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2022

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Articles 8521 - 8550 of 23770

Full-Text Articles in Medicine and Health Sciences

Self-Objectification, Eating Disorders, And Mental Health Of Senior High School Female Students In Bangkok, Gunchanon Khawda, Siriluck Suppapitiporn Jul 2022

Self-Objectification, Eating Disorders, And Mental Health Of Senior High School Female Students In Bangkok, Gunchanon Khawda, Siriluck Suppapitiporn

Chulalongkorn Medical Journal

Background: High school female students have higher self-objectification more than others. Many studies showed that self-objectification was positively correlated with eating disorders and negative mental health outcomes. Objectives: To study relationships among self-objectification, eating disorders, and mental health of senior high school female students in Bangkok and to study predictors of eating disorders. Methods: The cross-sectional descriptive study was conducted in high school female students who was studying in Mathayom 6th from 6 schools in Bangkok. The data were collected by questionnaires including demographic data questionnaire, self-objectification questionnaire, the Eating Attitudes Test-26 in Thai version (EAT-26), and Thai Mental Health …


Effects Of A Dynamic Handgrip Exercise On Left Ventricular Diastolic Functions In Diabetes Mellitus Patients: A Preliminary Clinical Data, Pott Pongpaopattanakul, Thamonwan Imerbtham, Juthamat Kitimala, Suphavech Phatthanawayu, Phattarasuda Kaewkong Jul 2022

Effects Of A Dynamic Handgrip Exercise On Left Ventricular Diastolic Functions In Diabetes Mellitus Patients: A Preliminary Clinical Data, Pott Pongpaopattanakul, Thamonwan Imerbtham, Juthamat Kitimala, Suphavech Phatthanawayu, Phattarasuda Kaewkong

Chulalongkorn Medical Journal

Background: A diabetes mellitus (DM) patients sometimes exhibit a pseudo-normal diastolic relaxation during echocardiography examination, which may lead to an incorrect diagnosis. Exercise echocardiography help uncover this hidden alteration, but conventional exercise techniques contain movement artifacts. Recently, an isotonic handgrip exercise was introduced and caused hemodynamic and diastolic changes with less movement. Objective: To investigate hemodynamic and left ventricular diastolic that responses to a dynamic handgrip exercise (DHE) in DM patients. Methods: 12 controls and 12 DM patients were recruited and evaluated for hemodynamic and diastolic functions at rest and 3 minutes after performing DHE. Results: DHE increased systolic blood …


School Bullying Behaviors And Victimization In Thai Children And Adolescents With Comorbid Attention Deficit Hyperactivity Disorder, Anxiety Disorders, And Oppositional Defiant Disorder, Jirada Prasartpornsirichoke, Nuttorn Pityaratstian, Warunya Pongparadorn Jul 2022

School Bullying Behaviors And Victimization In Thai Children And Adolescents With Comorbid Attention Deficit Hyperactivity Disorder, Anxiety Disorders, And Oppositional Defiant Disorder, Jirada Prasartpornsirichoke, Nuttorn Pityaratstian, Warunya Pongparadorn

Chulalongkorn Medical Journal

Background: Bullying in school is a chronic social problem which has life-time impact. The prevalence of school bullying in Thai children and adolescents with attention deficit hyperactivity disorder (ADHD) is significantly higher than other groups. However, there is no research work has been done on the association and impact of the comorbidity of ADHD, anxiety disorder, and oppositional defiant disorder (ODD) on bullying in school. Objectives: This study aimed to examine the prevalence of school bullying in Thai children and adolescents with comorbid ADHD, anxiety disorders, and ODD at King Chulalongkorn Memorial Hospital and to investigate associations and effects of …


Factors Influencing Edentulous Patient Decision-Making While Choosing Dental Implant, Arnun Jukisalapong Jul 2022

Factors Influencing Edentulous Patient Decision-Making While Choosing Dental Implant, Arnun Jukisalapong

Chulalongkorn Medical Journal

Background: Edentulous patients suffer from the loss of natural teeth that results in chewing efficiency compromise. In addition, alveolar bone loss will occur in external width and height, these situations will decrease the quality of patient’s life. Accordingly, the patient should wear a proper prosthesis that replaces the lost natural tooth. Nowadays, dental implant is the gold standard in tooth replacement. Objective: This study aimed to investigate the factors influencing edentulous patient decision-making while choosing dental implants to replace the lost natural teeth by using the marketing mix theory and healthcare consumer behavior to assess the patient decision-making. Methods: In …


