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Full-Text Articles in Physical Sciences and Mathematics
A Simplified Model For Growth Factor Induced Healing Of Wounds, F. J. Vermolen, E. Van Baaren, J. A. Adam
A Simplified Model For Growth Factor Induced Healing Of Wounds, F. J. Vermolen, E. Van Baaren, J. A. Adam
Mathematics & Statistics Faculty Publications
A mathematical model is developed for the rate of healing of a circular or elliptic wound. In this paper the regeneration, decay and transport of a generic 'growth factor', which induces the healing of the wound, is taken into account. Further, an equation of motion is derived for radial healing of a circular wound. The expressions for the equation of motion and the distribution of the growth factor are related in such a way that no healing occurs if the growth factor concentration at the wound edge is below a threshold value. In this paper we investigate the influence of …
Healing Times For Circular Wounds On Plane And Spherical Bone Surfaces, J. A. Adam
Healing Times For Circular Wounds On Plane And Spherical Bone Surfaces, J. A. Adam
Mathematics & Statistics Faculty Publications
A mathematical model is developed for the rate of healing of a circular wound in a spherical "skull". The motivation for this model is based on experimental studies of the "'critical size defect" (CSD) in animal models; this has been defined as the smallest intraosseous wound that does not heal by bone formation during the lifetime of the animal [1]. For practical purposes, this timescale can usually be taken as one year. In [2], the definition was further extended to a defect which has less than ton percent bony regeneration during the lifetime of the animal. CSDS can "heal" by …
The Effect Of Surface Curvature On Wound Healing In Bone, J. A. Adam
The Effect Of Surface Curvature On Wound Healing In Bone, J. A. Adam
Mathematics & Statistics Faculty Publications
The time-independent nonhomogeneous diffusion equation is solved for the equilibrium distribution of wound-induced growth factor over a hemispherical surface. The growth factor is produced at the inner edge of a circular wound and stimulates healing in regions where the concentration exceeds a certain threshold value. An implicit analytic criterion is derived for complete healing of the wound. (C) 2001 Elsevier Science Ltd. All rights reserved.
A Simplified Model Of Wound Healing - Ii: The Critical Size Defect In Two Dimensions, J. S. Arnold, John A. Adam
A Simplified Model Of Wound Healing - Ii: The Critical Size Defect In Two Dimensions, J. S. Arnold, John A. Adam
Mathematics & Statistics Faculty Publications
Recently, a one-dimensional model was developed which gives a reasonable explanation for the existence of a Critical Size Defect (CSD) in certain animals [1]. In this paper, we examine the more realistic two-dimensional model of a circular wound of uniform depth to see what modifications are to be found, as compared with the one-dimensional model, in studying the CSD phenomenon. It transpires that the range of CSD sizes for a reasonable estimate of parameter values is 1 mm-1 cm. More realistic estimates await the appropriate experimental data.
A Simplified Model Of Wound Healing (With Particular Reference To The Critical Size Defect), J. A. Adam
A Simplified Model Of Wound Healing (With Particular Reference To The Critical Size Defect), J. A. Adam
Mathematics & Statistics Faculty Publications
This paper is an attempt to construct a simple mathematical model of wound healing/tissue regeneration which reproduces some of the known qualitative features of those phenomena. It does not address the time development of the wound in any way, but does examine conditions (e.g., wound size) under which such healing may occur. Two related one-dimensional models are examined here. The first, and simpler of the two corresponds to a "swath" of tissue (or more realistically in this case, bone) removed from an infinite plane of tissue in which only a thin band of tissue at the wound edges takes part …