Nephrology Commons^™

Association Of Time-Varying Blood Pressure With Chronic Kidney Disease Progression In Children., Ben Christopher Reynolds, Jennifer Lynn Roem, Derek Kai Sing Ng, Mina Matsuda-Abedini, Joseph Thomas Flynn, Susan Lynn Furth, Bradley A. Warady, Rulan Savita Parekh

Manuscripts, Articles, Book Chapters and Other Papers

Importance: Optimal blood pressure (BP) management in children with chronic kidney disease (CKD) slows progression to end-stage renal disease. Studies often base progression risk on a single baseline BP measurement, which may underestimate risk.

Objective: To determine whether time-varying BP measurements are associated with a higher risk of progression of CKD than baseline BP measurements.

Design, Setting, and Participants: The ongoing longitudinal, prospective cohort study Chronic Kidney Disease in Children (CKID) recruited children from January 19, 2005, through March 19, 2014, from pediatric nephrology centers across North America, with data collected at annual study visits. Participants included children aged 1 …

Calcium Alkali Thiazide Syndrome, Mehboob A. Rehan Md, Asma Rashid Md, Reema Singh Md, Gabutti Cristina, Luma Mohsin Md, Tausha Allen Md, Paul Stanford Md, James Thomson Md

Internal Medicine

No abstract provided.

Mir193a Modulation And Podocyte Phenotype, A. Jha, S. Saha, K. Ayasolla, H. Vashistha, A. Malhotra, K. Skorecki, P. C. Singhal

Journal Articles

Apolipoprotein L1 (APOL1)-miR193a axis has been reported to play a role in the maintenance of podocyte homeostasis. In the present study, we analyzed transcription factors relevant to miR193a in human podocytes and their effects on podocytes' molecular phenotype. The motif scan of the miR193a gene provided information about transcription factors, including YY1, WT1, Sox2, and VDR-RXR heterodimer, which could potentially bind to the miR193a promoter region to regulate miR193a expression. All structure models of these transcription factors and the tertiary structures of the miR193a promoter region were generated and refined using computational tools. The DNA-protein complexes of the miR193a promoter …

Inflammation And Erythropoiesis-Stimulating Agent Hyporesponsiveness: A Critical Connection, H. H. Shah, N. N. Uppal, S. Fishbane

Journal Articles

No abstract provided.

Covid-19 Therapeutic Options For Patients With Kidney Disease, H. Izzedine, K. D. Jhaveri, M. A. Perazella

Journal Articles

No abstract provided.

Acute Kidney Injury In Patients With Covid-19: An Update On The Pathophysiology., H. Izzedine, K. D. Jhaveri

Journal Articles

No abstract provided.

Response To Thrombotic Microangiopathy: Covid-19 Or Hydroxychloroquine?, R. Wanchoo, M. L. Barilla-Labarca, K. D. Jhaveri

Journal Articles

No abstract provided.

Home Dialysis In The Time Of Covid-19: Reflections On Rapidly Changing Policies., M. Sachdeva, K. D. Jhaveri, S. Fishbane

Journal Articles

No abstract provided.

Treatment Of Parvovirus B19 Viremia To Facilitate Kidney Transplantation In A Patient With Collapsing Glomerulopathy., V. Nair, N. Jandovitz, K. D. Jhaveri, D. Hirschwerk, E. Grodstein, V. Bijol, E. Molmenti, L. Teperman

Journal Articles

Collapsing glomerulopathy (CG) is a severe form of glomerulopathy which results in nephrotic syndrome and often ensues in rapid progression to end-stage kidney disease (ESKD). Although most commonly a result of HIV infection, other conditions such as parvovirus B19 (PB19) infection have been associated with CG. We present a case of an 18-year-old male with CG associated with PB19 infection who was heterozygous for APOL1 G1 and G2 genetic variants. In an attempt to treat, he was started on intravenous immunoglobulin (IVIg), however rapidly progressed to ESKD. During workup for a living donor kidney transplant he was found to have …

Clinical Management Of Hyperkalemia, B. F. Palmer, J. J. Carrero, D. J. Clegg, G. B. Colbert, M. Emmett, S. Fishbane, D. J. Hain, E. Lerma, M. Onuigbo, M. R. Weir, +3 Additional Authors

Journal Articles

© 2020 Mayo Foundation for Medical Education and Research Hyperkalemia is an electrolyte abnormality with potentially life-threatening consequences. Despite various guidelines, no universally accepted consensus exists on best practices for hyperkalemia monitoring, with variations in precise potassium (K+) concentration thresholds or for the management of acute or chronic hyperkalemia. Based on the available evidence, this review identifies several critical issues and unmet needs with regard to the management of hyperkalemia. Real-world studies are needed for a better understanding of the prevalence of hyperkalemia outside the clinical trial setting. There is a need to improve effective management of hyperkalemia, including classification …

Thrombotic Microangiopathy In A Patient With Covid-19., Kd Jhaveri, Lr Meir, Bs Flores Chang, R Parikh, R Wanchoo, Ml Barilla-Labarca, V Bijol, N Hajizadeh

Journal Articles

No abstract provided.

