COVID-19 Commons^™

Anticoagulation In Covid-19, Bassam Atallah

Faculty Scholarship

No abstract provided.

Geospatial Analysis Of Covid-19 And Otolaryngologists Above Age 60, Jeremy S. Ruthberg, Humzah A. Quereshy, Tarun K. Jella, Brian D'Anza, Nicole Maronian, Todd D. Otteson

Faculty Scholarship

Objective: The 2019 novel coronavirus (COVID-19) is disproportionately impacting older individuals and healthcare workers. Otolaryngologists are especially susceptible with the elevated risk of aerosolization and corresponding high viral loads. This study utilizes a geospatial analysis to illustrate the comparative risks of older otolaryngologists across the United States during the COVID-19 pandemic. Methods and materials: Demographic and state population data were extracted from the State Physician Workforce Reports published by the AAMC for the year 2018. A geospatial heat map of the United States was then constructed to illustrate the location of COVID-19 confirmed case counts and the distributions of ENTs …

A Marker Of Systemic Inflammation Or Direct Cardiac Injury: Should Cardiac Troponin Levels Be Monitored In Covid-19 Patients?, Bassam Atallah

Faculty Scholarship

No abstract provided.

Sars-Cov-2 Infection In A Patient On Chronic Hydroxychloroquine Therapy: Implications For Prophylaxis, Khalid M. Dousa, Sharad S. Malavade, Jennifer Furin, Barbara Gripshover, Marjorie Hatszegi, Leila Hojat, Elie Saade, Robert A. Salata

Faculty Scholarship

People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy.

Infectious Diseases Society Of America Guidelines On The Treatment And Management Of Patients With Covid-19, Amy Hirsch, Yngve Falck-Ytter

Faculty Scholarship

Background: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. Objective: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. Methods: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and …

It's Not The Heat, It's The Humidity: Effectiveness Of A Rice Cooker-Steamer For Decontamination Of Cloth And Surgical Face Masks And N95 Respirators, Sarah N. Redmond, Lucas D. Jones, Curtis J. Donskey

Faculty Scholarship

No abstract provided.

What Constitutes Urgent Endoscopy? A Social Media Snapshot Of Gastroenterologists' Views During The Covid-19 Pandemic, Zachary L. Smith

Faculty Scholarship

Background and study aims: There is a consensus among gastroenterology organizations that elective endoscopic procedures should be deferred during the COVID-19 pandemic. While the decision to perform urgent procedures and to defer entirely elective procedures is mostly evident, there is a wide "middle ground" of time-sensitive but not technically urgent or emergent endoscopic interventions. We aimed to survey gastroenterologists worldwide using Twitter to help elucidate these definitions using commonly encountered clinical scenarios during the COVID-19 pandemic. Methods: A 16-question survey was designed by the authors to include common clinical scenarios that do not have clear guidelines regarding the timing or …

Working During Covid-19, Wku Staff Senate

Staff Council

Email from WKU Senate to WKU staff regarding working conditions during COVID-19.

Virtual Visits For Care Of Patients With Heart Failure In The Era Of Covid-19: A Statement From The Heart Failure Society Of America, Eiran Z. Gorodeski

Faculty Scholarship

In response to the COVID-19 pandemic, US federal and state governments have implemented wide-ranging stay-at-home recommendations as a means to reduce spread of infection. As a consequence, many US healthcare systems and practices have curtailed ambulatory clinic visits—pillars of care for patients with heart failure (HF). In this context, synchronous audio/video interactions, also known as virtual visits (VVs), have emerged as an innovative and necessary alternative. This scientific statement outlines the benefits and challenges of VVs, enumerates changes in policy and reimbursement that have increased the feasibility of VVs during the COVID-19 era, describes platforms and models of care for …

Practice Recommendations For Lung Cancer Radiotherapy During The Covid-19 Pandemic: An Estro-Astro Consensus Statement, Gregory Videtic

Faculty Scholarship

Background: The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic. Methods: For this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk-benefit ratio of radiotherapy for lung …

Covid-19 Pandemic Through The Lens Of A Gastroenterology Fellow, Raj Shah, Sagarika Satyavada, Mayada Ismail, Michael Kurin, Zachary L. Smith, Gregory S. Cooper, Amitabh Chak

Faculty Scholarship

On Tuesday, March 10, 2020, an institutional e-mail sent from our hospital president confirmed the first 3 cases of the novel coronavirus disease 2019 (COVID-19) in our healthcare system. Twenty-four hours later, we learned that one of our co-fellows had been exposed and was forced into self-quarantine. Suddenly, what had seemed to be a distant problem hit close to home. As we sat around the “fellows’ room” (socially distanced as much as possible in the luxurious expanse that is common to fellows’ quarters), the uncertainty about our future raised several questions. How would we be impacted as we journeyed through …

Ua35/8 Reveille, Vol. 28, No. 1, Wku Veterans Upward Bound

WKU Administration Documents

Newsletter created by and about WKU Veterans Upward Bound.

