Medicine and Health Sciences Commons^™

Effect Of Race On Prediction Of Brain Amyloidosis By Plasma Aβ42/Aβ40, Phosphorylated Tau, And Neurofilament Light, Suzanne E Schindler, Rachel L Henson, Yan Li, Benjamin Saef, Krista L Moulder, David Bradford, Anne M Fagan, Brian A Gordon, Tammie L S Benzinger, Joyce Balls-Berry, Randall J Bateman, Chengjie Xiong, John C Morris, Et Al

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: To evaluate whether plasma biomarkers of amyloid (Aβ42/Aβ40), tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain [NfL]) detect brain amyloidosis consistently across racial groups.

METHODS: Individuals enrolled in studies of memory and aging who self-identified as African American (AA) were matched 1:1 to self-identified non-Hispanic White (NHW) individuals by age,

RESULTS: There were 76 matched pairs of AA and NHW participants (n = 152 total). For both AA and NHW groups, the median age was 68.4 years, 42% were

DISCUSSION: Models predicting brain amyloidosis using a high-performance plasma Aβ42/Aβ40 assay may provide an accurate and …

Activation Domains Can Decouple The Mean And Noise Of Gene Expression, Kaiser Loell, Yawei Wu, Max V Staller, Barak Cohen

2020-Current year OA Pubs

Regulatory mechanisms set a gene's average level of expression, but a gene's expression constantly fluctuates around that average. These stochastic fluctuations, or expression noise, play a role in cell-fate transitions, bet hedging in microbes, and the development of chemotherapeutic resistance in cancer. An outstanding question is what regulatory mechanisms contribute to noise. Here, we demonstrate that, for a fixed mean level of expression, strong activation domains (ADs) at low abundance produce high expression noise, while weak ADs at high abundance generate lower expression noise. We conclude that differences in noise can be explained by the interplay between a TF's nuclear …

Sox9 Directs Divergent Epigenomic States In Brain Tumor Subtypes, Debosmita Sardar, Hsiao-Chi Chen, Amanda Reyes, Srinidhi Varadharajan, Antrix Jain, Carrie Mohila, Rachel Curry, Brittney Lozzi, Kavitha Rajendran, Alexis Cervantes, Kwanha Yu, Ali Jalali, Ganesh Rao, Stephen C Mack, Benjamin Deneen

Duncan NRI Faculty and Staff Publications

Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible for these diverse epigenetic states remain unclear. Here, we show that the developmental transcription factor Sox9 differentially regulates epigenomic states in high-grade glioma (HGG) and ependymoma (EPN). Using our autochthonous mouse models, we found that Sox9 suppresses HGG growth and expands associated H3K27ac states, while promoting ZFTA-RELA (ZR

Hippo-Taz Signaling Is The Master Regulator Of The Onset Of Triple-Negative Basal-Like Breast Cancers, Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki

Faculty, Staff and Students Publications

A universal oncogenic driver of basal-like breast cancer (BLBC) has resisted identification. We show that continuous transcriptional coactivator with PDZ-binding motif (TAZ) activation in precancerous murine luminal cells generates luminal cancers that later become BLBCs. Subsequent TP53 alteration, a feature of invasive human BLBCs, accelerates tumor progression. Because BLBC development is inhibited by TAZ inactivation in vivo, our work provides a sound rationale for targeting Hippo-TAZ signaling as therapy for human BLBC. Our mouse model of BLBC represents a powerful tool for evaluating such drugs.

Cardiovascular Adverse Events In Oncology Trials: Understanding And Appreciating The Differences Between Clinical Trial Data And Real-World Reports, Michael S Ewer, Jay Herson

Duncan NRI Faculty and Staff Publications

Reports of cardiac adverse events from oncology clinical trials often are at variance with reports derived from clinical observations or data-base reviews. These differences may lead to confusion, as different levels of risks abound in the literature, and the true cardiac risk of using some agents is uncertain. Additionally, such discrepancies may lead to the creation of over-cautious surveillance algorithms. Reasons for these reported differences are complex and often reflect subtleties in the criteria for individual patient evaluation. Both clinical trial data and real-world data have potential flaws that make reconciliation problematic. Importantly, however, both provide crucial information regarding the …

Snmmi/Acr/Asnc/Scmr Joint Credentialing Statement For Cardiac Pet/Mri, Terrence D Ruddy, Mouaz Al-Mallah, James A Arrighi, John P Bois, David A Bluemke, Marcelo F Di Carli, Vasken Dilsizian, Robert J Gropler, Hossein Jadvar, Saurabh Malhotra, Matthieu Pelletier-Galarneau, Thomas H Schindler, Pamela K Woodard, Panithaya Chareonthaitawee

2020-Current year OA Pubs

No abstract provided.

