Physical Sciences and Mathematics Commons^™

Application Of In-Silico Computational Biology Strategies To Demonstrate Mechanism Of Oral Cancer Cell Death By Natural Peptide, Dr Dominic Augustine

Annual Research Symposium

This research work is designed to identify biomolecules from Earthworm Coelomic Fluid (ECF) of Eudrilus Eugeniae (EE) that can inhibit oral cancer cells from proliferating. The study aims to construct a homology model of the 18 kDa protein from ECF of EE (18-ECFP) with molecular dynamics simulation (MDS) to enable its molecular docking with pro-apoptotic caspase receptors with determination of binding energy scores. The study also evaluates the anti-cancer potential of 18-ECFP on SCC-9 cells in vitro by wet lab techniques.

Pathogenic Implications Of Candidal Species In Both Oral Cancer And Oral Potentially Malignant Disorders - A Review, Dr Dominic Augustine, Sowmya Sv, Kuntala Mondal

Annual Research Symposium

Oral squamous cell carcinoma (OSCC) is the 6th most common cancer in worldwide. Cigarette smoking, alcohol consumption, and betel quid chewing are its major risk factors other factors that can lead to OSCC include excessive sun exposure, viral or fungal infection, poor nutrition, and poor oral hygiene. The carcinogenesis of OSCC occurs gradually and oral epithelial dysplasia is considered a potential histologic precursor of OSCC. Most OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs). The aim of this review is to correlate the association between Candida species and oral potentially malignant disorders and its possible mechanisms …

Immunohistochemical Expression Of Cyclin D1 In Dentigerous Cyst, Odontogenic Keratocyst And Unicystic Ameloblastoma- An In-Vitro Study, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Cyclin D1, a G1 cyclin member, regulates the transition of the cell cycle from the G1 phase to the S phase. The uncontrolled and elevated expression of cyclin D1 has been associated with rapid growth, heightened proliferative activity and increased histologic aggressiveness. Unicystic ameloblastoma pertains to cystic lesions that present clinical, radiographic, or gross features akin to jaw cysts. Nevertheless, upon histological scrutiny, these lesions display a distinctive ameloblastomatous epithelium lining the cystic cavity, with or without luminal or mural proliferation. This cystic variant of tumor bears substantial resemblances to dentigerous cysts, and occasionally, both entities can become indistinguishable upon …

An Immunohistochemical Panel For The Accurate Differentiation Between Mucoepidermoid Carcinoma And Pleomorphic Adenoma, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Salivary Gland Tumors (SGTs) are a diverse group of neoplasms, with a wide range of histological subtypes, some of which can exhibit overlapping features. Amongst this group of tumors, Pleomorphic Adenoma (PA) and Mucoepidermoid Carcinoma (MEC) stand out as prevalent entities originating from the salivary glands. The accurate differentiation between these two entities is crucial for treatment planning, as it influences decisions regarding the extent of surgical resection. Because of the overlapping histopathological features, it is difficult to differentiate these two lesions with the help of conventional Hematoxylin & Eosin (H& E). The evaluation of Immunohistochemical (IHC) markers holds pivotal …

Cheiloscopic Characteristics Detection And Pattern Classification By Machine Learning Technique, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Machine Learning (ML) is a field enhancing the rapid growth of technology. Though use of digital softwares for cheiloscopic investigations have been attempted with limited success, the use of ML based techniques are scarce and seldom have been employed in forensic odontology. The present study aimed to identify cheiloscopic patterns through machine learning based methods and to correlate the segmented patterns with age and gender of individuals.

Association Between Abo Blood Grouping And Odontometry: An Unexplored Evidence In Forensics, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Recent research has exhibited a strong association between ABO blood groups and susceptibility to diseases. Extraoral and intraoral hard tissue landmarks provide a stable and reliable record for odontological and anthropological analysis, forensic investigations and identification. The association between anthropometric indices and ABO blood grouping have been reported in the past, however, the association between ABO blood groups and odontometric indices is yet to be comprehensively explored. This study aimed to establish the correlation of ABO blood groups with odontometric indices and extraoral hard tissue landmarks for personnel identification.

