Dentistry Commons^™

Oral Health Status In Children With Nephrotic Syndrome, Heba Mohamed Deghid, Salwa Adel Hegazy, Nasr Mohamed Attia

Mansoura Journal of Dentistry

Objective: To assess the oral health status of a group of nephrotic syndrome children in Mansoura City.

Methods: This case-control study was conducted on 200 children aged 4-14 years old, who were divided into two equal groups. Children with Nephrotic Syndrome were selected from the Nephrology clinic at Mansoura Children’s Hospital as a case group. Matched healthy children were selected as a control group from governmental schools in Mansoura city. The oral health status of the studied groups was evaluated by using DMFT & deft indices, gingival index (GI), simplified oral hygiene index (OHI-S), and developmental enamel defects index (DDE). …

Combatting Bacterial Infections: The Efficacy Of Poly-Gamma-Glutamic Acid On The Prevention Of Nasopharyngeal Infections Among Individuals With Cleft Lip And Palate, Florence Pun

Scripps Senior Theses

Cleft lip and palate (CLP) is a medical condition where children are born with an unfused lip and palate. While surgery is required to fuse the lip and palate, there are other conditions that children with CLP face after surgeries, such as otitis media (OM), speech impediments, and difficulty breathing. Particularly, OM occurs frequently in individuals with CLP because the tensor veli palatini muscles cannot open the Eustachian tube frequently and ventilate the middle ear properly, even after surgery. This thesis is a research proposal to evaluate whether γ-PGA can be used in nasal washes to safely prevent nasopharyngeal infections …

Pharmacological Management Of Oral Lesions, Tanishka Taori, Bhinika Wadher, Shefali Maheshwari, Swapnil Mohod, Suwarna Dangore

International Arab Journal of Dentistry

Oral ulcerations caused by aphtous lesions, leukoplakia, scarlet fever, syphilis, NOMA, mucormycosis herpetic lesions, candidiasis, discoid lupus erythematous, ulcerative lichen planus, mucous membrane pemphigoid, spongy nevus, oral submoucs fibrosis and pemphigus vulgaris are treated in a step-up fashion that may include topical, intralesional, and systemic pharmaceutical treatment. This page discusses the most often used therapy agents, methods, and dosages. Although the emphasis is on local pharmacologic therapy, systemic illnesses that frequently occur with such oral lesions are briefly discussed, as is the appropriate care.

Comparison Between Conventional And 3d Printed Implant Retained Mandibular Complete Overdentures Regarding Occlusion Using Digital Occlusion Analysis System (A Pilot Study), Hazem M. M. Al-Sappagh, Mohamed S.N. Taha, Noha A. Mansour, Radwa M.K. Emera

Mansoura Journal of Dentistry

Purpose

This within-patient study aimed to compare two different construction techniques (conventional and 3D printing) of two implant-assisted complete mandibular overdenture regarding occlusion using a digital occlusion analysis system (Occlusense).

Methods

Six patients were selected for this study from the prosthetic department, Faculty of Dentistry, Mansoura University. All patients received mandibular implant-assisted overdentures with two fabrication techniques, conventional overdenture (group I) and 3D printed overdenture (group II). Ball and socket attachments were used to retain the mandibular overdentures to the underlying implant fixtures. Conventional and 3D printed mandibular overdentures were compared and evaluated after 3 months of overdenture use regarding …

A Comparison Of Crestal Bone Loss Between Healing Abutment And Customized Abutment; 6 Months Clinical Observation, Adison Jirasuwannakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Adison Jirasuwannakul : A Comparison of crestal bone loss between healing abutment and customized abutment ; 6 months clinical observation. Advisor: Associate Professor Pravej Serichetaphongse, D.D.S., M.S . Co-advisor: Asst. Prof. Wareerat Chengprapakorn,, D.D.S., Ph.D. Objective : To compare the effect on marginal bone loss between using healing abutment and customized abutment (Definite abutment). Material and method : Thirdtyfour patients who required a single posterior implant-supported prosthesis were randomly divided into two groups which were healing abutment group (Control group)and customized titanium abutment group(Test group). Patients received one dental implant between 4.0 and 5.0 mm. diameter (Dentium Superline, Dentium, Seoul, …