Clinically Significant Anticardiolipin Antibodies Associated With Covid-19, S Hossri, M Shadi, Z Hamarsha, R Schneider, D El-Sayegh

Journal Articles

No abstract provided.

Outcomes Of Patients With End-Stage Kidney Disease Hospitalized With Covid-19., J. H. Ng, J. S. Hirsch, R. Wanchoo, M. Sachdeva, V. Sakhiya, S. Hong, K. D. Jhaveri, S. Fishbane, Northwell Covid-19 Research Consortium, Northwell Nephrology Covid-19 Research Consortium

Journal Articles

Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York. hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay), Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black, and …

Covid-19 And Solid Organ Transplant Outcomes, V. Nair, N. Jandovitz, K. D. Jhaveri, E. Molmenti

Journal Articles

No abstract provided.

Covid-19 In Hospitalized Patients On Chronic Peritoneal Dialysis: A Case Series, M. Sachdeva, N. N. Uppal, J. S. Hirsch, J. H. Ng, D. Malieckal, S. Fishbane, K. D. Jhaveri

Journal Articles

No abstract provided.

De Novo Anca-Associated Vasculitis With Glomerulonephritis In Covid-19., N. N. Uppal, N. Kello, H. H. Shah, Y. Khanin, I. R. De Oleo, E. Epstein, P. Sharma, C. P. Larsen, V. Bijol, K. D. Jhaveri

Journal Articles

No abstract provided.

Novel Approaches To Arteriovenous Access Creation, Maturation, Suitability, And Durability For Dialysis, M. V. Devita, S. K. Khine, H. Shivarov

Journal Articles

© 2020 Since the arteriovenous fistula (AVF) was first conceived over 50 years ago, the goal to create a vascular conduit with predictable and reproducible maturation and durability continues to elude caregivers. Recently, however, advances in the understanding of vascular biology and new technologies now provides us with some optimism; we are moving toward a viable solution. A quickly maturing, sustainable, and durable arteriovenous access may soon be attainable. This review will discuss these advances. There are novel approaches to AVF creation and devices to enhance maturation, advances in arteriovenous graft material(s), and devices to safely prolong the use of …

Covid-19 In Kidney Transplant Recipients, V. Nair, N. Jandovitz, J. S. Hirsch, G. Nair, M. Abate, M. Bhaskaran, E. Grodstein, I. Berlinrut, D. Hirschwerk, S. L. Cohen, K. W. Davidson, A. J. Dominello, G. A. Osorio, S. Richardson, L. W. Teperman, E. P. Molmenti

Journal Articles

No abstract provided.

Acute Kidney Injury In Patients Hospitalized With Covid-19, J. S. Hirsch, J. H. Ng, D. W. Ross, H. H. Shah, R. L. Barnett, A. D. Hazzan, S. Fishbane, K. D. Jhaveri, M. Abate, A. Bellucci, M. C. Bhaskaran, M. Gitman, C. Halinski, S. Hasan, S. Hong, Y. Khanin, A. Kuan, V. Madireddy, D. Malieckal, A. Muzib

Journal Articles

© 2020 International Society of Nephrology The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at 13 academic and community hospitals in metropolitan New York. Patients younger than 18 years of age, with end stage kidney disease or with a kidney transplant were excluded. AKI was defined according to KDIGO criteria. Of 5,449 patients admitted …

Erythropoiesis-Stimulating Agent Treatment In Patients With Covid-19., S. Fishbane, J. S. Hirsch

Journal Articles

No abstract provided.

Randomized Controlled Trial Of Difelikefalin For Chronic Pruritus In Hemodialysis Patients, S. Fishbane, V. Mathur, M. J. Germain, S. Shirazian, S. Bhaduri, C. Munera, R. H. Spencer, F. Menzaghi

Journal Articles

No abstract provided.

Renal Infarction In Covid-19 Patient, A. Ammous, M. A. Ghaffar, E. El-Charabaty, S. El-Sayegh

Journal Articles

No abstract provided.

