Medicine and Health Sciences Commons^™

Driving Impairment And Healthcare Provider Counseling In Rheumatoid Arthritis And Osteoarthritis Patients: A Cross-Sectional Survey., Cristina E Romaniello, Anna C Falls, Petagay Ricketts, Amulya Dega, John O Elliott, Kim M Jordan

Ambulatory and Primary Care Articles

BACKGROUND/OBJECTIVE: To examine rates of counseling on driving for individuals with osteoarthritis (OA) and/or rheumatoid arthritis (RA) and evaluate the Health Assessment Questionnaire Disability Index (HAQ-DI) as a screening tool for further driving evaluation.

METHODS: A cross-sectional survey was completed by individuals recruited via ResearchMatch (a national web-based recruitment tool) between March 5 and April 20, 2020. Individuals with a current US driver's license, ≥18 years old, with self-reported OA and/or RA diagnosis were surveyed about driving difficulty and vehicle modification and completed a HAQ-DI assessment. Respondents were dichotomized based on reporting vehicle modification(s) due to arthritis versus no modification(s) …

Identification Of Healthspan-Promoting Genes In Caenorhabditis Elegans Based On A Human Gwas Study, Nadine Saul, Ineke Dhondt, Mikko Kuokkanen, Markus Perola, Clara Verschuuren, Brecht Wouters, Henrik Von Chrzanowski, Winnok H. De Vos, Liesbet Temmerman, Walter Luyten

School of Medicine Publications

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn’s disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healthspan markers. Thirteen homologous or closely related genes were selected in the model organism C. elegans for evaluating healthspan after targeted RNAi-mediated knockdown using pathogen resistance, muscle integrity, chemotaxis index and the …

Crispr/Cas13 Effectors Have Differing Extents Of Off-Target Effects That Limit Their Utility In Eukaryotic Cells, Yuxi Ai, Dongming Liang, Jeremy E Wilusz

Faculty, Staff and Students Publications

CRISPR/Cas13 effectors have garnered increasing attention as easily customizable tools for detecting and depleting RNAs of interest. Near perfect complementarity between a target RNA and the Cas13-associated guide RNA is required for activation of Cas13 ribonuclease activity. Nonetheless, the specificity of Cas13 effectors in eukaryotic cells has been debated as the Cas13 nuclease domains can be exposed on the enzyme surface, providing the potential for promiscuous cleavage of nearby RNAs (so-called collateral damage). Here, using co-transfection assays in Drosophila and human cells, we found that the off-target effects of RxCas13d, a commonly used Cas13 effector, can be as strong as …

Efficacy And Outcomes Of Faecal Microbiota Transplantation For Recurrent Clostridioides Difficile Infection In Children With Inflammatory Bowel Disease, Maribeth R Nicholson, Erin Alexander, Sonia Ballal, Zev Davidovics, Michael Docktor, Michael Dole, Jonathan M Gisser, Alka Goyal, Suchitra K Hourigan, M Kyle Jensen, Jess L Kaplan, Richard Kellermayer, Judith R Kelsen, Melissa A Kennedy, Sahil Khanna, Elizabeth D Knackstedt, Jennifer Lentine, Jeffery D Lewis, Sonia Michail, Paul D Mitchell, Maria Oliva-Hemker, Tiffany Patton, Karen Queliza, Sarah Sidhu, Aliza B Solomon, David L Suskind, Madison Weatherly, Steven Werlin, Edwin F De Zoeten, Stacy A Kahn, North American Society Of Pediatric Gastroenterology And Nutrition Faecal Microbiota Transplantation Special Interest Group

Faculty, Staff and Students Publications

BACKGROUND: Children with inflammatory bowel disease [IBD] are disproportionally affected by recurrent Clostridioides difficile infection [rCDI]. Although faecal microbiota transplantation [FMT] has been used with good efficacy in adults with IBD, little is known about outcomes associated with FMT in paediatric IBD.

METHODS: We performed a retrospective review of FMT at 20 paediatric centres in the USA from March 2012 to March 2020. Children with and without IBD were compared with determined differences in the efficacy of FMT for rCDI. In addition, children with IBD with and without a successful outcome were compared with determined predictors of success. Safety data …

Dialysis Service In The Embattled Tigray Region Of Ethiopia: A Call To Action, Ephrem Berhe, Will Ross, Hale Teka, Hiluf Ebuy Abraha, Lewis Wall

2020-Current year OA Pubs

Haemodialysis is extremely limited in low-income countries. Access to haemodialysis is further curtailed in areas of active conflict and political instability. Haemodialysis in the Tigray region of Ethiopia has been dramatically affected by the ongoing civil war. Rapid assessment from the data available at Ayder Hospital's haemodialysis unit registry, 2015-2021, shows that enrollment of patients in the haemodialysis service has plummeted since the war broke out. Patient flow has decreased by 37.3% from the previous yearly average. This is in contrary to the assumption that enrollment would increase because patients could not travel to haemodialysis services in the rest of …