The Effect Of Different Functional Monomer Of Zirconia Primer And Universal Adhesive On Shear Bond Strength Of Zirconia To Composite Resin Using Resin Cement, Pimchanok Pitakassawakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Zirconia has been increasing used due to its good mechanical properties but the study about the ability to bond to zirconia ceramic is still limited. The purpose of this study is to evaluate the bond strength of zirconia using MDP-containing zirconia primer and GPDM-containing universal adhesive. Twenty-one super-high translucent zirconia discs (Ceramil zolid fx White; AMANN GIRRBACH, Austria), 8.5 mm in diameter and 3.2 mm in thickness, were prepared. The specimens were divided into 3 groups (n=7) according to primer application, Group I: no primer application (control group), Group II: Z-Prime plus® (Bisco, Schaumburg, Illinois, USA) and Group III: Optibond …

M2 Macrophages In Human Periapical Lesions In Relation To Histopathological Diagnosis, Clinical Features, And Lesion Volume, Supanant Visarnta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated M1 and M2 macrophage polarization in human periapical cysts and granulomas through an immunohistochemical analysis and investigated the correlation between the macrophage polarization and histopathological diagnosis, clinical features and lesion volume using cone-beam computed tomography. The periapical biopsies histopathologically diagnosed as radicular cyst (n=52) and periapical granuloma (n=51) were analyzed by immunohistochemical method. Immuno-expressions of CD68 and CD163 were quantified. The CD68/CD163 ratio was adopted to represent M1 or M2 macrophage polarization. Pathological diagnosis, patients’ age, gender, clinical signs and symptoms, tooth location of the periapical lesion, and history of root canal treatment were obtained from treatment …

Comparison Of Removal Torques Among Different Abutments In Single Implant Crowns After Cyclic Loading: An In Vitro Study, Suppanut Jongsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To evaluate the effect of different restoration designs on the removal torque loss of implant-supported maxillary first premolar crowns after cyclic loading and to measure the impact of cyclic loading on removal torque. Materials and Methods: Thirty-two dental implants (4.0*10 mm), embedded in resin blocks and their abutments, were divided into 4 groups (n=8) based on restoration design: screwmentable group, 2 cement-retained groups: cemented with adhesive resin cement (Panavia V5) or provisional cement (RelyX Temp NE), and screw-retained one-piece titanium group. Monolithic zirconia crowns were fabricated and cemented in the first three groups. Their removal torques were recorded using …

The Alleviating Effects Of Epidermal Growth Factor On An In Vitro Oral Mucositis Model In The Presence Of Fusobacterium Nucleatum, Tien Thi Trieu Truong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: 5-fluorouracil (5-FU) is commonly used as a chemotherapy drug for head and neck cancers. However, it often produces an adverse cytotoxic effect on the oral epithelia leading to oral mucositis (OM) in cancer patients. Thus, reversing this cytotoxic effect locally with novel bioactive drugs or factors is necessary. This study aimed to investigate the rescue effect of Nicotiana benthamiana plant-derived epidermal growth factor (P-EGF) on human normal oral keratinocytes (NOKs) exposed to 5-FU-induced cytotoxicity in the presence of Fusobacterium nucleatum (Fn). Materials and Methods: Cytotoxicity and ATP-dependent proliferation and metabolism of NOK monolayer cultures were assessed after 48 hours …

Effects Of Self-Adhesive Resin Cements On Human Gingival Fibroblasts, Kittipat Termteerapornpimol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To investigate the response of primary human gingival fibroblasts (HGFs) to self-adhesive resin cement (SARC) extracts. Methods: Two types of SARCs, RelyXTM U200 (RX) and Maxcem EliteTM Chroma (MC), were polymerized using various curing methods (light-cured, light-cured through 1- or 2-mm zirconia, and self-cured) (n=9/group). HGFs were exposed to cement extracts at different concentrations. Treated HGFs were assessed for cell viability, vitality, wound healing, and gene expression at different time points. Results: Dual-cured MC left self-cured and MC cured through 2 mm zirconia at high concentration significantly decreased the viability of HGFs. Delayed wound healing was observed in MC …

