Medicine and Health Sciences Commons^™

Targeting Tmem205 Mediated Drug Resistance In Ovarian Clear Cell Carcinoma Using Oncolytic Virus, Uksha Saini, Brentley Q Smith, Kalpana Deepa Priya Dorayappan, Ji Young Yoo, G Larry Maxwell, Balveen Kaur, Ikuo Konishi, David O'Malley, David E Cohn, Karuppaiyah Selvendiran

Faculty, Staff and Student Publications

BACKGROUND: Ovarian clear cell carcinoma (OCCC) accounts for approximately 8-10% of epithelial ovarian cancers in the United States. Although it is rare, OCCC usually presents with treatment challenges and the overall prognosis is far worse than high grade serous ovarian cancer HGSOC. The objective of this study was to examine the therapeutic relevance of combining oncolytic virus with cisplatin for ovarian cancer clear cell carcinoma (OCCC).

RESULTS: We identified that TMEM205, a recently discovered transmembrane protein, contributes to chemoresistance in OCCC cells via the exosomal pathway. Mechanistically, TMEM205 undergoes ligand-independent constitutive endocytosis and co-localizes with Rab11 to contribute to the …

A Gbd 2019 Study Of Health And Sustainable Development Goal Gains And Forecasts To 2030 In Spain, Jeffrey V Lazarus, Alberto Ortiz, Stefanos Tyrovolas, Esteve Fernández, Danielle Guy, Trenton M White, Rui Ma, Simon I Hay, Mohsen Naghavi, Joan B Soriano, Gbd 2019 Spain Collaborators

Faculty, Staff and Student Publications

This study aimed to report mortality, risk factors, and burden of diseases in Spain. The Global Burden of Disease, Injuries, and Risk Factors 2019 estimates the burden due to 369 diseases, injuries, and impairments and 87 risk factors and risk factor combinations. Here, we detail the updated Spain 1990-2019 burden of disease estimates and project certain metrics up to 2030. In 2019, leading causes of death were ischaemic heart disease, stroke, chronic obstructive pulmonary disease, Alzheimer's disease, and lung cancer. Main causes of disability adjusted life years (DALYs) were ischaemic heart disease, diabetes, lung cancer, low back pain, and stroke. …

Heavy Metals In Four Marine Fish And Shrimp Species From A Subtropical Coastal Area: Accumulation And Consumer Health Risk Assessment, Mohammad Belal Hossain, Nurer Zaman Bhuiyan, Abul Kasem, Md Kamal Hossain, Salma Sultana, As-Ad Ujjaman Nur, Jimmy Yu, Mohammed Fahad Albeshr, Takaomi Arai

Faculty, Staff and Student Publications

Trace-element or heavy-metal pollution has emerged as a serious concern in terms of both environmental and human health issues. This study measured six trace and toxic heavy metals (Pb, Cd, Cr, Ni, Cu, and Zn) in four marine fish and shrimp species to assess their accumulation levels and evaluate the risks to human health. The mean concentrations of the metals in fish and shrimp species (Labeo bata, Sillaginopsis panijus, Platycepalus fuscus, and Penaeus monodon) followed the decreasing order of Zn (40.8 ± 9.7 μg/g) > Cu (17.8 ± 7.1 μg/g) > Pb (6.2 ± 1.8 μg/g) > Ni (0.4 ± 0.3 μg/g) > Cd …

Notch Signaling Pathway: A Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah

School of Medicine Faculty Publications

Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast cancer progression through the abnormal expression of the Notch up-and down-stream effectors. To date, there are only a few patient-centered clinical studies using datasets characterizing the role of Notch signaling pathway regulators in breast cancer; thus, we investigate the role and functionality of these factors in different subtypes using publicly available databases containing records from large studies. High-throughput genomic data and clinical information extracted …

Evidence-Based Selection Of A Fall Risk Assessment Tool: A Program Evaluation Review, Lindsey Adams

Student Scholarly Projects

Fall prevention strategies are a consistent topic of discussion for healthcare regarding patient safety, as patient falls are costly to the patient and the organization. This project uses the CDC Framework for Program Evaluation to assess the fall prevention policy of a local hospital system, with particular emphasis on the fall risk assessment tool, Hester Davis. This project also explores the risks and benefits of adopting an alternative fall risk assessment tool, predictive analytics. Predictive analytics uses electronic health record (EHR) data analysis to provide a highly individualized patient fall risk score based on a large variety of patient and …

Increasing Equitable Access To Care: Implementation Of Universal Palliative Care Screening In The Intensive Care Unit, Sarah Weaver

Student Scholarly Projects

Practice Problem: At a small community hospital in Virginia, there is an absence of standardized screening processes for identifying intensive care unit (ICU) patients with unmet palliative care needs, contributing to delayed and unequitable access to palliative care consultations.