Effects Of A Multicomponent Resistance-Based Exercise Program With Protein, Vitamin D And Calcium Supplementation On Cognition In Men With Prostate Cancer Treated With Adt: Secondary Analysis Of A 12-Month Randomised Controlled Trial, Niamh Liana Mundell, Patrick J. Owen, Jack Dalla Via, Helen Macpherson, Robin Daly, Patricia M. Livingston, Timo Rantalainen, Stephen Foulkes, Jerremy Millar, Declan G. Murphy, Steve Fraser

Research outputs 2022 to 2026

OBJECTIVES: The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT). DESIGN: 12-month, two-arm, randomised controlled trial. SETTING: University clinical exercise centre. PARTICIPANTS: 70 ADT-treated men were randomised to exercise-training plus supplementation (Ex+ Suppl, n=34) or usual care (control, n=36). INTERVENTION: Men allocated to Ex + Suppl undertook thrice weekly resistance training with weight-bearing exercise training plus daily whey protein (25 g), calcium (1200 …

Reaching Out To Occupational Therapists, Alan Fyall

Rosen Research Review

Accessible tourism is a growing area of tourism research. The belief that all tourism facilities, products, and services should be accessible to those with disabilities drives research in tourism ethics and sustainability. However, a key voice is being ignored. Occupational therapists play a critical role in enabling people with disabilities to participate in the activities of daily life, including leisure. Dr. Alan Fyall believes it is time for interdisciplinary research with occupational therapists to properly understand accessible tourism.

Understanding Perceptions Of Indian Urban Older Women Regarding Social Participation: A Qualitative Study, Shah Hally

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Influence Of Blood Flow Rate On Kt/V In Hemodialysis Patients, Dhruv Joshi

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Investigation Of Diet Pattern, Anthropometry, And Handgrip Strength Of Chronic Kidney Disease Patient Undergoing Hemodialysis In Tertiary Care Hospital., Prithiviraj P G

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Assessment Of Cognitive Functioning In Individuals On Maintenance Hemodialysis, Lavita Shanya

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Assessment Of Sleep Disturbance And Its Impact On Quality Of Life In Patients On Hemodialysis, Aksa Shibu

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Uremic Pruritus: Prevalence, Factors Associated, Its Influence On Health-Related Quality Of Life And Sleep In Individuals On Maintenance Hemodialysis At A Tertiary Care Hospital, Deeksha .

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Medical School Watercooler Newsletter - June 23, 2022, Lindsey Lyle

Watercooler Newsletter

This is the June 23, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Graduate students and faculty present at ATS International Conference
• Meet a Med Student: Sarah Blackstock
• USA Health residents, fellows compete in 2022 scholarship exposition

Identifying Factors Affecting Adherence To Dialysis Treatment In End-Stage Kidney Disease Using Translated Kannada Esrd-Aq: An Observational Study, Hriiziini D

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

Cdc20 Regulates Sensitivity To Chemotherapy And Radiation In Glioblastoma Stem Cells., Diane D Mao, Ryan T Cleary, Amit D Gujar, Tatenda Mahlokozera, Albert H Kim

Faculty Research 2022

Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim. Our results identify a CDC20 signaling pathway that regulates chemo- and radiosensitivity in GSCs, with the potential for CDC20-targeted therapeutic strategies in the treatment …

An Unusual Case Of Perforated Appendicitis In Situs Inversus Totalis In Indonesia, Valencia J. Martin, Imanuel T. Parinding

The New Ropanasuri Journal of Surgery

Situs inversus is a rare congenital anomaly where the internal organs are transposed in a mirror image. It is commonly unrecognized until a patient comes with a complaint, especially in developing countries where people do not have a routine medical checkup. We report a case of a young female with unusual left lower quadrant pain abdominal pain. Perforated appendicitis leading to peritonitis was confirmed using ultrasonography and successfully treated with laparotomy. Appendicitis should be considered a working diagnosis in lower left quadrant abdominal pain

Review: Partial Splenic Embolization Outcome On Liver Cirrhosis With Esophageal Varices, Raden Suhartono, Muhammad F. A Irsal

The New Ropanasuri Journal of Surgery

Introduction. Liver cirrhosis may be followed by complications such as esophageal varices for 30 days mortality rate up to 15-20%. Partial splenic embolism (PSE) or partial splenic embolization has been developed as a safe and effective alternative therapy for managing bleeding in esophageal varices. This study aims to determine the outcome of PSE in patients with liver cirrhosis with esophageal varices.

Method. In this review, the literature search proceeded on three online databases (Cochrane Library, MEDLINE (PubMed), and ScienceDirect) according to PRISMA protocol. Through selections, six articles were included, and all were the reports.

