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A Simplified Model Of Wound Healing - Ii: The Critical Size Defect In Two Dimensions, J. S. Arnold, John A. Adam
A Simplified Model Of Wound Healing - Ii: The Critical Size Defect In Two Dimensions, J. S. Arnold, John A. Adam
Mathematics & Statistics Faculty Publications
Recently, a one-dimensional model was developed which gives a reasonable explanation for the existence of a Critical Size Defect (CSD) in certain animals [1]. In this paper, we examine the more realistic two-dimensional model of a circular wound of uniform depth to see what modifications are to be found, as compared with the one-dimensional model, in studying the CSD phenomenon. It transpires that the range of CSD sizes for a reasonable estimate of parameter values is 1 mm-1 cm. More realistic estimates await the appropriate experimental data.
A Simplified Model Of Wound Healing (With Particular Reference To The Critical Size Defect), J. A. Adam
A Simplified Model Of Wound Healing (With Particular Reference To The Critical Size Defect), J. A. Adam
Mathematics & Statistics Faculty Publications
This paper is an attempt to construct a simple mathematical model of wound healing/tissue regeneration which reproduces some of the known qualitative features of those phenomena. It does not address the time development of the wound in any way, but does examine conditions (e.g., wound size) under which such healing may occur. Two related one-dimensional models are examined here. The first, and simpler of the two corresponds to a "swath" of tissue (or more realistically in this case, bone) removed from an infinite plane of tissue in which only a thin band of tissue at the wound edges takes part …