Medicine and Health Sciences Commons^™

Nysda Records Impressive Wins In Albany, Lance Plunkett Jd, Llm

The New York State Dental Journal

Legislatively speaking, it was a very good year for the New York State Dental Association.

The Effect Of Interventions To Prevent Type 2 Diabetes On The Development Of Diabetic Retinopathy: The Dpp/Dppos Experience, Neil H White, Qing Pan, William C Knowler, Emily B Schroeder, Dana Dabelea, Emily Y Chew, Barbara Blodi, Ronald B Goldberg, Xavier Pi-Sunyer, Christine Darwin, Mathias Schlögl, David M Nathan

Children’s Nutrition Research Center Staff Publications

Objective: To determine whether interventions that slow or prevent the development of type 2 diabetes in those at risk reduce the subsequent prevalence of diabetic retinopathy.

Research design and methods: The Diabetes Prevention Program (DPP) randomized subjects at risk for developing type 2 diabetes because of overweight/obesity and dysglycemia to metformin (MET), intensive lifestyle intervention (ILS), or placebo (PLB) to assess the prevention of diabetes. During the DPP and DPP Outcome Study (DPPOS), we performed fundus photography over time on study participants, regardless of their diabetes status. Fundus photographs were graded using the Early Treatment Diabetic Retinopathy Study grading system, …

An Analysis Of The Recent Us Dietary Guidelines Process In Light Of Its Federal Mandate And A National Academies Report, Cheryl Achterberg, Arne Astrup, Dennis M Bier, Janet C King, Ronald M Krauss, Nina Teicholz, Jeff S Volek

Children’s Nutrition Research Center Staff Publications

The US Dietary Guidelines for Americans is an enormously influential policy that has guided US nutrition programs since 1980. During these last 40 years, some researchers have expressed concern that the guidelines are based on an insufficiently rigorous assessment of the scientific evidence, a view that was largely substantiated by a Congressionally mandated 2017 report by the National Academies of Sciences, Engineering, and Medicine, which identified a need for enhanced transparency, greater scientific rigor, and updates to the scientific methodology for the DGA process. This paper traces the history of these ideas and contextualizes the DGA within the law and …

The Truth About The Truth, Chester Gary Dds, Jd

The New York State Dental Journal

Dentists and patients must question the authority and motivation of purveyors of oral health information

Medication-Related Osteonecrosis Of The Jaw: Important Clinical Considerations, Bard J. Levey Dds, Franklin Garcia-Godoy Ds, Ms, Phd

The New York State Dental Journal

Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition for dental practitioners. Despite the plethora of published literature on this topic, widespread clinical awareness and recognition is still not common as clinicians still do not recognize the common, early presentations of this disease. This has been shown in different studies conducted in different parts of the world.1-4 The present paper highlights the important clinical considerations for practitioners to evaluate.

N Y State Dent J June-July 2022

The New York State Dental Journal

In the June-July 2022 issue, the reader will find the following feature articles:

• The Challenges are Many, but There’s Reason for Optimism
• Medication-Related Osteonecrosis of the Jaw: Important Clinical Considerations
• Retained Third Molars Protect Against Fractures of Mandibular Condylar Region
• Patient Recall in the Informed-Consent Process
• Clinical Report on Restoration of Patient with Immediate Loaded Maxillary Restoration Supported by Zygomatic/Endosseous Implants and Mandibular Prothesis Utilizing Three-implant Solution

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Patient Recall In The Informed Consent Process, Natasha Bhalla Dds, Nishant Suneja Md, Sungyub Lew Md, Harry Dym Dds

The New York State Dental Journal

Introduction: Informed consent is extremely important in the practice of medicine. It is a frequently discussed topic in medical ethics. Research shows that patient often sign a consent form although do not understand the information that was presented to them. Research also shows that they do not recall the information that was provided to them. The authors attempt to determine how much information patients retain. Methods: This is a prospective, double blinded, pilot study of patients presenting to the Oral and Maxillofacial Surgery Outpatient Clinic of the Brooklyn Hospital Center (TBHC) for the extraction of wisdom teeth. The number of …

Retained Third Molars Protect Against Fractures Of The Mandibular Condylar Region, Jamie S. Luria Dds, J. H. Campbell Dds, Ms, Facs

