Medicine and Health Sciences Commons^™

Factors Related To Father’S Behavior In Preventing Childhood Stunting Based On Health Belief Model, Eka Mishbahatul Mar'ah Has, Candra Panji Asmoro, Wilhelmus Petrus Gua

Jurnal Keperawatan Indonesia

Childhood stunting is still a significant public health burden in Indonesia. Fathers' engagement in childcare could improve a child's health and help to prevent stunting. This study aimed to analyse factors related to the father's behaviour in preventing childhood stunting based on Health Belief Model. This study was used a correlational study design with a cross-sectional approach. This study involved 199 fathers who had children under five years old, recorded at Puskesmas (Public Health Center) Maronggela, East Nusa Tenggara, Indonesia. Samples were taken using the cluster random sampling technique. The independent variables were the father's perceived susceptibility, perceived severity, perceived …

Does Acute Pancreatitis Herald Pancreatic Ductal Adenocarcinoma? A Multicenter Electronic Health Research Network Study., Ritu R. Singh, Alison P Klein, Neil Sharma Md, Eileen M O'Reilly

PCI Publications and Projects

BACKGROUND AND OBJECTIVES: High mortality in pancreas ductal adenocarcinoma (PDAC) is related to delayed diagnosis and lack of cost-effective early detection strategies. Retrospective studies have demonstrated an association between PDAC and acute pancreatitis (AP). Herein, we explore the incidence of PDAC in patients with non-biliary and non-alcoholic AP.

METHODS: A population-based, retrospective cohort study was conducted utilizing TriNetX (Cambridge, MA). Patients ≥40 years with AP (ICD-10-CM code: K85) and without biliary AP (K85.1), alcohol-induced AP (K85.2) or chronic pancreatitis (K86.0, K86.1), were identified. The primary outcome was incidence of PDAC (C25) in patients at defined intervals following AP. We compared …

Mental Health Problems Among Adolescent Students, Windu Astutuk, Ni Luh Made Asri Dewi

Jurnal Keperawatan Indonesia

Concern for adolescents usually focuses on physical problems, such as reproductive health and nutrition, including anemia and obesity. Nowadays, adolescent mental health has been recognized as essential, particularly in low- and middle-income countries. Mental health problems that often occur in adolescents include anxiety, depression, and the risk of suicide. This study aimed to determine the prevalence of mental health problems and the risk of suicide among adolescent students in Bali Province, Indonesia. The sample consisted of 435 students from four junior high schools (Grades 7, 8, and 9) aged 12–15 years who were selected with a multistage sampling technique. This …

Determinants Of Nurses’ Safety Attitudes In A Hospital Setting, Frima Ulfa Agustina, Hanny Handiyani, Tuti Afriani

Jurnal Keperawatan Indonesia

Hospital patient safety socialization is a routine part of nursing care. Although nurses’ knowledge of patient safety affects nurses’ safety attitudes, such knowledge may not be optimal. This study explored potential factors determining nurses’ safety attitudes in a hospital setting. This was a quantitative study with a cross-sectional design. The study population comprised 376 nurses who were recruited using the purposive sampling method. The instruments were valid and reliable. The test results were as follows: job satisfaction: 0.356 – 0.575 (Cronbach’s alpha: 0.724); workload: 0.338 – 0.613 (Cronbach alpha: 0.736), job stress: 0.542 – 0.719 (Cronbach’s alpha: 0.756); head nurse’s …

Are Residents In Urban Areas Of Nigeria Exposed To Health-Impacting Levels Of Noise Pollution?, Obinna C.D. Anejionu, Elijah S. Ebinne, Kelechi I. Nwosu, Miriam G. U. Anejinou, Raphael I. Ndukwu

Journal of Environmental Science and Sustainable Development

Across the world urban dwellers are facing increasing risks of exposure to noise pollution. The World Health Organization (WHO) described noise pollution as an underestimated threat that can cause various health problems to humans and wildlife. In Nigeria, urban areas are experiencing increasing levels of noise pollution. In this study, a combination of low-cost noise sensors and GIS modelling were used to conduct a preliminary investigation of the spatiotemporal patterns of noise pollution in a prominent urban area in Nigeria. This was to ascertain whether residents are exposed to dangerous noise levels that could affect their health as well as …

Ligand-Based Design, Synthesis, Computational Insights, And In Vitro Studies Of Novel N-(5-Nitrothiazol-2-Yl)-Carboxamido Derivatives As Potent Inhibitors Of Sars-Cov-2 Main Protease, Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M Abo Shama, Eman Y Santali, Bahaa Elgendy, Ahmed A Al-Karmalawy

2020-Current year OA Pubs

The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt development of new effective therapeutic interventions for the battle against SARS-CoV-2. A new series of

3d Media Stabilizes Membrane And Prolongs Lifespan Of Defolliculated Xenopus Laevis Oocytes, Nikhil D Aggarwal, Steven L Zeng, Ryan J Lashgari, Leland C Sudlow, Mikhail Y Berezin

2020-Current year OA Pubs

No abstract provided.