PICOT: The PICOT question that guided this project was “In adult ICU patients, how does implementing a palliative care screening tool upon ICU admission, as compared to standard ICU admission protocol, affect palliative care consultations within an 8-week time frame?"

Evidence: This project was guided by consensus reports from the World Health Organization and the Centers to Advance …

Genetic Diversity Fuels Gene Discovery For Tobacco And Alcohol Use, Gretchen R. B. Saunders, Xingyan Wang, Fang Chen, Seon-Kyeong Jang, Mengzhen Liu, Chen Wang, Shuang Gao, John Blangero, Joanne E. Curran, Ravindranath Duggirala

School of Medicine Publications

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1,2,3,4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association …

Mental Health And Physical Activity Motivation During Covid-19, Cian Foley

Honors Program Theses and Research Projects

The COVID-19 pandemic resulted in worldwide lockdown measures which saw individuals confined to their homes and isolated from one another. This isolation led to reduced opportunities to engage in physical activity. The aim of this study was to investigate the impact that the COVID-19 pandemic had on individuals’ motivation to be physically active. Subsequently the impact of COVID-19 on various motivation types was investigated. Individuals
/="/">who reported higher levels of autonomous physical activity motivation did not report greater satisfaction with mental health than participants with less autonomous motivation. However, 90.9% of individuals who reported less autonomous motivation reported that …

Prognostic Significance Of P16 And Its Relationship With Human Papillomavirus Status In Patients With Penile Squamous Cell Carcinoma: Results Of 5 Years Follow-Up, Jad Chahoud, Niki M Zacharias, Rachel Pham, Wei Qiao, Ming Guo, Xin Lu, Angelita Alaniz, Luis Segarra, Magaly Martinez-Ferrer, Frederico Omar Gleber-Netto, Curtis R Pickering, Priya Rao, Curtis A Pettaway

Faculty, Staff and Student Publications

Penile Squamous Cell Carcinoma (PSCC) is associated with high-risk human papillomavirus (HR-HPV). The immunohistochemical (IHC) test for p16INK4a (p16) is highly correlated with HR-HPV expression in other SCCs. To investigate whether the expression of p16 IHC or HR-HPV is associated with survival in PSCC, we conducted a single institution analysis of 143 patients with a diagnosis of PSCC and, available tissue were tested for p16 IHC staining patterns, histological subtype, tumor grade, and lymphovascular invasion (LVI) by an experienced pathologist. HR-HPV status using the Cobas PCR Assay or the RNAScope high-risk HPV in situ hybridization kit were also assessed. Patient …

Transient Receptor Potential Channels In Cardiovascular And Renal Diseases, Shuangtao Ma, Michael X Zhu

Faculty, Staff and Student Publications

Transient receptor potential (TRP) channels belong to a superfamily of integral membrane proteins with diverse functions in sensory perception and cellular physiology [...].

Covid-19 Alcoholic Cirrhosis And Non-Alcoholic Steatohepatitis Cirrhosis Outcomes Among Hospitalized Patients In The United States: Insight From National Inpatient Sample Database, Devika Kapuria, Karthik Gangu, Prabal Chourasia, Aniesh Boba, Anthony Nguyen, Moon Ryu, Mark Peicher, Mario Flores, Harleen Kaur Chela, Ebubekir S Daglilar, Abu Baker Sheikh, Rahul Shekhar

2020-Current year OA Pubs

Patients with co-morbidities like cirrhosis are at risk of worse outcome from COVID-19 infection. Given limited prior studies, we evaluated outcomes associated with COVID-19 infection in alcoholic and non-alcoholic steatohepatitis cirrhotic (CC+) versus cirrhotic without COVID-19 (CC-). We performed retrospective analysis of 822,604 patients including 28,610 COVID-19 patients from the National Inpatient Sample database with alcoholic and NASH cirrhosis enrolled between 1 January 2020 to 31 December 2020, with univariate and multivariate regression analyses. Primary outcome was mortality and secondary outcomes was mechanical ventilation, vasopressor use, length of stay, hospitalization expense and predictors of mortality. In-hospital mortality was three time …

