Physical Sciences and Mathematics Commons^™

A Simplified Model For Growth Factor Induced Healing Of Wounds, F. J. Vermolen, E. Van Baaren, J. A. Adam

Mathematics & Statistics Faculty Publications

A mathematical model is developed for the rate of healing of a circular or elliptic wound. In this paper the regeneration, decay and transport of a generic 'growth factor', which induces the healing of the wound, is taken into account. Further, an equation of motion is derived for radial healing of a circular wound. The expressions for the equation of motion and the distribution of the growth factor are related in such a way that no healing occurs if the growth factor concentration at the wound edge is below a threshold value. In this paper we investigate the influence of …

On The Existence Of Strong Solutions To Autonomous Differential Equations With Minimal Regularity, Charlie H. Cooke

Mathematics & Statistics Faculty Publications

For proving the existence and uniqueness of strong solutions to

dY/dt = F(Y), Y(0) = C,

the most quoted condition seen in elementary differential equations texts is that F(Y) and its first derivative be continuous. One wonders about the existence of a minimal regularity condition which allows unique strong solutions. In this note, a bizarre example is seen where F(Y) is not differentiable at an equilibrium solution; yet unique non-global strong solutions exist at each point, whereas global non-unique weak solutions are allowed. A characterizing theorem is obtained.

A System Equivalence Related To Dulac's Extension Of Bendixson's Negative Theorem For Planar Dynamical Systems, Charlie H. Cooke

Mathematics & Statistics Faculty Publications

Bendixson's Theorem [H. Ricardo, A Modem Introduction to Differential Equations, Houghton-Mifflin, New York, Boston, 2003] is useful in proving the non-existence of periodic orbits for planar systems

dx/dt = F(x, y), dy/dt = G (x, y)

in a simply connected domain D, where F, G are continuously differentiable. From the work of Dulac [M. Kot, Elements of Mathematical Ecology, 2nd printing, University Press, Cambridge, 2003] one suspects that system (1) has periodic solutions if and only if the more general system

dx/d tau = B(x, y)F(x, y), dy/d tau = B(x, y)G(x, y)

does, which makes the subcase (1) more …

Bounds On Element Order In Rings Z(M) With Divisors Of Zero, C. H. Cooke

Mathematics & Statistics Faculty Publications

If p is a prime, integer ring Zp has exactly ¢¢(p) generating elements ω, each of which has maximal index Ip(ω) = (p) = p − 1. But, if m = ΠRJ = ₁p^αJ_J is composite, it is possible that Zm does not possess a generating element, and the maximal index of an element is not easily discernible. Here, it is determined when, in the absence of a generating element, one can still with confidence place bounds on the maximal index. Such a bound is usually less than ¢(m …

Computational Protein Biomarker Prediction: A Case Study For Prostate Cancer, Michael Wagner, Dayanand N. Naik, Alex Pothen, Srinivas Kasukurti, Raghu Ram Devineni, Bao-Ling Adam, O. John Semmes, George L. Wright Jr.

Mathematics & Statistics Faculty Publications

Background: Recent technological advances in mass spectrometry pose challenges in computational mathematics and statistics to process the mass spectral data into predictive models with clinical and biological significance. We discuss several classification-based approaches to finding protein biomarker candidates using protein profiles obtained via mass spectrometry, and we assess their statistical significance. Our overall goal is to implicate peaks that have a high likelihood of being biologically linked to a given disease state, and thus to narrow the search for biomarker candidates.

Results: Thorough cross-validation studies and randomization tests are performed on a prostate cancer dataset with over 300 patients, obtained …

Healing Times For Circular Wounds On Plane And Spherical Bone Surfaces, J. A. Adam

Mathematics & Statistics Faculty Publications

A mathematical model is developed for the rate of healing of a circular wound in a spherical "skull". The motivation for this model is based on experimental studies of the "'critical size defect" (CSD) in animal models; this has been defined as the smallest intraosseous wound that does not heal by bone formation during the lifetime of the animal [1]. For practical purposes, this timescale can usually be taken as one year. In [2], the definition was further extended to a defect which has less than ton percent bony regeneration during the lifetime of the animal. CSDS can "heal" by …

The Effect Of Surface Curvature On Wound Healing In Bone, J. A. Adam

Mathematics & Statistics Faculty Publications

The time-independent nonhomogeneous diffusion equation is solved for the equilibrium distribution of wound-induced growth factor over a hemispherical surface. The growth factor is produced at the inner edge of a circular wound and stimulates healing in regions where the concentration exceeds a certain threshold value. An implicit analytic criterion is derived for complete healing of the wound. (C) 2001 Elsevier Science Ltd. All rights reserved.

