Medicine and Health Sciences Commons^™

Dual-Mode Tumor Imaging Using Probes That Are Responsive To Hypoxia-Induced Pathological Conditions, S A Amali S Subasinghe, Robia G Pautler, Md Abul Hassan Samee, Jason T Yustein, Matthew J Allen

Faculty, Staff and Students Publications

Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several imaging modalities have been used to study hypoxia, but each modality has inherent limitations. The use of a second modality can compensate for the limitations and validate the results of any single imaging modality. In this review, we describe dual-mode imaging systems for the detection of hypoxia that have been reported since the start of the 21st century. First, we provide a brief overview of the hallmarks of hypoxia used for imaging and the imaging modalities used …

High-Throughput Profiling Of Histone Post-Translational Modifications And Chromatin Modifying Proteins By Reverse Phase Protein Array, Xuan Wang, Zhongcheng Shi, Hsin-Yi Lu, Jean J Kim, Wen Bu, Jose A Villalobos, Dimuthu N Perera, Sung Yun Jung, Tao Wang, Sandra L Grimm, Bethany C Taylor, Kimal Rajapakshe, Hyekyung Park, Julia Wulfkuhle, Nicolas L Young, Yi Li, Cristian Coarfa, Dean P Edwards, Shixia Huang

Faculty, Staff and Students Publications

Epigenetic variation plays a significant role in normal development and human diseases including cancer, in part through post-translational modifications (PTMs) of histones. Identification and profiling of changes in histone PTMs, and in proteins regulating PTMs, are crucial to understanding diseases, and for discovery of epigenetic therapeutic agents. In this study, we have adapted and validated an antibody-based reverse phase protein array (RPPA) platform for profiling 20 histone PTMs and expression of 40 proteins that modify histones and other epigenomic regulators. The specificity of the RPPA assay for histone PTMs was validated with synthetic peptides corresponding to histone PTMs and by …

The Evolution And Structure/Function Of Bhlh-Pas Transcription Factor Family, Hailey E Edwards, Daniel A Gorelick

Faculty, Staff and Students Publications

Proteins that contain basic helix-loop-helix (bHLH) and Per-Arnt-Sim motifs (PAS) function as transcription factors. bHLH-PAS proteins exhibit essential and diverse functions throughout the body, from cell specification and differentiation in embryonic development to the proper function of organs like the brain and liver in adulthood. bHLH-PAS proteins are divided into two classes, which form heterodimers to regulate transcription. Class I bHLH-PAS proteins are typically activated in response to specific stimuli, while class II proteins are expressed more ubiquitously. Here, we discuss the general structure and functions of bHLH-PAS proteins throughout the animal kingdom, including family members that do not fit …

Dak Fisik Kesehatan To Reduce Maternal And Infant Mortality Rate, Rendy Alvaro, Ratna Christianingrum, Tio Riyono

Jurnal Ekonomi Kesehatan Indonesia

Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) are essential indicators of health development that are written on the national development plan documents. Nevertheless, Indonesia has not yet achieved the national target of MDG’s and SDG’s. In prediction, without extraordinary policies, the target of SDGs will not be reached by 2030. The government has allocated DAK Fisik Penugasan as one of the efforts to reduce MMR and IMR. So this study aims to capture the effect of DAK Fisik in decreasing MMR and IMR. Panel data from 34 provinces level in 2019 and 2020 are analyzed using mean difference …

Socioeconomic Factors And Smoking Habits In Indonesia: Analysis Of Indonesian Family Life Survey (Ifls) 2014/2015, Widiandini Prita Hapsari

Jurnal Ekonomi Kesehatan Indonesia

This study aims to find out what effects affect individuals to become smokers. So that the influence of socio-economic conditions and smoking habits in Indonesia can be helpful to literacy for policymakers. This study uses secondary data from the Indonesia Family Life Survey 2014/2015 (IFLS-5). The main variables in this study were smoking habits, while socio-economic conditions, social demographics and health conditions as control variables to see other factors that influence smoking habits. Using a logistic regression model, the results of this study indicate that several variables that represent socioeconomic conditions have a positive relationship and several other variables have …

