Medicine and Health Sciences Commons^™

Resilience Of S309 And Azd7442 Monoclonal Antibody Treatments Against Infection By Sars-Cov-2 Omicron Lineage Strains, James Brett Case, Samantha Mackin, John M Errico, Zhenlu Chong, Emily A Madden, Bradley Whitener, Ana Jung, Lindsay Droit, Scott A Handley, Daved H Fremont, Herbert W Virgin, Michael S Diamond, Et Al

2020-Current year OA Pubs

Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several monoclonal antibody therapies lose neutralizing activity against Omicron variants, the effects in vivo remain largely unknown. Here, we report on the protective efficacy against three SARS-CoV-2 Omicron lineage strains (BA.1, BA.1.1, and BA.2) of two monoclonal antibody therapeutics (S309 [Vir Biotechnology] monotherapy and AZD7442 [AstraZeneca] combination), which correspond to ones used to treat or prevent SARS-CoV-2 infections in humans. Despite losses in neutralization potency in cell culture, S309 or AZD7442 treatments reduced BA.1, BA.1.1, and …

Medicinal Plants And Herbs For Cancer Prevention, Madeline Mctigue, Julianna Goelzer, William Ranahan

Research Symposium

Modern medicine has yet to produce selective treatments for the vast majority of cancer types. Most chemotherapies, though complex, remain non-specific, and thus destroy healthy cells. Over 25% of cancer patients die from the effects of chemotherapy before the actual tumor would have progressed to the point of organismal death (Megget 2008). Early detection remains the most accurate indicator of successful treatment outcome. But why wait until the disease presents to deal with it? Here the authors argue that a well supported immune system coupled with a dietary regimen of key food-based medicines is a far superior strategy. Given that …

Eeg Neurofeedback And Isolation Stressor. A Systematic Review, Kacper Gotner, Marcin Dornowski

Baltic Journal of Health and Physical Activity

Introduction. One of the factors increasing the body's response to a stressful situation is isolation. The feeling of loneliness in isolation can be caused by biological, psychological or medical factors. Material and methods: This paper is a review of publications issued in 2009–2021, the most up-to-date in terms of information on the topic of stress and its links with EEG neurofeedback. Results: 5 publications on stress caused by isolation and the reaction of the human body in a stressful situation were selected. The papers were selected based on the use of EEG neurofeedback in reducing the body's stress reactions to …

Utility Of Av Nodal Characteristics In Identification Of Atrioventricular Nodal Reentrant Tachycardia And Risk Of Recurrence, Kimberly M. Decarr

Longitudinal Scholar's Project

Background: Catheter ablation of the slow atrioventricular (AV) nodal pathway is a safe and effective treatment for atrioventricular nodal reentrant tachycardia (AVNRT). While AVNRT occurs frequently in both children and adults, pediatric patients experience higher rates of AVNRT recurrence.

Objective: The purpose of this study was to characterize changes in AV nodal conduction properties following catheter ablation and correlate these properties with AVNRT recurrence in pediatric patients.

Methods: This was a retrospective review of patients aged(AVRT) at a single tertiary care center between January 01, 2010 and September 01, 2021. Demographics, pre- and post-ablation ECG intervals, and AV nodal conduction …

Development Of A Prototype Of Personalised Electronic Diabetes Diary For A Two-Way Communication Between Patients And Health Care Professionals, Ashika K Shetty

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

China’S Internet Health Marketplace, Singapore Management University

Perspectives@SMU

Beijing wants to leverage the e-commerce sector’s expertise to address overcrowded hospitals and long waiting times

Screening And Assessment Of Cancer-Related Fatigue: A Clinical Practice Guideline For Health Care Providers, Mary I. Fisher, Joy C. Cohn, Shana Harrington, Jeannette Lee, Daniel Malone