The New York State Dental Journal

Purpose: Assess mandibular condylar/subcondylar and angle fracture patterns in the presence or absence of third molars. Patients and Methods: Retrospective cohort study of 234 patients with mandibular fractures. Odds ratios were calculated to determine relative risk of angle and condylar/subcondylar fractures when third molar teeth were present or absent. Results: Condylar/subcondylar fractures were twice as likely to be avoided if a third molar was present; angle fractures were twice as likely to occur with retained third molars. Conclusions: A twofold decrease occurs in the risk of condylar/subcondylar fracture if a third molar is present and a twofold increase occurs in …

Clinical Report On Restoration Of Patient With Immediate Loaded Maxillary Restoration Supported By Zygomatic/Endosseous Implants And Mandibular Prothesis Utilizing Three-Implant Solution, Frank J. Tuminelli Dmd, Facp, Jay Neugarten Dds, Md, Elphida G. Ayvazian Dmd

The New York State Dental Journal

This is a Case Report of a 72 y/ old patient that was wearing two removable prostheses, a maxillary complete denture and a mandibular complete denture retained by two implants and locator attachments. The patients’ medical condition is complicated, the patient is blind, has suffered from kidney failure and has a donated kidney. She also suffers from diabetes. The patient’s desires were to convert both prostheses to fixed restorations. The lack of maxillary osseous tissue required the use of skeletal anchorage outside the immediate oral cavity to retain a maxillary prostheses. The current placement of mandibular implants would not allow …

The Racial Diversity Lag In Audiology: Improvement Of Recruitment And Retention Of Black Doctor Of Audiology Students, Jacquelyn Jouett, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

The racial composition of the Audiology workforce is, by no means, a reflection of the US population. Black and African American audiologists are disproportionately represented in the United States. Diverse audiologists are significantly underrepresented in clinical and academic fields. Inversely, students in the racial majority are overrepresented in Audiology and most medical specialties for that matter. This disparity may limit access to hearing-healthcare for some populations in the country. Several factors that contribute to this condition must be more fully understood before this issue can be corrected. Recruitment and retention must be improved to increase diversity, particularly students of color, …

Behavioral Intention Factors For Prescription Deliveries By Small Unmanned Aircraft In Rural Communities, Sarah M. Talley

Doctoral Dissertations and Master's Theses

Nearly half of the U.S. population regularly use and depend on prescription medications; however, pharmacy availability and access to pharmacy services are often lacking, particularly in rural communities. In an effort to meet local healthcare needs, delivery by sUAS is proposed to ensure the nearly 60 million rural residents have access to their prescription medications.

As an emerging technology with little research into home delivery applications, the successful implementation of sUAS for prescription medication delivery requires public acceptance and positive behavioral intention toward its use. At the time of the current research, no prior studies have specifically focused on the …

A Retrospective Cross Sectional Study Assessing Factors Associated With Retention And Non-Viral Suppression Among Hiv Positive Fsws Receiving Antiretroviral Therapy From Primary Health Care Facilities In Kampala, Uganda, Lydia Atuhaire, Constance Shumba, Lovemore Mapahla, Peter S. Nyasulu

School of Nursing & Midwifery, East Africa

Background: Patient retention in care and sustained viral load suppression are a cornerstone to improved health and quality of life, among people living with HIV. However, challenges of retention on ART remain among female sex workers (FSWs). We report lost to follow up (LTFU), viral load suppression, and the associated factors among FSWs that access HIV treatment at primary health care facilities in Kampala.

Methods: We retrospectively abstracted and analysed patient management data of HIV positive FSWs who enrolled in care between January 2018 to December 2020. LTFU was defined as failure of a FSW to return for …

A Cross-Sectional Study Of Self-Perceived Educational Needs Of Emergency Nurses In Two Tertiary Hospitals In Nairobi, Kenya, Anthony Ndung’U, Eunice Ndirangu, Ahmed Sarki, Lilian Isiaho

School of Nursing & Midwifery, East Africa

Background: Many low- and middle-income countries lack resources for well-functioning emergency care systems. Emer- gency nurses interact with injured and critically ill patients as the first contact in many health care settings. However, insuffi- cient training limits nurses from providing ideal emergency care. The purpose of this research was to highlight educational needs specific to nurses working in 2 emergency departments in Nairobi, Kenya.

