Medicine and Health Sciences Commons^™

Love And Fear: A Special Issue, C Sue Carter, Robert Dantzer

Faculty, Staff and Student Publications

Love and fear were forged by the same fundamental evolutionary processes that permitted life on Earth. Both love and fear are deeply interwoven with the adaptive management of stress and disease. Love and fear share common roots and both can play a role in reproduction, survival, perceived safety and wellbeing. This special issue of Comprehensive Psychoneuroendocrinology focuses specifically on the causes and consequences of love from the interactive perspectives of evolution, neurobiology and culture.

Clinical Activity Of Mitogen-Activated Protein Kinase-Targeted Therapies In Patients With Non-V600 Braf-Mutant Tumors, Matthew Dankner, Yifan Wang, Rouhi Fazelzad, Benny Johnson, Caroline A Nebhan, Ibiayi Dagogo-Jack, Nathaniel J Myall, Georg Richtig, Jillian W P Bracht, Marco Gerlinger, Eiji Shinozaki, Takayuki Yoshino, Daisuke Kotani, Jason R Fangusaro, Oliver Gautschi, Julien Mazieres, Jeffrey A Sosman, Scott Kopetz, Vivek Subbiah, Michael A Davies, Anna L Groover, Ryan J Sullivan, Keith T Flaherty, Douglas B Johnson, Andrea Benedetti, David W Cescon, Anna Spreafico, George Zogopoulos, April A N Rose

Faculty, Staff and Student Publications

Purpose: Non-V600 mutations comprise approximately 35% of all BRAF mutations in cancer. Many of these mutations have been identified as oncogenic drivers and can be classified into three classes according to molecular characteristics. Consensus treatment strategies for class 2 and 3 BRAF mutations have not yet been established.

Methods: We performed a systematic review and meta-analysis with published reports of individual patients with cancer harboring class 2 or 3 BRAF mutations from 2010 to 2021, to assess treatment outcomes with US Food and Drug Administration-approved mitogen-activated protein kinase (MAPK) pathway targeted therapy (MAPK TT) according to BRAF class, cancer type, …

Selinexor In Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial, Mrinal M Gounder, Albiruni Abdul Razak, Neeta Somaiah, Sant Chawla, Javier Martin-Broto, Giovanni Grignani, Scott M Schuetze, Bruno Vincenzi, Andrew J Wagner, Bartosz Chmielowski, Robin L Jones, Richard F Riedel, Silvia Stacchiotti, Elizabeth T Loggers, Kristen N Ganjoo, Axel Le Cesne, Antoine Italiano, Xavier Garcia Del Muro, Melissa Burgess, Sophie Piperno-Neumann, Christopher Ryan, Mary F Mulcahy, Charles Forscher, Nicolas Penel, Scott Okuno, Anthony Elias, Lee Hartner, Tony Philip, Thierry Alcindor, Bernd Kasper, Peter Reichardt, Lore Lapeire, Jean-Yves Blay, Christine Chevreau, Claudia Maria Valverde Morales, Gary K Schwartz, James L Chen, Hari Deshpande, Elizabeth J Davis, Garth Nicholas, Stefan Gröschel, Helen Hatcher, Florence Duffaud, Antonio Casado Herráez, Roberto Diaz Beveridge, Giuseppe Badalamenti, Mikael Eriksson, Christian Meyer, Margaret Von Mehren, Brian A Van Tine, Katharina Götze, Filomena Mazzeo, Alexander Yakobson, Aviad Zick, Alexander Lee, Anna Estival Gonzalez, Andrea Napolitano, Mark A Dickson, Dayana Michel, Changting Meng, Lingling Li, Jianjun Liu, Osnat Ben-Shahar, Dane R Van Domelen, Christopher J Walker, Hua Chang, Yosef Landesman, Jatin J Shah, Sharon Shacham, Michael G Kauffman, Steven Attia

Faculty, Staff and Student Publications

Purpose: Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.