The Heart's "Little Brain"

Thomas Jefferson University Research Magazine

Researchers develop the first ever 3D map of the heart’s nervous system, providing a foundation for understanding the complexities of heart health.

A Path Towards Digital Equity

Thomas Jefferson University Research Magazine

Telemedicine is a vital tool in health care, but it’s leaving some patients behind. Jefferson researchers are on a mission to improve ‘digital readiness’ in under-resourced communities to bridge inequities.

Inflecting The Narrative On African Studies

Thomas Jefferson University Research Magazine

Inflection points can be powerful events. They can prompt an individual to take on a new career challenge. And on occasion, that individual’s decision can redound to the benefit of thousands of others. Such may be the case for Marcella McCoy-Deh, PhD, associate professor of American Studies and director of the Philadelphia University Honors Institute.

A Journey Of Adaptation

Thomas Jefferson University Research Magazine

Consider Haloferax volcanii, a single celled organism that thrives in extreme conditions such as the very salty Dead Sea. Scientists study it for clues about potential life on Mars and about how organisms may adapt to Earth’s changing climate. Much like the organism she studies, H. volcanii researcher Manuela Tripepi, PhD, is an expert at adapting to challenging situations.

Covid Briefs

Thomas Jefferson University Research Magazine

• Intellectual Disability a High Risk for COVID-19 Death
• Design Solutions for COVID-19 Problems
• The Secret Sauce in COVID-19 Vaccines
• At Home with Dementia during the Pandemic
• Predicting the Severe Cases of COVID-19

Enveloping Buildings In Textiles

Thomas Jefferson University Research Magazine

There are myriad elements that determine how well a building functions. One of the most important and complex is the design and composition of its envelope. Similar to the human skin, the building envelope is the boundary between interior and exterior, and it has multiple functions: protecting the indoor environment, facilitating climate control and reducing the building’s energy consumption.

Learning From Drowsy Flies

Thomas Jefferson University Research Magazine

Who knew that fruit flies slept—or that humans might benefit from studying their sleep? Kyunghee Koh, PhD, does. The associate professor of Neuroscience uses fruit flies (Drosophila melanogaster) to identify the cellular and molecular mechanisms underpinning sleep. Two of her lab’s recent studies offer results that are both interesting and potentially far-reaching

Cancer Prediction Model Misses High-Risk Black Patients

Thomas Jefferson University Research Magazine

Black men are more likely to die from lung cancer than persons of any other racial or ethnic group. A new study suggests that better detection could reduce that disparity.

Antitrust Laws Don't Hinder Foreign Investment

Thomas Jefferson University Research Magazine

Using data on the period from 1970 to 2019 from the World Bank’s World Development Indicators, this study considered the question of whether anti-trust laws encourage or diminish foreign investment in developing and transition countries

Bursts Of Power

Thomas Jefferson University Research Magazine

Mitochondria fire oxidants to communicate with organelles nearby, a communication that could be important in various diseases.

Reaching Across The Globe And To The Stars

Thomas Jefferson University Research Magazine

From maternal health to science in space, Jefferson’s global initiatives are attacking pressing problems through connected learning and investigation.

Research blooms in an interconnected world. Research that is open to the rich knowledge, experience and culture of collaborators across the globe is stronger for it. Thomas Jefferson University is building international partnerships to tackle health disparities and innovations in medicine, and to broaden access and opportunities that have lasting impact. Read about Jefferson’s global footprint.

