Medicine and Health Sciences Commons^™

Listening To Voices From African American Communities In The Southern States About Covid-19 Vaccine Information And Communication: A Qualitative Study, Ran Zhang, Shan Qiao, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

The high uptake of COVID-19 vaccines is one of the most promising measures to control the pandemic. However, some African American (AA) communities exhibit vaccination hesitancy due to mis- or disinformation. It is important to understand the challenges in accessing reliable COVID-19 vaccine information and to develop feasible health communication interventions based on voices from AA communities. We conducted 2 focus group discussions (FGDs) among 18 community stakeholders recruited from 3 counties in South Carolina on 8 October and 29 October 2021. The FGDs were conducted online via Zoom meetings. The FGD data were managed and thematically analyzed using NVivo …

Eeg Evidence Of Altered Functional Connectivity And Microstate In Children Orphaned By Hiv/Aids, Huang Gu, Xueke Shan, Hui He, Junfeng Zhao, Xiaoming Li Ph.D.

Faculty Publications

Children orphaned by HIV/AIDS (“AIDS orphans”) suffer numerous early-life adverse events which have a long-lasting effect on brain function. Although previous studies found altered electroencephalography (EEG) oscillation during resting state in children orphaned by HIV/AIDS, data are limited regarding the alterations in connectivity and microstate. The current study aimed to investigate the functional connectivity (FC) and microstate in children orphaned by HIV/AIDS with resting-state EEG data. Data were recorded from 63 children orphaned by HIV/AIDS and 65 non-orphan controls during a close-eyes resting state. The differences in phase-locking value (PLV) of global average FC and temporal dynamics of microstate were …

Presence Of Blaper-1 And Blaveb-1 Beta-Lactamase Genes Among Isolates Of Pseudomonas Aeruginosa From Burn And Trauma Hospital Peshawar, Pakistan, Suleman Khan, Samiyah Tasleem, Alfarah Rehmat Ullah,, Sarwat Moon, Saad Alghamdi, Raina Saad Suliman, Muhammad Ateeq, Muhmmad Salman, Anas S. Dablool,, Banan Atwah, Farkad Bantun

Journal of Bioresource Management

Pseudomonas aeruginosa spp are the most prevalent bacteria that cause nosocomial infections in hospitals. Most antibiotics, including novel new β-lactams, are already resistant to them, and they can become resistant during treatment, which can make the treatment fail. P. aeruginosa isolates from ICU patients who had Per-1 and VEB-1 were the main focus of this study. These two ESBLs are the two most common in ICU patients who had them. 50 isolates were gathered from Peshawar's LRH ICU facilities in the year 2021. The antibiotic susceptibility test was conducted in accordance with the Clinical and Laboratory Standards Institute's standards (CLSI). …

Worsening Glycemia Increases The Odds Of Intermittent But Not Persistent Staphylococcus Aureus Nasal Carriage In Two Cohorts Of Mexican American Adults, Heather T Essigmann, Craig L Hanis, Stacia M Desantis, William B Perkison, David A Aguilar, Goo Jun, D Ashley Robinson, Eric L Brown

Faculty, Staff and Student Publications

Numerous host and environmental factors contribute to persistent and intermittent nasal Staphylococcus aureus carriage in humans. The effects of worsening glycemia on the odds of S. aureus intermittent and persistent nasal carriage was established in two cohorts from an adult Mexican American population living in Starr County, Texas. The anterior nares were sampled at two time points and the presence of S. aureus determined by laboratory culture and

Validation Of A High Flow Rate Puff Topography System Designed For Measurement Of Sub-Ohm, Third Generation Electronic Nicotine Delivery Systems, Evan Floyd, Toluwanimi Oni, Changjie Cai, Bilal Rehman, Jooyeon Hwang, Tyler Watson

Faculty, Staff and Student Publications

There are few known puff topography devices designed solely for gathering electronic cigarette puff topography information, and none made for high-powered sub-ohm devices. Ten replicate Bernoulli flow cells were designed and 3D printed. The relationship between square root of pressure difference and flow rate was determined across 0−70 L/min. One representative flow cell was used to estimate puff volume and flow rate under six simulated puffing regimes (0.710 L, 2.000 L and 3.000 L, at low and high flow rates) to determine the system’s accuracy and utility of using dual pressure sensors for flow measurement. The relationship between flow rate …