Methods: SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of …

Probing The Structure And Function Of Polymerase Θ Helicase-Like Domain, Scott Vanson, Yuzhen Li, Richard D Wood, Sylvie Doublié

Faculty, Staff and Student Publications

DNA Polymerase θ is the key actuator of the recently identified double-strand break repair pathway, theta-mediated end joining (TMEJ). It is the only known polymerase to have a 3-domain architecture containing an independently functional family A DNA polymerase tethered by a long central region to an N-terminal helicase-like domain (HLD). Full-length polymerase θ and the isolated HLD hydrolyze ATP in the presence of DNA, but no processive DNA duplex unwinding has been observed. Based on sequence and structure conservation, the HLD is classified as a member of helicase superfamily II and, more specifically, the Ski2-like family. The specific subdomain composition …

Chronic Poetics: A Waiting Room Of One's Own, Madeleine Simmons

Electronic Theses, Projects, and Dissertations

This article explores chronic poetics, through my personal lens I take readers on a walk- through of poetry and the discussions surrounding chronic illnesses. I examine the current state of chronic illness and the nuances to its discussion. I analyze chronic illness in the context of disability studies, and touch on the tensions of categorizing chronic illness as a disability. As well as how to best navigate reading chronic poetics, as poets engage in new territories as they form a new language to describe their circumstances. While analyzing multiple poems from different authors, I explore why specifically the vessel of …

Sar Study Of Niclosamide Derivatives In The Human Glioblastoma U-87 Mg Cells, Shizue Mito, Benxu Cheng, Benjamin A. Garcia, Daniela Gonzalez, Xin Yee Ooi, Tess C. Ruiz, Francisco Xavier Elisarraras, Andrew Tsin, Sue Anne Chew, Marco A. Arriaga

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Glioblastoma is a lethal malignant brain tumor, and the development of efficient chemotherapeutic agents remains an urgent need. Niclosamide, an anthelmintic drug, which has been used to treat tapeworm infections more than 50 years, has recently attracted renewed attention due to its evident anticancer activities. It has been shown that niclosamide induces cytotoxicity in human glioblastoma U-87 MG cells corresponding with increased protein ubiquitination, ER stress, and autophagy. Furthermore, niclosamide showed down regulation of multiple pro-survival signaling pathways including Wnt/β-catenin, PI3K/AKT, MAPK/ERK, and STAT3, which further caused reduction of U87-MG cell viability. However, the molecular mechanisms of niclosimide and its …

Lgbtq+ And Dental Education: Analyzing The Present And Recommendations For The Future, Diana V. Macri, Colin Haley Dds, Herminio Perez Dmd, Scott Schwartz Dds

Publications and Research

LGBTQ+ populations constitute increasing proportions of children, adolescents, and adults in the United States. Compared to their heterosexual counterparts, this group suffers from health inequities, including oral health. The report “Oral Health: Advances and Challenges” identified the LGBTQ+ community as an underserved population which faces significant barriers in accessing oral health care. Coverage of LGBTQ+ topics in formal education settings in both dental schools and dental hygiene programs is scarce, which contributes to inequities within this group. Increasing curriculum content related to LGBTQ+ populations is of utmost importance to promote optimal patient-provider interactions while improving oral health outcomes. Ensuring equity …

Assessment Of Ems Response And Hospital Arrival Times In Nebraska, Tina Vu

Capstone Experience: Master of Public Health

Timely EMS response and ground transport to the appropriate hospital are essential to patients’ survival and health outcomes during emergencies. This study utilizes interactive Geospatial Information System (GIS) mapping to assess emergency medical service (EMS) response and hospital arrival times in rural and urban Nebraska counties. The goal is to determine if there are underserved areas in the State and to propose potential interventions if identified. 2018 Social Vulnerability Index Scores (SVI) collected from Census Data were also reviewed for these areas to see possible correlations. The interactive GIS map revealed the Western and Central regions of Nebraska to be …

