Physical Sciences and Mathematics Commons^™

Dose Coefficient (Dc) Methodology Report, John P. Shanahan, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

The purpose of this report is to present the methodology developed to calculate internal and external dose coefficients for radionuclides produced in the spallation process. Much of the information regarding computer codes in this report comes from various technical manuals and professional papers. References are provided at the beginning of each section for documentation and for the user who requires more specific information. The report also includes the results of applying the methodology to determine dose coefficients for five radionuclides. This effort identified potential areas of concern that will need to be addressed when the methodology is used in the …

Il-10 And Alveolar Bone Loss, Abdulaziz Saud Al-Rasheed

Loma Linda University Electronic Theses, Dissertations & Projects

Interleukin-10 (IL-10) is a cytokine with anti-inflammatory activities. IL-10 knockout (KO) mice exhibit severe intestinal inflammation in the presence of normal gut flora. We hypothesized that IL-10 KO mice would also be susceptible to inflammatory periodontal disease resulting in alveolar bone loss (ABL). The purpose of this study was to compare naturally occurring ABL in IL-10 KO and wild type (WT) mice. Twelve IL-10 KO and 12 WT mice, age-(7 months) and sex-(male) matched, were used. Half of the mice were on 129/SvEv and half on C57BL/6J background. Animal heads were defleshed and treated to remove all organic material. ABL …

Challenges, Strategies, And Tools For Research Scientists: Using Web-Based Information Resources, Danielle Bodrero Hoggan

E-JASL: Electronic Journal of Academic and Special Librarianship (1999-2009, Volumes 1-10)

Scientists face many challenges in harnessing web-based resources. Information overload, misinformation, fees, poorly designed navigation, and loss of browsability all hamper the scientist searcher. In addition, many scientists rely on only one or two databases and often miss unique information that is available through other sources. Librarians can team up with scientists to develop strategies to overcome the challenges of web-based information. For example, a librarian can teach effective information seeking techniques, including how to use controlled vocabularies, how to evaluate information on the web, and how to complement web-based resources with print resources. Librarians can also help scientists to …

Modular Machine Learning Methods For Computer-Aided Diagnosis Of Breast Cancer, Mia Kathleen Markey '94

Doctoral Dissertations

The purpose of this study was to improve breast cancer diagnosis by reducing the number of benign biopsies performed. To this end, we investigated modular and ensemble systems of machine learning methods for computer-aided diagnosis (CAD) of breast cancer. A modular system partitions the input space into smaller domains, each of which is handled by a local model. An ensemble system uses multiple models for the same cases and combines the models' predictions.

Five supervised machine learning techniques (LDA, SVM, BP-ANN, CBR, CART) were trained to predict the biopsy outcome from mammographic findings (BIRADS™) and patient age based on a …

Development Of Dose Coefficients For Radionuclides Produced In Spallation Neutron Sources, Phillip W. Patton

Transmutation Sciences Physics (TRP)

A research consortium comprised of representatives from several universities and national laboratories has been established as part of this on-going project to generate internal and external dose conversion coefficients for radionuclides produced in spallation neutron sources. Information obtained from this multi-year study will be used to support the siting and licensing of future accelerator-driven nuclear initiatives within the U.S. Department of Energy complex, including the Spallation Neutron Source (SNS) and Accelerator Production of Tritium (APT) Projects. Determination of these coefficients will also fill data gaps for several hundred radionuclides that exist in Federal Guide Report No. 11 and in Publications …

Residential Radon Exposure And Lung Cancer: Variation In Risk Estimates Using Alternative Exposure Scenarios, R. William Field, Brian J. Smith, Daniel J. Steck, Charles F. Lynch

Physics Faculty Publications

The most direct way to derive risk estimates for residential radon progeny exposure is through epidemiologic studies that examine the association between residential radon exposure and lung cancer. However, the National Research Council concluded that the inconsistency among prior residential radon case-control studies was largely a consequence of errors in radon dosimetry. This paper examines the impact of applying various epidemiologic dosimetry models for radon exposure assessment using a common data set from the Iowa Radon Lung Cancer Study (IRLCS). The IRLCS uniquely combined enhanced dosimetric techniques, individual mobility assessment, and expert histologic review to examine the relationship between cumulative …

2002 - The Seventh Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Seventh Annual Symposium of Student Scholars, held on April 5, 2002. Includes abstracts from the presentations and posters.