• COVID-19 Temporarily Closes Veterans Upward Bound
• Veternas Administration Partners with Treasury Department to Deliver Economic Impact Payments to Veternans & Survivors

Ua3/10 President's Message - Spring Semester, Wku President's Office - Caboni

WKU Administration Documents

President's Message emails sent by Timothy Caboni to faculty & staff during spring semester, 2020.

• Announcing WKU Restart Committees & Commencement Update
• Big Red is in the Final Four! Vote Now!
• Big Red Restart Draft
• Big Red Restart Panel
• Big Red Restart Plan Answers
• COVID-19 & Holiday Schedule
• COVID-19 Testing
• COVID-19 Update
• COVID-19 Update – March 13^th
• COVID-19 Update 4.6.20
• COVID-19 Update: 3/17/20
• End of Semester
• Executive Order to Close Non-Life-Sustaining Businesses to In-Person Traffic
• Healthy On the Hill
• New Vice President for Enrollment & Student Experience – Ethan Logan

Aga Institute Rapid Recommendations For Gastrointestinal Procedures During The Covid-19 Pandemic, Perica Davitkov, Yngve Falck-Ytter

Faculty Scholarship

Multiple questions have been raised regarding the GI and liver manifestations of COVID-19 infection and the implications of SARS-CoV-2 infection on GI endoscopy. A joint society statement by the American Gastroenterological Association (AGA), the American Association for the Study of Liver Diseases, the American College of Gastroenterology, and the American Society for Gastrointestinal Endoscopy on March 15, 2020 highlighted the potential for SARS-CoV-2 transmission through droplets, an established mode of transmission, and possibly fecal shedding, and the associated risk for transmission to endoscopy personnel during GI endoscopy procedures. In this document, we seek to summarize the data and provide evidence-based …

Unprecedented Solutions For Extraordinary Times: Helping Long-Term Care Settings Deal With The Covid-19 Pandemic, Robin L.P. Jump

Faculty Scholarship

No abstract provided.

Correspondence Re: Covid-19, Wku Board Of Regents

Board of Regents Documents

Letter from WKU Board of Regents to WKU faculty & staff thanking them for professionalism under strain of COVID-19 restrictions.

Role Of Changes In Sars-Cov-2 Spike Protein In The Interaction With The Human Ace2 Receptor: An In Silico Analysis, Joseph Thomas Ortega

Faculty Scholarship

Many human viral diseases are a consequence of a zoonotic event. Some of the diseases caused by these zoono- tic events have affected millions of people around the world, some of which have resulted in high rates of mor- bidity/mortality in humans. Changes in the viral proteins that function as ligands of the host receptor may pro- mote the spillover between species. The most recent of these zoonotic events that have caused an ongoing epi- demic of high magnitude is the Covid-19 epidemics caused by SARS-CoV-2. The aim of this study was to de- termine the mutation(s) in the sequence …

Unrevealing Sequence And Structural Features Of Novel Coronavirus Using In Silico Approaches: The Main Protease As Molecular Target, Joseph Thomas Ortega

Faculty Scholarship

Direct-acting antivirals are effective tools to control viral infections. SARS-CoV-2 is a coronavirus associated with the epidemiological outbreak in late 2019. Previous reports showed that HIV-1 protease inhibitors could block SARS-CoV main protease. Based on that and using an in silico approach, we evaluated SARS-CoV-2 main protease as a target for HIV-1 protease inhibitors to reveal the structural features related to their antiviral effect. Our results showed that several HIV inhibitors such as lopinavir, ritonavir, and saquinavir produce strong interaction with the active site of SARS-CoV-2 main protease. Furthermore, broad library protease inhibitors obtained from PubChem and ZINC (www.zinc.docking.org) were …

Network-Based Drug Repurposing For Novel Coronavirus 2019-Ncov/Sars-Cov-2, Yuan Hou, Feixiong Cheng

Faculty Scholarship

Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV-host interactome and drug targets in the human protein-protein interaction network. Phylogenetic analyses of 15 …

Is Romania Ready To Face The Novel Coronavirus (Covid-19) Outbreak? The Role Of Incoming Travelers And That Of Romanian Diaspora, Iulian Gherghel

Student Scholarship

Letter to editor of Travel Medicine and Infectious Disease

Covid-19 Update, Wku Staff Senate

Staff Council

COVID-19 update issued by WKU Staff Senate.