Connectomic Analysis Of The Drosophila Lateral Neuron Clock Cells Reveals The Synaptic Basis Of Functional Pacemaker Classes, Orie T. Shafer, Gabrielle J. Gutierrez, Kimberly Li, Amber Mildenhall, Daphna Spira, Jonathan Marty, Aurel A. Lazar, Maria De La Paz Fernandez

Advanced Science Research Center

The circadian clock orchestrates daily changes in physiology and behavior to ensure internal temporal order and optimal timing across the day. In animals, a central brain clock coordinates circadian rhythms throughout the body and is characterized by a remarkable robustness that depends on synaptic connections between constituent neurons. The clock neuron network of Drosophila, which shares network motifs with clock networks in the mammalian brain yet is built of many fewer neurons, offers a powerful model for understanding the network properties of circadian timekeeping. Here, we report an assessment of synaptic connectivity within a clock network, focusing on the …

Retrospective Clinical Evaluation Of A Decision-Support Software For Adaptive Radiotherapy Of Head And Neck Cancer Patients, Sebastien A. A. Gros, Anand P. Santhanam, Alec M. Block, Bahman Emami, Brian H. Lee, Cara Joyce

Biostatistics Collaborative Core: Faculty Publications and Other Works

Purpose: This study aimed to evaluate the clinical need for an automated decisionsupport software platform for adaptive radiation therapy (ART) of head and neck cancer (HNC) patients.

Methods: We tested RTapp (SegAna), a new ART software platform for deciding when a treatment replan is needed, to investigate a set of 27 HNC patients’ data retrospectively. For each fraction, the software estimated key components of ART such as daily dose distribution and cumulative doses received by targets and organs at risk (OARs) from daily 3D imaging in real-time. RTapp also included a prediction algorithm that analyzed dosimetric parameter (DP) trends against …

Regulation Of Age-Associated Insulin Resistance By Mt1-Mmp-Mediated Cleavage Of Insulin Receptor, Xuanming Guo, Pallavi Asthana, Susma Gurung, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Chi Fung Willis Chow, Sijia Che, Lixiang Zhai, Zening Wang, Xin Ge, Zhixin Jiang, Jiayan Wu, Yijing Zhang, Xiaoyu Wu, Keyang Xu, Cheng Yuan Lin, Hiu Yee Kwan, Aiping Lyu, Zhongjun Zhou, Zhao-Xiang Bian, Hoi Leong Xavier Wong

Faculty, Staff and Student Publications

Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of insulin sensitivity during ageing. Ageing promotes MMP14 activation in insulin-sensitive tissues, which cleaves Insulin Receptor to suppress insulin signaling. MT1-MMP inhibition restores Insulin Receptor expression, improving insulin sensitivity in aged mice. The cleavage of Insulin Receptor by MT1-MMP also contributes to obesity-induced insulin resistance and inhibition of MT1-MMP activities normalizes metabolic dysfunctions in diabetic mouse models. Conversely, overexpression of MT1-MMP in the liver reduces the level of Insulin Receptor, impairing hepatic insulin …

Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations In The Alpine Chris Cohort, Eva König, Johannes Rainer, Vinicius Verri Hernandes, Giuseppe Paglia, Fabiola Del Greco M, Daniele Bottigliengo, Xianyong Yin, Lap Sum Chan, Alexander Teumer, Peter P Pramstaller, Adam E Locke, Christian Fuchsberger

2020-Current year OA Pubs

Metabolites are intermediates or end products of biochemical processes involved in both health and disease. Here, we take advantage of the well-characterized Cooperative Health Research in South Tyrol (CHRIS) study to perform an exome-wide association study (ExWAS) on absolute concentrations of 175 metabolites in 3294 individuals. To increase power, we imputed the identified variants into an additional 2211 genotyped individuals of CHRIS. In the resulting dataset of 5505 individuals, we identified 85 single-variant genetic associations, of which 39 have not been reported previously. Fifteen associations emerged at ten variants with >5-fold enrichment in CHRIS compared to non-Finnish Europeans reported in …

Selective Whole-Genome Amplification As A Tool To Enrich Specimens With Low Treponema Pallidum Genomic Dna Copies For Whole-Genome Sequencing, Charles M Thurlow, Sandeep J Joseph, Lilia Ganova-Raeva, Samantha S Katz, Lara Pereira, Cheng Chen, Alyssa Debra, Kendra Vilfort, Kimberly Workowski, Stephanie E Cohen, Hilary Reno, Yongcheng Sun, Mark Burroughs, Mili Sheth, Kai-Hua Chi, Damien Danavall, Susan S Philip, Weiping Cao, Ellen N Kersh, Allan Pillay

