Medicine and Health Sciences Commons^™

Combination Of Statistical Shape Modeling And Statistical Parametric Mapping To Quantify Cartilage Contact Mechanics In Hip Dysplasia, Penny R. Atkins Phd, Shireen Y. Elhabian Phd, Jeffrey A. Weiss Phd, Ross T. Whitaker Phd, Christopher L. Peters Md, Andrew E. Anderson Phd

PanaSoMM

Finite element models can predict subject-specific chondrolabral stresses and help to elucidate the effect of under-coverage and incongruency of the hip joint in patients with dysplasia. However, complex stress patterns are difficult to generalize and evaluate statistically. With an established correspondence across shapes from statistical shape modeling (SSM), statistical parametric mapping (SPM) allows for evaluation of local variability while preserving model subject-specificity. Herein, we evaluated the combined application of SSM and SPM to compare cartilage contact stress between control subjects and patients with dysplasia.

Previously published hip joint contact stresses were mapped onto chondrolabral surface meshes and incorporated into an …

Application Of Statistical Shape Modeling To Predict Clinical Metric Of Femoral Head Coverage In Patients With Developmental Dysplasia, Penny R. Atkins Phd, Praful Agrawal Phd, Joseph D. Mozingo Phd, Keisuke Uemura Md, Phd, Kunihiko Tokunaga Md, Christopher L. Peters Md, Shireen Y. Elhabian Phd, Ross T. Whitaker Phd, Andrew E. Anderson Phd

PanaSoMM

Developmental dysplasia of the hip (DDH) is described as under-coverage of the femoral head by the acetabulum, resulting in mechanical instability. Though DDH is often diagnosed using plain film radiographs, these images cannot adequately capture 3D joint coverage. Herein, we applied a 3D statistical shape model (SSM) to the femur and hemi-pelvis of patients with DDH to objectively measure shape variation and evaluated whether SSM outputs could predict measurements of joint coverage.

The femur and hemi-pelvis were semi-automatically segmented from CT images (83 hips from 47 females with DDH). Surfaces of each hip were reconstructed from segmentations, aligned, and input …

Pruritic Annular Erythematous Eruption After Receiving The Covid-19 Vaccine, Devon E. Cross, James Garritano, Amanda E. Zubek, Alicia J. Little

COVID-19 Papers, Posters, and Presentations

No abstract provided.

2022-07-12_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The K-12 Aged ISD Reporting page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/k-to-12-aged-isd-reporting.

This report is created from data reported by the Michigan Disease Surveillance System (MDSS) the Michigan Department of Health and Human Services' web-based communicable disease reporting system. Data is updated every week.

The purpose of the dashboard is to report the 7 day average of COVID-19 cases in Michigan school students aged 5 through 18 at the intermediate school district and school district levels, as well as display trends over time to better illustrate the changing nature of the COVID-19 pandemic. Cases are attributed to …

2022-07-12_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Utilizing Vitamin D Supplementation In Heart Failure, Rachel Alexanian, Justin Gambini, Heather Rollins, Timothy Aylward

Doctor of Medical Science (DMSc)

Background: The purpose of this article is to procure a literature review on a relatively new area of research, ultimately aimed at improving the lives of those with heart failure. This article sheds light on the benefits of vitamin D supplementation, and it contributes significantly to the conversation regarding mitigating the complications of heart failure. Herein we aim to offer insight into whether vitamin D supplementation is beneficial for a patient with heart failure.

Method: PubMed, MeSH, and PLOS One literature searches were conducted with the following search terms: heart failure, hospitalization, vitamin D, quality of life, and …

Evaluating Sbirt In A Behavioral Health Urgent Care, Christina L. Williams

Dissertations

Background: Adolescent substance use (SU) is a major health concern. Most youth who engage in alcohol and other SU do not meet criteria for SU disorder (SUD). Nonetheless, evidence shows SU during adolescence impacts cognitive, social, and emotional development, increases risk of physical injury, and may progress to SUD in adulthood. Only half of clinicians properly screen adolescents for SU; those identified with SUD often receive no intervention. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based intervention to address this problem. The purpose of this project was to evaluate implementation of SBIRT using CRAFFT 2.1+N, a SU …