Overlaps And Gaps Of Preterm Birth Programs In The Triangle Area Of North Carolina, Amber Bobbitt

Capstone Experience: Master of Public Health

Background: Preterm birth rates are a long-standing issue that has yet to be adequately addressed and prioritized. Nationally about 1 in every 10 infants are born prematurely in the United States. In the state of North Carolina, 1 in every 9 live births was preterm in the year 2020. The aim of the study was to determine the strategies organizations use in North Carolina to reduce preterm births in comparison to the CDC’s Five Strategy framework and to understand how the organizations address health equity and measure/evaluate the success of their initiatives.

Methods: Semi-structured one-on-one interviews were conducted with four …

Analysis Of The Utilization Of Nebraska Medicine's Price Transparency Tool, Ingrid A. Olson

Capstone Experience: Master of Public Health

Healthcare costs have become a significant concern for patients, healthcare facilities, economists, and politicians within the United States. In an effort to understand and reduce health-related costs, price transparency laws were enacted at the beginning of 2021. Because of these new laws, hospitals must provide a price transparency tool for their patients. “Price transparency in healthcare makes pricing information more readily available, defines the value of services, and enables patients and other care purchasers to identify, compare, and choose providers that offer the desired level of value” (AAMC, 2022). However, research results on price transparency tools use and efficacy is …

Exploring Stakeholder Attitudes Towards Tobacco 21 Implementation, Enforcement, And Outcomes, Summer L. Woolsey

Capstone Experience: Master of Public Health

Objectives: This qualitative study seeks to assess the impact of the federal Tobacco 21 (T21) law by analyzing data collected from a nationwide sample of key tobacco control stakeholders towards the implementation, enforcement, and outcomes of the T21 law. Methods: A series of five focus groups were conducted in December 2021 with stakeholders (n=31) who were asked about T21 implementation and enforcement measures used in their own communities. Participating stakeholders included tobacco policy experts, tobacco evaluation experts, subject matter experts, and implementation personnel. Results: We conducted a thematic analysis of the data resulting in eight themes found under four broad …

The Differences In Mental Well-Being For Individuals With And Without Service Dogs, Katelyn Morales

Capstone Experience: Master of Public Health

Trained service dogs can be used for many tasks, but the growing literature focuses on the benefits of the psychosocial health and well-being of individuals experiencing depression or anxiety. This study analyzes the effects of service dogs on the mental well-being of individuals with a diagnosed disability who have depression or anxiety. This quasi-experimental design assesses the mental well-being of individuals who have a service dog compared to those who do not have a service dog. Mental well-being was measured using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) and focused on individuals with a service dog and diagnosed depression or anxiety …

Beyond The Plant: Facing Systemic Barriers As A Meatpacking Community During The Covid-19 Pandemic, Shannon Barrientos

Capstone Experience: Master of Public Health

The COVID-19 pandemic has revealed and magnified health disparities and social inequities that disproportionately burden racial and ethnic minorities. These disparities are readily seen within meatpacking communities, considering a lack of protections offered by the meatpacking industry have heightened COVID-19 susceptibility. These conditions have aggravated health inequities within rural communities throughout the span of the pandemic. Despite significant advances in research investigating the effect of COVID-19 on essential workers within the meatpacking plants, this research remains isolated within the meat processing industry. Moreover, research has focused predominantly on the pandemic’s impact on rural communities and the institutional barriers that hinder …

Trends Of Human Papilloma Virus- Related Cancers And Hpv Vaccination In Nebraska From 2010 To 2018, Christelle Massumbu

Capstone Experience: Master of Public Health

Background:

Approximately 46,143 human papillomaviruses (HPV) related cancers are diagnosed annually in the United States. Although the HPV vaccine has been available in the United States since 2006, more than half of adolescents have not completed the HPV vaccine series. In Nebraska, the incidence rates of HPV-related cancers have increased from 2006 (5.7%) to 2018 (6.3%). Although cervical cancer has been highly studied, there is limited research and surveillance on head and neck, vaginal, vulvar, anal, and penile cancers in a state such as Nebraska, which experiences limited access to healthcare in its rural areas. Clarity about these aspects could …

Disparities And Attitudes Toward Sars Cov2 Vaccine Among People With Disabilities, Ahmed A. Omar

Capstone Experience: Master of Public Health

The pandemic caused by SARSCOV2 that began in late 2019 posed a significant public health challenge for communities worldwide. The pandemic negatively impacted people's health, economy, and living conditions. Pharmaceutical companies worldwide have begun a race against time to invest in vaccine development to control and eliminate the worst outcomes of the COVID 19 associated disease. Scientific research resulted in several effective vaccines being developed and authorized for use in people (Salmeron Ríos S et al.).

Public health agencies like the Center for Disease Control and Prevention (CDC) prioritized high-risk populations for vaccination. This process is meant to accomplish the …

Effects Of Imu Sensor Location And Number On The Validity Of Vertical Acceleration Time-Series Data In Countermovement Jumping, Dianne Althouse

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Many devices are available for measuring the height of a CMJ. An inertial measurement unit (IMU) measures linear acceleration, orientation, and angular velocity. As an alternative to using IMU estimates of flight time, CMJ height could be estimated by integrating the IMU time-series signal for vertical acceleration to derive CMJ take-off velocity in order to track whole-body center of mass (WBCoM) movement, yet this approach would require valid IMU acceleration data. Thus, the purpose of this study was to quantify the effects of IMU sensor location and number on the validity of vertical acceleration estimation in CMJ. Thirty young adults …

Association Between Visuomotor Skills And The Effects Of Stroboscopic Vision On Depth Jump Performance, Riley Welch

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The reactive strength index (RSI) is a popularized method of evaluating depth jump performance. Performance in anticipation of ground impact is influenced by the proprioceptive, vestibular, and visuomotor systems through multisensory integration. The contribution of vision to depth jump performance has been studied through use of stroboscopic goggles, but no study has evaluated which visuomotor skills may be a predictor for DJ performance. The purpose of this investigation was to evaluate the association between visuomotor skills and the effects of stroboscopic vision on DJ performance. Participants consisted of 9 female and 13 male college aged adults. DJ performance was evaluated …

Mda At Your Service: Is It Too Late To File For An Employee Retention Tax Credit?, Eric Tye Dds, Angela Kanazeh Ms, Cmp

The Journal of the Michigan Dental Association

The Employee Retention Tax Credit (ERTC) remains available for businesses affected by COVID-19, allowing them to claim a tax credit of up to $26,000 per employee. Eligibility criteria include a mandated shutdown, revenue decrease, COVID-19 impact, or supply chain disruption. Even businesses with forgiven PPP loans can apply for ERTC. The credit covers 2020 and the first three quarters of 2021 and must be filed by December 31, 2023. Dental Business Specialists can assist with ERTC filings. Changing your name upon marriage as a licensed professional, obtaining labor employment posters, and reducing credit card processing fees through MDA-endorsed programs are …

J Mich Dent Assoc August 2022

The Journal of the Michigan Dental Association

Monthly, The Journal of the Michigan Dental Association brings news, information, and feature articles to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists! In this August 2022 issue, the reader will find the following original content:

• A cover story on choosing to partner with a Dental Service Organization (DSO)
• A conversation with three dentists on how and why they are involved with organized dentistry.
• A 10-Minute EBD on the efficacy of vacuum-formed removable orthodontic retainers
• News you need, an Editorial, a report from our ADA Trustee and regular department articles, Dentistry and …

Ada Trustee Report: Does The Ada Have A Long-Term Vision For Oral Health In America?, Michele Tulak-Gorecki Dds

The Journal of the Michigan Dental Association

This trustee report discusses the need for a long-term vision for oral health in America within the context of changing trends in dentistry. It highlights key questions related to evolving member value propositions, improving insurance coverage, expanding collaboration with primary care providers, and establishing dentistry as an essential part of the primary care system. A Board workgroup has been formed to explore potential actions and recommendations. The report underscores the importance of addressing these challenges. It encourages the dental profession to have meaningful conversations and work together to shape a future that aligns with new generations' evolving needs and expectations.