Work-Related Happiness And General Well-Being Of Personnel In Addiction Management, Thanaporn Suwanvaraboon, Rasmon Kalayasiri Jul 2022

Work-Related Happiness And General Well-Being Of Personnel In Addiction Management, Thanaporn Suwanvaraboon, Rasmon Kalayasiri

Chulalongkorn Medical Journal

Background: Personnel working in addiction management are required to keep improving the quality of their roles which may cause pressure and impact to their work-related happiness and general well-being. Objective: To explore the level of work-related happiness, general well-being, and factors related to work-related happiness among personnel in addiction management. Methods: A cross-sectional design was employed with participation of 193 personnel in addiction management, Princess Mother National Institute on Drug Abuse Treatment. A structured questionnaire was applied to ask about demographic information, work-related happiness (Thai version of the job satisfaction), and general wellbeing (Thai version of The General Well-Being Schedule). …


Clinical And Imaging Findings Correlation In Difference Stage Of Neurocysticercosis, Surachat Sittiyot, Wiyada Supadun Jul 2022

Clinical And Imaging Findings Correlation In Difference Stage Of Neurocysticercosis, Surachat Sittiyot, Wiyada Supadun

Chulalongkorn Medical Journal

Background: The common clinical manifestations of neurocysticercosis (NCC) was determined by several important factors. There is no previous study showing a correlation between difference stage of NCC and clinical presentation. The propose of this study was to determine correlation between different stages of NCC and its clinical presentation. Methods: A retrospective descriptive study was performed using medical records and picture archiving and communication system from October 14, 2004 to October 18, 2019 in patients who definite diagnosed NCC from computerized tomography (CT) or magnetic resonance imaging (MRI) of brain. Neuroimaging was reviewed by two observers. The correlation between stage of …


Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores In Older Adults, Timothy J. Libecap, Valentinos Zachariou, Christopher E. Bauer, Donna M. Wilcock, Gregory A. Jicha, Flavius D. Raslau, Brian T. Gold Jul 2022

Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores In Older Adults, Timothy J. Libecap, Valentinos Zachariou, Christopher E. Bauer, Donna M. Wilcock, Gregory A. Jicha, Flavius D. Raslau, Brian T. Gold

Sanders-Brown Center on Aging Faculty Publications

Emerging evidence suggests that enlarged perivascular spaces (ePVS) may be a clinically significant neuroimaging marker of global cognitive function related to cerebral small vessel disease (cSVD). We tested this possibility by assessing the relationship between ePVS and both a standardized measure of global cognitive function, the Montreal Cognitive Assessment (MoCA), and an established marker of cSVD, white matter hyperintensity volume (WMH) volume. One hundred and eleven community-dwelling older adults (56–86) underwent neuroimaging and MoCA testing. Quantification of region-specific ePVS burden was performed using a previously validated visual rating method and WMH volumes were computed using the standard ADNI pipeline. Separate …


Impact Of The Covid-19 Pandemic On Daily Life, Mood, And Behavior Of Adults With Down Syndrome, Sigan L. Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M. Ances, Michael A. Yassa, Adam M. Brickman, Benjamin L. Handen, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Ira T. Lott, Eric Doran, Shahid Zaman, Sharon Krinsky-Mchale, Frederick A. Schmitt, Christy L. Hom, Nicole Schupf Jul 2022

Impact Of The Covid-19 Pandemic On Daily Life, Mood, And Behavior Of Adults With Down Syndrome, Sigan L. Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M. Ances, Michael A. Yassa, Adam M. Brickman, Benjamin L. Handen, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Ira T. Lott, Eric Doran, Shahid Zaman, Sharon Krinsky-Mchale, Frederick A. Schmitt, Christy L. Hom, Nicole Schupf

Sanders-Brown Center on Aging Faculty Publications

Background: The Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread of COVID-19 may also have taken a heavy toll on the daily lives of individuals with Down syndrome.

Objective/hypothesis: The goal of the study was to understand how the COVID-19 pandemic has altered daily life (including residence, employment, and participation in adult disability day programs) and influenced the mood and behavior of adults with Down syndrome.