Methods: A descriptive cross-sectional study involving emer- gency units of 2 of the largest referral and teaching hospitals (Aga Khan University Hospital, Nairobi, and Kenyatta National Hospital) in Nairobi, Kenya, was conducted. Data were …

Solution Focused Brief Therapy And Vicarious Resilience In Bolivian Protective Family Services Workers, Marcos Pérez Lamadrid, Adam S. Froerer

Journal of Solution Focused Practices

Vicarious resilience (VR) is defined as the positive effects caregivers experience within their personal lives, their work lives, and within their worldview as a whole, that come from witnessing the resilience that clients demonstrate in facing their traumatic experiences. This research study is a quasi-experimental pilot study about how solution focused brief therapy (SFBT) influences the vicarious resilience of family protective system (SLIM) workers in Bolivia. The Vicarious Resilience Inventory (VRI) was administered in a pretest/posttest design for an experimental group (applying SFBT) and a control group (training as usual). Both groups experienced an increase in vicarious resilience, but the …

Muc1 And Polarity Markers Inadl And Scrib Identify Salivary Ductal Cells, D Wu, P J Chapela, C M L Barrows, D A Harrington, D D Carson, R L Witt, N G Mohyuddin, S Pradhan-Bhatt, M C Farach-Carson

Faculty, Staff and Student Publications

Current treatments for xerostomia/dry mouth are palliative and largely ineffective. A permanent clinical resolution is being developed to correct hyposalivation using implanted hydrogel-encapsulated salivary human stem/progenitor cells (hS/PCs) to restore functional salivary components and increase salivary flow. Pluripotent epithelial cell populations derived from hS/PCs, representing a basal stem cell population in tissue, can differentiate along either secretory acinar or fluid-transporting ductal lineages. To develop tissue-engineered salivary gland replacement tissues, it is critical to reliably identify cells in tissue and as they enter these alternative lineages. The secreted protein α-amylase, the transcription factor MIST1, and aquaporin-5 are typical markers for acinar …

A Pilot Phase Ib/Ii Study Of Whole-Lung Low Dose Radiation Therapy (Ldrt) For The Treatment Of Severe Covid-19 Pneumonia: First Experience From Africa, Mansoor Saleh, Karishma Sharma, Jasmit Shah, Farrok Karsan, Angela Waweru, Martin Musumbi, Reena Shah, Shahin Sayed, Innocent Abayo, Noureen Karimi, Stacey Gondi, Sehrish Rupani, Grace Kirathe, Heldah Amariati

Internal Medicine, East Africa

Background: Low dose radiation therapy (LDRT) has been used for non-malignant conditions since early 1900s based on the ability of single fractions between 50–150 cGy to inhibit cellular proliferation. Given scarcity of resources, poor access to vaccines and medical therapies within low and middle income countries, there is an urgent need to identify other cost-effective alternatives in management of COVID-19 pneumonia. We conducted a pilot phase Ib/II investigator-initiated clinical trial to assess the safety, feasibility, and toxicity of LDRT in patients with severe COVID-19 pneumonia at the Aga Khan University Hospital in Nairobi, Kenya. Additionally, we also assessed clinical …

Finding The Right Scope: Dermoscopy For Primary Care, Peggy Cyr, Elizabeth Seiverling

MaineHealth Maine Medical Center

Background

• Primary care physicians (PCPs) frequently address skin concerns and perform clinical skin examinations1

• For PCPs, the use of dermoscopy has been shown to increase the sensitivity for skin cancer diagnosis compared to unassisted examinations2,3

• Prior to this study, no formal consensus existed on the fundamental knowledge and skills that PCPs should have with respect to dermoscopy

Objectives

• To develop an expert opinion consensus statement on 2 proficiency standards for PCPs using dermoscopy

Impact Of Dermoscopy Training For Pcps On Nnb To Detect Melanoma, Madeline Prentiss, Kathryn Stevens, Henry Stoddard, Peggy Cyr, Laura Houk, Hadjh Ahrns, Elizabeth Seiverling

MaineHealth Maine Medical Center

The goal of this project was to analyze the impact of dermoscopy training on the number of melanocytic nevi needed to biopsy (NNB) to detect a melanoma in the primary care setting .

Pediatric Dermatology Econsult Program With Dermoscopy: Sub Analysis Of Infantile Hemangiomas, Peggy R. Cyr, Madeline Prentiss, Hadjh Ahrns, Abby Markham, Elizabeth V Seiverling

MaineHealth Maine Medical Center

Here we present an analysis of pediatric dermatology eConsults with emphasis on dermoscopy utilization and the impact on eConsult on infantile hemangiomas (IH) management.