Thrombotic Microangiopathy And Acute Kidney Injury Induced After Intravitreal Injection Of Vascular Endothelial Growth Factor Inhibitors Vegf Blockade-Related Tma After Intravitreal Use, R. M. Hanna, N. Tran, S. S. Patel, J. Hou, K. D. Jhaveri, R. Parikh, U. Selamet, L. Ghobry, V. Bijol, I. B. Kurtz, +6 Additional Authors

Journal Articles

No abstract provided.

Pathophysiology And Pathology Of Acute Kidney Injury In Patients With Covid-19, J. H. Ng, V. Bijol, M. A. Sparks, M. E. Sise, H. Izzedine, K. D. Jhaveri

Journal Articles

© 2020 National Kidney Foundation, Inc. Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to …

Alterations In Plasma Membrane Ion Channel Structures Stimulate Nlrp3 Inflammasome Activation In Apol1 Risk Milieu, A. Jha, V. Kumar, S. Haque, K. Ayasolla, S. Saha, X. Lan, A. Malhotra, M. A. Saleem, K. Skorecki, P. C. Singhal

Journal Articles

© 2019 Federation of European Biochemical Societies We evaluated alterations in the structural configurations of channels and activation of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome formation in apolipoprotein L1 (APOL1) risk and nonrisk milieus. APOL1G1- and APOL1G2-expressing podocytes (PD) displayed enhanced K+ efflux, induction of pyroptosis, and escalated transcription of interleukin (IL)-1β and IL-18. APOL1G1- and APOL1G2-expressing PD promoted the transcription as well as translation of proteins involved in the formation of inflammasomes. Since glyburide (a specific inhibitor of K+ efflux channels) inhibited the transcription of NLRP3, IL-1β, and IL-18, the role of K+ efflux in the activation …

The Relationship Between Medication Discrepancies And Hospitalization Risk Among Patients With Advanced Ckd, V. Sakhiya, J. James, K. D. Jhaveri, M. Zhang, J. H. Ng, C. Halinski Np, J. Tomanguillo-Chumbe, S. Fishbane

Journal Articles

No abstract provided.

'Whatsapp (R)' Ening In Nephrology Training, K. D. Jhaveri, B. Pascarelli, A. Hasan, A. Kozikowski, S. Fishbane, R. Pekmezaris

Journal Articles

No abstract provided.

Refractory Scleroderma Renal Crisis Precipitated After High-Dose Oral Corticosteroids And Concurrent Intravitreal Injection Of Bevacizumab., Ramy M Hanna, Lama Abdelnour, Jonathan E Zuckerman, Antoney J Ferrey, Alex Pai, Kambiz Vahabzadeh, James Wilson, Everado A Torres, Kamyar Kalantar-Zadeh, Ira B Kurtz

Articles, Abstracts, and Reports

Scleroderma renal crisis is a serious complication that can develop in certain patients with systemic sclerosis. Some risks have been identified as potential triggers of scleroderma renal crisis, including the high-dose oral corticosteroids. Here, we present a patient who developed clinically severe systemic sclerosis and scleroderma renal crisis after exposure to oral corticosteroids and intravitreal vascular endothelial growth factor blockade with bevacizumab for cotton wool spots. The patient's scleroderma renal crisis was severe, progressive, and refractory to the standard of care therapy: oral captopril. Biopsy showed a diffuse thrombotic microangiopathy and findings consistent with scleroderma renal crisis. We hypothesize that …

Patient And Renal Outcomes Of Posttransplant Lymphoproliferative Disorder Following Solid Organ Transplantations - A Single Center Experience, Kashka Mallari, Goni Katz-Greenberg, Maria Martinez Cantarin

Phase 1

Introduction: Post-transplant Proliferative Disorder (PTLD) is a significant complication after solid organ transplantation (SOT). Major risk factors that contribute to the development of PTLD include Epstein-Barr Virus (EBV) infection and degree of immunosuppression. Despite novel therapies, the 5-year survival rate of PTLD only improved from 40% to 50% over the years. The reported 5-year survival rate of PTLD also remains significantly lower compared to around 90% in other malignancies such as breast and colon cancer. In our center, we hypothesize better transplant outcomes compared to those reported in preceding literatures.

Methods: We retrospectively reviewed the electronic medical records of …

Kidney Stone Analysis And Spiritual Guides (Pir Faqir): The Known-Unknowns, Lena Jafri, Aysha Habib Khan, Humaira Asif

Department of Pathology and Laboratory Medicine

No abstract provided.