Implications Of The Dunning-Kruger Effect: Finding Balance Between Subjective And Objective Assessment In Debriefing Professional Development, Cynthia Sherraden Bradley, Kristina Dreifuerst, Anne Loomis, Brandon Kyle Johnson, Aimee A. Woda, Jamie Hansen

College of Nursing Faculty Research and Publications

Background

The ability to debrief is considered an essential clinical and simulation teaching skill because of the deep learning cultivated. Regulatory bodies identify the need for debriefing training and professional development followed by formative and summative assessment.

Method

The Debriefing for Meaningful Learning Evaluation Scale (DMLES) is a behaviorally anchored rating scale developed to assess 20 behaviors aligned with Debriefing for Meaningful Learning (DML). Participants from five baccalaureate pre–licensure nursing programs were recruited to receive DML training, then facilitate and record a debriefing for subjective and objective assessment using the DMLES.

Results

A total of 52 debriefers submitted 81 recorded …

Examining Social Determinants Of Health And Cervical Cancer Risk And Outcomes In Ecuadorian Women, Pooja Tewari

Open Access Theses & Dissertations

Background and Significance: The burden of cervical cancer in the Latin American region is high. The crude incidence rate and the crude mortality rate in Ecuador are significantly higher than that of South America and the World. Riobamba, Ecuador, where the Fundación Internacional Buen Samaritano Paul Martel (FIBUSPAM) hospital is located, has been found to be one of the cities most affected with cervical cancer in the country. Risk factors for cervical cancer that have been identified in Latin American women include chronological age, age of first sexual intercourse, number of sexual partners, number of pregnancies, use of oral contraceptives, …

From Nepantla To Aztlan: Testimonios Of Faculty Mothers Of Color With Disabilities, Maria Bridges

Theses and Dissertations

From Nepantla to Aztlan: This dissertation sheds light on the supports and barriers that tenured/tenure-track Faculty Mothers of Color with Disabilities experience/d in their careers as students and faculty. Drawing from Indigenous methodologies (Relationality, Decoloniality, and Autoethnography), Liberation Psychology (Decolonial Designs, Conscientização, and Psicología social de la liberación), and Critical Theories (Latina Critical Theory, Pedagogies of the Home, Autohistoria-teoría and Disability Critical Theory), the researcher uses testimonios/pláticas as a method of inquiry to uncover the experiences of eight Nepantleras, Faculty Mothers of Color with Disabilities. The researcher initially hypothesized that she would find supports and barriers that fell into 4 …

Running For Office 101, William Sullivan Jd

The Journal of the Michigan Dental Association

The pull-out section presents the MDA resources and support available from the MDA for members considering public service. It discusses the importance of having dentists in the Michigan Legislature and provides a guide to encourage dentists to run for public office. Running for public office is a significant decision, and the guide "Running for Office 101," offers information and insights for potential candidates.