The Novel Data Collection And Analytics Tools For Remote Patient Monitoring In Heart Failure (Nov-Rpm-Hf) Trial: Protocol For A Single-Center Prospective Trial, Ankit Bhatia, Gregory Ewald, Thomas Maddox

2020-Current year OA Pubs

BACKGROUND: Heart failure remains a leading cause of mortality and a major driver of health care utilization. Despite numerous medical advances in heart failure, associated hospitalizations continue to increase, owing largely to suboptimal outpatient management. Remote patient monitoring (RPM) aims to further address this current need in heart failure care by providing data to clinical teams to act pre-emptively to address clinical decompensation. However, to date, RPM approaches using noninvasive home-based patient sensors have failed to demonstrate clinical efficacy.

OBJECTIVE: The Novel Data Collection and Analytics Tools for Remote Patient Monitoring in Heart Failure (Nov-RPM-HF) Trial aims to address current …

Enabling Hotspot Detection And Public Health Response To The Covid-19 Pandemic, Randi Foraker, Joshua Landman, Ian Lackey, Matthew D Haslam, Alison L Antes, Dennis Goldfarb

2020-Current year OA Pubs

INTRODUCTION: Public-facing maps of COVID-19 cases, hospital admissions, and deaths are commonly displayed at the state, county, and zip code levels, and low case counts are suppressed to protect confidentiality. Public health authorities are tasked with case identification, contact tracing, and canvasing for educational purposes during a pandemic. Given limited resources, authorities would benefit from the ability to tailor their efforts to a particular neighborhood or congregate living facility.

METHODS: We describe the methods of building a real-time visualization of patients with COVID-19-positive tests, which facilitates timely public health response to the pandemic. We developed an interactive street-level visualization that …

Gambaran Kebiasaan Merokok Di Indonesia Berdasarkan Indonesia Family Life Survey 5 (Ifls 5), Nisa Nisrina Salsabila, Noormarina Indraswari, Budi Sujatmiko

Jurnal Ekonomi Kesehatan Indonesia

The characteristics and patterns of smoking behavior are very important data to develop smoking control programs in Indonesia. However, until now there is no comprehensive and systematic data that represents all Indonesian people. This study aims to determine smokers, smoking habits, and smoking addiction in smoking habits in Indonesia based on IFLS 5. Using cross-sectional descriptive using IFLS 5 data. The research subjects are residents aged 15 years and over with a total of 12,591. The results show that smokers in Indonesia are mostly male (95%), only elementary school graduates (35%), work (80%), have a low economy (79%), and live …

Satisfaction Of Non-Covid-19 Patients Under National Health Insurance (Jkn) In Changes In Health Services During The Covid-19 Pandemic And Associated Factors, Istianah Surury, Nastiti Dyah Prastiwi, Luthfiah Haifah Ali

Jurnal Ekonomi Kesehatan Indonesia

Currently, health care services follow the first edition of the COVID-19 Prevention Guidelines from the Indonesian Health Ministry. Therefore, health care services should continue to deliver services equally between COVID-19 patients and general patients. Since the onset of the COVID-19 pandemic, a non-COVID-19 patient satisfaction survey has not been conducted at the hospital. Inpatient services are the most affected by COVID-19 because large capacity of bed is allocated for COVID-19. The aims of this study is to determine the level of satisfaction of non-COVID-19 patients under JKN and its associated factors regarding the changes in health care services during the …

Probabilitas Risiko Terkena Penyakit Jantung Dan Tb Berdasarkan Faktor Sosio-Ekonomi Dan Demografi, Ni Putu Mia Tarani, Achmad Kautsar

Jurnal Ekonomi Kesehatan Indonesia

This study aims to examine the effect of socioeconomic status and demographics on the probability of health status represented by heart disease and tuberculosis (TB). This study uses data from the Indonesian Family Life Survey (IFLS), an ongoing longitudinal survey in Indonesia. There are several independent variables in this study such as the amount of cigarette consumption, nutritional status and also blood pressure, with marginal effects as a measure of the relationship. In this study there are two dependent variables, namely heart disease and TB with the same independent variables, this is done to measure and compare how much influence …