Efficacy Of Nanogel From Grafted Hyaluronic Acid Saliva Substitutes In The Treatment Of Dry Mouth, Nongnapat Eakpunyakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study was to evaluate the efficacy of HA-pNIPAM spray or Hy-N spray in treating dry mouth and to evaluate patient satisfaction with Hy-N spray. This study was a randomized double-blind crossover study conducted on patients with dry mouth. They were given three saliva substitutes: Hy-N, placebo, and Biotène spray, which were randomly allocated in a different order. Each spray was used for 1 week, followed by a 3-day wash-out period. The instruction was to use the sprays four times a day. A total of twenty-nine patients completed the study. A significant increase in unstimulated whole saliva …

Comparing Medium To Long-Term Esthetic, Clinical And Patient-Reported Outcomes Between Freehand And Computer-Assisted Dental Implant Placement, Sun Heng

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: The aim of the study was to compare medium to long-term clinical and patient reported outcomes between implants placed with Computer-assisted Implant Surgery (CAIS) and freehand protocols. Materials and Methods: Thirty dental implants in the anterior maxillary region with an average of 4 years after loading were assessed by means of Pink Esthetic Scores (PES), Marginal Bone Level (MBL), clinical and patient reported outcomes. Results: CAIS significantly outperformed freehand placement with regards to PES scores (p=0.011). Likewise, implants placed with CAIS showed significantly higher marginal bone levels (p<0.001). Bleeding on Probing, Probing depth and prevalence of mucositis did not differ between the groups, while no peri-implantitis was diagnosed. Conclusions: The use of CAIS lead to superior outcomes in terms of esthetics and marginal bone levels for implants placed in the aesthetic zone as observed in medium to long-term follow-up. No difference was however observed with regards to peri-implant mucosa inflammation.

Comparison Of Learning Curve In Novice And Experienced Operators Between Anterior And Posterior Implant Placement Using Dynamic Computer Assisted-Surgical Implant Placement: Randomized Controlled Trials, Pitsinee Kundaechanont

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To observe the equivalence of learning curve between anterior and posterior implant placement and between novice and experienced operators using dynamic computer assisted-surgical implant placement (CAIS) with type-III bone model simulated maxilla. Materials and Methods: Eight participants, including four novices and four experienced operators, were randomly assigned in blocks to either anterior or posterior placement group. Prior to the experiment, participants underwent video-training. Each participant performed four single implant placements per session with a 7±1 days wash-out period, totaling five attempts. The operating time, coronal, depth, and angle deviations in each attempt were recorded and analyzed by a blind …

Analysis Of Gene Expression And Histology Of Bone Regeneration Using Mrna Encoding Bone Morphogenetic Protein-2 In Rat Femur, Duangporn Yongyosrungrueng

Chulalongkorn University Theses and Dissertations (Chula ETD)

The quality of bone healing is an important factor in dental implant treatment. Currently, there is only limited research on using mRNA encoding BMP-2 to improve the quality and quantity of bone. This study aimed to evaluate the effectiveness of bone healing in rat femur defect after delivery of dPBS, rhBMP-2 and mRNA-encoding BMP-2 (BMP-2 mRNA-LNP). Histology approach was used to measure the quantity of newly formed bone. RT-qPCR was used to study gene expression levels of BMP-2, OCN, BSP and TNF-α. Subsequently, RNA-Seq analysis was performed at six weeks post-operation. Histological study revealed that BMP-2 mRNA-LNP group had significantly …

The Effect Of Different Self-Adhesive Resin Cements On Shear Bond Strength Of Hybrid Ceramic And Dentin, Rattawich Hoonsuwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

