of Pb risk in urban areas, composite samples were collected from 142 residential, privately owned, parcels in Detroit, Hamtramck, and Highland Park, Michigan, with approval from the property owners. The proximity of soil sampling and former smelter locations were also reported. Sample were collected from areas covered with turf grass. Four samples were collected, one from each cardinal direction (north, south, east, and west), 20 cm from an aluminum tent stake driven into the center of the sampling site. Soils were collected …

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Probing Microscopic Properties Of Next Generation Materials Using Coherent Vibrational And Electronic Spectroscopy, S Mudiyanselage Sachithra Tikiri Kumara Wanasinghe Jan 2024

Probing Microscopic Properties Of Next Generation Materials Using Coherent Vibrational And Electronic Spectroscopy, S Mudiyanselage Sachithra Tikiri Kumara Wanasinghe

Wayne State University Dissertations

The dissertation research focused on understanding the relationship between the chemical structure of organic molecules and their photophysical properties, particularly examining coherent electronic and vibrational coupling within and between molecules, with implications for next-generation energy technologies. In Chapter 2, we employed both steady-state and transient optical and magnetic spectroscopic techniques to understand the electronic delocalization in both singlet and triplet exciton delocalization in weakly bound porphyrin dimeric molecules. Our results highlight that the delocalization of singlet exciton delocalization does not guarantee the delocalization of triplet excitons between weakly bound porphyrin macromolecules. Our studies demonstrate how one can access the electronic …

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Design, Synthesis, And Evaluation Of Class Iia Histone Deacetylase (Hdac) Inhibitors, Lauren Nicole Kotsull Jan 2024

Design, Synthesis, And Evaluation Of Class Iia Histone Deacetylase (Hdac) Inhibitors, Lauren Nicole Kotsull

Wayne State University Dissertations

Histone deacetylase (HDAC) proteins are linked to disease states, including cancer, and have become important targets for therapeutic development. Many inhibitors have been developed to target HDAC proteins, including FDA-approved inhibitors Vorinostat (SAHA), Belinostat, Romidepsin, and Panobinostat. These inhibitors non-specifically influence most of the 11 metal-dependent HDAC isoforms, which might contribute to the side effects that patients experience during treatment. The lack of selectivity also diminishes the use of HDAC inhibitors as biomedical research tools. To address these drawbacks, the development of selective inhibitors has been heavily studied. Yet, reported inhibitors are predominantly selective for class I HDAC isoforms (HDACs …

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Improving The Accuracy And Practicality Of Patient-Specific Dosimetry In 177lu Radiopharmaceutical Therapies, Avery Britvec Peterson Jan 2024

Improving The Accuracy And Practicality Of Patient-Specific Dosimetry In 177lu Radiopharmaceutical Therapies, Avery Britvec Peterson

Wayne State University Dissertations

Radiopharmaceutical therapies (RPTs) have their roots in the initial discoveries of radiation and radiotherapy at the turn of the 20th century, but recent interest in the 177Lu- based RPTs 177Lu-DOTATATE and 177Lu-PSMA-617 have highlighted the need to investigate patient-specific, dosimetry-guided approaches to planning these therapies. These RPTs are currently administered in “one-size-fits-all” regimens of fixed activity injections and current dosimetry methodologies often have large uncertainties and are reliant upon reference values that do not necessarily apply to all patients. In this work, several ways to make patient-specific dosimetry in 177Lu-DOTATATE and 177Lu-PSMA- 617 RPTs more accurate or more accessible are …

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Jets And Underlying Event In √S_Nn = 200 Gev P+Au Collisions At Rhic, Veronica Verkest Jan 2024

Jets And Underlying Event In √S_Nn = 200 Gev P+Au Collisions At Rhic, Veronica Verkest

Wayne State University Dissertations

Small collision systems, such as that between a proton or deuteron and a heavy-ion, were originally studied to assess cold nuclear matter (CNM) effects but have produced surprising results at RHIC and the LHC over the last several years. Namely, observations of jet yield suppression (enhancement) in central (peripheral) p/d+A events have motivated further investigations into small systems, including the search for signs of Quark-Gluon Plasma (QGP) formation. This thesis focuses primarily on an analysis of correlations of hard and soft particle production in √s_NN = 200 GeV p+Au collisions in STAR. Jets and Underlying Event (UE) are measured at …