Comparative Genomic Hybridization Array Analysis, Annette M. Molinaro, Mark J. Van Der Laan, Dan H. Moore

U.C. Berkeley Division of Biostatistics Working Paper Series

At the present time, there is increasing evidence that cancer may be regulated by the number of copies of genes in tumor cells. Through microarray technology it is now possible to measure the number of copies of thousands of genes and gene segments in samples of chromosomal DNA. Microarray comparative genomic hybridization (array CGH) provides the opportunity to both measure DNA sequence copy number gains and losses and map these aberrations to the genomic sequence. Gains can signify the over-expression of oncogenes, genes which stimulate cell growth and have become hyperactive, while losses can signify under-expression of tumor suppressor genes, …

Santa Clara Magazine, Volume 43 Number 4, Spring 2002, Santa Clara University

Santa Clara Magazine

3 - BIG GIFT FOR BUSINESS SCHOOL BUILDING By SCM Staff. Silicon Valley investor Don Lucas donates $15 million to the Leavey School of Business.

8 - REACHING THE GOAL By Barry Holtzclaw. The women's soccer program has steadily become a national power.

16 - THE ART OF ADMISSION By John Kovacevich. The admissions office shapes the classes of the future by seeking a mix of diversity, creativity, and promise .

Production Of A Monoclonal Antibody Against Benzo[Α]Pyrene Diol Epoxide Dna Adducts, Brian Peden Austin

Chemistry & Biochemistry Theses & Dissertations

Benzo[α]pyrene is a ubiquitous pollutant produced from the incomplete combustion of organic material such as fossil fuels. It is found in the workplace, urban air, drinking water, and the food supply. Recently, it has been proposed that benzo[α]pyrene may be the causative agent in the formation of lung adenocarcinomas among some Taiwanese women exposed to cooking oil fumes without adequate ventilation. In this study, calf thymus DNA was modified in vitro with benzo[α]pyrene-diol epoxide (BPDE) to a level consistent with that found in biological samples. This DNA of low modification was used as an immunogen in the production of a …

Western Michigan University Occupational Therapy Department Web Page, Holly Pietrzak, Melissa Byrne

Honors Theses

Website designed for WMU's Occupational Therapy department.

Breast Cancer On The World Wide Web: Cross Sectional Survey Of Quality Of Information And Popularity Of Websites, Frederick C Ames, Merrick I Ross, Henry M Kuerer, Raphael E Pollock, Mark A Musen, S Eva Singletary

Faculty, Staff and Student Publications

OBJECTIVES: To determine the characteristics of popular breast cancer related websites and whether more popular sites are of higher quality.

DESIGN: The search engine Google was used to generate a list of websites about breast cancer. Google ranks search results by measures of link popularity---the number of links to a site from other sites. The top 200 sites returned in response to the query "breast cancer" were divided into "more popular" and "less popular" subgroups by three different measures of link popularity: Google rank and number of links reported independently by Google and by AltaVista (another search engine).

MAIN OUTCOME …

Inside Unlv, Diane Russell, Betty Blodgett, Kevin Force, Jennifer Vaughan, Cate Weeks, Jonathan Paver

Inside UNLV

No abstract provided.

Comparing Bottled Water And Tap Water: Experiments In Risk Communication, Branden B. Johnson

RISK: Health, Safety & Environment (1990-2002)

The author discusses results of experiments in risk communication comparing bottled water and tap water.

Prevalence Of Various Upper Extremity Disorders In Patients With Carpal Tunnel Syndrome Versus Patients Without Carpal Tunnel Syndrome, Daniel C. Buda

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose: Increasingly larger numbers of patients present with repetitive strain injuries of the upper extremities, especially carpal tunnel syndrome (CTS). A large number of these patients appear to have more than one upper extremity condition. The purpose of this study was to determine the probability that a patient diagnosed with carpal tunnel syndrome will also be diagnosed with other upper extremity and/or cervical spine disorders.

Subjects: A group of 188 subjects diagnosed with carpal tunnel syndrome and a group of 203 subjects without carpal tunnel syndrome were selected through a chart review of patients at Loma Linda …

Estimating Causal Parameters In Marginal Structural Models With Unmeasured Confounders Using Instrumental Variables, Tanya A. Henneman, Mark Johannes Van Der Laan, Alan E. Hubbard

U.C. Berkeley Division of Biostatistics Working Paper Series

For statisticians analyzing medical data, a significant problem in determining the causal effect of a treatment on a particular outcome of interest, is how to control for unmeasured confounders. Techniques using instrumental variables (IV) have been developed to estimate causal parameters in the presence of unmeasured confounders. In this paper we apply IV methods to both linear and non-linear marginal structural models. We study a specific class of generalized estimating equations that is appropriate to these data, and compare the performance of the resulting estimator to the standard IV method, a two-stage least squares procedure. Our results are applied to …

Santa Clara Magazine, Volume 44 Number 3, Winter 2002, Santa Clara University

Santa Clara Magazine

10 - GLOBALIZATION EMPOWERS GOOD AND EVIL By Rob Elder. Thomas Friedman, Pulitzer Prizewinning author and international affairs columnist for The New York Times, discusses this complex issue during a visit to campus.