All-In-Focus Fine Needle Aspiration Biopsy Imaging Based On Fourier Ptychographic Microscopy, Mingshu Liang, Cory Bernadt, Soon Boon Justin Wong, Changsoon Choi, Richard Cote, Changhuei Yang

2020-Current year OA Pubs

Context: Cytology is the study of whole cells in diagnostic pathology. Unlike standard histologic thinly sliced specimens, cytologic preparations consist of preparations of whole cells where cells commonly cluster and aggregate. As such, cytology preparations are generally much thicker than histologic slides, resulting in large patches of defocus when examined under the microscope. A diagnostic aggregate of cells often cannot be viewed in focus together, requiring pathologists to continually manipulate the focal plane, complicating the task of accurately assessing the entire cellular aggregate and thus in making a diagnosis. Further, it is extremely difficult to acquire useful uniformly in-focus digital …

Comparative Effectiveness Of Jade Stone Mobilisation, Non-Abrasive Cupping, And Manual Drainage Technique In Subjects With Chronic Sinusitis: A Randomized Clinical Trial, Monali Gandhi, Peeyoosha Gurudut Dr.

Internet Journal of Allied Health Sciences and Practice

Purpose: Sinusitis in recent times has been known as one of the major causes for reduced quality of life and work absenteeism. Chronic sinusitis being one of the health hazards affecting QOL of subjects of any age and gender requires a specific therapeutic intervention. Clinical trials that can demonstrate the effectiveness of manual therapy intervention in sinusitis cases are lacking. Hence, this study aims to evaluate and compare the effectiveness of three manual therapy techniques in subjects with chronic sinusitis. Method: The current study is a prospective, parallel arm, randomised clinical trial performed at physiotherapy OPD, tertiary health …

The Feasibility And Efficacy Of Telespirometry For Pulmonary Monitoring Of Cystic Fibrosis: A Systematic Review, Tessa Yap, Anne Jones

Internet Journal of Allied Health Sciences and Practice

Background: Spirometry via telehealth (telespirometry) involves remote monitoring of lung function, which is useful to detect pulmonary changes and increase continuity of care for patients with cystic fibrosis (CF). Purpose: This systematic review aims to evaluate the feasibility and efficacy of telespirometry assessments for paediatric and adult CF patients. Method: A comprehensive search of health-related databases (CINAHL, Emcare (Ovid), Medline (Ovid), PEDRo and Scopus) was conducted. For inclusion, patients had to be clinically diagnosed with CF and studies could be of any study design or level according to the National Health and Medical Research Council (NHMRC) evidence hierarchy, had to …

Quality Delivered: How A Pandemic Fostered Innovation And Creative Solutions In Clinical Education, Alice M. Davis, Laura Laporta, Nancy F. Mulligan, Stacy Carmel, Shelene Thomas, Denise O'Dell

Internet Journal of Allied Health Sciences and Practice

Background: Clinical education placements for students enrolled in healthcare programs were abruptly upended in March 2020 due to COVID-19. Programs were faced with decisions of how to mitigate substantive challenges due to an unforeseen pandemic within timeframes that would align with curricular sequences and graduation dates. Schools quickly modified curriculum formats, implemented alternative teaching and learning instruction and developed safety protocols to protect students, clinical faculty, and patients. Purpose: The aim of this study explored the strategies employed by one physical therapy school’s clinical education team, which resulted in successful completion of clinical course requirements and on-time graduation. Method: Data …

Implementation Of Home Exercise Programs In A Pro-Bono Clinic: An Exploratory Study, Joseph M. Day

Internet Journal of Allied Health Sciences and Practice

Purpose: Because the number of return visits in a pro-bono setting is low and distributed over a longer timeframe, home exercise programs (HEP) adherence is crucial for patient success. The purpose of this study is to describe a process for HEP delivery and to collect measures of HEP adherence on patients at a pro- bono physical therapy clinic. Methods: Thirteen participants were instructed to perform at least four exercises at home. Exercises were chosen based on best available practice. Exercise images, instructions, and daily logs were populated using PHYSIOTEC® software. A follow up phone call was conducted approximately 4 days …