Assessing Food Insecurity During Covid-19 Pandemic, Kevin Fitzpatrick

COVID-19

Presentation: Assessing Food Insecurity During COVID-19 Pandemic

Ua35/3 Memoranda, Wku Provost

WKU Administration Documents

2020 memoranda issued by the WKU Provost to faculty & staff via email.

• Center for Innovative Teaching & Learning January Workshops
• Fall to Fall Retention of All FFY as of Census by Selected Categories
• Updates fromt the Provost
• COVID-19
• COVID-19 or Coronavirus Update
• COVID-19 Update from the Provost's Office
• Announcing the 2020 College Faculty Award Winners
• WKU Announces New Associate Provost for Research & Graduate Education
• Budget Communication
• Summer School Updates from the Provost
• Amendment to PDF Policy
• FY2020-21 Budget Executive Committee Recommendations
• Provost's Message

Food Insecurity And Covid-19 Infographic, Community And Family Institute

COVID-19

Infographic on food insecurity and COVID-19 in America.

Ua25 Memoranda, Wku Strategy, Operations & Finance

WKU Administration Documents

Memoranda issued by WKU Strategy, Operations & Finance to faculty & staff via email.

• Bookstore
• Staff Excellence Awards
• Campus Update

Seafarers’ Experiences During The Covid-19 Pandemic, B. Pauksztat, M. Grech, M. Kitada, R.B. Jensen

Reports

This report provides an overview of preliminary findings of a study on the experiences of seafarers during the COVID-19 pandemic. The purpose was to examine the impact of the pandemic on seafarers’ work and life on board as well as on their mental health and exhaustion, and identify factors that may mitigate the negative impact of the pandemic

Assessing Food Insecurity In The United States During Covid-19 Pandemic, Kevin M. Fitzpatrick, Casey Harris, Grant Drawve

COVID-19

Means and number/percentage of respondents for each state are presented in Table 1. These responses are based on a representative, post-strata weighted national sample (n=10,368) of US adults collected in the last week of March 2020. Even though the responses are weighted, in those states where fewer than 50 respondents are surveyed, those states are treated as missing cases and food insecurity percentages are not provided.

Welcome To Cordell Perspectives, Neil M. Richards, Jonathan W. Heusel

Scholarship@WashULaw

The world around us is changing. Let’s talk about it together. Introducing a series of articles and opinions by the world’s leading experts concerning COVID-19 as it relates to precision medicine and data privacy: Welcome to Cordell Perspectives.

Covid-19 Sampling From The Middle Ear And Mastoid: A Case Report, George B Wanna, Zachary G Schwam, Vivian F Kaul, Maura K Cosetti, Enrique Perez, Peter Filip, Waleed Javaid, Avi Kandel, Alberto Paniz-Mondolfi, Satish Govindaraj, Eric M Genden

Faculty, Staff and Student Publications

No abstract provided.

The Fms21 (Pila)-Fms20 Locus Encoding One Of Four Distinct Pili Of Enterococcus Faecium Is Harboured On A Large Transferable Plasmid Associated With Gut Colonization And Virulence, Louis Maximilian Buja, Dwayne A Wolf, Bihong Zhao, Bindu Akkanti, Michelle Mcdonald, Laura Lelenwa, Noah Reilly, Giulia Ottaviani, M Tarek Elghetany, Daniel Ocazionez Trujillo, Gabriel M Aisenberg, Mohammad Madjid, Biswajit Kar

Faculty, Staff and Student Publications

This paper collates the pathological findings from initial published autopsy reports on 23 patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of America, including 3 cases from Houston, Texas. Findings confirm that COVID-19 is a systemic disease with major involvement of the lungs and heart. Acute COVID-19 pneumonia has features of a distinctive acute interstitial pneumonia with a diffuse alveolar damage component, coupled with microvascular involvement with intra- and extravascular fibrin deposition and intravascular trapping of neutrophils, and, frequently, with formation of microthombi in arterioles. Major pulmonary thromboemboli with pulmonary infarcts and/or hemorrhage occurred in …