2022-07-12_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

A Research Agenda To Support The Development And Implementation Of Genomics-Based Clinical Informatics Tools And Resources., Ken Wiley, Laura Findley, Madison Goldrich, Tejinder K Rakhra-Burris, Ana Stevens, Pamela Williams, Carol J Bult, Rex Chisholm, Patricia Deverka, Geoffrey S Ginsburg, Eric D Green, Gail Jarvik, George A Mensah, Erin Ramos, Mary V Relling, Dan M Roden, Robb Rowley, Gil Alterovitz, Samuel Aronson, Lisa Bastarache, James J Cimino, Erin L Crowgey, Guilherme Del Fiol, Robert R Freimuth, Mark A Hoffman, Janina Jeff, Kevin Johnson, Kensaku Kawamoto, Subha Madhavan, Eneida A Mendonca, Lucila Ohno-Machado, Siddharth Pratap, Casey Overby Taylor, Marylyn D Ritchie, Nephi Walton, Chunhua Weng, Teresa Zayas-Cabán, Teri A Manolio, Marc S Williams

Faculty Research 2022

OBJECTIVE: The Genomic Medicine Working Group of the National Advisory Council for Human Genome Research virtually hosted its 13th genomic medicine meeting titled "Developing a Clinical Genomic Informatics Research Agenda". The meeting's goal was to articulate a research strategy to develop Genomics-based Clinical Informatics Tools and Resources (GCIT) to improve the detection, treatment, and reporting of genetic disorders in clinical settings.

MATERIALS AND METHODS: Experts from government agencies, the private sector, and academia in genomic medicine and clinical informatics were invited to address the meeting's goals. Invitees were also asked to complete a survey to assess important considerations needed to …

Pharmacists Role In Preventing Drug Abuse, Renae L. Wilson

College of Pharmacy Student Research

In 2019, there were approximately 332,000 pharmacists active in the US workforce, Data USA, 2019. A survey of 1,700 American adults, discovered, that 34% of Americans still rely on healthcare providers such as pharmacists, for information in relation their health, KRC Research, 2018. Pharmacists are one of the three most trusted health care professions and were found to be the second most trusted source for health information by Americans in 2005. Blendon et al., 2006 found, that information from pharmacist was trusted by 67%, of participants in their survey. One of the oaths pledged by pharmacist is, ‘ …

Prevalence Of Health-Risk Behaviors And Mental Well-Being Of Asean University Students In Covid-19 Pandemic, Hanif Abdul Raman, Areekul Amornsriwatanakul, Khadizah H. Abdul-Mumin, Denny Agustiningsih, Surasak Chaiyasong, Michael Chia, Supat Chupradit, Le Quang Huy, Katiya Ivanovitch, Ma. Henrietta Teresa O. De La Cruz

Ateneo School of Medicine and Public Health Publications

The prevalence of epidemiological health-risk behaviors and mental well-being in the COVID-19 pandemic, stratified by sociodemographic factors in Association of South East Asian Nations (ASEAN) university students, were examined in the research. Data were collected in March–June 2021 via an online survey from 15,366 university students from 17 universities in seven ASEAN countries. Analyzed data comprised results on physical activity, health-related behaviors, mental well-being, and sociodemographic information. A large proportion of university students consumed sugar-sweetened beverages (82.0%; 95%CI: 81.4, 82.6) and snacks/fast food daily (65.2%; 95%CI: 64.4, 66.0). About half (52.2%; 95%CI: 51.4, 53.0) consumed less than the recommended daily …

Evaluasi Sistem Informasi Surveilans Malaria (Sismal) Di Wilayah Kerja Dinas Kesehatan Kota Malang, Muhammad Irvan Indrayana, Iwan Ariawan

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Malaria merupakan salah satu penyakit menular yang memiliki potensi tinggi dalam penyebarluasan penyakit. Berdasarkan dari Badan Pusat Statistik, Jawa Timur memiliki 7.256 kasus malaria suspek dan di kota Malang memiliki 11 kasus suspek pada tahun 2020 dan mayoritas berasal dari kasus impor dimana pasien berasal atau pernah melakukan perjalanan di luar wilayah Kota Malang yang kemudian merasakan gejala dan melakukan pemeriksaan di Kota Malang. Sistem Informasi Surveilans Malaria (SISMAL) adalah instrumen guna melakukan kegiatan pencatatan, pelaporan dan untuk meningkatkan validitas dan kelengkapan dalam pelaporan data malaria yang merupakan salah satu hal penting untuk mendukung terselenggaranya sistem Surveilans yang baik. Sistem …