Paramedics’ Confidence And Perceived Competence When Attending To Varied Patient Presentations: A Mixed-Method Study, Nicholas J. Waltrich, Jade Sheen, Mathew Ling

Internet Journal of Allied Health Sciences and Practice

Purpose: Paramedics are routinely called to patients presenting with mental health concerns. Previous literature suggests paramedics find this patient group challenging. However, no study has investigated whether paramedics find mental health presentations (MHP) more challenging relative to other patient presentations, or whether certain paramedic variables relate to their perceived ability to manage MHP. This study investigates differences in paramedics’ perceived ability to attend to MHP compared to other patient presentations, and whether their perceived ability is related to their level of experience or location of work (metropolitan or rural). The study also explores paramedic’s experiences and perspectives of MHP. Method: …

Impact And Experiences Relative To Critical Incidents And Critical Incident Stress Management, Peggy N. Haller, Elizabeth R. Neil, Justin P. Young, Matthew J. Drescher, Lindsey E. Eberman

Internet Journal of Allied Health Sciences and Practice

Purpose: Typically, athletic trainers (ATs) have relied on external support networks to debrief after a critical incident (CI). ATs report focusing on improving work-related processes after a CI rather than their emotional response to the CI. The purpose of this study was to identify both the short-term emotional impacts of CIs and what coping strategies ATs use to address their emotional response to CIs. Methods: We used a cross-sectional, web-based survey, distributed to a random sample of NATA members to explore the perceived effects of CIs on ATs. Participants (n=73, 36±11y) were primarily women (n=53, 72.6%), working in the college/university …

A Survey Of Interventions For Cancer Survivors Provided By Occupational Therapy Practitioners, Katie M. Polo, Mary F. Baxter

Internet Journal of Allied Health Sciences and Practice

Purpose: Currently, there is a lack of research exploring evidence-based occupational therapy intervention practices at the activity level in survivorship care, which is important to identify for future research and clinical needs of the profession. The purpose of this study was to describe what activity level interventions OT practitioners are using and report any practice trends that might exist. Method: A cross-section design was used with non-probability purposive sampling to recruit occupational therapy practitioners working with adults living with and beyond cancer. A three-phase process for survey development and implementation was used, as recommended by the literature, for improving content …

Initial Efforts To Manage Ipe During The Covid-19 Pandemic: Reports From The Big Ten Academic Alliance, Laura J. Smith, Laura Romito, Heather B. Congdon, Frank J. Ascione, Mark Fitzgerald, Kelly Karpa, Andrea Pfeifle, Brian Sick, Hossein Khalili

Internet Journal of Allied Health Sciences and Practice

Purpose: The COVID-19 pandemic required higher education institutions to quickly transition to a virtual platform. This was challenging for those involved in interprofessional education (IPE), given the goal that students from two or more professions learn about, from, and with one another. The Big Ten IPE Alliance is a subgroup of the larger Big Ten Academic Alliance. The purpose of this paper is to share the collective experiences of multiple large, research intensive universities in addressing the challenge of implementing IPE programs under the conditions established by the COVID-19 pandemic. Methods: To better understand how the Big Ten schools dealt …

Are Attitudes Toward Evidence-Based Practice Different Between The United States And Chinese Occupational Therapy And Physical Therapy Students?, Yongyue Qi, Bobbi S. Greiner, Angela Patterson, Keli Mu, Heather Javaherian-Dysinger, Kate E. Decleene Huber

Internet Journal of Allied Health Sciences and Practice

Purpose: Evidence-based practice (EBP) integrates the best evidence from research, clinician expertise, and patient preferences and values to deliver the highest quality of care to improve patient outcomes. Occupational therapy (OT), physical therapy (PT), and rehabilitation students gain exposure to EBP through both didactic and experiential learning. The differences in cultural, educational systems, and student learning styles between the United States and China may lead to different students’ perceptions and attitudes towards EBP. The purpose of the study was to characterize and compare the perceptions of and attitudes towards EBP between the U.S. and Chinese OT and PT students. Methods: …

