COVID-19 Commons^™

Development Of A Survey And Worry Score To Evaluate Physician Burnout And Wellness Interventions During Covid-19 In The Rio Grande Valley: A Pilot Study, Victoria Jacobsen, Ericka Vazquez, Lauren Herrera, Ruth Escalera, Daniel Salinas, Bharathi Gadad, Juan Carlos Lopez-Alvarenga, Kelsey Potter-Baker

School of Medicine Publications

Background: Current research on physician burnout is limited in rural communities and physicians caring for the medically underserved. This study aimed to create an instrument to quantify the rate of physician burnout during the COVID-19 pandemic and identify effective coping interventions in an underserved mixed rural-urban region along the Texas-Mexico border.

Methods: We conducted a regional study in a sample of US physicians using a structured questionnaire developed by a multidisciplinary group. Thirty-one participants were contacted over a five-week period between December 2022 to January 2023. Participants self-selected based on their experiences of burnout during various phases of the COVID-19 …

Unveiling The Clinical Profiles Of Critically Ill Covid-19 Patients: Insights From Ezhou During The Early Spread, Guohui Yang, Zewen Liu, Tabitha Abraham, Linwei Li, Tingyang Zhou, Qing Zhang, Li Zuo

School of Medicine Publications

The coronavirus disease 2019 (COVID-19) started in December 2019 in Wuhan. This article evaluated clinical characteristics, and imaging manifestations in Ezhou, an early locked-down city, 80 kilometers east of Wuhan. We analyzed data from 98 confirmed severe COVID-19 patients in Ezhou Central Hospital between February 1st and March 22nd, 2020. We compared patients' laboratory results, imaging manifestations, and treatments between survival and death groups. Of these 98 confirmed COVID-19 patients, 24 individuals (24.6%) had chronic diseases. The main symptoms of critically ill patients were fever (86.7%), cough (83.7%), and dyspnea (59.1%). Common complications were acute respiratory distress syndrome (ARDS; 49%), …

Protein Subunit Vaccines: Promising Frontiers Against Covid-19, Vivek P. Chavda, Eswara Naga Hanuma Kumar Ghali, Pankti C. Balar, Subhash Chauhan, Nikita Tiwari, Somanshi Shukla, Mansi Athalye, Vandana Bharat Patravale, Vasso Apostolopoulos, Murali Yallapu

School of Medicine Publications

The emergence of COVID-19 has posed an unprecedented global health crisis, challenging the healthcare systems worldwide. Amidst the rapid development of several vaccine formulations, protein subunit vaccines have emerged as a promising approach. This article provides an in-depth evaluation of the role of protein subunit vaccines in the management of COVID-19. Leveraging viral protein fragments, particularly the spike protein from SARS-CoV-2, these vaccines elicit a targeted immune response without the risk of inducing disease. Notably, the robust safety profile of protein subunit vaccines makes them a compelling candidate in the management of COVID-19. Various innovative approaches, including reverse vaccinology, virus …

Implications Of Helminth Immunomodulation On Covid-19 Co-Infections, Nathalie Chacon, Leonor Chacin-Bonilla, Italo M. Cesar

School of Medicine Publications

Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity …