Medical Sciences Commons^™

Ocular Toxocariasis With Bilateral Virtually Symmetrical Optic Nerve Head Granulomas, Gülay Güllülü, İlknur Akyol Salman, Ahmet Özbek, Nesli̇han Astam, Akin Levent

Turkish Journal of Medical Sciences

LLÜLÜ^1 İlknur AKYOL^1 Ahmet ÖZBEK^2 Neslihan ASTAM^1 Akın LEVENT^3 Departments of ^1Ophthalmology, ^2Microbiology and Clinical Microbiology, ^3Radiology, Faculty of Medicine, Atatürk University, Erzurum - TURKEY

Primary Malignant Schwannoma Of The Small Bowel: A Case Report, Fahri̇ Yilmaz, Ali̇ Kemal Uzunlar, Yaşar Bükte, Selver Özeki̇nci̇, Yilmaz Akgün

Turkish Journal of Medical Sciences

Malignant Schwannoma of the Small Bowel Fahri YILMAZ^1 Ali Kemal UZUNLAR^1 Yaşar BÜKTE^2 Selver ÖZEKİNCİ^1 Yılmaz AKGÜN^3 Departments of ^1Pathology, ^2Radiology, ^3General Surgery Faculty of Medicine, Dicle University, Diyarbakır - TURKEY

Paget's Disease Of The Male Breast - A Case Report, Sema Hücümenoğlu, Handan Kaya, Fati̇h Mehmet Avşar

Turkish Journal of Medical Sciences

ÜMENOĞLU^1 Handan KAYA^2 Fatih Mehmet AVŞAR^3 ^1Department of Pathology, SSK Ankara Training and Research Hospital, Ankara, ^2Department of Pathology, Faculty of Medicine, Marmara University, Istanbul, ^3Department of 1st Surgery, Ankara Numune Training and Research Hospital, Ankara - TURKEY

A Case Of Bisatellited-Isodicentric Supernumerary Chromosome 15, Y. Selma Süngü, Bi̇rsen Karaman, E. Ferda Perçi̇n, Sevi̇m Balci, İlhan Sezgi̇n

Turkish Journal of Medical Sciences

SÜNGÜ^1 Birsen KARAMAN^2 E. Ferda PERÇİN^1 Sevim BALCI^3 İlhan SEZGİN^1 ^1Department of Medical Biology and Genetics, Faculty of Medicine, Cumhuriyet University 58140-Sivas, ^2Department of Medical Genetics, Faculty of Medicine, Istanbul University, Çapa -Istanbul, ^3Department of Pediatrics, Faculty of Medicine, Hacettepe University Ankara - TURKEY

Nitric Oxide I: Advances In The Measurements For Clinical Applications, Ayşe Baysal

Turkish Journal of Medical Sciences

Nitric oxide (NO) is a colorless gas with high affinity to ferrous hemoproteins. This simple molecule is a powerful messenger in the body. This study reviews a literature search using keywords and abstracts in English through Medline. Recent advances in the therapeutic uses of inhaled nitric oxide in lung diseases and other pathologic states urges the efficient and convenient use of nitric oxide in hospital practice. In addition, methods of inhaled nitric oxide delivery, chemiluminescence and electrochemical analyzers were reviewed. The performance characteristics of different equipment were compared. The novel methods of nitric oxide measurements that utilize simple and cheaper …

Purification And Characterization Of Carbonic Anhydrase From Human Erythrocyte Plasma Membrane, Nazan Demi̇r, Yaşar Demi̇r, Fatma Coşkun

Turkish Journal of Medical Sciences

Carbonic anhydrase is the basic enzyme in inhalation function. Untill now no research had been done to determine whether CA is in the human erythrocyte plasma membrane or not. Carbonic anhydrase (CA) was purified from human erythrocyte plasma membrane and described in this study. For this purpose, the blood samples taken from young human test subjects were hemolyzed, then the membrane fraction was separated, and this fraction was repeatedly washed. The enzyme (CA) was removed from the membrane with buffered TritonX-100 (1%), which was purified with a factor of 119.19 by affinity chromatography. The CA obtained from the erythrocyte membrane …

Colicin Production And Colicin Typing Of Uropathogenic Escherichia Coli, Ayli̇n İmren Çarikçi, Güner Coşar

Turkish Journal of Medical Sciences

Colicins are bactericidal macromolecules in protein structures and they are produced by some strains of Escherichia coli and Shigella, which are members of the Enterobacteriaceae. They have a bactericidal effect on the same species or closely related bacteria, but have no effect on the strains which produce them. In this study, 129 E. coli strains isolated from urine samples of patients in Izmir and Manisa were examined for colicin production, and the colicinogenic strains were examined for their colicin types by means of Horak specific indicator strains. Indicator strains were obtained from the National Type Culture Collection Hygiene and Epidemiology …

Antifungal Activities Of Different Extracts And Echimidine-N-Oxide From Symphytum Sylvaticum Boiss. Subsp. Sepulcrale (Boiss. & Bal.) Greuter & Burdet Var. Sepulcrale, Murat Kartal, Semra Kurucu, Muhammad I. Choudary

Turkish Journal of Medical Sciences

Antifungal activity was determined by the tube dilution method on different extracts of Symphytum sylvaticum Boiss. subsp. sepulcrale (Boiss. & Bal.) Greuter & Burdet var. sepulcrale. The antifungal activity of the isolated compound from the root alkaloid fraction (Echimidine-N-Oxide) was also tested against ten fungal cultures. The activity was found to be mainly due to Echimidine-N-Oxide (ENO). The quantitative determination of ENO was also carried out with capillary gas chromatography in the roots and the aerial parts of the plant.

Brain Stem And Cerebral Cortex Histamine Concentrations In The Rem Sleep Deprived Rats, Hale Sayan, Ethem Geli̇r, Aydan Babül

Turkish Journal of Medical Sciences

Histamine is a biogenic amine widely distributed in the central nervous system that acts in a neuroregulatory role in controlling the waking state. The aim of this study was to determine whether 120 h of REM sleep deprivation (REMSD) causes changes in histamine concentrations in rat brain stems and cerebral cortex areas that are involved in the homeostatic regulation of sleep. A number of rats were subjected to 120 h of REM sleep deprivation using the flower pot water tank technique. This method used to induce REMSD is believed to be stressful. To control for the stress caused by the …

Human Herpesvirus 8 (Hhv-8) In Non-Hiv Associated Forms Of Kaposi's Sarcoma From Turkey, Ni̇lgün Şentürk, Sedef Şahi̇n, Serpi̇l Erci̇ş, Tanil Kocagöz, Ni̇lgün Atakan

Turkish Journal of Medical Sciences

Objective: Kaposi's sarcoma (KS), first described in 1872 by Moritz Kaposi, is a spindle cell, multifocal vascular tumor. Despite the intense work on the pathogenesis of KS, its etiology remains in doubt. The aim of this study was to determine the presence of HHV-8 sequences in non-HIV associated Kaposi's sarcoma patients, namely classical and immunosuppression-associated, and compare the results with normal healthy subjects. Materials and Methods: Nineteen patients with classical Kaposi's sarcoma (CKS), and nine patients with immunosuppression-associated Kaposi's sarcoma (ISKS) (6 renal transplantation, 1 Behçet's disease, 1 high grade lymphoma, 1 ataxia telangiectasia) were included in this study. Skin …

Detection Of Human Papilloma Virus In Benign, Malignant And Pre-Cancerous Lesions Of Oral Mucosa By In Situ Hybridization, Mehmet Yaltirik, Ayla Özveren, Canan Alatli, Nevi̇n Büyükakyüz

Turkish Journal of Medical Sciences

HPV is an epitheliotropic virus, predominantly associated with human skin and mucosal lesions. In many studies, the presence of HPV types 6/11, 16/18 and 31/33/51 have been demonstrated in oral lesions. The aim of this study is to investigate the presence of specific types of HPV in oral benign and precancerous epithelial lesions and oral carcinomas, and the etiological significance of HPV in oral epithelial malignancies. In the present study, twenty oral lesions, of which seven were papilloma, seven squamous cell carcinoma, four leukoplakia and two lichen planus, were tested for different types of HPV. In addition, these patients were …

Expression Of Fas Antigen And Bcl-2 Protein In Liver Tissues Of Patients With Chronic Hepatitis B, Ayşe Polat, Fazi̇let Kayaselçuk, Reyhan Eği̇lmez, İlhan Tuncer

Turkish Journal of Medical Sciences

The aim of this study was to evaluate the role of apoptosis in chronic hepatitis B, and correlate it with disease severity. We studied the expression of the Fas antigen (FasAg) and Bcl-2 protein in a group of patients with chronic hepatitis B at various stages of the disease. Four liver biopsy specimens taken from the patients with chronic hepatitis B infection and five control liver tissue specimens with normal histology were studied. Liver specimens were scored for disease severity according to Knodell's hepatic activity index (HAI). The percentage of hepatic expression was evaluated semi-quantitively. Our immunohistochemical study showed that …

Hormonal Profile And Agnor Values In Pituitary Adenomas, Sema Hücümenoğlu, Handan Kaya, Esi̇n Koti̇loğlu, Gülben Erdem, Evri̇m Demi̇ray, Gülsün Eki̇ci̇oğlu

Turkish Journal of Medical Sciences

Nucleolar organizer regions (NORs) are chromosomal segments in which ribosomal RNA is encoded. The AgNOR technique, which reveals these regions, has rarely been used in diagnosis and preceding the prognosis of pituitary adenoma. The purpose of this study was to evaluate the correlation of hormonal profile with the AgNOR counts, and the correlation of recurrence with the AgNOR counts and to determine the concordance between the evaluations of two different observers. This study included 33 patients wıth pituitary adenoma. The slides were stained with hematoxylin and eosin, silver colloid method for NORs and immunohistochemistry for the hormone expressions. Consistency was …

Lung Carbon Dioxide Elimination Corralates With Physiologic Dead Space Volume During Mechanical Ventilatory Support, Murat Sungur, Muhammed Güven

Turkish Journal of Medical Sciences

Increased mean airway pressure (Paw) predisposes to increased alveolar dead space volume and, hence, physiologic dead space volume (V{Dphys}. This is the result of overdistending alveoli, converting Zone 2 and Zone 3 units to Zone 1 units. Lung carbon dioxide elimination (LCO_2) is a reflection of pulmonary capillary blood flow. It is hypothesized that as Zone 1 units form or V{Dphys} increases, LCO_2 decreases proportionately and eventually PaCO_2 increases. The purpose of this study is to determine if LCO_2 correlates with V{Dphys} during mechanical ventilation. Six sheep (66.3 ± 6.5 kg), anesthetized with sodium thiopental and paralyzed using pancronium, had …

Effects Of Oral L-Glutamine, Insulin And Laxative On The Severity Of Acute Pancreatitis, Fati̇h Mehmet Avşar, Mustafa Şahi̇n, Oral Saygun, İ. Hakan Özel, Süleyman Hengi̇rmen, Hüsametti̇n Vatansev, Ertuğrul Kafali, Osman Yilmaz

Turkish Journal of Medical Sciences

Aim: To investigate the effects of oral L-glutamine, insulin and laxative on the severity of acute pancreatitis. Materials and Methods: Forty adult male Sprague-Dawley rats were divided into 4 groups. Experimental pancreatitis was induced by ligating the main biliopancreatic duct. All groups were given standard rat pellets and tap water. In addition Group II was given 15 mg/kg/day of L-glutamine via a catheter enterally, Group III was given a 3 ml/day fleet enema via a catheter enterally, and Group IV was given 3 IU/kg/day of NPH insulin via a catheter enterally. The rats were sacrificed 96 hours after the induction …

Evaluation Of Thyroid Hormones And Goitre In A Rural Community In A Region Of Anatolia, Meti̇n Kilinç, Güneş T. Yüregi̇r, Fi̇kret Ezberci̇, Hasan Ekerbi̇çer, Mehmet Aki̇f Büyükbeşe

Turkish Journal of Medical Sciences

This study was conducted in an endemic goitre area to determine thyroid profiles TSH, freeT4 (fT4), T4, fT3 and T3, as well as the degree of the severity of hypothyroidism and the prevalence of the disease. Tonbak is a small village in Kahramanmaraş. The iodine content of the water is < 1 mg/L. A randomly selected group of 121 subjects aged 16-55 were included in the study. The percentage of goitre was 71.1% upon physical examination. Subjects with primary hypothyroidism were 16.5%. Mean scores of fT4 were 8.9±2.6 pmol/l (range: 2.7-12.9) and mean scores of TSH were 18.1±26.1 mU/ml (range: 4.33-100