Three New Dentists Talk About ‘Getting Involved’, Gabriel Holdwick Dds

The Journal of the Michigan Dental Association

Three new dentists discuss their involvement in organized dentistry and its impact on their professional growth. Dr. Sarah Tomaka and Dr. Danny Miller share their experiences with the Michigan Dental Association (MDA) and their engagement with various committees. They explain how these leadership roles have provided them with expanded networks, personal growth, and a platform to influence the dental profession. They emphasize that getting involved with MDA leadership is highly rewarding and encourage others to participate, suggesting the MDA's Leadership Exploration And Development (LEAD) program as a starting point. The article also provides information on ways to get involved with …

10-Minute Ebd: Can A Vacuum-Formed Retainer Replace A Bonded Orthodontic Retainer?, Joshua Dickie

The Journal of the Michigan Dental Association

The Ten-Minute Evidence-Based Dentistry Column illustrates how to implement the evidence-based dentistry search process to quickly identify and apply the best literature to answer a clinical question. Through critical appraisal, the author of this article answers the clinical question of the effectiveness of vacuum-formed retainers (VFRs) compared to bonded orthodontic retainers in maintaining tooth positioning and promoting oral hygiene. The study reviews existing literature and highlights the challenges in evaluating the two types of retainers, primarily due to patient compliance with VFRs. While some studies suggest that bonded retainers provide better short-term retention, the choice between retainers depends on various …

Chondronecrosis With Osteomyelitis In Broilers: Bacterial Species Involvement And Influence Of Probiotics And Synbiotics, Amer Abdullah Hasan

Graduate Theses and Dissertations

Since 1945, the market for broiler production has evolved from a collection of smallholder poultry farms into an industry worth billions of dollars. Poultry production has not gone without challenges. Lameness in young broilers is presently a serious issue in the poultry industry for reasons of animal health and welfare, as well as significant lost production and revenue. Bacterial chondronecrosis with osteomyelitis (BCO) is a major form of lameness in broilers. This dissertation contains information about (i) the influence of Staphylococcus agnetis, Staphylococcus saprophyticus, Staphylococcus epidermidis and Enterococcus faecalis on inducing BCO lameness, (ii) evaluation of of probiotics for reducing …

Intestinal Microbiota Analysis Of Broiler Chickens Under Necrotic Enteritis Challenge And Tributyrin Supplementation, Taylor Nicole Mckinney

Graduate Theses and Dissertations

Poultry is a staple protein source for most of the planet. Until recently, antibiotic growth promoters (AGPs) were used to prevent illnesses in commercial chicken production. Currently, this is not possible due to regulations and consumer concern, but without such a preventative, diseases like necrotic enteritis (NE) have reemerged, posing a threat to bird health, and ultimately, our food source. Necrotic enteritis is a severe gastrointestinal disease caused by the gram-positive pathogen, Clostridium perfringens. Clinical features of this disease are diarrhea, intestinal lesions, and death, with a high transmission rate. In a subclinical form, growth performance is diminished and is …

The Child In The Basement: Debilitating Mechanisms In American Science Fiction, Tessa Swehla

Graduate Theses and Dissertations

This project examines the tension between progressive narratives about the future that often frame disability as a medical condition with no place in the future and deliberate debilitation of certain populations for the sake of commodification. These two ideas would seem in conflict with one another, but together, they form a strategy of control. Using the interconnected discourses of medicine and US science fiction, this project synthesizes ideas from debility and disability theory, posthuman studies, medical humanities, and computer science and programming to demonstrate how these two ideas coexist. Each section includes an interchapter that introduces the key idea and …

An Evaluation Of The Convergent Construct Validity Of The Boldness Inventory Of Psychopathy Using A Five-Minute, 10% Carbon-Dioxide-Enriched Air Challenge, Morgan Alexandra Hill

Graduate Theses and Dissertations

Psychopathy is a constellation of maladaptive interpersonal, affective, and behavioral features, including grandiosity, manipulativeness, emotional detachment, and impulsivity (Hare, 2003). Fearlessness, immunity to stress, self-assurance, and social dominance are considered to be adaptive features of psychopathy. Patrick and colleagues (2009) sought to reconcile differences between opposing conceptualizations of psychopathy by formulating a triarchic model of the condition. One core construct in this model, boldness, captures an ability to remain calm in the face of threat, an appetite for dangerous or risky activities, and an increased tolerance for uncertainty and danger. Boldness is believed to originate from differences in the brain’s …