ActivaTM bioactive is the first developed of dual cured, self-adhesive resin cement. For this in vitro study was to compare and evaluate the three differentsshear bond strength among ActivaTM bioactive, Maxcem EliteTM and RelyXTMU200 cement, when used as adhesive between CAD-CAM hybrid ceramic; Vita EnamicTM and dentin surface. The Vita EnamicTM block was designed and fabricated into forty-two discs shaped with CAD software. Forty-two extracted third maxillary molars was also collected. The all teeth were free of dental caries, restoration and cracked line were mounted vertically in the epoxy resin with exposedthe occlusal surface. Dentin surfaces were flatted surface by …

Micro-Computed Tomography And Mechanical Test Of Bone Regeneration Using Mrna Encoding Bone Morphogenetic Protein-2 With Implant Placement In Rat Femur, Kanoksiri Jriyasetapong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research evaluates the effectiveness of a modified mRNA encoding bone morphogenetic protein-2 (m1Ψ-BMP-2 mRNA) with N1-methylpseudouridine modifications on bone regeneration and integration after implantation into rat femur defects. In the study, twelve femurs from six Sprague-Dawley rats underwent titanium wire insertation. These femur defects were then filled with either 5 μg of m1Ψ-BMP-2 mRNA, 15 μg of m1Ψ-BMP-2 mRNA, or Dulbecco's phosphate-buffered saline (dPBS) in a randomized manner (N=4 each group) Six weeks post-implantation, the rats were euthanized for evaluation using micro-computed tomography and a mechanical push-out test. The Micro-CT analysis focused on several parameters including total bone volume, …

Effect Of Different Implant Angulations And Insertion-Removal Cycles On The Retentive Force Of Locator And Locator R-Tx Attachments, Jidapha Tangtrongmit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to assess the implant of varying angulations and insertion-removal cycles on the retentive force of 2 denture attachments. The blocks were produced via 3D printing and divided into 2 groups: the LOCATOR attachment with orange retentive inserts and the LOCATOR R-Tx attachment with pink retentive inserts. Each group was divided into 3 subgroups based on implant angulation at 0-, 15-, and 30-degree implant angulation. The insertion-removal cycles were performed in 37 ±1°C deionized water using an INSTRON E1000 machine. Retentive force tests were conducted using a universal testing machine at baseline, after 270, 540, 810, 1080, 2160, …

The Effect Of Water Sorption And Solubility On Surface Properties Of Cad/Cam Materials, Chatchalanya Wansudon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this research was to examine sorption, solubility, and surface properties of three widely used CAD/CAM materials: resin composite (Cerasmart; CS), polymer-infiltrated ceramic network (Vita Enamic; VE) and lithium disilicate glass ceramic (IPS e.max CAD; LS). 45 rectangular-shaped specimens were prepared and immersed in deionized water for varying durations. These specimens were then subjected to evaluate their water sorption, solubility, surface roughness, and surface hardness. The results showed that immersion time significantly impacted water sorption of the tested materials (P.05). The 2-way ANCOVA revealed that water immersions had significant effects on surface hardness among tested CAD/CAM blocks (P.05). …

The Effect Of Universal Adhesives On Repairability Of Four Cad/Cam Blocks, Tanyaporn Treyasorasai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to assess the repairability among four CAD/CAM blocks repaired with different universal adhesives after aging. The CAD/CAM blocks evaluated were polymer infiltrated ceramic network (VE), zirconium-reinforced lithium silicate ceramic (VS), feldspathic ceramic (VM), and lithium disilicate ceramic (IE). Each original block was prepared to create 120 specimens. After 10,000 cycles of thermocycling, surface pretreatment of each specimen was carried out by grinding and etching with a 9% hydrofluoric acid. Subsequently, specimens were divided into three groups: Clearfil™ TRI-S BOND (CUB), Scotchbond Universal Plus® (SUP), and Monobond N® (MN). Resin composite was then applied. All samples underwent another …