Prevalence Estimates Of Trafficking In Persons Using Statistical Definitions: A Cross-Sectional High-Risk Community Survey In Cape Town, South Africa, Rumi Kato Price, Annah K Bender, Floriana H Milazzo, Edna G Rich, Nicolette V Roman, Sheldon X Zhang, Erica L Koegler

2020-Current year OA Pubs

OBJECTIVES: Current research on trafficking in persons (TIP) relies heavily on legal and prosecutorial definitions. A public health approach has called for population-level assessment; however, identification of TIP victims lacks a standardised operational definition. This study applied the Prevalence Reduction Innovation Forum (PRIF) statistical definitions, developed by the US Department of State, to a community survey in Cape Town, South Africa.

DESIGNS: A high-risk sampling strategy was used. TIP screening questions from two instruments were matched with PRIF domain indicators to generate prevalence estimates. Sensitivity, specificity and receiver operating characteristics analyses were conducted to assess the performance of the two …

The Subcortical And Neurochemical Organization Of The Ventral And Dorsal Attention Networks, Pedro Nascimento Alves, Stephanie J Forkel, Maurizio Corbetta, Michel Thiebaut De Schotten

2020-Current year OA Pubs

Attention is a core cognitive function that filters and selects behaviourally relevant information in the environment. The cortical mapping of attentional systems identified two segregated networks that mediate stimulus-driven and goal-driven processes, the Ventral and the Dorsal Attention Networks (VAN, DAN). Deep brain electrophysiological recordings, behavioral data from phylogenetic distant species, and observations from human brain pathologies challenge purely corticocentric models. Here, we used advanced methods of functional alignment applied to resting-state functional connectivity analyses to map the subcortical architecture of the Ventral and Dorsal Attention Networks. Our investigations revealed the involvement of the pulvinar, the superior colliculi, the head …

Genetic Diversity Fuels Gene Discovery For Tobacco And Alcohol Use, Gretchen R B Saunders, Charles C Gu, John P Rice, Nancy L Saccone, Laura J Bierut, Et Al.

2020-Current year OA Pubs

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury

Reducing Readmission (And Mortality) For Older Patients & Survivors Of Life-Threatening Conditions: A Study Using The Staarr Protocol, Akhenaten Amun

Symposium of Student Scholars

Readmission rates for patients admitted for heart failure, pneumonia, chronic obstructive pulmonary disorder, a myocardial infarction, a hip or knee arthroplasty, or coronary artery bypass surgery tend to have high readmission and mortality rates within 30 days of their discharge from a hospital. Starting in October 2012, the Healthcare Reimbursement Reduction Program enforced penalties on Medicare reimbursements for hospitals with readmission rates, for patients with the conditions above, were higher than averages based on facilities with similar characteristics and patient populations. Teach-back and verify (Klingbeil & Gibson, 2018), interdisciplinary teams that engage in patient care and support (Reiter-Palmon et al., …

Interventions To Decrease Readmission Rates In Lvad Patients, Karolina Jackson

Symposium of Student Scholars

Interventions to Decrease Readmission Rates in LVAD Patients

Karolina Jackson

WellStar School of Nursing, Kennesaw State University

NURS 4417: Advanced Clinical Practicum

Lynnda Campbell

October 21, 2022

Abstract

Background: Patients who have undergone implantation of a left ventricular assistive device are at a higher risk for readmission- whether that be due to driveline dressing infections, thrombosis, bleeding at the site of implantation, or electrolyte imbalances. These readmission rates in the LVAD population can be decreased through appropriate intervention methods. Literature Review: This study’s main purpose was to discover interventions healthcare facilities and core LVAD staff can implement in practice to …

Effects Of Educational Weight Loss Interventions On Knee Arthroplasty For Obese Patients, Ashley Tomasetto, Emily Anderson, Grace Hodgson, Annabelle Hudgins, Katelin Hartley

Symposium of Student Scholars

Background: Obese patients (BMI > 30) with osteoarthritis undergoing total knee arthroplasty (TKA) surgery are at an increased risk for operative failure, higher pain level, lengthier recovery time, and decreased mobility post-surgery.

Objective: To analyze and synthesize existing evidence to determine the efficacy of educational weight loss interventions prior to TKA on adult obese patients’ recovery time, pain level, and mobility post-surgery. Weight loss intervention education was provided to obese patients aged 35-55 years in the form of nutrition and exercise programs to encourage weight loss. The study group was compared to patients who did not receive this pre-surgical education.

Methods: …

The Evaluation Of Prevention Measures Against Hospital-Acquired C. Difficile, Lauryn Glover

Symposium of Student Scholars

Today, many hospitals struggle with the increase in hospital-acquired infections, but more specifically the spread of Clostridioides Difficile (C. Difficile) infections among patients. It has caused not only a burden on the patient’s health but has also created a financial burden on hospitals. Due to the spread of C. Diff infections in the hospital setting, many hospitals are implementing strategies to combat the spread of C.Diff. One essential prevention method starts with healthcare workers. Hospital staff is required to use hand sanitizer and frequent handwashing to prevent the spread of disease to their patients. The overall purpose of this research …

Impact Of Alarm Management Classes In Reducing Alarm Fatigue, Elizabeth Laegen

Symposium of Student Scholars

Alarm fatigue is becoming a more and more common problem for nurses working in inpatient hospital units, especially critical care units. Monitoring systems, ventilators, vital signs monitors, and other electronic devices designed to detect critical or pending critical values and alterations in patients have become more of a nuisance than the lifesaving systems they were designed to be. With alarms sounding frequently for what are typically nonactionable alerts, nurses to have developed a decrease in sensitivity to all alarms, regardless of importance. Research of alarm fatigue has shown that while the significance of the problem is clear and studies have …

In Adult Icu Patients With Central Lines, Does Improved Staff Adherence To The Clabsi Prevention Clinical Practice Guidelines Reduce The Incidence Of Clabsis?, Job Waihiga

Symposium of Student Scholars

A central line-associated bloodstream infection (CLABSI) is a serious infection that occurs when bacteria or viruses enter the bloodstream through the central line. Background: This project is important because central line-associated bloodstream infections increase hospital mortality rates, lengths of stay, and 30-day readmission rates. They also impose heavy financial burdens on hospital systems. Furthermore, out of all the nosocomial infections, central line-associated bloodstream infections have the highest and most recent incidence rates in this adult ICU unit. Purpose: This project aims to identify an intervention to improve staff adherence to the CLABSI prevention bundle and decrease the rate of …

Reducing Noise Levels In Intensive Care Units Using Noise Monitoring Technology, Kayla Kloes

Symposium of Student Scholars

Intensive care units require many medical procedures, activities, machines, and staff that contribute to high levels of noise. These high noise levels have been found to cause adverse psychological and/or physiological health effects related to sleep disturbances, increased anxiety, and increased stress. These health effects may lead to decreased patient satisfaction. The purpose of this proposal is to explore the effectiveness of the SoundEar 3-300 device in decreasing levels of noise and as a result, increasing patient satisfaction. The current research indicates that the SoundEar 3-300 device is successful at reducing hospital noise levels. This device allows for the measurement …

Can Non-Pharmacological Interventions Effectively Reduce Anxiety And Pain In Chronic Pediatric Patients?, Kiara Harvey

Symposium of Student Scholars

Abstract

Pediatric anxiety and pain have been historically poorly managed. The failure of providers to adequately address medically-induced anxiety and pain in pediatric patients has been shown to prevent them from proactively seeking medical care in the future and has been linked with both altered brain development and increased risk of opioid abuse. Furthermore, poorly managed pain leads to sustained levels of cortisol and exposes patients to several long-term health risks like hypertension. Because non-pharmacological interventions are often preferred by providers, patients, and their caregivers, this research question poses an exploration of the efficacy of non-traditional methods in alleviating procedure-related …

Protocols For Postpartum Hemorrhage, Jackleen Chambers

Symposium of Student Scholars

The occurrence of postpartum hemorrhages (PH) within the healthcare system are on the rise. The detrimental effects that can occur are extremely serious and require an intervention of education and proper training. Labor and delivery units experience traumatic PHs due to lack of proper training regarding early warning signs and correct technical interventions needed for a quick turnaround. This project will use research from scholarly articles to take a closer look at statistical evidence based on the outcomes of being prepared versus underprepared. The project will discuss various methods on how to better prepare nurses to care for hemorrhagic situations. …

Postpartum Depression For Mothers With Early Fetal Death Or Stillbirths, Callie Goldman