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Autonomous Robot For Indoor Enhanced Living (Ariel), Prabhjot Kaur Jan 2024

Autonomous Robot For Indoor Enhanced Living (Ariel), Prabhjot Kaur

Wayne State University Dissertations

The global population is aging rapidly, with the total percentage of older adults (65 years and older) projected to increase from 10\% of the total population in 2022 to 16\% by 2050, according to the World Population Prospectus 2022 issued by the United Nations. For certain parts of the world such as Europe and North America, this translates to 1 in every 4 persons is projected to be 65 years or older by 2060. This trend raises concerns about providing quality long-term care for the older population. Moreover, according to the 2021 survey by the American Association of Retired Persons …

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Crossing The “Valley Of Death”: How Climate Technology Entrepreneurs Navigate Relationships With Venture Capital Investors, Allison Lucas Jan 2024

Crossing The “Valley Of Death”: How Climate Technology Entrepreneurs Navigate Relationships With Venture Capital Investors, Allison Lucas

Wayne State University Dissertations

As the world faces the ongoing and intensifying impacts of climate change, a group of innovative changemakers known as climate tech entrepreneurs (CTEs) are working on climate adaptation, mitigation, and/or resilience efforts by brining innovative technologies to the global market (UNFCC, 2018; Endeavor 2022). To realize the full potential of these technologies—tools, techniques, specialized knowledge or skillsets—they must be developed, deployed, and implemented at scale (IPCC, 2000). To do this, CTEs require external funding support, especially during a crucial period of the start-up lifecycle known as the “valley of death”. In this period between development and commercialization, production costs and …

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Security Information And Event Management Optimization Using Deep Federated Learning In Cloud-Based Autonomous Cyber-Physical Systems, Mohamed Mounir Moussa Jan 2024

Security Information And Event Management Optimization Using Deep Federated Learning In Cloud-Based Autonomous Cyber-Physical Systems, Mohamed Mounir Moussa

Wayne State University Dissertations

The integration of cloud-based technologies into Connected and Autonomous Vehicles (CAVs) is reshaping the field by combining Deep Federated Learning (DFL), Security Information and Event Management (SIEM), and cloud-dew computing. This solution leverages cloud-based resource provisioning, which is crucial for allocating scalable and efficient computational resources in a dynamic manner. These resources are essential for managing the intricate data and computing requirements of distributed systems, especially in the intelligent vehicle sector. This provisioning facilitates the efficient control of route mapping and cybersecurity in Connected Autonomous Vehicles (CAVs), guaranteeing the ability to process and make decisions in real-time.The research evaluates the …

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Towards An Experimental Bibliography Of Hemispheric Reconstruction Newspapers, Joshua Ortiz Baco, Benjamin Charles Germain Lee, Jim Casey, Sarah H. Salter Jun 2023

Towards An Experimental Bibliography Of Hemispheric Reconstruction Newspapers, Joshua Ortiz Baco, Benjamin Charles Germain Lee, Jim Casey, Sarah H. Salter

Criticism

Digital collections of newspapers have drawn broader attention to the fragmented and scattered print histories of minoritized communities. Attempts to survey these histories through bibliography, however, quickly meet with a fundamental problem: the practice of bibliographic description calls for creating a static record of social affiliations. Given the overwhelming scholarly consensus that categories such as race, ethnicity, and language are socially constructed, this article introduces an experimental bibliographic method for mapping the vast landscape of historical newspapers. This method extends the machine learning affordances of a recent project called Newspaper Navigator to enumerate the newspapers in Chronicling America according to …

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Assessing Boil Water Notices As Health-Risk Communication: Risk Perceptions, Efficacy, And Compliance During Winter Storm Uri, Ashleigh M. Day, Sydney O'Shay, Khairul Islam, Matthew W. Seeger, Shawn P. Mcelmurry Jun 2023

Assessing Boil Water Notices As Health-Risk Communication: Risk Perceptions, Efficacy, And Compliance During Winter Storm Uri, Ashleigh M. Day, Sydney O'Shay, Khairul Islam, Matthew W. Seeger, Shawn P. Mcelmurry