Microleakage Of Class Ii Restoration Using Short-Fiber Reinforced Flowable Resin Composite, Parichat Panyawisitkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective. With short-fiber reinforced resin composite (SFRC), improved mechanical strength and good workability could be achieved within a single material. However, there remains concerns related to microleakage, which could restrict the application of this material in certain clinical situations. Materials and Methods. Class II cavities were prepared in 80 premolars. Each group, consisting of 10 specimens, was restored with different materials: flowable bulk-fill SFRC (EverX Flow, EXF), bulk-fill SFRC (EverX Posterior, EXP), flowable bulk-fill (Tetric N-Flow, TNF), and conventional resin composite (Z350 XT, Z350). The specimens were divided into two subgroups: one underwent thermocycling of 20,000 cycles, while the other …

Gene Expression Of Soft Tissue Covering Bone Grafted With Xenograft In Human, Atithan Termworasin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Soft tissue is one of many factors that influence the esthetic success of dental implants. This study explores soft tissue reaction between soft tissue covering bone grafted with xenograft and soft tissue in normal healing by analyzing the levels of inflammatory cytokine including TNF-α, IL-6, IL-8 and NF-kB1. Soft tissues are collected after 4 to 6 months of healing and analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The result shows that the relative gene expression of TNF-α, IL-6, IL-8, and NF-kB1 are not significantly different in soft tissue covering xenograft compared to the ones in soft tissue covering …

Effect Of Variations In Translucency Of Cad/Cam Lithium-Disilicate Ceramic And Abutment Color On Optical Color Of Veneer Restoration, Wichaya Likitnuruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to evaluate the optical color of different translucencies of CAD/CAM lithium-disilicate ceramics on backgrounds with different values. Low translucency (LT) and medium translucency (MT) rectangular-shaped specimens (0.6 mm thickness, shade A1) were fabricated from IPS e.max CAD (EMC; Ivoclar Vivadent) and Amber Mill (AM; HASS). Six specimens of EMC-MT, EMC-LT, AM-MT, and AM-LT were fabricated, resulting in 24 specimens in total. The specimens were placed on six background colors (1M1(reference), 1M2, 2M2, 3M2, 4M2, and 5M2) made of light-cured resin composite (Vita VM LC Base Dentine, Vita Zahnfabrik) using glycerine as a medium. The CIE L*a*b* coordinates …

The Effect Of Surface Treatment And Types Of Translucent Monolithic Zirconia On The Shear Bond Strength Of Porcelain Repaired To Zirconia, Karnkanith Hansomwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the event of proximal contact loss in a zirconia crown on an implant, the zirconia crown can be modified by adding porcelain to recreate the proximal contact. This study investigated the shear bond strength between translucent zirconia (4Y-PSZ) and veneering porcelain compared to conventional zirconia (3Y-TZP). Zirconia substructures were treated with airborne-particle abrasion with Al2O3. The results of the shear bond strength test were analyzed by One-way ANOVA and post-hoc comparisons with Tukey’s honest significant difference (HSD) test. The shear bond strengthranged from 21.87 and 27.79 MPa. The failure mode was mixed failure in all groups. From the results, …

Influence Of Ceramic Translucency, Ceramic Thickness, And Shades Of Luting Resin Cement On Final Color Of Cad/Cam Lithium Disilicate Veneers, Ploypailin Radeesujalitkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose. To evaluate the effect of ceramic translucency, ceramic thickness, and cement color on the final optical color of a CAD/CAM lithium disilicate ceramic. Methods. A total of 180 ceramic specimens were prepared into two thicknesses, 0.5 and 1.0 mm, from high translucency (HT), medium translucency (MT), and low translucency (LT) CAD/CAM lithium disilicate ceramics (IPS e.max CAD; Ivoclar Vivadent) in shade A1. Substrates were fabricated from resin composite in shade A3. Two shades of light-cure resin cement, neutral and light plus (Variolink Esthetic LC; Ivoclar Vivadent), were used for cementation, whereas glycerine was used for the control groups. CIE …