Evaluating The Relationship Between Short- And Long-Term Neural Adaptations To Motor Skill Acquisition And Retention, Federico Iacoangeli

Journal for Sports Neuroscience

Attempting to understand the neurophysiological underpinnings of learned behaviors and the process of learning itself has yielded interesting findings relating to what happens in the brain and across the nervous system when learning a new skill. The nervous system displays several structural, functional and neurochemical adaptations to motor learning which have been highlighted through the use of neuroimaging techniques such as fMRI, EEG and TMS. This review attempts to outline the neural adaptations governing the acquisition and retention of motor skills, as well as build a timeline for these adaptations following Fitt’s model of motor learning (Fitts and Posner 1967). …

Trait Anxiety In Mixed Martial Artists, Julian Pino, Olivier Van Hauwermeiren, Jordan Kwamanakweenda, Corey Peacock, Jaime Tartar

Journal for Sports Neuroscience

ABSTRACT

Mixed Martial Arts (MMA) is a hybrid combat sport incorporating techniques from boxing, wrestling, Judo, Jiu-Jitsu, Karate, Muay Thai (Thai boxing), and other disciplines. Having only been deemed a competitive sport in 1993 by the Ultimate Fighting Championship (UFC), not a lot of research has been done on these athletes. Research done so far on other areas of athletics has shown that personality traits can predict various cognitive, affective, and behavioral outcomes. Furthermore, elevated levels of Trait Anxiety have been shown to deteriorate non-MMA athletes’ overall performance in high-pressure situations. The present study aimed to investigate the presence of …

2022-07-18 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Implementing Recova® To Adjust Estimated Dry Weight In An Outpatient Hemodialysis Clinic, Ayomide Aruwajoye

Dissertations

Problem: The purpose of this project is to implement the Recova® tool to adjust estimated dry weight supporting interdisciplinary team management of fluid overload in dialysis patients. Fluid overload can lead to high rates of morbidity and mortality. A total sample of 26 hemodialysis patients in an outpatient clinic located in a metropolitan city in a midwestern state was included in the project. Data collected shows there was poor knowledge familiarity with how fluid should be managed in patients suffering from chronic kidney disease. The nurses utilized the Recova tool for a period of 8 weeks to help aid in …

Congregational Leaders And Covid-19: Human Flourishing And Future Directions For Research, Isaac Voss

Essays

No abstract provided.

A Resident Retreat With Emergency Medicine Specific Mindfulness Training Significantly Reduces Burnout And Perceived Stress, James O'Shea, Mark Dannenfelser, Melissa White, Anwar Osborne, Timothy P. Moran, Michelle D. Lall

Journal of Wellness

Introduction: We hypothesize that a resident retreat with mindfulness training tailored for Emergency Medicine (EM) physicians can significantly reduce levels of burnout and perceived stress in EM residents.

Methods: We conducted an intervention study of 60 EM residents undergoing an annual resident retreat with a 2.5-hour mindfulness training. The retreat was a department-funded 2-day off-site experience with a wellness theme. The training was developed and delivered by an EM physician (JO'S) who is a Mindfulness-Based Stress Reduction (MBSR) teacher trainee, and a certified MBSR teacher (MD). The training focused on techniques that can be used on shift, such as mindful …

On Job Resiliency Training, Tailored For Hospital Nurses: A Feasibility Study, Zach Gerber, Sigal Shafran-Tikva, David Anaki

Journal of Wellness

Introduction: Burnout is a primary threat to professional wellness and performance. It reflects work-related emotional stress and is commonly manifested among professional caregivers. This study explores whether self-compassion training can alleviate hospital nurses' work-related emotional stress and burnout.

Methods: In the present study, we conducted a weekly, 7-session, self-compassion training program among 15 hospital nurses, primarily working in critical care units, between January 22, 2020, and March 4, 2020. A group of nine other nurses, comprising a waiting list for the following training workshop, served as a control group. Beyond feasibility assessment, we also measured outcome effects according to previous …

In-Silico Analysis Of Interacting Pathways Through Kim-1 Protein Interaction In Diabetic Nephropathy, Fatima Abid, Z Rubab, Syeda Sadia Fatima, A Qureshi, Arfa Azhar, A Jafri