Open Data at Wayne State

Winter Storm Uri was an extreme disaster that impacted much of the United States during February of 2021. Texas and Oklahoma were generally not prepared for such an event and experienced massive power grid failures. This led to cascading risks including water system disruptions and many boil water notices (BWNs). The breakdown of some communication channels and the inability to enact protective actions due to power outages, as well as travel limitations on public roads, complicated both dissemination and implementation. Under these conditions, a non-representative, cross-sectional, survey was collected to assess individuals experience BWNs and how perceived efficacy impacts compliance. …

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Brif: A Novel And Efficient Implementation Of Random Forests Based On Bit Packing And Parallel Computing, Yanchao Liu May 2023

Brif: A Novel And Efficient Implementation Of Random Forests Based On Bit Packing And Parallel Computing, Yanchao Liu

Industrial and Systems Engineering Faculty Research Publications

Random forests are powerful and popular machine learning methods. While general principles of tree induction are straightforward and well-understood, the numerous algorithmic treatments implemented in software tools, as well as their impacts on performance, are less familiar to most users. This paper introduces a new random forest toolkit (the ‘brif’ package in R and Python) along with its key algorithmic design features, and demonstrates the effects of the forest’s hyper-parameters such as the split search method, tree depth and the voting mechanism, on the classification performance. Summaries of benchmarking experiments are also presented. Results show that ‘brif’ stands out among …

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Two Sample Statistical Test For Location Parameters, Narinder Kumar, Arun Kumar Apr 2023

Two Sample Statistical Test For Location Parameters, Narinder Kumar, Arun Kumar

Journal of Modern Applied Statistical Methods

A class of distribution-free tests for the homogeneity of location parameters is proposed and compared with different competitors in terms of Pitman asymptotic relative efficiency. A numerical example is provided and a simulation study is made to check the performance of the tests.

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Exploring The Association Of Brownfield Remediation Status With Socioeconomic Conditions In Wayne County, Mi, Brendan F. O'Leary, Alex B. Hill, Colleen Linn, Mei Lu, Carol J. Miller, Andrew Newman, F. Gianluca Sperone, Qiong Zhang Apr 2023

Exploring The Association Of Brownfield Remediation Status With Socioeconomic Conditions In Wayne County, Mi, Brendan F. O'Leary, Alex B. Hill, Colleen Linn, Mei Lu, Carol J. Miller, Andrew Newman, F. Gianluca Sperone, Qiong Zhang

Urban Studies and Planning Faculty Research Publications

Urban neighborhoods with locations of environmental contamination, known as brownfields, impact entire neighborhoods, but corrective environmental remedial action on brownfields is often tracked on an individual property basis, neglecting the larger neighborhood-level impact. This study addresses this impact by examining spatial differences between brownfields with unmitigated environmental concerns (open site) and sites that are considered fully mitigated or closed in urban neighborhoods (closed site) on the US census tract scale in Wayne County, MI. Michigan’s Department of Environment, Great Lakes, and Energy’s leaking underground storage tank (LUST) database provided brownfield information for Wayne County. Local indicators of spatial association (LISA) …

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Correlation And Balance Functions Of Identified Hadron Pairs In Au+Au Collisions At Rhic, Launa Di Carlo Jan 2023

Correlation And Balance Functions Of Identified Hadron Pairs In Au+Au Collisions At Rhic, Launa Di Carlo

Wayne State University Dissertations

Heavy-ion collisions are used to study the properties of the Quark Gluon Plasma (QGP), a hot and dense strongly-interacting system of deconfined quarks and gluons. Such systems can be formed in collisions of 197Au nuclei at the RHIC facility. Correlation and balance functions will be used to study these collisions. The correlation functions provide information on reaction mechanisms and the balance functions indicate the conditional probability that a pair of particle species was locally produced together during the collision. The correlation and balance functions of the full 3×3 matrix of (π, K, p)x(π, K, p) species pairs versus the relative …

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A Theoretical Framework For 3+1d Dynamics Of Relativistic Heavy-Ion Collisions, Sahr Alzhrani Jan 2023

A Theoretical Framework For 3+1d Dynamics Of Relativistic Heavy-Ion Collisions, Sahr Alzhrani