14 - ON THE COLLISION OF WORLDS By Fred White. Corny science fiction movies inspire an SCU English professor to ponder deeply cosmic questions.

18 - THE CAMPAIGN FOR SANTA CLARA By Elizabeth Kelley Gillogly '93. SCU launches the largest campaign in its history, with plans for endowed scholarships, a new library, a new building for the Leavey School of Business, and much more.

Filling Preposition-Based Templates To Capture Information From Medical Abstracts, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

Due to the recent explosion of information in the biomedical field, it is hard for a single researcher to review the complex network involving genes, proteins, and interactions. We are currently building GeneScene, a toolkit that will assist researchers in reviewing existing literature, and report on the first phase in our development effort: extracting the relevant information from medical abstracts. We are developing a medical parser that extracts information, fills basic prepositional-based templates, and combines the templates to capture the underlying sentence logic. We tested our parser on 50 unseen abstracts and found that it extracted 246 templates with a …

Cognitive Rehab Solutions: A Computer-Assisted Cognitive Training Program, Avani Rajnikant Patel

Theses Digitization Project

The purpose of this project is to offer a functionally comprehensive application, Cognitive Rehab Solutions (CRS), that is designed for neuropsychologists to deliver restorative cognitive training in areas of attention and memory of persons with brain impairment.

Actiononaias Ligamentina As A Biomonitor In The Green River: An Unique Approach For Analysis Of Environmental Impacts, Robert Kirkland

Masters Theses & Specialist Projects

Biomonitoring has become an important component in bioassessment programs. It is used to maintain high water quality standards, and determine contaminant levels and biological affects in areas that have been heavily disturbed. The objectives of this research were 1) to improve and apply certain modern biomonitoring techniques and 2) to locate possible contaminant sources affecting the flora and fauna of the Green River and of Mammoth Cave. Actinonaias ligamentina (Lamarck, 1819), a freshwater mussel, was used for interpretation of these impacts as well as refinement of biomonitoring techniques. The mussels were collected in the Lawler Bend region of the Green …

Medtextus: An Ontology-Enhanced Medical Portal, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

In this paper we describe MedTextus, an online medical search portal with dynamic search and browse tools. To search for information, MedTextus lets users request synonyms and related terms specifically tailored to their query. A mapping algorithm dynamically builds the query context based on the UMLS ontology and then selects thesaurus terms that fit this context. Users can add these terms to their query and meta-search five medical databases. To facilitate browsing, the search results can be reviewed as a list of documents per database, as a set of folders into which all the documents are automatically categorized based on …

Synthesis And Chemistry Of Naphthalene Annulated Trienyl Iron Complexes: Potential Anticancer Dna Alkylation Reagents, Traci Means

Inquiry: The University of Arkansas Undergraduate Research Journal

Iron complex chemistry that opens a new door to the medicinal and pharmaceutical worlds is the aim of this research. Specifically, ortho-quinone methide moieties are intermediates in several antitumor drugs and have been identified as bioreductive alkylators of DNA. In our research, a class of iron compounds has been targeted to resemble these quinone methides. It is hoped that these new compounds could be modified to provide a window of opportunity toward the discovery of a selective mode of drug delivery. We have focused our efforts on generating a reactive transition metal complexed 5-membered ring analog of o-quinone methide based …

Level Set Segmentation Of Mr Images For Extraction Of Femur Bone And Tissues, Christina Shanti Nayagam

Student Works (2000-2009)

This research explores a potentially useful segmentation algorithm, known as the level set method. It is suitable for images obtained from the Magnetic Resonance Imaging (MRJ) modality, despite the fact that MR images have low contrast between bone and tissue. The level set method is a numerical technique designed to track the evolution of an interface. The fast marching version of the method is implemented for two-dimensional (2-D) and three-dimensional (3-D) segmentation in this research. Femur segmentation is the main thrust of this thesis, however brain and heart images are also presented. Pre-processing steps are first performed for the 2-0 …

Material Classification Of Magnetic Resonance Images Using Neural Fuzzy Technique And Fuzzy Neural Technique, Mangalam Sankupellay

Student Works (2000-2009)