Prevalence And Clustering Of Congenital Heart Defects Among Boys With Hypospadias, Melissa A Richard, Jenil Patel, Renata H Benjamin, Emine Bircan, Stephen J Canon, Lisa K Marengo, Mark A Canfield, A J Agopian, Philip J Lupo, Wendy N Nembhard

Faculty, Staff and Student Publications

IMPORTANCE: Hypospadias is a common birth defect of the male urinary tract that may be isolated or may co-occur with other structural malformations, including congenital heart defects (CHDs). The risk for co-occurring CHDs among boys with hypospadias remains unknown, which limits screening and genetic testing strategies.

OBJECTIVE: to characterize the risk of major CHDs among boys born with hypospadias.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used data from population-based birth defect surveillance programs on all male infants born in 11 US states from January 1, 1995, to December 31, 2014. Statistical analysis was performed from September 2, 2020, …

Potential Impact Of Revised Nci Eligibility Criteria Guidance: Prior Malignancy Exclusion In Breast Cancer Clinical Trials, Matthew Perez, Caitlin C Murphy, Sandi L Pruitt, Sawsan Rashdan, Asal Rahimi, David E Gerber

Faculty, Staff and Student Publications

BACKGROUND: Many individuals with cancer have survived a prior cancer and for this reason may have been excluded from clinical trials. Recent NCI guidance recommends including these individuals, especially when the risk of the prior malignancy interfering with either safety or efficacy endpoints is very low. Using breast cancer as an example, we determined the potential effect this policy change may have on clinical trial accrual.

PATIENTS AND METHODS: We reviewed protocols of NCI-sponsored breast cancer clinical trials activated in 1991 through 2016. We quantified prevalence of prior cancer-related exclusion criteria and assessed the association with trial characteristics using Fisher's …

Cas9/Nickase-Induced Allelic Conversion By Homologous Chromosome-Templated Repair In Drosophila Somatic Cells, Sitara Roy, Sara Sanz Juste, Marketta Sneider, Ankush Auradkar, Carissa Klanseck, Zhiqian Li, Alison Henrique Ferreira Julio, Victor Lopez Del Amo, Ethan Bier, Annabel Guichard

Faculty, Staff and Student Publications

Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a

Vaccine Hesitancy And Betrayal Aversion, Abdelaziz Alsharawy, Esha Dwibedi, Jason Aimone, Sheryl Ball

Faculty, Staff and Student Publications

The determinants of vaccine hesitancy remain complex and context specific. Betrayal aversion occurs when an individual is hesitant to risk being betrayed in an environment involving trust. In this pre-registered vignette experiment, we show that betrayal aversion is not captured by current vaccine hesitancy measures despite representing a significant source of unwillingness to be vaccinated. Our survey instrument was administered to 888 United States residents via Amazon Mechanical Turk in March 2021. We find that over a third of participants have betrayal averse preferences, resulting in an 8-26% decline in vaccine acceptance, depending on the betrayal source. Interestingly, attributing betrayal …

Micronutrient Fortified Soymilk Processing Supplemental Data Tables, Michael L. Dunn, Oscar A. Pike, Bradley J. Taylor, Dallin M. Hardy

ScholarsArchive Data

This data set contains Supplemental Tables (created using Microsoft Word) for the following manuscript submitted for publication:

Vitamin stability and sensory acceptability in micronutrient-fortified soymilk prepared by small-scale batch processing

Authors: Dallin M. Hardy, Oscar A. Pike, Bradley J. Taylor, Michael L. Dunn

The above manuscript was prepared with modifications from portions of the M.S. thesis of Dallin M. Hardy, which can be found at: https://scholarsarchive.byu.edu/etd/8284/

The data set includes five supplementary tables containing data values for vitamin retention during processing and sensory acceptance of micronutrient fortified soymilk. The data in these tables had no statistically significant differences between treatments.