Wayne State University Dissertations

The primary goal is to enhance a theoretical tool for studying 3D dynamics in relativistic heavy-ion collisions. We aim to explore the effects of stochastic fluctuations within these systems as part of the Beam Energy Scan program at the Relativistic Heavy-Ion Collider. Our approach involves constructing 3D initial conditions using minimal model parameters based on Glauber collision geometry, energy, and momentum conservation principles. We validate the model by comparing its predictions on particle rapidity distributions and anisotropic flow coefficients in specific collision scenarios. Model parameters are calibrated by comparing predictions to observed data from central Au+Au collisions. Additionally, we extend …

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Exploration Of Electron Dynamics In A Strong Field By Time Dependent Configuration Interaction With A Complex Absorbing Potential, Paul Hoerner Jan 2023

Exploration Of Electron Dynamics In A Strong Field By Time Dependent Configuration Interaction With A Complex Absorbing Potential, Paul Hoerner

Wayne State University Dissertations

Strong field electron dynamics are a quickly developing field of study in physical chemistry. In order to better understand experimental observations, there is a need for computational tools to simulate electron dynamics in a strong field. Due to the nature of strong electric fields, this requires the solving of the time dependent Schrödinger equation (TDSE). Various methods have been used to solve the TDSE in a strong field. In order to look at molecular systems while accurately treating the underlying physics, a method that balances computational affordability with theoretical rigor is necessary. The chosen method that matches these criteria is …

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Alternating Current Electrolysis For Amine Functionalization And Hydrogen Isotope Exchange, Disni Gunasekera Jan 2023

Alternating Current Electrolysis For Amine Functionalization And Hydrogen Isotope Exchange, Disni Gunasekera

Wayne State University Dissertations

Electrochemical organic synthesis is experiencing a renaissance driven by the increasing demand for green chemistry and engineering in the pharmaceutical industry. Synthetic organic electrochemical methods can be divided into three types: anodic, cathodic, and paired electrolysis. Paired electrolysis, in which two desirable half-reactions are performedsimultaneously at the two electrodes, is mostly underdeveloped. However, paired electrolysis can be technologically significant because it not only improves energy efficiency by using both electrodes but also provides a unique reaction environment where two redox-opposite reactions of substrates take place in the same pot. A major challenge for paired electrolysis is that the difficulties associated …

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Synthesis Of Putative Microcystin-Lr Degradation Products And Full Macrocyclic Cyanopeptide, Mahesh Kumar Yadab Jan 2023

Synthesis Of Putative Microcystin-Lr Degradation Products And Full Macrocyclic Cyanopeptide, Mahesh Kumar Yadab

Wayne State University Dissertations

This thesis primarily focuses on synthesizing fragments of microcystin-LR, which is a natural product, with the aim of establishing them as analytical standards for investigating the biodegradation pathways of MC-LR. Despite of the substantial interest in synthesizing, isolating, and degrading Microcystins over the past few decades, the availability of high-purity microcystin standards at known concentration for quantitative analysis of using LC-MS/MS remains limited. The synthesis of the proposed MC-LR fragments employs the Fmoc/t-Bu protecting group strategy to prevent isomerization. Additionally, novel methods for the total synthesis of N-Boc-Adda are explored, incorporating atom-economic approaches, cross-metathesis, and oxidative boron Heck reactions. The …

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Lanthanide-Based Responsive Contrast Agents For Magnetic Resonance Imaging, Md Mamunur Rashid Jan 2023

Lanthanide-Based Responsive Contrast Agents For Magnetic Resonance Imaging, Md Mamunur Rashid

Wayne State University Dissertations

This thesis is a collection of seven chapters that discuss the contributions to the field oflanthanide-based contrast agents for magnetic resonance imaging (MRI), particularly in the context of imaging hypoxia and extracellular pH. These physiological changes play a significant role in life-threatening conditions such as cancer, making it essential to develop effective imaging tools to aid in diagnosis and treatment. The thesis provides insights for the rational development of lanthanide-based contrast agents for MRI. A comprehensive review of divalent europium as a tool for imaging hypoxia using magnetic resonance imaging and how coordination chemistry can be used to tune the …

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