2020-Current year OA Pubs

Downstream next-generation sequencing (NGS) of the syphilis spirochete Treponema pallidum subspecies

Development Of Enhanced Food Packaging Systems Based On Blends Of Bio-Based And Biodegradable Polymers Exhibiting Antimicrobial Properties, Aishat Agboluaje

Theses and Dissertations

Food packaging is one of the important aspects of food processing, which contributes greatly to decreasing post-harvest food losses. While ensuring that foods are adequately packaged, it is also important to consider the impact of these food packaging materials on the environment. Accordingly, this research work was aimed at investigating the potential of bio-based and biodegradable blends of polyvinyl alcohol (PVA) and chitosan loaded with antimicrobial agents such as turmeric, clove, and cinnamon for use in food packaging applications. The methodology involved creating PVA/chitosan films with varying compositions via solvent casting method and selecting the best composition exhibiting the highest …

The Integration Of Positive Psychology And Positive Behavioral Interventions & Supports To Improve Minoritized Students' Social, Emotional, And Behavioral Outcomes, Jasmine L. Gray

USF Tampa Graduate Theses and Dissertations

This study aimed to examine the effectiveness of a culturally adapted 9-session group positive psychology intervention with and without an added peer reporting intervention on student levels of social, emotional, and behavioral functioning. Many studies have evaluated either school-wide positive behavioral interventions and supports (SWPBIS) or positive psychology interventions (PPIs) in isolation, but very few studies have examined the extent to which combining these interventions and approaches may promote complete mental health. The Well-Being Promotion Program is a multitarget positive psychology intervention that has been evaluated in both elementary and middle school populations (Roth et al., 2017; Lenz et al., …

Dietary Fatty Acid Intake And The Colonic Gut Microbiota In Humans, Anthony A Xu, Luke K Kennedy, Kristi Hoffman, Donna L White, Fasiha Kanwal, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

A high-fat diet has been associated with systemic diseases in humans and alterations in gut microbiota in animal studies. However, the influence of dietary fatty acid intake on gut microbiota in humans has not been well studied. In this cross-sectional study, we examined the association between intake of total fatty acids (TFAs), saturated fatty acids (SFAs), trans fatty acids (TrFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), n3-FAs, and n6-FAs, and the community composition and structure of the adherent colonic gut microbiota. We obtained 97 colonic biopsies from 34 participants with endoscopically normal colons. Microbial DNA was used to …

2022-06-28_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

2022-06-28_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2022-06-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

Transcriptional And Translational Dynamics Of Zika And Dengue Virus Infection., Kamini Singh, Maria Guadalupe Martinez, Jianan Lin, James Gregory, Trang Uyen Nguyen, Rawan Abdelaal, Kristy Kang, Kristen Brennand, Arnold Grünweller, Zhengqing Ouyang, Hemali Phatnani, Margaret Kielian, Hans-Guido Wendel

Faculty Research 2022

Zika virus (ZIKV) and dengue virus (DENV) are members of the Flaviviridae family of RNA viruses and cause severe disease in humans. ZIKV and DENV share over 90% of their genome sequences, however, the clinical features of Zika and dengue infections are very different reflecting tropism and cellular effects. Here, we used simultaneous RNA sequencing and ribosome footprinting to define the transcriptional and translational dynamics of ZIKV and DENV infection in human neuronal progenitor cells (hNPCs). The gene expression data showed induction of aminoacyl tRNA synthetases (ARS) and the translation activating PIM1 kinase, indicating an increase in RNA translation capacity. …

Obesity: Policy And Practice Recommendations For High-Risk Populations Influenced By The Covid-19 Pandemic, Kathryn N. Robinson, Deborah A. Saber

Faculty Research 2022

Obesity has been linked to higher morbidity and mortality in those that contract novel viruses, such as H1N1 and SARS-CoV-2. Loss of life and the high cost of obesity highlight the need to focus on preventative measures. The state of Maine (United States) is profiled as a rural state with high rates of obesity and low health literacy that benefits from programs to improve health. However, more multidirectional efforts are needed. Four recommendations for building a healthier, more resilient patient population are discussed here: (i) state incentives and subsidies, (ii) employers to incentivize healthy living, (iii) federal incentives and initiatives, …