Methods: Between September 2020 and February 2021, caregivers of 171 adults with Down syndrome (aged …


Perceptions And Attitudes Of Physicians And Midwives Towards Patient Safety At The Maternity Department Of A Tertiary Teaching Hospital In Kenya: A Mixed Method Study, Albert Kiretia Gichuki Jul 2022

Perceptions And Attitudes Of Physicians And Midwives Towards Patient Safety At The Maternity Department Of A Tertiary Teaching Hospital In Kenya: A Mixed Method Study, Albert Kiretia Gichuki

Master of Medicine in Obstetrics and Gynecology

Introduction: The maternal mortality ratio (MMR) has declined across the world over the last 17 years. This has been attributed to more women delivering in health facilities with trained birth attendants. Despite this there is still a high maternal mortality rate with over 86% of the mortalities occurring in Sub-Saharan Africa and South East Asia. This has led to increased focus on improving quality of care and patient safety in the health facilities. A positive safety culture, which is the product of individual and group values, attitudes, perceptions and patterns of behaviour that determine the commitment to an organization’s safety …


‘Mapping’ Moral Engagement In The Solution-Focused Approach Through Macintyre’S Model Of Practice, Brian K. Jennings Jul 2022

‘Mapping’ Moral Engagement In The Solution-Focused Approach Through Macintyre’S Model Of Practice, Brian K. Jennings

Journal of Solution Focused Practices

I attempt to answer Trish Walsh’s two questions about the ‘maps’ that might exist for moral engagement in the ‘helping’ professions and how these might relate to the Solution-Focused Approach (Walsh, 2010). I seek to do this by exploring the narrative of the emergence of the Solution Focused Approach from the perspective of Alasdair MacIntyre’s concept of a ‘practice’ (MacIntyre, 1985) with the aim of providing the basis for ‘map’ for moral engagement by Solution-Focused Practitioners. To this end I attempt to interpret the Solution Focused Approach as a MacIntyreian ‘practice’ in which virtues (as ‘human qualities’) emerge out of …


Exceptional And Able: Supporting The Social Communication Skills Of Gifted Neurodiverse Students In The Classroom, Victoria S. Henbest, Brenda L. Beverly Jul 2022

Exceptional And Able: Supporting The Social Communication Skills Of Gifted Neurodiverse Students In The Classroom, Victoria S. Henbest, Brenda L. Beverly

APLL Lab Presentations

These are the presentation slides from the 2022 MEGA Conference (Mobile, AL) sponsored by the Alabama State Department of Education.


The Curious Case Of An Isolated Right Coronary Artery Aneurysm Complicated By Thrombosis And Distal Embolization, Hussam Al Hennawi, Mohammad F. Mathbout, Katrina Bidwell, Christopher D. Nielsen Jul 2022

The Curious Case Of An Isolated Right Coronary Artery Aneurysm Complicated By Thrombosis And Distal Embolization, Hussam Al Hennawi, Mohammad F. Mathbout, Katrina Bidwell, Christopher D. Nielsen

Abington Jefferson Health Papers

No abstract provided.


The Undesirable Communication: A Case Of Cerebral Air Emboli In The Setting Of Atrio-Esophageal Fistula Following Atrial Fibrillation Catheter Ablation, Momin Islam, Hussam Al Hennawi, Anwar Khedr, Khaled Harmouch, Mohammad F. Mathbout Jul 2022

The Undesirable Communication: A Case Of Cerebral Air Emboli In The Setting Of Atrio-Esophageal Fistula Following Atrial Fibrillation Catheter Ablation, Momin Islam, Hussam Al Hennawi, Anwar Khedr, Khaled Harmouch, Mohammad F. Mathbout

Abington Jefferson Health Papers

Atrial-esophageal fistula is an extremely rare condition but is often a deleterious complication following catheter ablation for atrial fibrillation. The associated iatrogenic communication acts as a conduit for air and bacterial translocation, which may lead to cerebral air embolism and polymicrobial sepsis, respectively. Coupled with a history of invasive procedures, the diagnosis is largely based on the accompanying neurological symptoms. In this report, we present the case of a 73-year-old female who presented with neurological deficits attributed to cerebral vascular emboli three weeks after catheter ablation for the treatment of chronic atrial fibrillation.