Symposium of Student Scholars

Background: Many times, prevention of early fetus death and stillbirths is possible; however, some mortality events are spontaneous or unavoidable. While existing research reveals the likelihood of postpartum depression for mothers following birth, few studies address the potential for postpartum depression of mothers of stillbirth or demised fetuses. The purpose of this study is to determine how mothers can be better prepared for the hardship of losing a baby during childbirth, while going through common difficulties, such as postpartum depression, following birth. Methods: A mixed method approach will be conducted to gather qualitative (interview) and quantitative (Edinburgh Postnatal Depression Scale …

Impact Of Alarm Fatigue In Critical Care Nurses On Patient Outcomes, Addie Mctyre

Symposium of Student Scholars

Background

Critical care units are equipped with extensive amounts of patient monitoring equipment that sound alarms to alert nursing staff to changes in the patient’s condition. The constant beeping of alarms can result in a phenomenon known as alarm fatigue, when nursing staff becomes accustomed to the continuous sound of alarms and either tune it out or ignore it completely. This can result in poor patient outcomes. The purpose of this project is to propose techniques to decrease false alarms to reduce the overall number of alarms during a shift. This will lead to a reduction in the occurrence of …

Pediatric Spinal Cord Injury Spasticity Interventions, Zola Lopeman

Symposium of Student Scholars

Muscle spasticity is a common spinal cord injury sequela that causes muscle stiffness, spasms, and painful involuntary contractions. Spasticity can result in difficulty walking, deformed joints, lack of head control, and impairment performing activities of daily living. Spasticity is dynamic and often requires a multifaceted approach to manage symptoms and achieve patient goals. The leading treatment for spasticity is oral Baclofen. Additional treatment methods include electrical stimulation and phenol injections. Oral baclofen is frequently prescribed in combination with these.

Research suggests SCI induced spasticity can cause changes in the muscle. Thus, it is important to assess neural and muscle impacts …

Improving Discharge Planning In The Nicu, Jessica Fleming

Symposium of Student Scholars

The birth of a child is an exciting time for parents. They spend months preparing for the arrival of their baby, but parents aren’t prepared for complications that can occur at birth. Events such as early arrival or respiratory issues can result in a newborn being admitted to the NICU. This can create stress and anxiety for parents. Once a child is admitted to the NICU, it is important that discharge planning and education begin promptly, to alleviate parental distress, prepare them to care for their child upon discharge, and improve patient outcome, but some NICUs struggle to provide and …

Reducing The Risk Of Chemotherapy Exposure, Miranda Susman

Symposium of Student Scholars

Concerns about antineoplastic drugs (ANPDs), also known as chemotherapy, began in the early 1970s by the National Institute for Occupational Safety and Health. Although ANPDs are used as a standard treatment for cancer, these drugs are considered hazardous due to their adverse health effects. About eight million healthcare workers are exposed to ANPDs and therefore essential that we continue to educate on ways to reduce the risk of exposure to occupational and home health hazards. The overall purpose of this study is to determine if additional education and use of surface wipe samplings reduce the risk of exposure. A literature …

Botulism Toxin And Its Affects On Spasticity, Paige Nicholas

Symposium of Student Scholars

Abstract

Spasticity is a symptom associated with spinal cord injury patients that is caused from an influx in excitatory and inhibitory signals controlling muscles and reflexes generating a pattern of spasms in a period of time. When not treated properly adverse effects include: contractures, respiratory arrest, pain, paralysis and decrease in efficiency of nursing and therapeutic care. Interventions including medications (i.e. baclofen, dantrolene, gabapentin), physical therapy, surgery and orthotic devices are used to decrease spasticity however show minimal effect, short duration and multiple side effects. These side effects include dizziness, weakness, confusion, headaches, nausea and constipation. Recent research has shown …

Training In The Use Of Interpretive Services For Patients With Limited English Proficiency, Kristina Wooten

Symposium of Student Scholars

In clinical settings, there is a disconnect between health care professionals (HCPs) and patients with limited English proficiency (LEP). HCPs rely on ad hoc interpreters to communicate with patients with LEP (e.g. nurses using untrained friends and family or nursing students to interpret care information). Refusing to use or misusing professional interpreters and other interpretive services may lead patients with LEP to avoid seeking necessary care, misunderstand their diagnoses and treatment regimens, and fail to return for follow-up care. This increases the already existing health care disparity between patients who speak English and patients with LEP. Studies show that if …