Advanced Techniques For Tooth Pulp Rna Extraction In Forensic Investigations-A Systematic Review, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Teeth are fundamental structures in a forensic context due to their high strength and specificity. It is challenging to obtain high quality RNA from pulpal tissues. It has been described that pulp RNA degradation could be an indicator of post-mortem interval. Researchers have been in the quest to develop optimal techniques for tooth RNA extraction. The systematic review aimed to determine the most reliable method of RNA extraction from dental tooth pulp for forensic investigations.

Assessment Of Micrometastasis In Lymph Nodes Of Oral Squamous Cell Carcinoma –Attaining Excellence Through Immunohistochemistry, Dr Dominic Augustine, Sowmya Sv, Kuntala Mondal

Annual Research Symposium

Cervical lymph node metastasis is the most important prognostic factor in Squamous Cell Carcinoma of Head and Neck (SCCHN). Lymph node prognostic determinants hold immense significance in influencing both patient’s survival outcomes and the propensity for recurrence. The current study aimed to evaluate the diagnostic accuracy of Cyclin D1 and Pan-CK for the detection of lymph node micrometastasis in oral squamous cell carcinoma tissue sections and re-evaluate the tumor staging.

Harm Reduction Measures In Substance Use Disorder (Sud), Kent Wood

Annual Research Symposium

This literature review aims to comprehensively analyze harm reduction strategies employed in addressing Substance Use Disorder (SUD). Focusing on key interventions such as fentanyl testing strips, naloxone distribution, syringe exchange programs, and methadone/buprenorphine clinics, the study seeks to evaluate the effectiveness of these approaches in reducing the associated harms of substance misuse.

Substance Use Disorder –The Role Of The Pharmacist, Mackenzie Cruzan

Annual Research Symposium

The study illuminates the pivotal role of community pharmacists as accessible healthcare providers, offering medication management, patient education, and preventive care services. Simultaneously, it explores the intricate responsibilities of inpatient pharmacists, emphasizing their involvement in therapeutic monitoring and collaboration with healthcare teams.

Clinical, Radiographic And Biochemical Evaluation Of One-Piece Vs Two-Piece Single Implants After 5 Years Of Functional Loading, Ippolito Caputo

Annual Research Symposium

The aim of this study was to compare the clinical and radiographic conditions and the expression of proinflammatory cytokines in peri-implant crevicular fluid (PICF) of two-piece/bone level (TP/BL) versus one-piece/tissue level (OP/TL) single implants with a laser-microgrooved collar after at least 5 years of functional loading.

Anti-Erosion Potential Of Fluoride Solutions Associated With Aminomethacrylate Copolymer: In Situ Randomized Crossover Study, Taiana Paola Prado, Karine Carvalho Dos Santos, Carlos Rocha Gomes Torres, Tais Scaramucci, Idalina Vieira Aoki, Alessandra Buhler Borges

Annual Research Symposium

The anti-erosion potential of fluoride solutions associated with aminomethacrylate (AMC) was evaluated in the presence of acquired pellicle on enamel and dentin. It is concluded that AMC was able to increase the anti-erosion potential of fluoride solutions in the presence of acquired pellicle.

Detection Of Cervical Lymph Node Micrometastasis - A Machine Learning Based Approach, Dr. Sowmya Sv, Dominic Augustine, Kuntala Mondal

Annual Research Symposium

No abstract provided.

Influence Of Abutments Surface (Machined Vs. Laser-Microgrooved) In Soft-Tissue Response During One Year Of Function: Clinical And Biochemical Outcomes Of A Rct With Split-Mouth Design, Elisa Maccari

Annual Research Symposium

To evaluate peri-implant soft tissue behaviour around machined vs laser-microgrooved implants/healing/prosthetic abutments during 1 year of function by assessing IL-6, IL-1b and MMP-8 levels in peri-implant crevicular fluid (PICF).

Clinical Success Of Restorations With Bioactive And Non-Bioactive Materials: Systematic Review And Network Meta-Analysis, Juliana Benace Fernandes, Sheila Mondragón Contreras, Eduardo Bresciani, Taciana Marco Ferraz Caneppele

Annual Research Symposium

The oral cavity is a complex and dynamic environment with frequent pH and temperature changes that can affect the longevity of dental restorations. Consequently, bioactive restorative materials, capable of advantageous interactions with the oral environment and dental tissues, are promising alternatives. However, there is limited scientific evidence of their clinical performance. Therefore, we conducted this systematic review and network meta-analysis of clinical studies to address the research question: Does the clinical evaluation of restorations on permanent teeth with bioactive materials show greater success rates than those with non-bioactive materials?

