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Articles 1 - 30 of 36
Full-Text Articles in Chemicals and Drugs
Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake
Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake
Senior Theses
Protein-protein interactions are important targets in cancer biology as they can make historically “undruggable” proteins viable drug targets. However, the current approach to targeting protein-protein interactions relies on the use of small molecule drugs, which have low efficiencies as they must cover a large surface area of the interaction. Further, traditional drug therapies often lead to off-target toxicity, limiting therapeutic specificity. The objective of this project is to develop a selection system in yeast to identify short peptide sequences that can disrupt protein-protein interactions specific to cancer cells. Following proof of principle and development of the AH109 yeast strain having …
Mango And Mango Juice, Robert Yokel
Mango And Mango Juice, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Processed Cheese, Robert Yokel
Processed Cheese, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Plums, Prunes And Their Juices, Robert Yokel
Plums, Prunes And Their Juices, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Lentils, Robert Yokel
Lentils, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Wheat, Robert Yokel
Wheat, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Other Specific Fruits And Their Juices, Robert Yokel
Other Specific Fruits And Their Juices, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table D: Salt Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Table D: Salt Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Banana, Robert Yokel
Banana, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Spinach, Robert Yokel
Spinach, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Celery, Robert Yokel
Celery, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Legumes (Beans, Peas, Tofu), Robert Yokel
Legumes (Beans, Peas, Tofu), Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Cocoa, Robert Yokel
Cocoa, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Herbal Tea Infusion, Robert Yokel
Herbal Tea Infusion, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
White Tea Infusion, Robert Yokel
White Tea Infusion, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Meat Alternatives, Robert Yokel
Meat Alternatives, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Coffee, Ground, Robert Yokel
Coffee, Ground, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Molluscs, Clams, Cockles, Limpets, Barnicles, Robert Yokel
Molluscs, Clams, Cockles, Limpets, Barnicles, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Crustaceans, Crabs, Robert Yokel
Crustaceans, Crabs, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Jelly And Jam, Robert Yokel
Jelly And Jam, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Tuna, Robert Yokel
Tuna, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Seafood, General Categories, Robert Yokel
Seafood, General Categories, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Yeast, Robert Yokel
Yeast, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Condiments And Spreads, Robert Yokel
Condiments And Spreads, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Tap Vs. Bottled Water, Robert Yokel
Tap Vs. Bottled Water, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Puer Tea, Dry, Robert Yokel
Puer Tea, Dry, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Wine, Other, Robert Yokel
Wine, Other, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table E: Aluminum Lakes Of Permitted Colors Allowed By The European Union, Robert Yokel
Table E: Aluminum Lakes Of Permitted Colors Allowed By The European Union, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Global Acetylation Dynamics In The Heat Shock Response Of Saccharomyces Cerevisiae, Rebecca E. Hardman
Global Acetylation Dynamics In The Heat Shock Response Of Saccharomyces Cerevisiae, Rebecca E. Hardman
Graduate Theses and Dissertations
All organisms face a constant barrage of environmental stresses. Single-cell organisms such as Saccharomyces cerevisiae, or common Baker’s yeast, must rely solely on cellular responses in order to survive. This response must occur in a rapid and highly coordinated manner to quickly inhibit all unnecessary processes and shuttle all available resources to those necessary for survival. One method that cells utilize for rapid protein regulation is the use of post-translational modifications. Enzymes within the cell add or remove a variety of chemical modifications, thus altering the local chemical environment of a protein. This creates a conformational change in the protein …
Discovery Of Selective Probes Targeting Rna Polymerase I, Xiao Tan
Discovery Of Selective Probes Targeting Rna Polymerase I, Xiao Tan
Theses and Dissertations--Chemistry
RNR Polymerase I (RNA Pol I) is a “factory” that orchestrate the transcription of ribosomal rRNA for constructing ribosomes as a primary workshop for protein translation to sustain cell growth. Misregulation of RNA Pol I can cause uncontrolled cell proliferation, which leads to the development of cancer. Yeast (Saccharomyces cerevisiae) is a valuable model system to study RNA Pol I. Recently, the X-ray crystal structure of the yeast homologue of RNA Pol I was elucidated, offering the structural basis to selectively target this transcriptional machinery. The approach to selective RNA Pol I targeting was to disrupt the interaction …