Examining P3 And N2 Amplitudes Following Social Exclusion And Provocation In College Students With High And Low Narcissistic Traits, Kathleen Ramsey

Dissertations

Adults with narcissistic traits are prone to reacting aggressively following provocation due to elevations in emotional reactivity and perceived threat to their grandiose self-views. Prior studies have examined event-related potentials (ERPs) measures in college students with narcissistic traits in the context of risky decision making and facial emotion processing; however, no known studies have examined how those with narcissistic traits react to rejection and provocation at the neurophysiological level during an externally valid social rejection task (i.e., Cyberball). For the purposes of this study, it was predicted that participants with higher levels of narcissistic traits (both total narcissism and grandiose …

Perception Of Covid-19 And Reproductive Health Of Female And Male Adolescents In Urban Areas In The Sustainable Development Goals, Terry Y. R. Pristya, Chahya Kharin Herbawani, Ulya Qoulan Karima, Arnur Oktafiyanti, Nadia Ramadhanty, Asto Ginawang

Journal of Environmental Science and Sustainable Development

Sustainable Development Goals (SDGs) in goal 3 (good health and well-being) and goal 4 (equality in education) for all specifically targeted at vulnerable groups. Adolescents were a part of it. A decade of progress in reproductive health could be stalled by covid-19. The study aimed to analyze reproductive health and adolescents’ perceptions during the covid-19 pandemic era in urban areas. This descriptive study used an online survey conducted in Jakarta. The sample consisted of 438 adolescents selected by convenience sampling technique. The results were that both female and male adolescents had poor knowledge about HIV/AIDS transmission (female = 77.0%; male …

Evaluation Of An Australian Neurological Nurse-Led Model Of Postdischarge Care, Judith Dianne Pugh, Kathleen Mccoy, Merrilee Needham, Leanne Jiang, Margaret Giles, Elizabeth Mckinnon, Kym Heine

Research outputs 2014 to 2021

Neurological disorders are a leading cause of disease burden worldwide, placing a heavy demand on health systems. This study evaluated the impacts and cost savings of a community-based nursing service providing supported discharge for neurological patients deemed high-risk for unplanned emergency department presentations and/or hospital readmissions. It focused on adult patients with stroke, epilepsy, migraine/headache or functional neurological disorders discharged from a Western Australian tertiary hospital. An observational design was used comprising prospective enrolment of patients receiving nurse-led supported discharge and follow-up (Neurocare), 21 August 2018 to 6 December 2019 (N = 81), and hospital administrative data, 1 February …

Depression, Gerardo Serrano

Nursing Student Class Projects (Formerly MSN)

Depression is a common illness worldwide, with an estimated 3.8% of he population affected, including 5.0% among adults and 5.7% among adults older than 60 years (Schomerus et at., 019). Approximately 280 million people in the world have depression (Schomerus et at., 2019). Depression is different from usual mood fluctuations nd short-lived emotional responses to challenges in everyday life. Especially hen recurrent and with moderate or severe intensity, depression may become serious health condition. It can cause he affected person to suffer greatly and unction poorly at work, at school and in he family. At its worst, depression can lead …

Enhancing Physician Perspectives Of Skilled Occupational Therapy Services For Patients With Rheumatoid Arthritis, Valerie S. Trinidad

Department of Occupational Therapy Entry-Level Capstone Projects

This Capstone Project, with a focus in research, sought to identify a relationship between self-reported functional performance and participation restriction as described by satisfaction with one’s execution or participation in a described occupation. A correlational study design was employed under the mentorship of Dr. Thomas Decker, EdD, OTD, OTR/L who oversaw all IRB processes, documentation, study development and deployment, as well as co-authored and provided mentorship for creation of a publishable manuscript of this project. The established Health Assessment Questionnaire Disability Index (HAQ-DI) and the newer Keele Assessment of Participation (KAP) were the two outcome measures of focus for surveying …

Non-Nutritive Suck Burst Pattern Stability In Extremely Premature Infants, Alejandra Marquez