Matlab Based Phenotypic Evaluation And Gene Expression Of Cd44 And Cd133 Biomarkers In The Prediction Of Oral Squamous Cell Carcinoma Metastasis, Dr. Sowmya Sv

Annual Research Symposium

Oral cancer accounts to 20–30% of all cancers in India. The major difficulty in managing carcinomas is due to failure in the control and detection of metastases (>90% deaths). Cancer stem cells (CSCs) are tumor-initiating cells that survive even after extensive radiotherapy and chemotherapy. Recently, the use of computer-assisted quantification methods employing image processing is drawing attention wherein information can be automatically extracted from the immunostained digitized images. The aim of the study was to assess the metastatic risk of Oral Squamous Cell Carcinoma (OSCC) by the phenotypic evaluation and gene expression of CD44 and CD133 biomarkers with clinical …

Determination Of The Correlation Between Age And Gender With Canine Index, Intermolar Width And Palatal Rugae Patterns, Dr. Sowmya Sv, Dominic Augustine

Annual Research Symposium

Dental records are of paramount importance in human identification considering the distinct traits of every individual. Although DNA and finger print analysis are techniques employed for faster and secure identification, in mass disasters, odontometric analysis can play a vital role in identification. Studies in the past have used parameters like arch perimeters, lip prints and palatal rugae pattern to determine age and gender of an individual. However, these studies correlated one parameter at a time and concluded that there was no significant correlation of the parameters to age and gender. The present study aimed to assess the canine index, intermolar …

Efficacy Of Bone Marrow Aspirates In Bone Regeneration Compared To Conventional Bone Grafts- A Systematic Review, Hannah Kadic, Shilpa Bhandi, Kamran H. Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

The search for a superior bone graft substitute compared to the gold standard of harvesting autogenous bone grafts has plagued dentists for decades. With the advent of tissue engineering, the search has been aimed at bone graft substitutes with osteogenic potential, in addition to the osteoinductive and osteoconductive properties. Bone Marrow Aspirates (BMAs) has evolved as a potential adjunct to conventional bone grafts that can substantially enhance the bone regeneration potential of these materials. The present systematic review aims to explore and assess the literature on the efficacy of bone marrow aspirates in new bone formation.

Association Of Sleep Quality With Academic Performance Among Undergraduate Dental Students, Kamyar Bagheri, Shilpa Bhandi, Kamran Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

This systematic review aimed to assess the association between sleep quality and academic performance among undergraduate dental students.

Methods: Electronic databases of Scopus, Embase, Medline, and Web of Science were searched for relevant papers published in the English language in May 2023.Study selection, data extraction and quality assessment were performed in duplicate with JBI Institute’s Critical Appraisal Checklist used to quality assessment. GRADEwas used to assess certainty of evidence.

Influence Of Sleep Pattern And Oral Hydration On Academic Performance Among Undergraduate Dental Students-A Pilot Study, Bassam Alibrahim

Annual Research Symposium

Sound sleep is important for preserving good physical, mental, and emotional health. An association with learning skills, critical decision making and thinking is also observed [1]. Poor hydration is associated with several health outcomes including poor oral health and academic performance. Timely assessment of oral hydration of students holds a potential to improve their oral health and academic performance [1, 2]. This study is designed to investigate the influence of oral hydration status and sleep deprivation on academic achievements of dental college undergraduates

Effect Of Low Intensity Pulsed Ultrasound (Lipus) And Emdogain On Root Resorption In Amelogenin Knockout (Amex) Mice, Caitlin Huynh

Annual Research Symposium

In amelogenesis imperfecta, mutations are often found in the amelogenin gene. Inactivation of this amelogenin gene in 6-12 month old mice has led to root resorption in teeth and an increased number of osteoclasts in their bones. The objective of this study was to determine whether local injection of Emdogain (EMD) and low intensity pulsed ultrasound (LIPUS) application to the jaw has a synergistic effect on the regeneration of root resorption (RR) in Amelogenin knockout (AMEX) mice; the ideal model representing Amelogenesis Imperfecta.