Results. Of six reports, three were …

Revascularization Techniques For Infra-Popliteal Peripheral Artery Disease In Diabetic Foot: A Literature Review, Raden Suhartono, Ghany H. Wijaya

The New Ropanasuri Journal of Surgery

Foot ulcers are one of the problems that are often encountered in uncontrolled diabetes mellitus. With diabetic peripheral neuropathy, the typical clinical symptoms of PAD (peripheral arterial disease) may be obscured, leading to critical limb ischemia (CLTI). Diabetes may accelerate atherosclerosis that diminishes blood flow in PAD—further, diabetic patients with PAD often enfaces infra-popliteal lesions and require revascularization. However, studies on revascularization techniques in infra-popliteal PAD remain minimal. We reviewed the literature on EBSCO, and PubMed focused on the revascularization techniques in PAD, namely: expanded polytetrafluoroethylene (ePTFE), saphenous vein graft (SVG), atherectomy, surgical revascularization first, revascularization with endovascular bypass, direct …

Effect Of Ischemia-Reperfusion Injury And Preconditioning On Lung Parenchyma After Acute Limb Ischemia, David Hutagaol, Dhama S. Susanti, Wuryantoro Soeharto, Muhammad A. Putra, Suprayitno Wardoyo, William Makdinata, Moira Setiawan

The New Ropanasuri Journal of Surgery

Introduction. Acute limb ischemia, a sudden decrease of perfusion to the extremities, can compromise the survival of the limbs. Medical intervention and surgery are often needed to return perfusion. However, reperfusion injury can trigger oxidative stress and inflammatory response, leading to local and remote tissue damage, such as the lungs, which increases morbidity and mortality. This research aims to study the effects of hypothermia and remote ischemic preconditioning (RIPC) on the lung parenchyma after being exposed to reperfusion after acute limb ischemia in rabbits.

Method. Eighteen New Zealand White rabbits were divided into three groups of 6. The …

Review: Conventional Thrombectomy With Intraoperative Fluoroscopy In Acute Limb Ischemia Rutherford Iib, Heru Angkoso, Dedy Pratama

The New Ropanasuri Journal of Surgery

Introduction. Acute limb ischemia (ALI) is a severe condition affecting the extremities and the patient’s survival that requires immediate treatment. It can be treated with either surgical or endovascular revascularization or both (hybrid procedure). It is crucial to evaluate the defect using intraoperative fluoroscopy or angiography in each case. The review aimed to find out the outcomes of the thrombectomy with intraoperative fluoroscopy for ALI Rutherford IIb.

Method. According to the PRISMA protocol, the literature search proceeded in online databases, i.e., Cochrane, Scopus, PubMed, and EBSCOhost, with no year limitation on the publication. All articles were screened and critically appraised. …

Mini-Review: Omental Patch Repair Of Giant Perforated Peptic Ulcer, Ridho A. Syaiful, Muhammad F. Agustian

The New Ropanasuri Journal of Surgery

Introduction. A perforated giant peptic ulcer is an emergency that requires surgery. Closure of the perforation with an omental patch has been reported in several cases of perforated giant peptic ulcers. However, there is insufficient evidence regarding the option of preferred treatment. This review to discuss published reports of a perforated giant peptic ulcer closed with an omental patch that focused on the complications

Method. The literature search was conducted through the Cochrane, PubMed, Scopus, and EBSCO data sites. The articles obtained were screened for duplication, title, abstracts, and full-text based on inclusion and exclusion criteria.

Result: Two articles were …

Review: Management Of Complex Anal Fistula, Agi S. Putranto, Winda J. Layardi

The New Ropanasuri Journal of Surgery

Introduction. Complex anal fistula has a high postoperative recurrence rate and incontinence as well. There have been many emerging surgical techniques, but there are no new recommendations for managing complex anal fistula. One of the critical parameters in evaluating surgical technique outcomes is the recurrence rate and incontinence. This study describes postoperative results in recurrence rates and incontinence in various surgical techniques in managing complex anal fistula.

Method. This review commenced with literature searches on online databases, including Cochrane Library, MEDLINE (PubMed), ScienceDirect, and CINAHL (EBSCOhost).

Results. The study enrolled two RCTs, four systematic reviews, 14 retrospective and prospective studies, …

Graduated Compression Stockings For Deep Vein Thrombosis Prevention In Surgical Patients: A Systematic Review, Dedy Pratama, Satria M.H Simatupang

The New Ropanasuri Journal of Surgery

Introduction. Oral anticoagulant therapy is commonly used to prevent deep vein thrombosis (DVT). However, it might increase the risk of intraoperative and postoperative bleeding. Graduated compression stockings (GCS) reduced DVT risk, but there is a lack of supporting evidence. Thus, the study aimed to find the efficacy of GCS compared to the pharmacological method in high-risk surgical patients.