The objective of this research is to automatically segment the region of interest from medical images obtained from a Magnetic Resonance Imaging (MRI) scanner. The Magnetic Resonance (MR) images of the human femur are used in the segmentation algorithms. MR images are complex images, providing details of different types of tissues. This poses a challenging segmentation problem. A region of interest (ROI) is therefore defined manually, in order to reduce image complexity. Two hybrid algorithms, namely the neural fuzzy algorithm and the fuzzy neural algorithm were explored for the segmentation of the bone from MR images. In the neural fuzzy …

Sistem Pakar Pergigian, Ibrahim Muhammad Nazim

Student Works (2000-2009)

Sistem pakar pergigian adalah suatu program berkomputer yang direkabentuk untuk memodelkan kebolehan untuk membantu dalam menjaga gigi dengan betul selain dari memberi maklumat tentang gigi dari segi rawatan, penyakit serta keadaan gigi. Ia berkebolehan memberi ulasan, cadangan dan penerangan. Komponen utama sistem pakar ini ialah pangkalan pengetahuan (knowledge base (KB)) dan enjin tadbir (inference engine). Pangkalan pengetahuan (KB) ialah komponen yang mengandungi segala bentuk pengetahuan yang khusus diperolehi dari pakar pergigian. Enjin tadbir (IE) pula bertindak sebagai pemproses pengetahuan yang bekerja dengan maklumat yang disediakan pada masalah yang diberikan bersama-sama dengan pengetahuan yang disimpan di dalam pangkalan pengetahuan tadi. Sistem …

Procurement System For A Clinic Group, Siau Huey Lee

Student Works (2000-2009)

Procurement System For A Clinic Group (PSCG) is a web-based application that provides an online procurement service for vendors of clinic group. This PSCG will be combined with Medical Record Management System, which done by my partner. This is a group project that aims to develop a medical records management and procurement system for aiding managing patient records and procurement process for a group of clinics. Literature review has been carried out on the information that is related to present online procurement system. PSCG will be developed using Active Server Pages .NET (ASP.NEn with VBSricpt as scripting language, HTML as …

Online Room Reservation And Scheduling System For A Hospital (Orrash), Heng Siong Lee

Student Works (2000-2009)

Online Room Reservation and Scheduling System For A Hospital (ORRASH) is a system that help the medical staff (nurse, physician) in a hospital to book a room ( a bed of a ward, an operation room) and administrate room scheduling in an easy way by eliminate the conventional manual way. This system also provides the online patient information for the patient and medical staff to view the patient records using network. Before develop this system, an interview was made with the authority of a hospital to know the process of booking a room in the hospital and a research was …

Medical Inference System On Arthritis Using Fuzzy Relational Theory, Chee Kau Lim

Student Works (2000-2009)

Fuzzy relational theory is a branch in the study of fuzzy sets theory. According to this theory, mapping among two sets can be carried out in four ways, which arc represented by circle product, sub-triangular product, super-triangular product and square product. Each of these products can be abstracted into inference structures. which is useful in designing the inference engine of an expert system. Based on the revised version [DeBaets and Kerre 1993. Hallam and Yew l998a] of fuzzy relational theory. a series of 18 inference structures, namely sub-K inference structures (denoted as Kt to Kl8) are constructed. Based on these …

Intergration Of Smart Healthcare Information Systems, Singh Dulku Premjit

Student Works (2000-2009)

This project presents a Smart Healthcare Information System (SHIS), which hospitals and medical centers can use to improve their services. SHIS provides a set of integrated services and is web based. The system comprises of several modules, which include patient, insurance and billing, pharmaceutical, healthcare provider, and medical center information systems. It also provides a data analysis system for analyzing medical data. With this system, hospital staff (e.g, administrators, nurses) can perform their tasks (e.g, retrieving patient information, recording diagnostic and treatment details) more quickly and efficiently. Patients can also use the system to view their records and make online …

Sistem Maklumat Pesakit, Said Nur Fadhlinawati

Student Works (2000-2009)

Latihan Ilmiah merupakan satu kursus wajib bagi pelajar tahun akhir bagi memenuhi keperluan Ijazah Sarjana Muda Sains Komputer di Universiti Malaya. Melalui kursus ini pelajar perlu membuat satu projek di mana pelajar dapat mengaplikasikan apa yang telah dipelajari selama ini. Sistem yang akan dibangunkan ini merupakan satu projek pembangunan sistem maklumat iaitu Sistem Maklumat Pesakit. Sistem ini diharap dapat menggantikan sistem manual yang digunakan sekarang. Sistem Maklumat Pesakit (SMP) ini merupakan satu sistem pangkalan data yang berasaskan komputer yang dibangunkan bagi menyimpan maklumat pesakit dengan lebih mudah dan berkesan. Sistem ini merupakan sistem pangkalan data yang membenarkan maklumat disimpan, ditambah …