A Comparison Of Fracture Load After Mechanical Cyclic Loading Between 3 Different Materials And 2 Designs On Implant-Supported Crown : An In Vitro Study, Thanus Liwwattanakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To compare the fracture resistance among ultra-translucent zirconia, lithium disilicate, and composite resin implant-supported maxillary premolar crowns with cement-retained or combined cement- and screw-retained designs after cyclic loading simulation. Materials and Methods: Forty-eight maxillary first premolar crowns and their abutments were attached on dental implants (ø4.0 x 10 mm) embedded in epoxy resin blocks. All specimens were equally divided into 6 groups (n=8) based on monolithic crown material (ultra-translucent zirconia (Z), lithium disilicate (L), and composite resin (C)) and restoration design (cement-retained and combined cement- and screw-retained). Each specimen was subjected to 500,000 cycles of cyclic loading. Subsequently, a …

Effects Of Self-Adhesive Resin Cements Cured With Different Light Sources On Human Gingival Fibroblasts, Siriwong Wongsirisuwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Improperly polymerized self-adhesive resin cements (SARCs) can lead to adverse effects such as periodontitis or peri-implantitis. This in vitro study investigated the effect of 2 light-polymerizing units (LPUs) on the physical and chemical properties of 2 SARCs under varying simulated clinical scenarios and the responses of primary human gingival fibroblasts (hGFs) exposed to such procedures. Dental cement discs of SARCs (depth=2 mm, diameter=5 mm) were prepared with cylindrical acrylic molds. Kerr DemiPlus and 3M Elipar DeepCure-S LED LPUs were used to polymerize 2 different SARCs (RelyX U200 and Maxcem Elite Chroma). The polymerization protocols were either directly light-polymerized or through …

The Ethical Basis For Student-To-Student Training In Dentistry, Larry E. Jenson Dds, Ma, Joel M. White Dds, Ms

Journal of the American College of Dentists

This article will focus on the most ethically contentious student-to student training practice: local anesthesia administration. We will examine the factors that contribute to a broader understanding of the ethical issues involved and introduce a framework that will help to clarify these issues. We have identified six stakeholders in this issue: the student-as-patient, the student-as-student, the university, the faculty, the general public and the profession.

Effects Of Intermittent Compressive Force On Extracellular Matrix Homeostasis Of Human Periodontal Ligament Stem Cells, Novena Dameria Pakpahan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Mechanical force, caused by orthodontic tooth movement, affects periodontal tissue homeostasis including destruction and formation. For instance, the compression side causes bone resorption while bone formation lines in the tension side. Periodontal ligament cells play roles in modulating periodontal tissue homeostasis as well as regeneration via immunomodulation, proliferation, and migration. Extracellular matrix (ECM) is a cellular microenvironment that aids in cell migration, cell growth, and differentiation and serves as a physical barrier against microorganisms. Matrix metalloproteinase (MMP) plays a key role in the degradation of ECM, including collagen, gelatines, and casein. The MMP functions can be inhibited by tissue …

Expert Search For "Direct Materials For Restoring Caries Lesions", Kelly K. O'Brien

Expert Search Strategies

This search strategy was constructed to support the research for the peer reviewed article listed above. Full article abstract:

Background

The goal of restoring caries lesions is to protect the pulp, prevent progression of the disease process, and restore the form and function of the tooth. The purpose of this systematic review was to determine the effect of different direct restorative materials for treating cavitated caries lesions on anterior and posterior primary and permanent teeth.

Type of Studies Reviewed

The authors included parallel and split-mouth randomized controlled trials comparing the effectiveness of direct restorative materials commercially available in the United …

Use Gpt-J Prompt Generation With Roberta For Ner Models On Diagnosis Extraction Of Periodontal Diagnosis From Electronic Dental Records, Yao-Shun Chuang, Xiaoqian Jiang, Chun-Teh Lee, Ryan Brandon, Duong Tran, Oluwabunmi Tokede, Muhammad F Walji

Faculty, Staff and Student Publications

This study explored the usability of prompt generation on named entity recognition (NER) tasks and the performance in different settings of the prompt. The prompt generation by GPT-J models was utilized to directly test the gold standard as well as to generate the seed and further fed to the RoBERTa model with the spaCy package. In the direct test, a lower ratio of negative examples with higher numbers of examples in prompt achieved the best results with a F1 score of 0.72. The performance revealed consistency, 0.92-0.97 in the F1 score, in all settings after training with the RoBERTa model. …