Bioactive Curcumin And Its Effects On Lowering Systemic Inflammation As Measured By Crp: A Systematic Review, Lauren A. Katakowski, Susan Hewlings

Internet Journal of Allied Health Sciences and Practice

Objectives: The purpose of this study was to analyze and evaluate evidence supporting curcumin lowering the systemic inflammatory marker, CRP in humans. Methods: A systematic literature search was completed using PubMed and MEDLINE databases. Results: After inclusion and exclusion criteria, 9 studies were evaluated, and the percent change of CRP blood levels was calculated and analyzed. Results: The results for these studies show strong statistical significance for the C3 complex with Bioperine and nano curcumin. Bioactive curcumin exhibits a higher percent decrease of blood level CRP than trials using only curcumin or turmeric. Conclusion: Overall bioactive curcumin/ curcumin with Bioperine …

State-Trait Anxiety And The Relationship With Patient Outcomes Following Tka, Alma K. Crouch, Jennifer Bunn, Michelle Green

Internet Journal of Allied Health Sciences and Practice

Purpose: To analyze the relationships between state (S) and trait (T) anxiety and functional outcome measure performance in patients following total knee arthroplasty (TKA) receiving physical therapy (PT). Methods: Nineteen patients (62.7±9.9 years) who recently underwent TKA completed testing post-TKA and at discharge that included the modified Lower Extremity Functional Scale (mLEFS), Numeric Pain Rating Scale (NPRS), State-Trait Anxiety Inventory (STAI), Pain Catastrophizing Questionnaire (PCQ), knee range of motion (ROM), thirty-second chair stand test (30s-CST), and the timed up and go (TUG) test. Additionally, NPRS, ROM, 30s-CST, and TUG measures were taken at three and five weeks following TKA. Results: …

Impact Of Student Debt On Decisions Of Terminal Clinical Education Experiences In Physical Therapist Education, Jennifer W. Rodriguez, Whitney Davidson, R Joseph Palmer Iii, Mary Jane Rapport

Internet Journal of Allied Health Sciences and Practice

Purpose: Student debt is of growing concern in physical therapy and other health professions in the United States. This study explored the extent to which finances and other factors influenced student decision making when applying to and selecting terminal clinical education experiences. Methods: An online survey was developed and distributed to 250 recent graduates of a Doctor of Physical Therapy Program (2016-19). A logistic regression model was used to determine the relationship between respondents’ reported student debt and other factors when choosing a nontraditional model (the yearlong internship model (YLI)/residency model) or the traditional 4-month model. A 5-point Likert scale …

Extended Scope Physiotherapists Are Effective And Safe In The Emergency Department: A Systematic Review And Meta-Analysis, Brittany Souter, Anne Jones, Lorraine Sheppard, Michael Crowe

Internet Journal of Allied Health Sciences and Practice

Purpose: Extended scope physiotherapists (ESPs) are an innovative approach to service delivery that have emerged in response to increasing pressures on emergency departments (EDs). While previous systematic reviews have suggested that ESPs have a positive impact on ED outcomes, clinical practice recommendations based on limited evidence highlight a pressing need for evaluation studies to truly determine their effectiveness and safety in this setting. Therefore, the objective of this systematic review and meta-analysis was to evaluate the clinical effectiveness and safety of ESPs when delivering services in EDs. Method: Systematic literature searches were conducted using the online databases: Medline (Ovid), CINAHL …

A Qualitative Study Of The Process Undergraduate Health Professions Students Utilize While Conducting A Scoping Review, Dawn De Vries, Betsy Williams

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this research study was to inform pedagogy on the effectiveness of journaling as a tool to gauge synthesis and application of course content to a scoping review. The research question asked is “Is reflective journaling effective in helping undergraduate health profession students understand and apply course research concepts and ideas directly to an academic project?” The researchers used a reflective journaling activity to enhance student learning and to explore student application of course lectures to a scoping literature review. Method: Students were required to complete the journaling activities as a class assignment. Four journal …