Physical Therapy Faculty Publications

Cancer-related fatigue (CRF) is the most common side effect of cancer treatment. Regular surveillance is recommended, but few clinical practice guidelines transparently assess study bias, quality, and clinical utility in deriving recommendations of screening and assessment methods. The purpose of this clinical practice guideline (CPG) is to provide recommendations for the screening and assessment of CRF for health care professions treating individuals with cancer. Following best practices for development of a CPG using the Appraisal of Guidelines for Research and Evaluation (AGREE) Statement and Emergency Care Research Institute (ECRI) Guidelines Trust Scorecard, this CPG included a systematic search of the …

Diabetic Ketoacidosis In Pediatric Patients, Jarrod Genther

Nursing Student Class Projects (Formerly MSN)

Diabetic Ketoacidosis in Pediatric Patients

Jarrod Genther

Otterbein University

NURS 6810- Advanced Pathophysiology

Deana Batross, DNP & Shivani Bhatnagar, DNP

July 29, 2022

Diabetic Ketoacidosis in Pediatric Patients

Abstract

Diabetic ketoacidosis is a life-threatening complication in children with type 1 diabetes. Children with type 1 diabetes cannot produce endogenous insulin and must receive exogenous insulin to allow glucose influx into cells throughout the body for energy consumption. Without insulin, the child will progress to diabetic ketoacidosis. The covid-19 pandemic introduced new obstacles for patients with a predisposition for type 1 diabetes, presenting with a more profound acidosis, greater need for …

Chemical Authentication And Speciation Of Salvia Botanicals: An Investigation Utilizing Gc/Q-Tof And Chemometrics, Joseph Lee, Mei Wang, Jianping Zhao, Bharathi Avula

Faculty and Student Publications

Members of the genus Salvia are used as culinary herbs and are prized for their purported medicinal attributes. Since physiological effects can vary widely between species of Salvia, it is of great importance to accurately identify botanical material to ensure safety for consumers. In the present study, an in-depth chemical investigation is performed utilizing GC/Q-ToF combined with chemometrics. Twenty-four authentic plant samples representing five commonly used Salvia species, viz. S. apiana, S. divinorum, S. mellifera, S. miltiorrhiza, and S. officinalis, are analyzed using a GC/Q-ToF technique. High-resolution spectral data are employed to construct a sample class prediction (SCP) model followed …

Synergistic Antibacterial Activity With Conventional Antibiotics And Mechanism Of Action Of Shikonin Against Methicillin‐Resistant Staphylococcus Aureus, Qian Qian Li, Hee Sung Chae, Ok Hwa Kang, Dong Yeul Kwon

Faculty and Student Publications

Methicillin‐resistant Staphylococcus aureus (MRSA) is a troublesome pathogen that poses a global threat to public health. Shikonin (SKN) isolated from Lithospermum erythrorhizon (L. erythro-rhizon) possesses a variety of biological activities. This study aims to explore the effect of the combined application of SKN and traditional antibiotics on the vitality of MRSA and the inherent anti-bacterial mechanism of SKN. The synergies between SKN and antibiotics against MRSA and its clinical strain have been demonstrated by the checkerboard assay and the time‐kill assay. The effect of SKN on disrupting the integrity and permeability of bacterial cell membranes was verified by a nucleotide …

Chemical Fingerprinting Profile And Targeted Quantitative Analysis Of Phenolic Compounds From Rooibos Tea (Aspalathus Linearis) And Dietary Supplements Using Uhplc‐Pda‐Ms, Omer I. Fantoukh, Yan Hong Wang, Abidah Parveen, Mohammed F. Hawwal

Faculty and Student Publications

Aspalathus linearis (Burm.f.) R. Dahlgren, commonly known as rooibos tea, was consumed traditionally by the indigenous South African inhabitants as an herbal remedy. Beside antioxidant properties, it displays antiallergic, antispasmodic, and hypoglycemic activities. An ultra‐high-performance liquid chromatography method coupled with photodiode array and mass spectrometry detectors were developed for the determination of 14 phenolic constituents from leaves and stems of A. linearis. The efficient separation was performed within 30 min at a temperature of 30 °C by using C‐18 column as the stationary phase and water/acetonitrile with 0.05% formic acid as the mobile phase. Method validation for linearity, repeatability, limits …

Santa Clara Magazine, Volume 63 Number 1, Summer 2022, Santa Clara University

Santa Clara Magazine

16 - SHARED DREAMS Meet incoming University President Julie Sullivan, the first layperson and woman selected to lead SCU. Leslie Griffy

20 - BD KNOWS BEST Discovering who you really are, being grateful, and dinosaurs with BD Wong. Lauren Loftus.