Comparison Of Remifentanil-Propofol And Sevoflurane For Preventing Cardiovascular Response And Quality Of Recovery In Paediatric Otolaryngologic Surgery, Zeli̇ha Özer Koçak, Ali̇ Aydin Altunkan, Şebnem Atici, İsmai̇l Ci̇nel, Uğur Oral

Turkish Journal of Medical Sciences

As the practice of outpatient paediatric surgery advances, the search continues for anaesthesia that provides rapid smooth induction, stable patient haemodynamics, rapid emergence and minimal unpleasant side effects. Therefore, this study was designed to compare the haemodynamic changes, emergence and recovery characteristics of remifentanil-propofol (TIVA) and sevoflurane anaesthesia for adenoidectomy with bilateral myringotomy and insertion of tubes and/or tonsillectomy (ENT surgery) in children. Children aged 6.3±1.6 years, undergoing elective ENT surgery, were randomly assigned to receive TIVA (n=15) and sevoflurane (n=15). In both groups, anaesthesia was induced with propofol and remifentanil and maintained either with infusion of propofol-remifentanil or sevoflurane …

Sublingual Valsartan In Hypertensıve Urgency, Yüksel Gökel, Sai̇me Paydaş, Güven Kuvandik, Nazan Alparslan

Turkish Journal of Medical Sciences

The objective of this study was to assess the effect of sublingual valsartan in a group of patients with hypertensive urgency. Forty-one patients with hypertensive urgency and systolic blood pressure >200 mmHg, diastolic blood pressure >100 mmHg were studied in an emergency room. Supine blood pressure readings were taken and the patients were given 80 mg of valsartan sublingually. Blood pressure and heart rate were recorded at 15 min intervals over a 90 min period. Systolic blood pressure decreased from 211.22±14.65 mmHg to 158.17±15.48 mmHg, diastolic blood pressure dropped from 120.12±13.44 mmHg to 93.05±6.01 mmHg. The differences were statistically significant. …

Reconstruction Of Temporomandibular Joint Using Distraction Osteogenesis, Reha Ş. Ki̇şni̇şçi̇, Doğan Dolanmaz, Hakan H. Tüz

Turkish Journal of Medical Sciences

KİŞNİŞCİ^1 Doğan DOLANMAZ^2 Hakan H. TÜZ^1 ^1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara ^2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Selçuk University, Konya-TURKEY

Acrodermatitis Enteropathica, Enver Şi̇mşek

Turkish Journal of Medical Sciences

No abstract provided.

Isolated Hydatic Cyst In The Subcutaneous Tissue, Tanju Acar, Ramazan Taçyildiz, Sali̇h Tuncal

Turkish Journal of Medical Sciences

No abstract provided.

Adenomyoma Of The Stomach Accompanying Gastric Adenocarcinoma, Sema Hücümenoğlu, Musa Zorlu, Hakan Güzel, Fati̇h Mehmet Avşar

Turkish Journal of Medical Sciences

ÜMENOĞLU^1 Musa ZORLU^2 Hakan GÜZEL^2 Fatih Mehmet AVŞAR^3 Departments of ^1Pathology, ^2General Surgery, SSK Ankara Training and Research Hospital, ^3Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara - TURKEY

Leptin And Mast Cells: A Novel Adipoimmune Link, Mariana Hristova, Luigi Aloe, Peter I. Ghenev, Marco Fiore, George N. Chaldakov

Turkish Journal of Medical Sciences

HRISTOVA^1 Luigi ALOE^2 Peter I. GHENEV^3 Marco FIORE^2 George N. CHALDAKOV^4 ^1Endocrinology Clinic, Medical University, Varna, Bulgaria, ^2Institute of Neurobiology, CNR, Rome, Italy, ^3Department of General and Clinical Pathology and ^4Division of Electron Microscopy, Department of Forensic Medicine, Medical University, Varna, Bulgaria

A Noninvasive Test For Vesico-Ureteric Reflux In Children, R. A. Mevorach, B. Cilento, S. Zahorian, C. Badgett, R. Walker, A. Atala, S. Iannello, M. Meyer

Electrical & Computer Engineering Faculty Publications

Objective To report the development and testing of a device for the noninvasive diagnosis of vesico‐ureteric reflux (VUR) which avoids the need for urethral catheterization (currently required to reliably determine the presence of VUR), and which thus avoids the anxiety of parents and patients that causes many families to refuse such evaluation.