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The development of non-nutritive suck (NNS) burst dynamics in preterm infants reflects the integrity of the brain and is used clinically to assess feeding readiness and orofacial motor development (Mizuno and Ueda, 2005). The application of NNS analytics in the present report represents one outcome measurement set that is part of an ongoing clinical trial involving extremely preterm infants (EPI’s,[GA]) randomized to receive either pulsed orocutaneous stimulation therapeutics or a sham (blind pacifier), in conjunction with salivary sampling twice weekly to map gene expression of key proteins involved in neural development and molecular sensing of feeding related pathways in the …

Confirming Multiplex Rt-Qpcr Use In Covid-19 With Next-Generation Sequencing: Strategies For Epidemiological Advantage, Rob E. Carpenter, Vaibhav Tamrakar, Harendra Chahar, Tyler Vine, Rahul Sharma

Human Resource Development Faculty Publications and Presentations

Rapid identification and tracking of emerging SARS-CoV-2 variants are critical for understanding the transmission dynamics and developing strategies for interrupting the transmission chain. Next-Generation Sequencing (NGS) is an exceptional tool for whole-genome analysis and deciphering new mutations. The technique has been instrumental in identifying the variants of concern (VOC) and tracking this pandemic. However, NGS is complex and expensive for large-scale adoption, and epidemiological monitoring with NGS alone could be unattainable in limited-resource settings. In this study, we explored the application of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) based detection of the variant identified by NGS. We analyzed a total …

Alterations In Executive Functioning Following Moderate Prenatal Alcohol Exposure: New Translational Insights, Sarah L. Olguin

Biomedical Sciences ETDs

While the lifelong difficulties that result from alcohol exposure in utero are well documented, Fetal Alcohol Spectrum Disorders (FASD) remain the most common neurodevelopmental syndrome. FASD patients struggle with executive control including attention, cognitive control, reward learning, and impulsivity. These self-regulation problems contribute to increased rates of school expulsion, incarceration, and substance use disorders. However, it is still unclear how prenatal alcohol exposure (PAE) affects executive control processes that lead to inappropriate behavior later in life. Here we examined the effect of PAE on 4 aspects of executive functioning paired with intervention or with translatable EEG-like recording, 1) control over …

Association Between Vitamin D Supplementation And Cancer Mortality: A Systematic Review And Meta-Analysis, Renjie Zhang, Yu Zhang, Zheran Liu, Yiyan Pei, Ping Xu, Weelic Chong, Yang Hai, Ling He, Yan He, Jiayi Yu, Jingjing Wang, Fang Fang, Xingchen Peng

Department of Medical Oncology Faculty Papers

Background: Vitamin D deficiency is related to increased cancer risk and deaths. However, whether vitamin D supplementation reduces cancer mortality remains unclear, and several randomized controlled trials yield inconsistent results.

Methods: Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from their inception until 28 June 2022, for randomized controlled trials investigating vitamin D supplementation. Pooled relative risks (RRs) and their 95% confidence intervals (CIs) were estimated. Trials with vitamin D supplementation combined with calcium supplementation versus placebo alone and recruiting participants with cancer at baseline were excluded in the present study.

Results: This study included 12 …

Assessment Of The Impact Of A Meningitis/Encephalitis Panel On Hospital Length Of Stay: A Systematic Review And Meta-Analysis, Kyle D Hueth, Philippe Thompson-Leduc, Todor I Totev, Katherine Milbers, Tristan T Timbrook, Noam Kirson, Rodrigo Hasbun

Faculty, Staff and Student Publications

Meningitis and encephalitis are central nervous system infections with considerable morbidity and mortality. The BioFire® FilmArray® Meningitis/Encephalitis Panel (multiplex ME panel) can identify pathogens rapidly potentially aiding in targeted therapy and curtail antimicrobial exposure. This systematic review and meta-analysis synthesized the literature on the association between the multiplex ME panel and length of hospital stay (LOS), length of acyclovir therapy, and days with antibiotics. MEDLINE and EMBASE were searched. Only studies presenting novel data were retained. Random-effects meta-analyses were performed to assess the impact of the multiplex ME panel on outcomes. Of 169 retrieved publications, 13 met the criteria for …

Advances In Management And Therapeutics Of Cutaneous Basal Cell Carcinoma, Olivia M Chen, Keemberly Kim, Chelsea Steele, Kelly M Wilmas, Nader Aboul-Fettouh, Carrick Burns, Hung Quoc Doan, Sirunya Silapunt, Michael R Migden