Using Community-Based Participatory Research To Tailor A Diabetes Education Program To An At-Risk Black Church Congregation In The Mid-Atlantic, Samantha A. Mielke Jul 2022

Using Community-Based Participatory Research To Tailor A Diabetes Education Program To An At-Risk Black Church Congregation In The Mid-Atlantic, Samantha A. Mielke

Doctor of Nursing Practice Projects

Background: Prediabetes and diabetes continue to have a high disease burden in the United States (Lin et al., 2018). Many individuals are unaware of their glucose state or the impact impaired glucose can have on their quality adjusted life years and cost of living. The Centers for Disease Control and Prevention (CDC) has underscored the importance of decreasing the incidence of diabetes and has resources available. Still, many communities, particularly minority populations, can benefit from tailoring programs to their specific populations, where typical approaches may not be as beneficial (Joo & Liu, 2020). Additionally, Black American (BA) congregations often have …


Sharksrx Newsletter Summer 2022, Nova Southeastern University Jul 2022

Sharksrx Newsletter Summer 2022, Nova Southeastern University

NSU Sharks Rx

No abstract provided.


Renal Cell Carcinoma Of Pelvic Kidney With Atypical Nodal Metastasis: A Diagnostic Challenge, Roshan-E-Shahid Rana, Muhammad Hammad Ather Jul 2022

Renal Cell Carcinoma Of Pelvic Kidney With Atypical Nodal Metastasis: A Diagnostic Challenge, Roshan-E-Shahid Rana, Muhammad Hammad Ather

Section of Urology

Ectopic pelvic kidney is a known congenital anomaly; however, the presence of renal cell carcinoma (RCC) in an ectopic kidney is rare with the evidence available in the form of a few case reports only. In this case report, we present a case of metastatic RCC in the pelvic kidney which became a diagnostic challenge because of atypical contrast-enhanced computed tomographic (CT) characteristics and unusual pattern of lymph node involvement including cervical lymph node in the absence of visceral metastasis. Because of its unusual location and uncertain vascular anatomy, ectopic kidney poses a surgical challenge. Owing to the rarity of …


The Role Of Bkca Channel Expression And Functional Regulation On The Development Of Pulmonary Hypertension In Type 2 Diabetic Individuals, Tahirah Nimi Jul 2022

The Role Of Bkca Channel Expression And Functional Regulation On The Development Of Pulmonary Hypertension In Type 2 Diabetic Individuals, Tahirah Nimi

PCOM Biomedical Studies Student Scholarship

Human pulmonary artery smooth muscle cells (HPASMC) maintain the vascular tone and exhibit myogenic reactivity in the pulmonary arteries. The BKCa channel, being the predominate K+ channel within the HPASMC, is important in regulating the pulmonary arterial pressure and because the BKCa channel’s activity can be modulated by various molecules, studies have evaluated the role that altered BKCa channel expression and function plays in the dysfunction of the HPASMC during type 2 diabetes (T2D). The results from those studies provided a basis for this project. In this study, cell cultures, western blot experiments, and cAMP assays …


Effect Of Pitching Restrictions And Mound Distance On Youth Baseball Pitch Counts., Hailey Mair, Nicholas A Kenney, Timothy L Uhl, L Robert Ullery, Robert G Hosey Jul 2022

Effect Of Pitching Restrictions And Mound Distance On Youth Baseball Pitch Counts., Hailey Mair, Nicholas A Kenney, Timothy L Uhl, L Robert Ullery, Robert G Hosey

Physical Therapy Faculty Publications

BACKGROUND: Studies have shown that higher pitch counts are directly related to a greater incidence of elbow and shoulder pain among youth baseball pitchers.

PURPOSE/HYPOTHESIS: The purpose of this study was to examine the effect of different pitching restriction rules on the number of pitches thrown in youth baseball leagues. We hypothesized that more pitches would be thrown in leagues with inning restrictions versus leagues with pitch count restrictions as well as in leagues with a longer mound distance (from pitching mound to home plate).

STUDY DESIGN: Cohort study; Level of evidence, 2.

METHODS: Pitch count data were collected for …


Obstetric Risk In Pregnancy Interacts With Hair Cortisone Levels To Reduce Gestational Length, Wangira Musana, Craig R. Cohen, Miriam Kuppermann, Roy Gerona, Anthony Wanyoro, David Aguilar, Nicole Santos, Sandra J. Weiss, Marleen Temmerman Jul 2022

Obstetric Risk In Pregnancy Interacts With Hair Cortisone Levels To Reduce Gestational Length, Wangira Musana, Craig R. Cohen, Miriam Kuppermann, Roy Gerona, Anthony Wanyoro, David Aguilar, Nicole Santos, Sandra J. Weiss, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Maternal psychological stress has been linked to preterm birth. However, the dierential contribution of psychological stress versus stress hormones is not clear. Studies focus primarily on perceived stress and cortisol, with few assessing its inter-convertible hormone cortisone. Furthermore, little is known about the potential moderating roles of obstetric risk and fetal sex in the relationship between maternal stress and gestational length. This gap in knowledge is particularly evident for rural women who typically experience chronic multiple stressors during pregnancy. We explored the relationship of hormonal and psychological stress to gestational length and the eects of obstetric risks and …


Differences In Hiv, Sti And Other Risk Factors Among Younger And Older Male Sex Workers Who Have Sex With Men In Nairobi, Kenya, Nicholas Muraguri, Jerry Okoth Okal, Marleen Temmerman, Helgar Musyoki, Peter Gichangi Jul 2022

Differences In Hiv, Sti And Other Risk Factors Among Younger And Older Male Sex Workers Who Have Sex With Men In Nairobi, Kenya, Nicholas Muraguri, Jerry Okoth Okal, Marleen Temmerman, Helgar Musyoki, Peter Gichangi

Obstetrics and Gynaecology, East Africa

Introduction: Previous surveys of male sex workers (MSW) in sub-Saharan Africa have not fully documented the HIV and sexually transmitted infections (STIs) rates and vulnerabilities by age category.

Methods: The bio-behavioral survey of MSW in Nairobi, Kenya, utilized respondent-driven sampling to recruit MSW. Structured interviews captured MSW's behavioral aspects, and biological tests for HIV and other STIs.

Results: Analysis of the two age categories, 18–24 years (younger MSW) and 25 years and above (older MSW), shows that of all participants, a significantly higher proportion of younger MSW (59.6% crude, 69.6% RDS-adjusted) were recruited compared to older MSW …


A Patient Risk Minimization Model For Post-Disaster Medical Delivery Using Unmanned Aircraft Systems, Mark J. Simpson Jul 2022

A Patient Risk Minimization Model For Post-Disaster Medical Delivery Using Unmanned Aircraft Systems, Mark J. Simpson

Doctoral Dissertations and Master's Theses

The purpose of this research was to develop a novel routing model for delivery of medical supplies using unmanned aircraft systems, improving existing vehicle routing models by using patient risk as the primary minimization variable.

The vehicle routing problem is a subset of operational research that utilizes mathematical models to identify the most efficient route between sets of points. Routing studies using unmanned aircraft systems frequently minimize time, distance, or cost as the primary objective and are powerful decision-making tools for routine delivery operations. However, the fields of emergency triage and disaster response are focused on identifying patient injury severity …


Preoperative Education For Cardiac Surgical Patients Benchmark Study, Jackson W. Payne Jul 2022

Preoperative Education For Cardiac Surgical Patients Benchmark Study, Jackson W. Payne

MSN Capstone Projects

Heart surgery is a term that scares a lot of people and rightfully so, as the heart is one of, if not the, most vital organ in the human body. So naturally, one can imagine the amount of fear and anxiety that patients feel when they are told they need heart surgery. This fear and anxiety is not unwarranted, either. Heart surgery, in most cases, is a major and highly complex operation with a lot of potential complications and negatives. Despite this, the majority of the time the benefits do outweigh the risks and patients elect to go forward with …


Knowledge Is Power: Using An Instructional Video Library To Provide Continuous Education In The Nicu, Leyna Fleischaker, Marybeth Browne Md, Dolores T. Suzansky Msn, Rnc-Nic Jul 2022

Knowledge Is Power: Using An Instructional Video Library To Provide Continuous Education In The Nicu, Leyna Fleischaker, Marybeth Browne Md, Dolores T. Suzansky Msn, Rnc-Nic

Research Scholars

No abstract provided.


Enhancing Lgbtq+ Care Provision At Lvhn, Anne Glowacki, Judith Sabino Mph, Cdp Jul 2022

Enhancing Lgbtq+ Care Provision At Lvhn, Anne Glowacki, Judith Sabino Mph, Cdp

Research Scholars

No abstract provided.


Duration Of Empiric Antibiotic Therapy In Young Febrile Infants, Emma Kelly, Tibisay Villalobos Md, Kristin M. Held Wheatley Pharmd, Bcop Jul 2022

Duration Of Empiric Antibiotic Therapy In Young Febrile Infants, Emma Kelly, Tibisay Villalobos Md, Kristin M. Held Wheatley Pharmd, Bcop

Research Scholars

No abstract provided.


Identifying The “Hole” Picture; Working Towards Personalizing Treatment For Pilonidal Disease, Carly Miller, Marybeth Browne Md, Olivia Hoening Jul 2022

Identifying The “Hole” Picture; Working Towards Personalizing Treatment For Pilonidal Disease, Carly Miller, Marybeth Browne Md, Olivia Hoening

Research Scholars

No abstract provided.


Identifying Factors Contributing To Lvise Improved Patient Experience, Spencer Owens, Alyssa Foley Jul 2022

Identifying Factors Contributing To Lvise Improved Patient Experience, Spencer Owens, Alyssa Foley

Research Scholars

No abstract provided.


Assessing The Patient Demographics And Clinical Characteristics Of Mechanically Ventilated Patients With Covid-19 At Lehigh Valley Health Network (Lvhn), Danielle Weaver, Kenneth Miller Med, Rrt-Nps Jul 2022

Assessing The Patient Demographics And Clinical Characteristics Of Mechanically Ventilated Patients With Covid-19 At Lehigh Valley Health Network (Lvhn), Danielle Weaver, Kenneth Miller Med, Rrt-Nps

Research Scholars

No abstract provided.


Gynecologic Preventative Care Of Women With Disabilities: What Are We Missing?, Caroline Mcgrath, Sweety Jain Md Jul 2022

Gynecologic Preventative Care Of Women With Disabilities: What Are We Missing?, Caroline Mcgrath, Sweety Jain Md

Research Scholars

No abstract provided.


Sex Differences In The Genetic Architecture Of Cognitive Resilience To Alzheimer’S Disease, Jaclyn M. Eissman, Logan Dumitrescu, Emily R. Mahoney, Alexandra N. Smith, Shubhabrata Mukherjee, Michael L. Lee, Phoebe Scollard, Seo Eun Choi, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse Mez, Catherine C. Kaczorowski, Hector Hernandez Saucedo, Keith F. Widaman, Rachel F. Buckley, Michael J. Properzi, Elizabeth C. Mormino, Hyun Sik Yang, Theresa M. Harrison, Trey Hedden, Kwangsik Nho, Shea J. Andrews, Douglas Tommet, Niran Hadad, R. Elizabeth Sanders, Douglas M. Ruderfer, Katherine A. Gifford, Xiaoyuan Zhong, Neha S. Raghavan, Badri Vardarajan, Margaret A. Pericak-Vance, Lindsay A. Farrer, Li San Wang, Carlos Cruchaga, Gerard D. Schellenberg, Nancy J. Cox, Jonathan L. Haines, C. Dirk Keene, Andrew J. Saykin, Eric B. Larson, Reisa A. Sperling, Richard Mayeux, Michael L. Cuccaro, David A. Bennett, Julie A. Schneider, Paul K. Crane, Angela L. Jefferson, Timothy J. Hohman Jul 2022

Sex Differences In The Genetic Architecture Of Cognitive Resilience To Alzheimer’S Disease, Jaclyn M. Eissman, Logan Dumitrescu, Emily R. Mahoney, Alexandra N. Smith, Shubhabrata Mukherjee, Michael L. Lee, Phoebe Scollard, Seo Eun Choi, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse Mez, Catherine C. Kaczorowski, Hector Hernandez Saucedo, Keith F. Widaman, Rachel F. Buckley, Michael J. Properzi, Elizabeth C. Mormino, Hyun Sik Yang, Theresa M. Harrison, Trey Hedden, Kwangsik Nho, Shea J. Andrews, Douglas Tommet, Niran Hadad, R. Elizabeth Sanders, Douglas M. Ruderfer, Katherine A. Gifford, Xiaoyuan Zhong, Neha S. Raghavan, Badri Vardarajan, Margaret A. Pericak-Vance, Lindsay A. Farrer, Li San Wang, Carlos Cruchaga, Gerard D. Schellenberg, Nancy J. Cox, Jonathan L. Haines, C. Dirk Keene, Andrew J. Saykin, Eric B. Larson, Reisa A. Sperling, Richard Mayeux, Michael L. Cuccaro, David A. Bennett, Julie A. Schneider, Paul K. Crane, Angela L. Jefferson, Timothy J. Hohman

Sanders-Brown Center on Aging Faculty Publications

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease neuropathology may uncover novel therapeutic targets to treat Alzheimer's disease. It is well established that there are sex differences in response to Alzheimer's disease pathology, and growing evidence suggests that genetic factors may contribute to these differences. Taken together, we sought to elucidate sex-specific genetic drivers of resilience.

We extended our recent large scale genomic analysis of resilience in which we harmonized cognitive data across four cohorts …