Targeting Ribosome Biogenesis For Pancreatic Cancer Treatment, Carlos Perez Iii

Theses and Dissertations

Pancreatic cancer (PanCa) is one of the leading causes of cancer-related death in the United States. Currently, PanCa is one of the recalcitrant cancers that has very limited therapeutic options available for its treatment. The current standard care of PanCa is gemcitabine (GEM) alone or in combination with FOLFIRINOX, nab-paclitaxel, erlotinib, or 5-FU PanCa, which often show poor response. Therefore, new treatment strategies are required for the prevention and treatment of cancer. Ribosome biogenesis process is dysregulated in most of the cancer types of results in production of more ribosomes and synthesis of oncoproteins which lead to the induction, progression, …

Innovative Use Of Biotrace Tempo Pacemaker Lead Following Cardiac Surgery, Jordan E Goldhammer, Regina E Linganna, Douglas S Pfeil, Scott D Witzeling, Alec Vishnevsky, Nicholas Ruggiero, T. Sloane Guy

Department of Anesthesiology Faculty Papers

The Tempo® Temporary Pacing Lead is a temporary, transvenous, active fixation pacemaker lead used exclusively in structural heart and electrophysiology procedures since regulatory approval in 2016. We utilized the Tempo lead for four patients undergoing redo-robotic cardiac surgery in which surgical epicardial leads could not be placed. No failure-to-pace events were encountered and patients were able to participate in various levels of physical activity without limitation.

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 71, Issue 2, Summer 2022

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• 4 - Dean's Column
• 8 - Time Capsule - Dr. Marion Siegman
• 11 - A Message from Elizabeth A. Dale
• 14 - ICYMI (In Case You Missed It)
• 18 - At the Intersection of Health and Design
• 20 - Discovery - A Path Toward Digital Equity
• 26 - Mark L. Tykocinski Takes the Helm as President of Thomas Jefferson University
• 28 - Student Profile - Kayla Holston
• 30 - Faculty Profile - Stephen D. Silberstein, MD
• 34 - Alumni Profile - Mahesh Krishnan, MD ’94
• 36 - Class Notes
• 42 - Reimagine
• 43 - Bookshelf
• 44- In …

Mratbn72: Familiar And Unfamiliar Features Of A New Rat Genome Reference Assembly, Tristan V De Jong, Hao Chen, Wesley A Brashear, Kelli J Kochan, Andrew E Hillhouse, Yaming Zhu, Isha S Dhande, Elizabeth A Hudson, Mary H Sumlut, Melissa L Smith, Theodore S Kalbfleisch, Peter A Doris

The Brown Foundation: Institute of Molecular Medicine

Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and improved rat reference genome, mRatBN7.2, in late 2020 is a welcome event. This assembly, like predecessor rat reference assemblies, is derived from an inbred Brown Norway rat. In this "user" survey we hope to provide other users of this assembly some insight into its characteristics and some assessment of its improvements as well as a few caveats that arise from the unique aspects of this assembly. mRatBN7.2 was generated by the Wellcome …

Promoting Best Practice In Cancer Care In Sub Saharan Africa, Karishma Sharma, Shahin Sayed, Mansoor Saleh

Internal Medicine, East Africa

Promoting best practice in the management of a cancer patient is rooted in the application of new knowledge derived through various sources including population science, laboratory advances, and translational research. Ultimately, the impact of these advances depends on their application at the patient’s bedside. A close collaboration between the oncologist and the pathologist is critical in underwriting progress in the management of the cancer patient. Recent advancements have shown that more granular characteristics of the tumor and themicroenvironment are defining determinants when it comes to disease course and overall outcome. Whereas, histologic features and basic immunohistochemical characterization were previously adequate …

Association Of Underweight And Weight Loss With Poor Prognosis And Poor Therapy Effectiveness In Brain Metastases: A Retrospective Study, Yan He, Yu Zhang, Weelic Chong, Yiyan Pei, Renjie Zhang, Zheran Liu, Jiayi Yu, Xingchen Peng, Fang Fang

Department of Medical Oncology Faculty Papers

Background: The prognostic role of body mass index (BMI) in patients with brain metastases is controversial. We aim to investigate the impact of BMI on prognosis and anti-cancer therapy effectiveness in brain metastases.

Methods: Patients diagnosed with brain metastases between Oct 2010 and July 2019 were followed for mortality through April 2021. The prognostic role of BMI on overall survival was assessed by a restricted cubic spline (RCS) using a flexible model to visualize the relationship between the BMI values and hazard ratios of all-cause mortality, followed by a cox regression model. The disparity of survival outcomes in patients receiving …