Faculty, Staff and Student Publications

Basal cell carcinoma (BCC), the most common cancer in humans, is a malignant neoplasm of cells derived from the basal layer of the epidermis. Tumor characteristics such as histologic subtype, primary versus recurrent tumor, anatomic location, size, and patient attributes determine the risk level and acceptable treatment options. Surgical options offer histologic confirmation of tumor clearance. Standard excision provides post-treatment histologic assessment, while Mohs micrographic surgery (MMS) provides complete margin assessment intraoperatively. Additional treatment options may be employed in the correct clinical context. Small and low-risk BCCs, broad field cancerization, locally-advanced disease, metastatic disease, cosmetic concerns, or morbidity with surgical …

Non-Targeted Metabolomics Of Cooked Cowpea (Vigna Unguiculata) And Pigeon Pea (Cajanus Cajan) From Ghana Using Two Distinct And Complementary Analytical Platforms, Brooke Sayre-Chavez, Bridget Baxter, Corey D Broeckling, María Muñoz-Amatriaín, Mark Manary, Elizabeth P Ryan

2020-Current year OA Pubs

Legumes are global staple foods with multiple human health properties that merit detailed composition analysis in cooked forms. This study analyzed cowpea [

Mirna Expression Is Increased In Serum From Patients With Semantic Variant Primary Progressive Aphasia, Maria Serpente, Laura Ghezzi, Chiara Fenoglio, Francesca R Buccellato, Giorgio G Fumagalli, Emanuela Rotondo, Marina Arcaro, Andrea Arighi, Daniela Galimberti

2020-Current year OA Pubs

Primary progressive aphasia (PPA) damages the parts of the brain that control speech and language. There are three clinical PPA variants: nonfluent/agrammatic (nfvPPA), logopenic (lvPPA) and semantic (svPPA). The pathophysiology underlying PPA variants is not fully understood, including the role of micro (mi)RNAs which were previously shown to play a role in several neurodegenerative diseases. Using a two-step analysis (array and validation through real-time PCR), we investigated the miRNA expression pattern in serum from 54 PPA patients and 18 controls. In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 …

Maladaptive Positive Feedback Production Of Chrebpβ Underlies Glucotoxic Β-Cell Failure, Liora S Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A Stanley, Dirk Homann, Andrew F Stewart, James C Lo, Mark A Herman, Adolfo Garcia-Ocaña, Donald K Scott

Faculty, Staff and Students Publications

Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show that the hyperactive isoform of carbohydrate response-element binding protein (ChREBPβ) is a nuclear effector of hyperglycemic stress occurring in β-cells in response to prolonged glucose exposure, high-fat diet, and diabetes. We show that transient positive feedback induction of ChREBPβ is necessary for adaptive β-cell expansion in response to metabolic challenges. Conversely, chronic excessive β-cell-specific overexpression of ChREBPβ results in loss of β-cell identity, apoptosis, loss of β-cell mass, and diabetes. Furthermore, β-cell "glucolipotoxicity" can be prevented by deletion of ChREBPβ. Moreover, ChREBPβ-mediated cell death is …

Genomic And Functional Characterization Of Vancomycin-Resistant Enterococci-Specific Bacteriophages In The Galleria Mellonella Wax Moth Larvae Model, Lynn El Haddad, Georgios Angelidakis, Justin R Clark, Jesus F Mendoza, Austen L Terwilliger, Christopher P Chaftari, Mark Duna, Serena T Yusuf, Cynthia P Harb, Mark Stibich, Anthony Maresso, Roy F Chemaly

Faculty, Staff and Students Publications

Phages are naturally occurring viruses that selectively kill bacterial species without disturbing the individual’s normal flora, averting the collateral damage of antimicrobial usage. The safety and the effectiveness of phages have been mainly confirmed in the food industry as well as in animal models. In this study, we report on the successful isolation of phages specific to Vancomycin-resistant Enterococci, including Enterococcus faecium (VREfm) and Enterococcus faecalis from sewage samples, and demonstrate their efficacy and safety for VREfm infection in the greater wax moth Galleria mellonella model. No virulence-associated genes, antibiotic resistance genes or integrases were detected in …

Computerized Cognitive Behavioral Therapy For Patients With Post-Treatment Lyme Disease Syndrome, Katherine Fry