22 - SWEPT AWAY Being homeless in Silicon Valley is particularly deadly. One professor explores why so many die in a land of such excess. Leslie Griffy .

28 - ON THE OUTSIDE A first-person account of being wrongly convicted, as told by Arturo Jimenez.

30 - BOOKED AND BUSY The secret behind the Hollywood success of so many Bronco …

Comprehensive Pain Assessment For Veterans In Long-Term Care., Christopher Jenkins

Doctor of Nursing Practice Papers

Background Literature supports the need for comprehensive pain assessment (CPA) in long-term care facilities. CPAs provide valuable information for facility providers and health care staff to intervene appropriately regardless of cognitive ability. Without the use of such tools, pain can go undertreated or ignored for this underserved population causing undue suffering and poor quality of life. Chronic pain perpetuates an endless cycle of immobility, falls, injury, functional decline, and eventual death for this population.

Purpose: A CPA was implemented, evaluated, and integrated into the care processes in a long-term care facility for veterans

Method: The IHI improvement model with a …

Impact Of Palliative Care Screening Process Implementation Among Intensive Care Unit Registered Nurses., Logan Marie Griffith

Doctor of Nursing Practice Papers

Background: Palliative care is specialized care for individuals living with serious illness(s), focusing on providing symptom relief and improving quality of life (Center to Advance Palliative Care, 2020), but not all hospitals have a process to assess for palliative care needs.

Significance: Without a well-defined process for assessing patients’ readiness for palliative care, patients’ needs may not be consistently met. Approximately only 14% of people worldwide who need palliative care services receive this care (World Health Organization, 2020).

Purpose: The purpose of this quality improvement project was to implement a palliative care screening process to identify patients with palliative care …

The Impact Of Perioperative Atrial Fibrillation On Patient Outcomes Following Repair Of Thoracic Aortic Aneurysms, Jennifer Morrone, Jonathan Price, Annie Laurie Shroyer

Department of Surgery Faculty Publications

No abstract provided.

Malignant Hyperthermia, Shannen Steinbrunner

Nursing Student Class Projects (Formerly MSN)

This poster aims to investigate the concept of malignant hyperthermia (MH). MH is a rare and fatal skeletal muscle reaction that can progress rapidly, especially if advanced practice nurses do not recognize the symptoms or know how to treat them (Hopkins et al., 2021). This hypermetabolic disorder has predisposing factors that should alert APRNs to avoid specific trigger agents such as volatile anesthetics and succinylcholine (Rosenbaum & Rosenburg, 2022). Genetic predispositions also play a significant role in the etiology of MH (Hopkins et al., 2021). Viewers will learn why dantrolene is the medication of choice for MH and why symptoms, …

Pathophysiology Of Aortic Stenosis, Melissa Lee

Nursing Student Class Projects (Formerly MSN)

Pathophysiology of Aortic Stenosis

Melissa J. Lee

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Deana Batross & Dr. Shivani Bhatnagar

July 29, 2022

Pathophysiology of Aortic Stenosis

Proper evaluation of co-morbidities is imperative for patient safety and successful outcomes for patients undergoing anesthesia. Aortic stenosis (AS) is one of the most complex diseases encountered in anesthesia, affecting five percent of older adults and ten percent of the 80-89-year-old-cohort (Joseph et al., 2017). The pathophysiological development of AS is the end result of an inflammatory process caused by endothelial damage from mechanical stress, …

Pathophysiology Of Pulmonary Hypertension, Kayla Thomsen

Nursing Student Class Projects (Formerly MSN)

Abstract

Understanding the pathophysiology behind various diseases is essential for nursing, especially those in advanced practice roles such as nurse anesthetists. Pulmonary hypertension (PH), characterized by vasoconstriction, vascular remodeling, and thrombosis, has a complex physiological process and a vast compilation of patient considerations (Sarkar & Desai, 2018). PH affects up to fifty million people worldwide, with 1-year survival rates of 90.4% and 5-year survival rate of 65.4%, further solidifying the importance of understanding the disease for quick diagnosis and treatment (Bandyopadhyay et al., 2021). Diagnosis of PH is often delayed, with some patients experiencing symptoms up to two years before …

Perioperative Management In Patients With Chronic Obstructive Pulmonary Disease, Jonathan Wagner

Nursing Student Class Projects (Formerly MSN)

Introduction: Chronic obstructive pulmonary disease (COPD) results in three million deaths a year globally; COPD is becoming the third leading cause of death worldwide (Shin et al., 2017). The prevalence of COPD has a significant impact on the delivery of anesthesia in surgery.

Purpose: This poster analyzes risk factors associated with COPD and the complications associated with the disease. The implications and nursing considerations are outlined to direct goals of care and ventilator management during surgery.

Methodology: The data was collected from various control trials and meta-analysis studies. Information was also derived from pathophysiology and anesthesia resources.

Results: Patients …

Acute Kidney Injury In Perioperative Patients, Matthew Hall

Nursing Student Class Projects (Formerly MSN)

In the surgical setting, caring for a patient in the operative and postoperative phases require perioperative care providers to be attentive to risk factors that can lead to potential harm. Of all the possible complications of surgical cases, acute kidney injury is more common than others. Acute kidney injury (AKI) is kidney function that abruptly declines over a few hours or days, increases serum creatinine, causes a period of oliguria, and has three levels of severity (Zarbock et al., 2018, p.1236-1237). Risk factors predispose patients to AKI, including age, diabetes, cardiac failure, previous history of AKI, sepsis, and many more. …

Congestive Heart Failure, Ostap Dvorakevych

Nursing Student Class Projects (Formerly MSN)

Abstract

Ostap Dvorakevych

Department of Nursing, Otterbein University

NURS 6810 – Advanced Pathophysiology

Dr. Batross & Dr. Bhatnagar

July 29, 2022

Abstract

To provide the highest quality care, multidisciplinary clinical teams in critical care settings must understand the pathophysiology of the patient conditions they encounter. Congestive heart failure (CHF) is an example of such a condition. CHF is “an abnormality of the myocardial function responsible for failure of the heart to pump blood at a rate commensurate with the requirements of the metabolizing tissue...a condition in which the heart fails to maintain an output sufficient for the needs of the …

Osteoarthritis (Oa), Ashley Smith

Nursing Student Class Projects (Formerly MSN)

Osteoarthritis (OA) is the most common type of arthritis that millions of people struggle with in their day to day lives. OA is often observed in an outpatient pain management setting as it is considered an unavoidable disease process expected in aging individuals. OA is a costly, painful, and debilitating disease. OA goes further than physically limiting patients, it can even affect mental and emotional stability. Although there is not an available cure for OA, there are many preventative manageable treatment options available. Education, evaluation and management of OA is important to be knowledgeable about in order to help patients …

Hypertension-A Global Epidemic, Marie Tanyi

Nursing Student Class Projects (Formerly MSN)

Hypertension is a major cause of premature death and a leading cause of cardiovascular diseases globally. Heart diseases, renal failure, stroke, premature deaths, and disability mostly if not all contribute to the cardiovascular burden and thus pose a public health issue worldwide. The trends in hypertension are similar globally with a high prevalence noted in low and medium-income countries. Studies have identified smoking, unhealthy diet, physical inactivity, alcohol consumption, overweight or obesity, and sedentary lifestyle as modifiable risk factors in these populations. However, hypertension remains a substantial public health concern despite providers’ engagement in multi-component hypertension treatment and patient involvement …