Covid-19 Newsletter (Vol. 125), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Glossopharyngeal Neuralgia: Epidemiology, Risk Factors, Pathophysiology, Differential Diagnosis, And Treatment Options, Andrew Han, Carver Montgomery, Alexandra Zamora, Emilie Winder, Adam M. Kaye, Caroline Carroll, Alfonzo Aquino, Juyeon Kakazu, Alan David Kaye

School of Pharmacy Faculty Articles

Purpose of Review
This is a comprehensive review of the most recent literature on glossopharyngeal neuralgia (GPN), a relatively rare form of neuropathic facial pain. It covers the epidemiology, risk factors, pathophysiology, and differential diagnosis given that glossopharyngeal neuralgia can often be confused with other facial pain syndromes. Finally, we extensively review recent findings regarding medical or conservative measures, minimally invasive, and surgical options for potentially treating and managing glossopharyngeal neuralgia.

Recent Findings
An in-depth analysis of the recent literature indicates that glossopharyngeal neuralgia is not only rare but its etiology and pathophysiology are complex and are often secondary to …

Dérivation De Règles De Prédiction Clinique Pour Dépister Les Patients Ayant Une Lombalgie Non Aiguë Manifestant Un Succès Thérapeutique Lors D’Un Programme D’Exercice De Stabilisation Lombaire, Christian Larivière, Marie-France Coutu, Sharon M. Henry, Richard Preuss, Nicolas Roy, Khalil Rabhi

Rapports de recherche scientifique

Les exercices physiques permettent de réduire la douleur et les incapacités chez les gens souffrant d’une lombalgie non aiguë (> 3-4 semaines), mais ces effets sont limités. Pour rehausser l’efficacité de ce type d’intervention, il faut déterminer quels patients répondent le mieux à chaque modalité d’exercice (arrimage patient/intervention) et pour quelles raisons (mécanismes sous-jacents). Dans la présente recherche, l’intérêt est porté à un programme d’exercices de stabilisation lombaire (PESL), une modalité active d’exercice gagnant en crédibilité et en popularité. Deux objectifs ont été poursuivis : (1) finaliser l’étape de dérivation de règles de prédiction clinique (RPC) de succès^[1] pour …

Progresemos En Comunidad Apoyados En La Colaboración Social, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez, Sandra Patricia Carmona Urueña, Sindy Alejandro Cifuentes Guerrero

Ciencias de la Salud

La cartilla educativa Manejo de intoxicacionespor plaguicidas, y primeros auxilios proporcionar información a lostrabajadores agrícolas y sus familias, con el fin degenerar acciones de promoción y prevención quedisminuyan los riesgos de intoxicación por plaguicidasy contribuir a la creación de ambientes saludables.Los plaguicidas ocasionan riesgo para la salud delos agricultores y las personas que manipulan estassustancias, lo que lleva a la población en generala realizar una manipulación incorrecta que puedeocasionar intoxicaciones y la muerte. La mayoríade los casos de intoxicación por plaguicidas sepueden prevenir; esta cartilla brinda informaciónsobre la forma de reducir los riesgos para la saludy acciones prácticas sobre primeros …

Usa Health Insider Newsletter - June 25, 2022, Bernell Dorrough, Marie Katz

USA Health Insider Newsletter

USA Health Newsletter for June 28, 2022.

Contents of newsletter include:

• Mitchell Cancer Institute, Accredited by the Commission on Cancer
• Davies Awarded $3.5 Million NIH Grant to Study Drug-Resistant Bacteria that Causes Gonorrhea
• Coastal OB/GYN Joins USA Health
• USA Health Tips: Avoiding Tick Bites
• GO Run to Take on New Course
• Watch Us Grow: Eastern Shore

Nf-Kb (P50/P65)-Mediated Pro-Inflammatory Microrna (Mirna) Signaling In Alzheimer's Disease (Ad), Walter J. Lukiw

School of Medicine Faculty Publications

No abstract provided.