Yale School of Medicine Physician Associate Program Theses

Lyme disease is the most common vector-borne illness in North America. Post-treatment Lyme disease syndrome is defined as a subset of patients appropriately treated for Lyme disease who continue to experience generalized symptoms, such as depression. However, treatment options for depressive symptoms in post-treatment Lyme disease syndrome largely remain unknown. The objective of this study is to examine whether computerized cognitive behavioral therapy, an internet-delivered form of traditional cognitive behavioral therapy, can reduce depressive symptoms in patients with post-treatment Lyme disease syndrome. Here, we conduct a parallel randomized controlled trial to evaluate whether computerized cognitive behavioral therapy can reduce depressive …

Chronic Obstructive Pulmonary Disease Pathophysiology, Alex Thompson

Nursing Student Class Projects (Formerly MSN)

This poster presentation overviews the pathophysiologic process and accompanying disease characteristics associated with Chronic Obstructive Pulmonary Disease (COPD). COPD is a leading cause of mortality worldwide. Studies suggest that its incidence will only increase in the future. COPD risk factors include smoking tobacco, environmental chemical/pollution irritants, and genetic predisposition. Smoking is the most common cause of COPD, and cessation can improve patient outcomes drastically. This chronic obstructive pulmonary disease overview discusses the importance of knowledge of COPD, signs, symptoms, pathophysiology, peri-operative management, treatments, and prevention.

Acute Kidney Injury, Chelsey Benner

Nursing Student Class Projects (Formerly MSN)

Acute kidney injury (AKI) is a common complication of surgical procedures and can lead to increased morbidity and mortality. AKI can be described by a sudden decline in kidney function, evidenced by elevation of serum creatinine, elevated blood urea nitrogen levels, and a decreased glomerular filtration rate (McCance & Huether, 2018, p. 1360). Optimal perioperative management and recognition of patients at high risk for AKI is important in preventing the development of acute kidney injury.

Myasthenia Gravis, Rebecca Wheeler

Nursing Student Class Projects (Formerly MSN)

Myasthenia gravis (MG), a neuromuscular and autoimmune disorder, is not completely understood by clinicians and scientists. The primary cause is thought to be anti-Acetylcholine receptor antibodies that attack the neuromuscular junction, causing destruction of post-synaptic junctional folds and blockade of the receptor. This causes frequent weakness and fatigability of voluntary muscles, making activities of daily living difficult for those living with MG. Although it is not an incredibly prevalent disease, the incidence is increasing in the United States due to better testing and diagnosis. Treatments are available, including cholinesterase inhibitors that raise the concentration of Acetylcholine at the neuromuscular junction …

Anesthetic Considerations For Patients With Aortic Stenosis, Owen Diehl

Nursing Student Class Projects (Formerly MSN)

Aortic Stenosis places surgical patients at greater risk for adverse events during surgery. Due to the pathological process of Aortic Stenosis, the left ventricle must generate high systolic pressures to ensure adequate cardiac output. These increased pressures result in left ventricular hypertrophy, placing the patient at greater risk for myocardial ischemia. For induction of anesthesia, it is imperative to maintain hemodynamic stability as this is where problems arise. Five research articles were reviewed to determine how to administer anesthesia to these patients safely. Additional sources were gathered for a background on the pathophysiology of aortic stenosis. The research articles reviewed …

2022-07-29 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Sex Differences In The Genetic Architecture Of Cognitive Resilience To Alzheimer's Disease., Jaclyn M Eissman, Logan Dumitrescu, Emily R Mahoney, Alexandra N Smith, Shubhabrata Mukherjee, Michael L Lee, Phoebe Scollard, Seo Eun Choi, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine C Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel F Buckley, Michael J Properzi, Elizabeth C Mormino, Hyun Sik Yang, Theresa M Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Douglas Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Xiaoyuan Zhong, Neha S Raghavan, Badri N Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li San Wang, Carlos Cruchaga, Gerard D Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, Michael L Cuccaro, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, Timothy J Hohman

Faculty Research 2022

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease neuropathology may uncover novel therapeutic targets to treat Alzheimer's disease. It is well established that there are sex differences in response to Alzheimer's disease pathology, and growing evidence suggests that genetic factors may contribute to these differences. Taken together, we sought to elucidate sex-specific genetic drivers of resilience. We extended our recent large scale genomic analysis of resilience in which we harmonized cognitive data across four cohorts …

Qtlviewer: An Interactive Webtool For Genetic Analysis In The Collaborative Cross And Diversity Outbred Mouse Populations, Matthew J Vincent, Isabela Gerdes Gyuricza, Gregory R Keele, Daniel Mario Gatti, Mark P. Keller, Karl W. Broman, Gary Churchill

Faculty Research 2022

The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50¬†M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross …