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Human Coronaviruses Are Uncommon In Patients With Gastrointestinal Illness, Frank Esper, Zhen Ou, Yung T. Huang
Human Coronaviruses Are Uncommon In Patients With Gastrointestinal Illness, Frank Esper, Zhen Ou, Yung T. Huang
Faculty Scholarship
BACKGROUND: Coronaviruses infect numerous animal species causing a variety of illnesses including respiratory, neurologic and enteric disease. Human coronaviruses (HCoV) are mainly associated with respiratory tract disease but have been implicated in enteric disease. OBJECTIVES: To investigate the frequency of coronaviruses in stool samples from children and adults with gastrointestinal illness by RT-PCR. STUDY DESIGN: Clinical samples submitted for infectious diarrhea testing were collected from December 2007 through March 2008. RNA extraction and RT-PCR was performed for stools negative for Clostridium difficile using primer sets against HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1. Clinical data from samples positive for coronaviruses were reviewed …