Method. Literature search proceeded in Cochrane, ClinicalKey, and PubMed. Using keywords graduated compression stockings" or "mechanic" or mechanical") and ("pharmacologic" or "oral anticoagulants" or "NOAC") and "comparison" and "prophylaxis" and ("DVT" or "deep vein thrombosis) and ("surgery" or "surgical").

Results …

Risk Of Upper Extremity Musculoskeletal Injury In Laparoscopy Training, Theddeus Oh Prasetyono, Christopher R. Andrian, Elisabet La Kinanthi

The New Ropanasuri Journal of Surgery

Introduction. The laparoscopy procedure still has an ergonomic burden that can increase the risk of musculoskeletal injury, especially in the upper extremity. Furthermore, the risk is compounded in laparoscopic training as the trainees have to repeat the same movements many times to achieve competencies. This study revealed the relation between the position and the risk of musculoskeletal injury in laparoscopy training.

Methods. A cross-sectional study on nine subjects was conducted during laparoscopy training. By fixing the table height at 77 cm, we measured the operator height and upper extremity positions to relate them to their VAS and DASH scores.

Results. …

Rowan Community Health Center’S Ask First Model: Building Authentic & Impactful Community Relationships By Asking A Simple Question, Patrick J. Tempera, Christian Diliberto, Ruchi Shah, Daniel Hurst

Cooper Rowan Medical Journal

Spring of 2017, Rowan University School of Osteopathic Medicine’s student-run free clinic, the Rowan Community Health Center, launched an outreach initiative named the Unity Project. This is an ongoing initiative aimed at fostering relationships with Camden, New Jersey organizations to both educate community members about our clinic services and collaborate on improving Camden’s health. The objective of the Unity Project is to work towards affecting long-term change by forming authentic and impactful relationships with organizations that are already participating in meaningful community work. In order to achieve such a goal, we needed to overcome the traditional model of medical school …

Paired Associative Stimulation Applied To The Cortex Can Increase Resting-State Functional Connectivity: A Proof Of Principle Study, Andrew Hooyman, Alexander Garbin, Beth E. Fisher, Jason J. Kutch, Carolee J. Winstein

Physical Therapy Faculty Articles and Research

Introduction
There is emerging evidence that high Beta coherence (hBc) between prefrontal and motor corticies, measured with resting-state electroencephalography (rs-EEG), can be an accurate predictor of motor skill learning and stroke recovery. However, it remains unknown whether and how intracortical connectivity may be influenced using neuromodulation. Therefore, a cortico–cortico PAS (ccPAS) paradigm may be used to increase resting-state intracortical connectivity (rs-IC) within a targeted neural circuit.

Purpose
Our purpose is to demonstrate proof of principle that ccPAS can be used to increase rs-IC between a prefrontal and motor cortical region.

Methods
Eleven non-disabled adults were recruited (mean age 26.4, sd …

Fecal Microbiota Transplantation In Decompensated Cirrhosis: A Systematic Review On Safety And Efficacy, Annie S. Hong, Kyaw Min Tun, Jenny M. Hong, Kavita Batra, Gordon Ohning

Department of Internal Medicine Faculty Research

Background and Aims: Due to increasing knowledge of the “gut–liver axis”, there has been growing interest regarding the use of fecal microbiota transplant in the management of chronic liver disease. There are limited data available and current guidelines are mostly based on expert opinions. We aim to perform the first systematic review investigating safety and efficacy of fecal microbiota transplant particularly among high-risk decompensated cirrhosis patient populations. Methods: Literature search was performed using variations of the keywords “fecal microbiota transplant” and “cirrhosis” on PubMed/Medline from inception to 3 October 2021. The resulting 116 articles were independently screened by two authors. …

Prescribed Pediatric Extended Care: A Program Evaluation On The Impact To Families Of Children With Medical Complexities., Jody Rogers

Graduate Theses, Dissertations, and Capstones

This is a paper about the impact of Prescribed Pediatric Extended Care (PPEC) on families of children with medical complexities.

Assessing The Reidentification Risks Posed By Deep Learning Algorithms Applied To Ecg Data, Arin Ghazarian, Jianwei Zheng, Daniele Struppa, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

ECG (Electrocardiogram) data analysis is one of the most widely used and important tools in cardiology diagnostics. In recent years the development of advanced deep learning techniques and GPU hardware have made it possible to train neural network models that attain exceptionally high levels of accuracy in complex tasks such as heart disease diagnoses and treatments. We investigate the use of ECGs as biometrics in human identification systems by implementing state-of-the-art deep learning models. We train convolutional neural network models on approximately 81k patients from the US, Germany and China. Currently, this is the largest research project on ECG identification. …