Validitas Dan Reliabilitas Kuesioner Chinese Positive Youth Development Scales (Cpyds) Mengukur Keterampilan Hidup Pelajar Smp Di Babakan Madang Kabupaten Bogor 2019, Rahastiwi Fadilah Utami, Sabarinah Prasetyo, Dion Zein Nurizin

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Masa remaja merupakan masa di mana individu mengalami peralihan dari anak-anak menjadi dewasa. Pada masa ini ada rasa keingintahuan yang besar dan banyak perubahan yang terjadi, akibatnya tidak sedikit remaja menghadapi berbagai masalah. Salah satu upaya untuk mempersiapkan remaja sehingga siap dan mampu menghadapi masalah adalah dengan membekali remaja keterampilan hidup. Pada tahun 2019, tim Pengabdian kepada Masyarakat FKM UI menerjemahkan kuesioner Chinese Positive Youth Development Scales (CPYDS) ke dalam bahasa Indonesia untuk mengukur keterampilan hidup siswa SMP di Babakan Madang. Data tersebut kemudian dianalisis lebih lanjut untuk tujuan melihat validitas dan reliabilitasnya. Validitas dinilai dengan korelasi point-biserial dan analisis …

Evaluasi Sistem Surveilans Tuberkulosis Di Dinas Kesehatan Kabupaten Banyumas Berdasarkan Pendekatan Sistem, Nadia Hasnanisa, Sabarinah Prasetyo, Arif Burhanudin

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Kabupaten Banyumas sebagai wilayah dengan jumlah kasus TB tertinggi di Provinsi Jawa Tengah mengalami penurunan angka pelaporan kasus TB. Tujuan penelitian ini adalah mengetahui gambaran dan kesesuaian pelaksanaan surveilans TB dari segi input, proses, dan output di wilayah kerja Dinas Kesehatan Kabupaten Banyumas berdasarkan pedoman yang ada. Penelitian kualitatif deskriptif menggunakan data primer melalui wawancara, observasi, dan dokumentasi, dengan jumlah informan sebanyak 2 orang yang dipilih dengan metode purposive sampling. Beberapa komponen surveilans yang belum memenuhi standar yaitu jumlah petugas (Man), pelatihan bagi petugas (Man), pendanaan (Money), sarana transportasi (Material), alat TCM (Material), sarana kepustakaan (Material), …

Hubungan Aktivitas Fisik, Konsumsi Buah Dan Sayur, Serta Cek Kesehatan Rutin Terhadap Kejadian Hipertensi Pada Siswa/I Sma Sederajat Di Wilayah Kerja Puskesmas Sawangan, Kota Depok, Milla Herdayati, Andito Yahya, Anggi Anitia, Anna Yulianti, Maulidyah Ananda, Meita Chairunnisa, Meliana Putri, Nabilah Huwaida, Nafa Shahira Anglila S, Nafikhatul Khikmah, Rofiq Firzatullah, Rouli Felicia

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Hipertensi adalah salah satu penyakit tidak menular tanpa gejala dengan kematian tertinggi yang mulai berkembang pada remaja. Studi CDC menunjukkan 1 dari 25 remaja usia 12 hingga 19 tahun menderita Hipertensi. Sementara di Indonesia, terdapat 34,11% dengan usia di atas 18 tahun terdiagnosis hipertensi oleh dokter. Pada tingkat lebih kecil, dalam penelitian di kota Depok ditemukan 57,1% kasus hipertensi pada remaja di usia 12-25 tahun. Studi ini bertujuan untuk menganalisis faktor-faktor perilaku yang berhubungan dengan kejadian hipertensi di wilayah kerja puskesmas Sawangan. Metode penelitian menggunakan desain studi cross sectional dengan teknik cluster random sampling. Sampel penelitian adalah hasil randomisasi pada …

Hubungan Beban Kerja Tenaga Kesehatan Dengan Kelelahan Kerja Di Puskesmas Kecamatan Sukmajaya Kota Depok Selama Pandemi, Herma Krisdiana, Jaslis Iljas, Dumilah Ayuningtyas, Eny Juliati