Impact Of Simulated Toothbrushing And Dentifrice Abrasiveness On The Surface Roughness, Gloss, And Microhardness Of Cad/Cam Hybrid Restorative Materials, Luana Souza

Annual Research Symposium

This study aimed to investigate the impact of toothpaste abrasiveness on the surface roughness, gloss, and microhardness of resin composite and CAD/CAM hybrid materials.

Evaluation Of Oropharyngeal Airway Changes In Skeletal Class11 Patients Undergoing Twin Block Appliance Therapy, K Saidath

Annual Research Symposium

The study investigated the changes in oropharyngeal airway dimensions in growing patients with retrognthic mandible and skeletal class 11 paterns, treated with twin block appliance.we evaluated skeletal changes post treatment and their relation to airway alterations

Parental Anxiety Associated With Children Undergoing Dental Treatment-Pulpectomy Procedure Under La, Swathikrishna G

Annual Research Symposium

The aim of this study was to evaluate the anxiety felt by parents of children undergoing dental treatment- pulpectomy procedure under LA.

The Impact Of Palatal Expansion On Airway And Breathing, Sanjeevani Ratti, Akhil Shetty, Pragati Nakra

Annual Research Symposium

Mini-implant assisted rapid palatal expansion (MARPE) is used to correct transverse maxillary deficiencies in orthodontics. While MARPE's influence on occlusal stability and maxillary expansion is recognized, its impact on facial aesthetics, soft tissue morphology, and nasal airway function requires further examination. Our study analyzed the changes in facial soft tissue and airway dimensions in patients undergoing MARPE treatment.

An Emg Study To Evaluate Chewing Efficiency And Maximum Voluntary Clenching (Mvc) For Different Malocclusion Groups Before And During Orthodontic Treatment, Vivek Reddy

Annual Research Symposium

The purpose of this study was to investigate the efficacy of chewing and maximum voluntary clenching (MVC) of patients with different malocclusion types by measuring the EMG activity in the masseter and temporalis muscles before and during orthodontic treatment.

Implications And Types Of Artefacts In Oral Histopathology Tissue Processing, Harshitha M, Sowmya S V, Domnic Augustine

Annual Research Symposium

There is a scarcity of information regarding the occurrence and appearance of artefacts in the literature studies observed till date. This study aims to provide a more a comprehensive approach on identifying the different types of artefacts and also attempts to provide with description regarding their relation to the parent slide and the remedies in order to prevent misinterpretation. This study aimed to prepare a comprehensive report of the commonly occurring artefacts in archival collection of pathology laboratory.

To Evaluate The Effect Of Surface Moisture On Dentinal Shear Bond Strength Of Glass Ionomer Restorations In Primary Teeth:An In -Vitro Study, Sherin C Jose

Annual Research Symposium

Glass ionomer cements that form aninevitable part of pediatric restorative dentistryare inherently sensitive to moisture. The influenceof different drying techniques on the shear bondstrength of glass ionomer cements to primaryteeth dentin has not been established.Thepurpose of the study was to evaluate the effects ofdifferent drying methods for different drying timeperiods on the shear bond strength of GC Fuji IX toprimary tooth dentine.

Perception Of Dental Students Regarding The Role Dentist In Smoking Cessation Counselling, Fathima Huda S, Dr Sudeep C. B

Annual Research Symposium

Tobacco use is one of the leading causes of premature death, disease and disability around the world. Six out of eight leading causes of death worldwide are attributed to the diseases related to tobacco use as a risk factor. Healthcare professionals rank high both in effectiveness and preference for providing tobacco cessation counselling. Surveys have found that 58% of smokers made regular appointments with their dentist. Cessation rates of up to 18% have been seen when dental professionals counselled their patients to quit tobacco. The study evaluated dental student’s views about tobacco cessation counselling and their skills as counsellors.

Comparative Evaluation Of Bone Thickness In Infrazygomatic Crest Region For Optimal Insertion Of Bone Screws : A Cbct Study, Kavya Mp

Annual Research Symposium

Infrazygomatic crest (IZC) is a palpable bony ridge running between the alveolar ridge and the zygomatic process of maxilla. IZC bone dimension is an important factor in the safety and stability of bone screws. IZC thickness depends on the site of insertion, angulation and height from the occlusal plane. This study embarks on a comprehensive Cone Beam Computed Tomography (CBCT) exploration, to assess infra zygomatic Crest bone thickness.