Patients and methods Fifty‐four children (49 girls and five boys, mean age 7.2 years, range 4–14) previously evaluated as having VUR volunteered to participate; no child was symptomatic at the time of the study. Refluxing units were known to be present by voiding cysto‐urethrography (within 1 year, mean …

Genetic Variation And Disease In The Roma (Gypsies), David J. Gresham

Theses: Doctorates and Masters

The Roma (Gypsies) are a European people composed of a mosaic of culturally heterogeneous populations. Linguistic analyses point to their origins in the Indian subcontinent. Cultural diversity in extant Romani populations suggests that they are descended from a mixture of Indian populations. Previous population genetic studies of the Roma have supported this claim by demonstrating the genetic heterogeneity of Romani populations. More recently, medical genetic research has detected identical founder mutations in separated Romani populations, which provides evidence of their relatedness. In this thesis, the genetic heritage of the Roma and its significance for genetic disease and research is investigated. …

Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih

Theses and Dissertations

The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the …

Teucrium Polium Inhibits Nerve Conduction And Carrageenan Induced Inflammation In The Rat Skin, Jumah Shakhanbeh, O. Adigüzel

Turkish Journal of Medical Sciences

The effects of acute and chronic perineural treatment of the rat saphenous nerve with Teucrium polium (L.) extract on the conduction property of primary afferent nerve fibers and carrageenan-induced skin inflammation were studied. Direct application of 2.0% T. polium extract to the nerve trunk caused immediate complete inhibition of compound action potentials (CAPs) of all types of primary afferent nerve fibers. Partial recovery of CAPs was seen in up to 37.5% of Aab-fibers, 30.4% of Ad-fibers and 32.4% for C-fibers over one hour after removal of the extract. Fifteen to twenty days after a single perineural application of 2% T. …

The Antioxidant Activity Of The Leaves Of Cydonia Vulgaris, Ali̇ Yildirim, Müni̇r Oktay, Vahi̇t Bi̇laloğlu

Turkish Journal of Medical Sciences

The antioxidant activities of water, ethanol, and ether extracts of the leaves of Cydonia vulgaris Pers. were determined by the thiocyanate method. The antioxidant activity of water extract was increased with the increasing amount of extract (200 µg-1000µg) added to the linoleic acid emulsion. Ether extract was the most effective antioxidant among the extracts. Like antioxidant activity, the reducing power of water extract was concentration dependent. However, ethanol extract was the highest in reducing power, and ether extract was the lowest. The results obtained in the present study indicate that the leaves of Cydonia vulgaris are a potential source of …

Difficulties Associated With The Study Of Action Potential After-Potentials In Rat Cultured Sensory Neurones, Ahmet Ayar, Roderick H. Scott

Turkish Journal of Medical Sciences

We investigated the properties of action potential after-potentials in cultured dorsal root ganglion neurones from neonatal rats using the whole cell patch clamp technique. The aims of this study were to characterize after-potentials and investigate the possible influences of Ca^{2+}-induced Ca^{2+}release (CICR) on neuronal excitability. The reversal potentials of action potential after-depolarizations and after-hyperpolarizations were estimated. Although evidence for both Ca^{2+}-activated chloride and potassium conductances was obtained, the data indicated that the after-potentials were contaminatied by a variety of distinct ionic events. Apamin was used to attenuate potassium conductances and appeared to enhance the after-depolarizations due to Ca^{2+}-activated chloride conductances. …

A Relation Between The Apolipoprotein E Genotypes And Microalbuminuria In Type 2 Diabetes Mellitus, Ersi̇n Akarsu, İbrahi̇m Pi̇ri̇m, İlyas Çapoğlu, Hasan Kaya, Güngör Akçay, Necdet Ünüvar

Turkish Journal of Medical Sciences

Various relations between apolipoprotein E (apo E) and diabetic nephropathy have been reported. In this study, the question of whether there is any relation between apo E genotypes and microalbuminuria in patients with type-2 diabetes mellitus was examined. Twenty-one male and 25 female patients, with ages the range of 37-62 years (mean 51.7±7.5) with type-2 diabetes mellitus were studied. The apo E genotypes were determined by PCR amplification of the 227 bp region followed by CfoI digestion to release specific band patterns. While 24 patients had microalbuminuria (microalbuminuria group), 22 patients had normoalbuminuria (normoalbuminuria group). The patients with microalbuminuria had …