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Beban kerja merupakan salah satu faktor risiko yang menyebabkan terjadinya kelelahan. Situasi pandemi saat ini memberikan dampak nyata khususnya pada sektor kesehatan. WHO menetapkan COVID-19 sebagai pandemi pada tahun 2020. Dampak pandemi COVID-19 menyebabkan tenaga kesehatan sebagai sumberdaya penyedia layanan kesehatan dihadapkan pada situasi berbeda, salah satunya terjadi peningkatan pada tuntutan pekerjaan. Tingginya tuntutan pekerjaan yang diterima tenaga kesehatan akan menjadi penyebab beban kerja menjadi tinggi sehingga lebih berisiko mengalami kelelahan kerja. Penelitian ini bertujuan untuk mengetahui hubungan antara beban kerja dengan kelelahan kerja di Puskesmas Kecamatan Sukmajaya selama masa pandemi. Desain penelitian yang digunakan adalah cross sectional dengan pengumpulan …

Synthesis And Evaluation Of Anti-Hiv Activity Of Mono- And Di-Substituted Phosphonamidate Conjugates Of Tenofovir, Aaminat Qureshi, Louise A. Ouattara, Naglaa Salem El-Sayed, Amita Verma, Gustavo F. Doncel, Muhammad Iqbal Choudhary, Hina Siddiqui, Keykavous Parang

Pharmacy Faculty Articles and Research

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by endogenous enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent these limitations, several prodrug approaches have been proposed. Herein, we hypothesized that the conjugation or combination of the lipophilic amide bond with nucleotide-based tenofovir (TFV) (1) could improve the anti-HIV activity. During the current study, the hydroxyl group of phosphonates in TFV was conjugated with the amino group of L-alanine, L-leucine, L-valine, and glycine amino acids and other long fatty ester hydrocarbon chains to synthesize 43 derivatives. Several …

Usa Health Insider Newsletter - July 12, 2022, Bernell Dorrough, Marie Katz

USA Health Insider Newsletter

USA Health Insider newsletter for July 12, 2022. The contents include:

• USA Health First on Gulf Coast to Secure the da Vinci SP
• Recent PTO DOnations Fulfill 10 Requests
• USA Health Expands Digestive Health Center with Addition of New Gastroenterologist
• Blessings for New Babies Offered
• Birthing Tours Now Offered Once a Week at Children's & Women's Hospital
• Calling Medical Alumni: Send Us Your Photos
• PathPic Contest Winners Announced
• Mental Health Conference to Feature Temple Grandin
• One of Us: Kerry Flowers
• Pathology Resident Graduates Bound for Fellowship Programs
• USA Health Recognizes You: July 12, 2022
• Watch Us Grow: Mapp Family Campus …

Increased Cytokine Gene Expression And Cognition Risk Associated With Androgen Deprivation Therapy, Shiv Verma, Prem Prakash Kushwaha, Eswar Shankar, Lee E. Ponsky, Sanjay Gupta

Faculty Scholarship

Background: Androgen deprivation therapy (ADT) is a standard treatment modality for locally advanced, high-risk, and metastatic hormone-sensitive prostate cancer. Long-term ADT treatment likely develops side-effects that include changes in cognition or onset of dementia. However, the molecular understanding of this effect remains elusive. We attempt to establish a link between ADT and changes in cognitive function using patient databases and bioinformatics analyses. Methods: Gene expression profiling was performed using RNA sequencing data from Alzheimer patient cohort and compared with the data from advanced-stage prostate cancer patients receiving neoadjuvant antiandrogen therapy. Differentially expressed genes (DEGs) were analyzed using the Ingenuity knowledge …

Mental Health, Chronic Disease, And Substance Use: Findings From Rural Texas, Subi Gandhi, Ryan Glaman, Elizabeth Wachira, Muna Bashir, Sushma Sharma, Chelsea Mowles, Jasmine Luttrell

Journal of Social, Behavioral, and Health Sciences

There are vital links among mental health conditions, chronic diseases, and substance use disorders. Simultaneous examination of the relationship among these three conditions is essential for providing well-integrated care to rural residents who have limited resources and for representing medically underserved areas. We aimed to assess the burden of behavioral health conditions and chronic diseases from a rural Texas community to garner context-specific insights and inform effective health promotion strategies in similar communities. We conducted a cross-sectional study among 181 residents from various zip codes in a rural Texas county. A self-administered, 18-item health-needs questionnaire was used to collect data …

Recognizing And Disrupting Stigma In Implementation Of Hiv Prevention And Care: A Call To Research And Action, Sarit A. Golub, Rachel A. Fikslin

Publications and Research

Introduction: There is robust evidence that stigma negatively impacts both people living with HIV and those who might benefit from HIV prevention interventions. Within healthcare settings, research on HIV stigma has focused on intra-personal processes (i.e. knowledge or internalization of community-level stigma that might limit clients’ engagement in care) or inter-personal processes (i.e. stigmatized interactions with service providers). Intersectional approaches to stigma call us to examine the ways that intersecting systems of power and oppression produce stigma not only at the individual and interpersonal levels, but also within healthcare service delivery systems. This commentary argues for the importance of analysing …

Novel Mechanisms For Post-Transplant Maintenance Therapy In Acute Myeloid Leukemia, Steven A Manobianco, Tara Rakiewicz, Lindsay Wilde, Neil D Palmisiano

Department of Medical Oncology Faculty Papers

Allogeneic stem cell transplantation has improved survival for patients with acute myeloid leukemia (AML), especially for patients with disease at high risk of relapse. However, relapse remains the most common cause of treatment failure and death in the post-transplant period. Maintenance therapy, an extended course of treatment after achieving remission to reduce the rate of relapse, is an important component of the treatment of various hematologic malignancies; however, its role in the treatment of AML is far less well-defined. Recently, there has been significant interest in the use of novel therapeutic agents as maintenance therapy after allogeneic stem cell transplant, …

A Conserved Signal-Peptidase Antagonist Modulates Membrane Homeostasis Of Actinobacterial Sortase Critical For Surface Morphogenesis, Nicholas A Ramirez, Chenggang Wu, Chungyu Chang, Sara D Siegel, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

Cell wall anchoring of surface proteins in Gram-positive bacteria requires a sortase enzyme. Here, we unveiled the hitherto unknown function of an evolutionarily conserved small transmembrane protein, named SafA, genetically linked to the housekeeping sortase in Actinobacteria. We show that Actinomyces oris SafA interacts with the housekeeping sortase SrtA via the conserved FPW motif and prevents SrtA cleavage by the signal peptidase LepB2, hence maintaining membrane homeostasis of SrtA. This function is conserved as ectopic expression of SafA from Corynebacterium diphtheriae and Corynebacterium matruchotii in the A. oris safA mutant rescues its defects in cell morphology, pilus assembly, surface protein …

Association Of Cardiovascular Health Through Young Adulthood With Genome-Wide Dna Methylation Patterns In Midlife: The Cardia Study, Yinan Zheng, Brian T Joyce, Shih-Jen Hwang, Jiantao Ma, Lei Liu, Norrina B Allen, Amy E Krefman, Jun Wang, Tao Gao, Drew R Nannini, Haixiang Zhang, David R Jacobs, Myron D Gross, Myriam Fornage, Cora E Lewis, Pamela J Schreiner, Stephen Sidney, Dongquan Chen, Philip Greenland, Daniel Levy, Lifang Hou, Donald M Lloyd-Jones

Faculty, Staff and Student Publications

Background: Cardiovascular health (CVH) from young adulthood is strongly associated with an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining epigenomic biomarkers of lifelong CVH exposure and understanding their roles in CVD development may help develop preventive and therapeutic strategies for CVD.

Methods: In 1085 CARDIA study (Coronary Artery Risk Development in Young Adults) participants, we defined a clinical cumulative CVH score that combines body mass index, blood pressure, total cholesterol, and fasting glucose measured longitudinally from young adulthood through middle age over 20 years (mean age, 25-45). Blood DNA methylation at >840 000 methylation markers was …

Renin-Angiotensin System In Huntington's Disease: Evidence From Animal Models And Human Patients, Lucas M Kangussu, Natalia P Rocha, Priscila A C Valadão, Thatiane C G Machado, Kívia B Soares, Julliane V Joviano-Santos, Leigh B Latham, Gabriela D Colpo, Ana Flávia Almeida-Santos, Erin Furr Stimming, Ana Cristina Simões E Silva, Antônio L Teixeira, Aline Silva Miranda, Cristina Guatimosim

Faculty, Staff and Student Publications

The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical and experimental studies have suggested that alterations in the brain RAS contribute to the development and progression of neurodegenerative diseases. However, there is limited information regarding the involvement of RAS components in Huntington's disease (HD). Herein, we used the HD murine model, (BACHD), as well as samples from patients with HD to investigate the role of both the classical and alternative axes of RAS in HD pathophysiology. BACHD mice displayed worse motor performance in different behavioral tests alongside …

End-To-End Commissioning & Treatment Plan Quality Assurance For Cranial Single-Isocenter Multi-Target (Simt) Radiosurgery, Cory Knill

Conference Presentation Abstracts

No abstract provided.

Newborn Weight Change And Predictors Of Underweight In The Neonatal Period In Guinea-Bissau, Nepal, Pakistan And Uganda, Valerie J. Flaherman, Amy S. Ginsburg, Muhammad Imran Nisar, Muddassir Altaf, Khushboo Liaquat, Benazir Baloch, Najeeb Rehman, Yasir Shafiq, Shabina Ariff, Fyezah Jehan

Department of Paediatrics and Child Health

In low- and middle-income countries (LMIC), growth impairment is common; however, the trajectory of growth over the course of the first month has not been well characterised. To describe newborn growth trajectory and predictors of growth impairment, we assessed growth frequently over the first 30 days among infants born ≥2000 g in Guinea-Bissau, Nepal, Pakistan and Uganda. In this cohort of 741 infants, the mean birth weight was 3036 ± 424 g. For 721 (98%) infants, weight loss occurred for a median of 2 days (interquartile range, 1-4) following birth until weight nadir was reached 5.9 ± 4.3% below birth …

Treatment-Free Remission After Ceasing Venetoclax-Based Therapy In Patients With Acute Myeloid Leukemia, Chong Chyn Chua, Danielle Hammond, Andrew Kent, Ing Soo Tiong, Marina Y Konopleva, Daniel A Pollyea, Courtney D Dinardo, Andrew H Wei

Faculty, Staff and Student Publications

The clinical benefit of adding venetoclax (VEN) to hypomethylating agents or low-dose cytarabine in older and/or unfit patients with newly diagnosed acute myeloid leukemia (AML) has been confirmed in phase 3 studies. With the increased uptake of VEN-based therapies for patients with AML, a pertinent question is whether treatment can be safely ceased among patients who have achieved sustained remission. We hypothesized that a proportion of patients opting to cease therapy may benefit from a treatment-free remission (TFR) period without indefinite treatment. We report the retrospective outcomes of 29 patients in remission for a minimum of 12 months on VEN-based …

High-Sensitivity Next-Generation Sequencing Mrd Assessment In All Identifies Patients At Very Low Risk Of Relapse, Nicholas J Short, Hagop Kantarjian, Farhad Ravandi, Marina Konopleva, Nitin Jain, Rashmi Kanagal-Shamanna, Keyur P Patel, Walid Macaron, Tapan M Kadia, Sa Wang, Jeffrey L Jorgensen, Joseph D Khoury, Musa Yilmaz, Partow Kebriaei, Koichi Takahashi, Guillermo Garcia-Manero, Naval Daver, Sean M Post, Xuelin Huang, Steven M Kornblau, Sara Pelletier, Wilmer Flores, Jairo Matthews, Rebecca Garris, Elias Jabbour

Faculty, Staff and Student Publications

Measurable residual disease (MRD) is highly prognostic for relapse and overall survival (OS) in acute lymphoblastic leukemia (ALL), although many patients with apparent "MRD negativity" by standard assays still relapse. We evaluated the clinical impact of a highly sensitive next-generation sequencing (NGS) MRD assay in 74 adults with ALL undergoing frontline therapy. Among remission samples that were MRD negative by multiparameter flow cytometry (MFC), 46% were MRD+ by the NGS assay. After 1 cycle of induction chemotherapy, MRD negativity by MFC at a sensitivity of 1 × 10-4 and NGS at a sensitivity of 1 × 10-6 was achieved in …

Beyond Efficiency: Surface Electromyography Enables Further Insights Into The Surgical Movements Of Urologists, Rahul Soangra, Pengbo Jiang, Daniel Haik, Perry Xu, Andrew Brevik, Akhil Peta, Shlomi Tapiero, Jaime Landman, Emmanuel John, Ralph V. Clayman

Physical Therapy Faculty Articles and Research

Introduction: Surgical skill evaluation while performing minimally invasive surgeries is a highly complex task. It is important to objectively assess an individual's technical skills throughout surgical training to monitor progress and to intervene when skills are not commensurate with the year of training. The miniaturization of wireless wearable platforms integrated with sensor technology has made it possible to noninvasively assess muscle activations and movement variability during performance of minimally invasive surgical tasks. Our objective was to use electromyography (EMG) to deconstruct the motions of a surgeon during robotic suturing (RS) and distinguish quantifiable movements that characterize the skill of an …