Department of Biological & Biomedical Sciences

Background: Human Kidney Injury Molecule-1, also known as HAVCR-1 (Hepatitis A virus cellular receptor 1), belongs to the cell-surface protein of immunoglobulin superfamily involved in the phagocytosis by acting as scavenger receptor epithelial cells. The study focused on pinpointing the mechanisms and genes that interact with KIM-1.
Methods: This in-silico study was done from March 2019 to December 2019. The Enrichment and protein-protein interaction (PPI) network carefully choose proteins. In addition, the diagramed gene data sets were accomplished using FunRich version 3.1.3. It was done to unveil the proteins that may affect the regulation of HAVCR1 or may be regulated …

The Impact Of Covid-19 On The Psychological Well-Being Of Surgeons In Pakistan: A Multicenter Cross-Sectional Study, Sana Zeeshan, Mehdia Rajab Ali, Rehan N. Khan, Asad R. Allana, Nida Zahid, Muhammad Kazim Najjad, Arslan A. Abro, Muhammad Ali Nadeem, Zeeshan Mughal, Irshad Ahmed

Section of General Surgery

Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic left a profound and pervasive impact on the healthcare infrastructure on a global scale. Since its onset, the pattern of reported cases and its associated mortality had shown variability with intermittent peaks causing a significant effect on the psychological well-being of the surgeons of Pakistan. The aim of this study was to assess the effects of the COVID-19 pandemic on the mental well-being of surgeons in Pakistan. Methods This multicenter cross-sectional study was carried out to assess the impact of COVID-19 on the psychological well-being of surgeons in Pakistan. The …

Structural Basis For The Simultaneous Recognition Of Nemo And Acceptor Ubiquitin By The Hoip Nzf1 Domain, Simin Rahighi, Mamta Iyer, Hamid Oveisi, Sammy Nasser, Vincent Duong

Pharmacy Faculty Articles and Research

Ubiquitination of NEMO by the linear ubiquitin chain assembly complex (LUBAC) is essential for activating the canonical NF-κB signaling pathway. While the NZF1 domain of the HOIP subunit of LUBAC recognizes the NEMO substrate, it is unclear how it cooperates with the catalytic domains in the ubiquitination process. Here, we report a crystal structure of NEMO in complex with HOIP NZF1 and linear diubiquitin chains, in which the two proteins bind to distinct sites on NEMO. Moreover, the NZF1 domain simultaneously interacts with NEMO and Ile44 surface of a proximal ubiquitin from a linear diubiquitin chain, where the C-term tail …

Editorial: Glia-Mediated Neurotoxicity: Uncovering The Molecular Mechanisms, Amit K Srivastava, Barbara Lukomska, Lorraine Iacovitti

Farber Institute for Neuroscience Faculty Papers

No abstract provided.

Assessment Of Vitamin D Among Male Adolescents And Young Adults Hospitalized With Eating Disorders, Jason M. Nagata, Anna Grandis, Paola Bojorquez-Ramirez, Anthony Nguyen, Amanda E. Downey, Kyle T. Ganson, Khushi P. Patel, Vanessa I. Machen, Sara M. Buckelew, Andrea K. Garber

Publications

PURPOSE: Medical complications of eating disorders in males are understudied compared to females, as is the case of vitamin D deficiency. The aim of this study was to assess vitamin D levels among male and female adolescents and young adults hospitalized for medical complications of eating disorders. METHODS: We retrospectively reviewed electronic medical records of patients aged 9-25 years (N = 565) admitted to the University of California, San Francisco Eating Disorders Program for medical instability, between May 2012 and August 2020. Serum vitamin D (25-hydroxy) level was assessed at admission as was history of prior calcium, vitamin D, or …

Virtual Behavioral Health Treatment Satisfaction And Outcomes Across Time, Mindy R. Waite, Sara Diab, James Adefisoye

Journal of Patient-Centered Research and Reviews

Purpose: The COVID-19 pandemic continues to have major and long-lasting impacts on health care delivery and mental health. As health care shifted to telehealth, legislation was adjusted to expand telehealth allowances, creating a unique opportunity to elucidate outcomes. The aim of this study was to assess long-term patient and clinician satisfaction and outcomes with virtual behavioral health.

Methods: Data were obtained over 16 months from surveys to patients and clinicians receiving/providing virtual treatment. Outcomes data also were collected from medical records of adults receiving in-person and virtual behavioral health treatment. Data were summarized using descriptive statistics. Groups were compared using …