Advances In Space Radiation Shielding Codes, John W. Wilson, Ram K. Tripathi, Garry D. Qualls, Francis A. Cucinotta, Richard E. Prael, John W. Norbury, John H. Heinbockel, John Tweed, Giovanni De Angelis

Mathematics & Statistics Faculty Publications

Early space radiation shield code development relied on Monte Carlo methods and made important contributions to the space program. Monte Carlo methods have resorted to restricted one-dimensional problems leading to imperfect representation of appropriate boundary conditions. Even so, intensive computational requirements resulted and shield evaluation was made near the end of the design process. Resolving shielding issues usually had a negative impact on the design. Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from …

The Range Of The Iterated Matrix Adjoint Operator, Tze-Jang Chen, Jenn-Tsann Lin, C. H. Cooke

Mathematics & Statistics Faculty Publications

The following inverse problem is considered: for a given n × n real matrix B, does there exist a real matrix A such that where the classical adjoint operation is intended? The rank of B and the number of applications of the adjoint operator determine the character of this general inverse problem for the iterated adjoint operator. Thus, for given B, the question of interest is whether or not B lies in the range of the iterated matrix adjoint operator. Maple V R5 is used as an aid to obtain results indicated here. (©) 2001 Elsevier Science Ltd. …

A Simplified Model Of Wound Healing - Ii: The Critical Size Defect In Two Dimensions, J. S. Arnold, John A. Adam

Mathematics & Statistics Faculty Publications

Recently, a one-dimensional model was developed which gives a reasonable explanation for the existence of a Critical Size Defect (CSD) in certain animals [1]. In this paper, we examine the more realistic two-dimensional model of a circular wound of uniform depth to see what modifications are to be found, as compared with the one-dimensional model, in studying the CSD phenomenon. It transpires that the range of CSD sizes for a reasonable estimate of parameter values is 1 mm-1 cm. More realistic estimates await the appropriate experimental data.

A Simplified Model Of Wound Healing (With Particular Reference To The Critical Size Defect), J. A. Adam

Mathematics & Statistics Faculty Publications

This paper is an attempt to construct a simple mathematical model of wound healing/tissue regeneration which reproduces some of the known qualitative features of those phenomena. It does not address the time development of the wound in any way, but does examine conditions (e.g., wound size) under which such healing may occur. Two related one-dimensional models are examined here. The first, and simpler of the two corresponds to a "swath" of tissue (or more realistically in this case, bone) removed from an infinite plane of tissue in which only a thin band of tissue at the wound edges takes part …

Algorithms For The Numerical Solution Of A Finite-Part Integral Equation, J. Tweed, R. St. John, M. H. Dunn

Mathematics & Statistics Faculty Publications

The authors investigate a hypersingular integral equation which arises in the study of acoustic wave scattering by moving objects. A Galerkin method and two collocation methods are presented for solving the problem numerically. These numerical techniques are compared and contrasted in three test problems.

Polynomial Construction Of Complex Hadamard Matrices With Cyclic Core, C. H. Cooke, I. Heng

Mathematics & Statistics Faculty Publications

Conditions are given which are necessary and sufficient to ensure invariance of an M-sequence under periodic rearrangement. In conjunction with a certain uniformity property of polynomial coefficients, these conditions yield a simple method by which complex Hadamard matrices with cyclic core can be constructed. In such cases, a real p-ary linear cyclic error correcting code may be associated with the complex Hadamard matrix.

(A Note On)(2) The Shape Of The Erythrocyte, J. A. Adam

Mathematics & Statistics Faculty Publications

A note on the shape of the red blood cell is revisited, utilizing variational calculus to to find an extremum for the surface area of such a cell, using the volume as a constraint. A fairly significant error in the value of the volume is corrected, and the note concludes with a discussion of measures of cell shape (such as the sphericity index) which are more appropriate than the dimensional surface area to volume ratio.

The Adjoint Alternative For Matrix Operators, C. H. Cooke

Mathematics & Statistics Faculty Publications

The following inverse problem is considered: given a matrix B of rank r, does there exist a matrix A such that

B = T(A) = adjoint (A)

where the classical adjoint operation is intended? Conditions are determined on the rank of B which decides whether or not B lies in the range of the matrix adjoint operator.

Uniform Lipschitz Continuity Of Best L(P)-Approximations By Polyhedral Sets, Martina Finzel, Wu Li

Mathematics & Statistics Faculty Publications

In this paper we prove that the metric projection Π_{k, p} onto a polyhedral subset K of ℝⁿ, endowed with the p-norm, is uniformly Lipschitz continuous with respect to p,1 , p , ∞. As a consequence the strict best approximation and the natural best approximation are Lipschitz continuous selections for the metric projections Π_k, _∞ and Π_k,1, respectively. This extends a recent analogous result in Berens et al. [J.Math. Anal. Appl. 213 1997, 183-201] on linear subspaces.