Electronic - Cigarettes And Anesthesia Implications, Duane Robinson

Nursing Student Class Projects (Formerly MSN)

Electronic cigarettes (ECs) became available in the United States in 2007. They were originally marketed as a safer alternative to smoking (Arndt et al., 2020). The number of users has exceeded 14M people in the U.S. (Bulat et al., 2022). ECs are not as regulated as tobacco cigarettes. The levels of nicotine in the e-liquid vary significantly and the Federal Drug Administration (FDA) does not regulate the non-nicotine ingredients in e-liquid (Krishna et al., 2020). The vapor from ECs contains heavy metals, volatile hydrocarbons, and over 70 carcinogenic substances. Lung damage from EC use has created a new respiratory ailment, …

2022-07-01 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Self-Compassion And Perceived Readiness For Practice Among Baccalaureate Nursing Students: A Mixed-Methods Study, Laurie A. Walter

Dissertations

There is increasing concern about how nursing students’ psychological health will impact their future nursing practice. The COVID-19 pandemic has enhanced these concerns. Nurse educators are being challenged with preparing nursing students to provide compassionate, patient-centered care despite the stress and psychological challenges of today’s healthcare environment. Self-compassion is a practice of mindfulness, self-kindness, and common humanity which positively influences and predicts psychological health. The purpose of this study was to explore the relationship between self-compassion and perceived readiness for professional practice among undergraduate nursing students.

A convergent mixed-method design utilizing correlational and directed content analyses explored this relationship. The …

Predictors Of Engagement In Nursing Professional Practice: Transforming Organizational Culture In The Post-Covid Healthcare Environment, Jennifer Garnand

Dissertations

Cultivating the shared belief that individuals matter within an organization enhances the empowerment of staff and supports enthusiastic engagement in organizational efforts aimed toward a common mission, vision, and goals (McShane & Von Glinow, 2019). The nursing profession has been plagued by an unprecedented decrease in engagement and diminished job satisfaction, particularly following the prolonged tenure of the COVID-19 pandemic, leading to subsequent attrition amidst a staffing crisis. This quantitative predictive correlational study seeks to determine whether proactive and persevering characteristics, professional identity, and passion of nurses are predictors of engagement in a post-COVID healthcare environment. The research was based …

An Investigation Of Anti-Intellectualism Among Nurses, Jamie Davis-Tubbs

Dissertations

Anti-intellectualism is often offered as an explanation for irrational actions, especially in the grips of uncertainty. The effects of the COVID-19 pandemic have uncovered the consequences of anti-intellectualism within the healthcare system. Nurses, the most identifiability trusted healthcare professionals, have been used to illustrate a healthcare paradox regarding COVID-19. The healthcare paradox presents nurses as highly trained healthcare professionals who do not believe in their own science and reject scientific expertise. Furthermore, nursing anti-intellectualism has been used to spread misinformation during a major health crisis. Yet, we do not know the depth in which anti-intellectualism exists within the nursing profession. …

Using Community-Based Participatory Research To Assess The Needs Of Hiv-Related Services For Infected Individuals In Rural Communities, Elizabeth Brown, Charles Brown, Owen Johnson, Wendelyn Inman, Revlon Briggs, Wanda Burrell, Rosemary Theriot, Elizabeth Williams, Alexis Heaston

Public Health, Health Administration, and Health Sciences Faculty Research

HIV/AIDS remains a significant health concern in rural communities, which may also experience many disparate issues including reduced access to health services (Department of Health and Human Services, 2015). Community efforts should be increased to improve services to people living with HIV/AIDS (PLWHA), especially in rural communities. In the state of Tennessee, using a community-based participatory research (CBPR) approach, a needs assessment was conducted to identify gaps, barriers, and strategies for improving HIV-related comprehensive care services for people diagnosed with HIV/AIDS in 26 rural counties. The paper describes the CBPR partnership and the needs assessment project that was conducted and …

Trustworthiness And Quality In Research For Clinical Application, Mary I. Fisher

Physical Therapy Faculty Publications

No abstract provided.