Manos En Acción, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez

Ciencias de la Salud

La cartilla Manos en acción está dirigida a los trabajadores agrícolas y sus familias, contiene prácticas que orientan el uso racional y aprovechamiento de los recursos naturales disponibles en el medioambiente, y busca crear conciencia ambiental y disminuir la explotación y contaminación ocasionada a este, facilitará información acerca de estrategiasagroecológicas y el aprovechamiento racional de los recursos ambientales presentes en las veredas donde se cultiva y viven los trabajadores agrícolas. Está divida en seis unidades: agroecología, recorrido gira técnica, bioplaguicidas, tipos de fungicidas, abonos orgánicoslumbricultura.

Intoxicaciones Por Plaguicidas Y Primeros Auxilios, Claudia Del Rocío Contreras Rodríguez, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila

Ciencias de la Salud

La cartilla educativa Manejo de intoxicacionespor plaguicidas, y primeros auxilios proporcionar información a lostrabajadores agrícolas y sus familias, con el fin degenerar acciones de promoción y prevención quedisminuyan los riesgos de intoxicación por plaguicidasy contribuir a la creación de ambientes saludables.Los plaguicidas ocasionan riesgo para la salud delos agricultores y las personas que manipulan estassustancias, lo que lleva a la población en generala realizar una manipulación incorrecta que puedeocasionar intoxicaciones y la muerte. La mayoríade los casos de intoxicación por plaguicidas sepueden prevenir; esta cartilla brinda informaciónsobre la forma de reducir los riesgos para la saludy acciones prácticas sobre primeros …

Deutetrabenazine For The Treatment Of Chorea Associated With Huntington’S Disease, Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

This is a comprehensive review of the literature regarding the use of Deutetrabenazine in treating chorea associated with Huntington’s disease. Unfortunately, treatment has been limited for many aspects of this neurodegenerative disease. The present investigation presents the background, evidence, and indications for the use Deutetrabenazine in the setting of Huntington’s disease. Huntington’s disease is characterized by a variety of motor, psychiatric, and cognitive symptoms with chorea being one of the more notable ones. Chorea is a movement disorder present in multiple neurologic diseases that causes involuntary and irregular muscle movements theorized to be stemming from high dopamine levels. Deutetrabenazine is …

Impacts Of Population Level Environmental Contaminants, Sex Hormones, And Fibroblast Cell Subsets On Systemic Sclerosis (Ssc), Noelle N. Kosarek

Dartmouth College Ph.D Dissertations

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and internal organs, vascular abnormalities, and autoantibody formation. The etiology of SSc is unknown, though the disease is thought to arise in genetically predisposed individuals after exposure to an environmental factor. There are few FDA approved disease modifying medications available to treat SSc.

The express aims of this dissertation are tripart. First, we aimed to validate a 3D tissue model known as the self-assembled skin equivalent (saSE) model. Second, we sought to describe the geographic distribution of SSc in a US Medicare population to better understand …

Recognition Of The Tdp-43 Nuclear Localization Signal By Importin Α1/Β, Steven G Doll, Hamed Meshkin, Alexander J Bryer, Fenglin Li, Ying-Hui Ko, Ravi K Lokareddy, Richard E Gillilan, Kushol Gupta, Juan R Perilla, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. Here, we study how importin α1/β recognizes TDP-43 bipartite nuclear localization signal (NLS). We find that the NLS makes extensive contacts with importin α1, especially at the minor NLS-binding site. NLS binding results in steric clashes with the C terminus of importin α1 that disrupts the TDP-43 N-terminal domain (NTD) dimerization interface. A putative phosphorylation site in the proximity of TDP-43 R83 at the minor NLS site destabilizes binding to importins by reducing …

Tannic Acid Exhibits Antiangiogenesis Activity In Nonsmall-Cell Lung Cancer Cells, Elham Hatami, Prashanth K.B. Nagesh, Mohammed Sikander, Anupam Dhasmana, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

School of Medicine Publications

Nonsmall-cell lung cancer (NSCLC) is the most common type of lung cancer, with a dismal prognosis. NSCLC is a highly vascularized tumor, and chemotherapy is often hampered by the development of angiogenesis. Therefore, suppression of angiogenesis is considered a potential treatment approach. Tannic acid (TA), a natural polyphenol, has been demonstrated to have anticancer properties in a variety of cancers; however, its angiogenic properties have yet to be studied. Hence, in the current study, we investigated the antiproliferative and antiangiogenic effects of TA on NSCLC cells. The (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) assay revealed that TA induced a dose- and time-dependent …