Error Correcting Codes Associated With Complex Hadamard Matrices, I. Heng, C. H. Cooke

Mathematics & Statistics Faculty Publications

For primes p > 2, the generalized Hadamard matrix H(p,pt) can be expressed as H = x^A, where the notation means h_ij = x^aij. It is shown that the row vectors of A represent a p-ary error correcting code. Depending upon the value of t, either linear or nonlinear codes emerge. Code words are equidistant and have minimum Hamming distance d = (p − 1)t. The code can be extended so as to possess N = p²t code words of length pt …

Steady Incompressible Magnetohydrodynamic Flow Near A Point Of Reattachment, J. M. Dorrepaal, S. Moosavizadeh

Mathematics & Statistics Faculty Publications

The oblique stagnation-point flow of an electrically conducting fluid in the presence of a magnetic field is a highly nonlinear problem whose solution is of interest even in the simplest of geometries. The problem models the flow of a viscous conducting fluid near a point where a separation vortex reattaches itself to a rigid boundary. A similarity solution exists which reduces the problem to a coupled system of four ordinary differential equations which can be integrated numerically. The problem has two independent parameters, the conductivity of the fluid and the strength of the magnetic field. Solutions are tabulated for a …

Corrigendum To “Post-Surgical Passive Response Of Local Environment To Primary Tumor Removal”: Mathl. Comput. Modelling, Vol. 25, No. 6, Pp. 7–17, 1997, J. A. Adam, C. Bellomo

Mathematics & Statistics Faculty Publications

The computer program that was used to generate the graphs for the concentration of inhibitor contained an error. This influenced the scaling in the original Figures 2 and 3. As an example, a sample of the corrected graphs are given below. Copies of other corrected figures can be obtained from the authors. It is important to note that the “pulse” appears for the function rC(r, t). As can be seen, it travels slowly outward with decreasing amplitude. The mathematical analysis in the paper remains unchanged.

Post-Surgical Passive Response Of Local Environment To Primary Tumor Removal, J. A. Adam, C. Bellomo

Mathematics & Statistics Faculty Publications

Prompted by recent clinical observations on the phenomenon of metastasis inhibition by an angiogenesis inhibitor, a mathematical model is developed to describe the post-surgical response of the local environment to the “surgical” removal of a spherical tumor in an infinite homogeneous domain. The primary tumor is postulated to be a source of growth inhibitor prior to its removal at t = 0; the resulting relaxation wave arriving from the disturbed (previously steady) state is studied, closed form analytic solutions are derived, and the asymptotic speed of the pulse is estimated to be about 2 × 10⁻⁴ cm/sec for the …

Hoffman’S Error Bounds And Uniform Lipschitz Continuity Of Best L(P) -Approximations, H. Berens, M. Finzel, W. Li, Y. Xu

Mathematics & Statistics Faculty Publications

In a central paper on smoothness of best approximation in 1968 R. Holmes and B. Kripke proved among others that on ℝⁿ, endowed with the l_ρ-norm, 1< p < ∞, the metric projection onto a given linear subspace is Lipschitz continuous where the Lipschitz constant depended on the parameter p. Using Hoffman’s Error Bounds as a principal tool we prove uniform Lipschitz continuity of best l_ρ -ap- proximations. As a consequence, we reprove and prove, respectively, Lipschitz. continuity of the strict best approximation (sba, p = ∞ and of the natural best approximation (nba, p = 1.

An Invariance Property Of Common Statistical Tests, N. Rao Chaganty, A. K. Vaish

Mathematics & Statistics Faculty Publications

Let A be a symmetric matrix and B be a nonnegative definite (nnd) matrix. We obtain a characterization of the class of nnd solutions Σ for the matrix equation AΣA = B. We then use the characterization to obtain all possible covariance structures under which the distributions of many common test statistics remain invariant, that is, the distributions remain the same except for a scale factor. Applications include a complete characterization of covariance structures such that the chisquaredness and independence of quadratic forms in ANOVA problems is preserved. The basic matrix theoretic theorem itself is useful in other characterizing …

Continuities Of Metric Projection And Geometric Consequences, Robert Huotari, Wu Li

Mathematics & Statistics Faculty Publications

We discuss the geometric characterization of a subset K of a normed linear space via continuity conditions on the metricprojection onto K. The geometric properties considered includeconvexity, tubularity, and polyhedral structure. The continuityconditions utilized include semicontinuity, generalized stronguniqueness and the non-triviality of the derived mapping. Infinite-dimensional space with the uniform norm we show thatconvexity is equivalent to rotation-invariant almost convexityand we characterize those sets every rotation of which has continuousmetric projection. We show that polyhedral structure underliesgeneralized strong uniqueness of the metric projection.

The Effect Of Three-Dimensional Freestream Disturbances On The Supersonic Flow Past A Wedge, Peter W. Duck, D. Glenn Lasseigne, M. Y. Hussaini

Mathematics & Statistics Faculty Publications

The interaction between a shock wave (attached to a wedge) and small amplitude, three-dimensional disturbances of a uniform, supersonic, freestream flow are investigated. The paper extends the two-dimensional study of Duck et al. [P W. Duck, D. G. Lasseigne, and M. Y. Hussaini, ''On the interaction between the shock wave attached to a wedge and freestream disturbances,'' Theor. Comput. Fluid Dyn. 7, 119 (1995) (also ICASE Report No. 93-61)] through the use of vector potentials, which render the problem tractable by the same techniques as in the two-dimensional case, in particular by expansion of the solution by means of …

Antiplane Shear Of A Strip Containing A Staggered Array Of Rigid Line Inclusions, G. Kerr, G. Melrose, J. Tweed

Mathematics & Statistics Faculty Publications

Motivated by the increased use of fibre-reinforced materials, we illustrate how the effective elastic modulus of an isotropic and homogeneous material can be increased by the insertion of rigid inclusions. Specifically we consider the two-dimensional antiplane shear problem for a strip of material. The strip is reinforced by introducing two sets of ribbon-like, rigid inclusions perpendicular to the faces of the strip. The strip is then subjected to a prescribed uniform displacement difference between its faces, see Figure 1. it should be noted that the problem posed is equivalent to that of the uniform antiplane shear problem for an infinite …

Superconvergence Of The Iterated Collocation Methods For Hammerstein Equations, Hideaki Kaneko, Richard D. Noren, Peter A. Padilla

Mathematics & Statistics Faculty Publications

In this paper, we analyse the iterated collocation method for Hammerstein equations with smooth and weakly singular kernels. The paper expands the study which began in [16] concerning the superconvergence of the iterated Galerkin method for Hammerstein equations. We obtain in this paper a similar superconvergence result for the iterated collocation method for Hammerstein equations. We also discuss the discrete collocation method for weakly singular Hammerstein equations. Some discrete collocation methods for Hammerstein equations with smooth kernels were given previously in [3, 18].

Scattering From Stellar Acoustic-Gravity Potentials: Ii. Phase Shifts Via The First Born Approximation, J. A. Adam, I. Mckaig

Mathematics & Statistics Faculty Publications

Using the first Born approximation, properties of the scattering phase shift are investigated for waves that are scattered by a schematic representation of a large-scale “stellar potential,” i.e., one for which the star itself is viewed as the potential inducing a phase shift in an incoming wave. In particular, the phase shift properties are examined as functions of the relative wavenumber (α) and the azimuthal wavenumber (l), high l-values being of interest in helioseismology.

Limiting Spheroid Size As A Function Of Growth Factor Source Location, J. A. Adam, K. Y. Ward

Mathematics & Statistics Faculty Publications

Solutions C(r) of the time-independent nonhomogeneous diffusion equation for three different piecewise-uniform source terms are used to examine the limiting size of multicell spheroids using a simple model which reproduces concentration-dependent mitotic behavior. A condition is derived under which nontrivial solutions do not exist (in all three cases), and a condition for the existence of a unique nontrivial solution is established for the case of growth-modifying factor (GMF) production throughout the spheroid. Qualitative behavior of the limiting size is established as a function of various physiological parameters. Of fundamental importance is the assumed GMF concentration threshold θ, …

The Hadamard Matroid And An Anomaly In Its Single Element Extensions, C. H. Cooke

Mathematics & Statistics Faculty Publications

A nonstandard vector space is formulated, whose bases afford a representation of what is called a Hadamard matroid, M_p. For prime p, existence of M_p is equivalent to the existence of both a classical Hadamard matrix H(p,p) and a certain affine resolvable, balanced incomplete block design AR(p). An anomaly in the representable single element extension of a Hadamard matroid is discussed.

A Dual Approach To Constrained Interpolation From A Convex Subset Of Hilbert Space, Frank Deutsch, Wu Li, Joseph D. Ward

Mathematics & Statistics Faculty Publications

Many interesting and important problems of best approximationare included in (or can be reduced to) one of the followingtype: in a Hilbert spaceX, find the best approximationPK(x) to anyx∈Xfrom the setK≔C∩A−1(b),whereCis a closed convex subset ofX,Ais a bounded linearoperator fromXinto a finite-dimensional Hilbert spaceY, andb∈Y. The main point of this paper is to show thatPK(x)isidenticaltoPC(x+A*y …