Pain Education Training In New York State Physical Therapy Programs: What We Do Well, Where The Gaps Are, And What Can Be Improved, Joseph Tatta, Marcia Spoto, Joseph Lorenzetti

Internet Journal of Allied Health Sciences and Practice

Purpose: Essential pain education produces graduates who are competent in contemporary pain management. Despite various educational resources, surveys demonstrate minimal pain content in entry-level physical therapist education programs. This paper examines 1) the learning content of pain education and faculty expertise teaching core pain content, 2) whether pain education content is sufficient to prepare physical therapists to meet the needs of contemporary pain management, and 3) whether standardization of pain education in entry level Doctor of Physical Therapy (DPT) programs is advantageous. Methods: A pain education survey was developed and sent to all accredited DPT program directors in New York …

Investigating Doctor Of Physical Therapy Student Stress During Pandemic Related Curricular Changes, Keithann Halle, Jennifer D. Hastings

Internet Journal of Allied Health Sciences and Practice

Introduction: Stress level in physical therapy students has been a focus of research due to multiple documented effects related to physical health, mental health, and ability to learn. Self-reflection has also been a focus of education research, relating it to personal learning, critical thinking, and demonstrable development of professional behaviors and skills. The aim of this study is to investigate student stress in response to programmatic changes wrought by the pandemic and whether stress impacted student self-reflection. Review of literature: Self-reflection is positively associated with growth of professional behavior and academic performance. Student level of self-reflection has been shown to …

Prevalence Of Sexual Harassment Toward And Burnout Among Allied Healthcare Professionals, Stephen A. Cage, Meredith N. Decker, Brandon J. Warner, Kendall Goldberg, Diana M. Gallegos, Julianne Goza

Internet Journal of Allied Health Sciences and Practice

Purpose: Burnout is a psychological cognitive-affective syndrome that is defined by emotional exhaustion, depersonalization, and reduced accomplishment. Burnout has been identified as a common issue in several allied healthcare professions, and is often contributed to by stress, workload, and social support. At the time of this study, there appears to be no published research on the relationship between levels of sexual harassment and levels of burnout. The purpose of this was to describe the prevalence of burnout and sexual harassment among allied healthcare professionals and students. A secondary purpose was to examine the potential relationship between sexual harassment and burnout …

The Effect Of Tai Chi On Dynamic Balance In Younger Adults: Implication For Physical Therapy Practice, Anthony O'Neill, Debra A. Beazley, Lori Bolgla

Internet Journal of Allied Health Sciences and Practice

Purpose: The objective of this study was to investigate the effect of Tai Chi on the dynamic balance in younger, active community-based adults with no history of lower extremity injury or balance problems. Methods: Fourteen subjects (4 males / 10 females; age 23.6 + 6.2 years-old; height 166.5 ± 11.1 cm; weight 75.9 ± 19.3 kg) completed a 13-week undergraduate Tai Chi course. Dynamic balance was assessed at the beginning and the end of the course using the Y-Balance test. Results: Post-hoc testing showed significant improvements in anterior (P=0.007) and posterior lateral (P=0.003) reach distances with …

Attitudes Toward Covid-19 Vaccination Among Occupational Therapy Professionals And Students In Early 2021, Stephen A. Cage, Brandon J. Warner, Diana M. Gallegos, Heidi M. Cage, Diane P. Brown Phd, Otr

Internet Journal of Allied Health Sciences and Practice

Purpose: After the widespread transmission of the novel coronavirus that causes COVID-19, the first COVID-19 vaccination received emergency use authorization in the United States in December of 2020. Current research has shown the authorized COVID-19 vaccines to be safe and effective at preventing severe illness. At the time of this study, there appears to be no published research on the attitudes and receipt of COVID-19 vaccinations among occupational therapy professionals and students. The purpose of this study is to describe the attitudes and receipt of COVID-19 vaccinations among occupational therapy professionals and students in early 2021. Methods: A total of …